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We evaluated the parameters variables including Standard Patient Evaluation of Eye Dryness (SPEED), Ocular Surface Disease Index (OSDI), Schirmer I test (SIT), noninvasive keratographic breakup time (NIKBUT), tear meniscus height (TMH), and lipid layer thickness (LLT), partial blink rate (PBR), meibomian gland loss, meibomian gland morphology with LipiView\u00ae. Meibomian gland expressibility and secretion quality were evaluated for OMGD subjects. All the results were recorded pre-therapy and 4\u00a0weeks, 8\u00a0weeks, 12\u00a0weeks post-therapy.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>SPEED, OSDI, and PB decreased, meanwhile, NIKBUT, TMH, SIT, and LLT increased compared with baseline in both groups after treatment (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), whereas the magnitude of the improvement in the OMGD group was greater than that in the HMGD group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). There was no significant posttreatment structural meibomian gland change in both groups. The meibomian gland expressibility and secretion quality score increased after treatment in the OMGD group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The Meibomian Thermal Pulsation LipiFlow\u00ae is effective for both obstructive and hyposecretory meibomian gland dysfunction and the therapeutic effect on obstructive meibomian gland dysfunction is greater than that on hyposecretory meibomian gland dysfunction.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s10792-020-01533-y","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T15:02:36Z","timestamp":1596294156000},"page":"3469-3479","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of the therapeutic effect of Meibomian Thermal Pulsation LipiFlow\u00ae on obstructive and hyposecretory meibomian gland dysfunction patients"],"prefix":"10.1007","volume":"40","author":[{"given":"Bowen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxue","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8364-1617","authenticated-orcid":false,"given":"Mei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,1]]},"reference":[{"issue":"4","key":"1533_CR1","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1167\/iovs.10-6997b","volume":"52","author":"NJ Daniel","year":"2011","unstructured":"Daniel NJ, Jun S, Benitez-Del-Castillo JM et al (2011) The international workshop on meibomian gland dysfunction: report of the definition and classification subcommittee meibomian gland dysfunction. 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