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Dry eye-related examinations and questionnaires were obtained from all participants. The levels of nine inflammatory molecules were determined through multiplex bead analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inflammatory molecules including ICAM-1, IFN-\u03b3, CXCL8\/IL-8, IL-6, TNF-\u03b1 and IL-12p70 were detected in 100% of the patients, while IL-1\u03b1, IL-1\u03b2 and IL-10 were detected in 56.25%, 13.60% and 45.83% of the patients, respectively. Moreover, ICAM-1, IL-8, IL-6, TNF-\u03b1, IL-12p70 and IFN-\u03b3 were detected in 86.67\u2013100% of the healthy subjects, and the detection rates of IL-10, IL-1\u03b1 and IL-1\u03b2 were below 50%. The levels of IL-8, IL-6, IFN-\u03b3 and ICAM-1 were significantly higher in the patient group compared with the control group. In addition, IL-8 and IL-6 were negatively correlated with Schirmer I test. Besides, IFN-\u03b3 was negatively correlated with tear film breakup time. Furthermore, ICAM-1 and IL-6 were positively correlated with meibography score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Collectively, patients with MGD-related EDE had higher levels of inflammatory molecules in their tears, and some molecules were correlated with ocular surface parameters. These findings suggested that inflammation played an important role in MGD-related EDE, and several inflammatory molecules could be used in the diagnosis and the treatment of MGD-related EDE.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s10792-020-01489-z","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T19:02:32Z","timestamp":1593457352000},"page":"3049-3058","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Analysis of tear inflammatory molecules and clinical correlations in evaporative dry eye disease caused by meibomian gland dysfunction"],"prefix":"10.1007","volume":"40","author":[{"given":"Xingdi","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenqi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6277-7136","authenticated-orcid":false,"given":"Wen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"issue":"Suppl 2","key":"1489_CR1","doi-asserted-by":"publisher","first-page":"S199","DOI":"10.1016\/S0039-6257(00)00202-2","volume":"45","author":"H Brewitt","year":"2001","unstructured":"Brewitt H, Sistani F (2001) Dry eye disease: the scale of the problem. 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