{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T06:52:20Z","timestamp":1779000740774,"version":"3.51.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s10792-021-01787-0","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T17:03:48Z","timestamp":1615914228000},"page":"2339-2346","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of the retinal and choroidal microvascularization in polycystic ovary syndrome: an optical coherence tomography angiography study"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4424-2215","authenticated-orcid":false,"given":"Ozge Pinar","family":"Akarsu Acar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin","family":"Cengiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail Umut","family":"Onur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya Ece","family":"Iliman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel","family":"Zirtiloglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadime Ulviye","family":"Yigit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"1787_CR1","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","volume":"370","author":"RJ Norman","year":"2007","unstructured":"Norman RJ, Dewailly D, Legro RS, Hickey TE (2007) Polycystic ovary syndrome. Lancet 370:685\u2013697","journal-title":"Lancet"},{"key":"1787_CR2","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1056\/NEJMra041536","volume":"352","author":"DA Ehrmann","year":"2005","unstructured":"Ehrmann DA (2005) Polycystic ovary syndrome. NEngl J Med 352:1223\u20131236","journal-title":"NEngl J Med"},{"key":"1787_CR3","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1007\/BF03350785","volume":"21","author":"JE Hall","year":"1998","unstructured":"Hall JE, Taylor AE, Hayes FJ, JrWF C (1998) Insights into hypothalamic pituitary dysfunction in polycystic ovary syndrome. J Endocrinol Invest 21:602\u2013611","journal-title":"J Endocrinol Invest"},{"issue":"4","key":"1787_CR4","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.rbmo.2010.01.007","volume":"20","author":"P Peitsidis","year":"2010","unstructured":"Peitsidis P, Agrawal R (2010) Role of vascular endothelial growth factor in women with PCO and PCOS: a systematic review. Reprod Biomed Online 20(4):444\u2013452","journal-title":"Reprod Biomed Online"},{"issue":"3","key":"1787_CR5","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1684\/ecn.2011.0289","volume":"22","author":"HH Al-Habboubi","year":"2011","unstructured":"Al-Habboubi HH, Sater MS, Almawi AW, Al-Khateeb GM, Almawi WY (2011) Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population. Eur Cytokine Netw 22(3):154\u2013158","journal-title":"Eur Cytokine Netw"},{"key":"1787_CR6","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/S0024-3205(98)00367-1","volume":"63","author":"D Thompson","year":"1998","unstructured":"Thompson D, Othman M, Lei Z, Li X, Huang Z-H, Eadie D et al (1998) Localization of receptors for luteinizing hormone\/chorionic gonadotropin in neural retina. Life Sci 63:1057\u20131064","journal-title":"Life Sci"},{"issue":"9","key":"1787_CR7","first-page":"1906","volume":"40","author":"SB Ogueta","year":"1999","unstructured":"Ogueta SB, Schwartz SD, Yamashita CK, Farber DB (1999) Estrogen receptor in the human eye: influence of gender and age on gene expression. Invest Ophthalmol Vis Sci 40(9):1906\u20131911","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"1787_CR8","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1034\/j.1600-0420.2000.078002146.x","volume":"78","author":"LA Wickham","year":"2000","unstructured":"Wickham LA, Gao J, Toda I, Rocha EM, Ono M, Sullivan DA (2000) Identification of androgen, estrogen and progesterone receptor mRNAs in the eye. Acta Ophthalmol Scand 78(2):146\u2013153","journal-title":"Acta Ophthalmol Scand"},{"issue":"7","key":"1787_CR9","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1136\/bjo.85.7.877","volume":"85","author":"C Munaut","year":"2001","unstructured":"Munaut C, Lambert V, Noel A, Frankenne F, Deprez M, Foidart JM et al (2001) Presence of oestrogen receptor type beta in human retina. Br J Ophthalmol 85(7):877\u2013882","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"1787_CR10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1167\/iovs.01-1276","volume":"44","author":"ME Marin-Castano","year":"2003","unstructured":"Marin-Castano ME, Elliot SJ, Potier M, Karl M, Striker LJ, Striker GE et al (2003) Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium. Invest Ophthalmol Vis Sci 44(1):50\u201359","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1787_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2018.05.049","volume":"385","author":"TZ Movsas","year":"2018","unstructured":"Movsas TZ, Wong KY, Ober MD, Sigler R, Lei ZM, Muthusamy A (2018) Confirmation of luteinizing hormone (LH) in living human vitreous and the effect of LH receptor reduction on murine electroretinogram. Neuroscience 385:1\u201310","journal-title":"Neuroscience"},{"issue":"10","key":"1787_CR12","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1080\/02713683.2018.1495740","volume":"43","author":"TZ Movsas","year":"2018","unstructured":"Movsas TZ, Sigler R, Muthusamy A (2018) Elimination of signaling by the luteinizing hormone receptor reduces ocular VEGF and retinal vascularization during mouse eye development. Curr Eye Res 43(10):1286\u20131289","journal-title":"Curr Eye Res"},{"issue":"8","key":"1787_CR13","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1080\/02713683.2018.1467932","volume":"43","author":"TZ Movsas","year":"2018","unstructured":"Movsas TZ, Sigler R, Muthusamy A (2018) Vitreous levels of Luteinizing Hormone and VEGF are strongly correlated in healthy mammalian eyes. Curr Eye Res 43(8):1041\u20131044","journal-title":"Curr Eye Res"},{"issue":"4","key":"1787_CR14","doi-asserted-by":"publisher","first-page":"4710","DOI":"10.1364\/OE.20.004710","volume":"20","author":"Y Jia","year":"2012","unstructured":"Jia Y, Tan O, Tokayer J, Potsaid B, Wang Y, Liu JJ et al (2012) Split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Opt Express 20(4):4710\u20134725","journal-title":"Opt Express"},{"key":"1787_CR15","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.phrs.2015.11.027","volume":"103","author":"M Amadio","year":"2016","unstructured":"Amadio M, Govoni S, Pascale A (2016) Targeting VEGF in eye neovascularization: What\u2019s new? A comprehensive review on current therapies and oligonucleotide-based interventions under development. Pharmacol Res 103:253\u2013269","journal-title":"Pharmacol Res"},{"issue":"2","key":"1787_CR16","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.survophthal.2010.08.006","volume":"56","author":"M Tolentino","year":"2011","unstructured":"Tolentino M (2011) Systemic and ocular safety of intravitreal anti-VEGF therapies for ocular neovascular disease. Surv Ophthalmol 56(2):95\u2013113","journal-title":"Surv Ophthalmol"},{"key":"1787_CR17","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3389\/fendo.2018.00066","volume":"9","author":"R Nuzzi","year":"2018","unstructured":"Nuzzi R, Scalabrin S, Becco A, Panzica G (2018) Gonadal hormones and retinal disorders: a review. Front Endocrinol 9:66","journal-title":"Front Endocrinol"},{"issue":"6","key":"1787_CR18","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1111\/j.1395-3907.2003.00160.x","volume":"81","author":"E Toker","year":"2003","unstructured":"Toker E, Yenice O, Akpinar I, Aribal E, Kazakoglu H (2003) The influence of sex hormones on ocular blood flow in women. Acta Ophthalmol Scand 81(6):617\u2013624","journal-title":"Acta Ophthalmol Scand"},{"issue":"7","key":"1787_CR19","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1111\/jog.12673","volume":"41","author":"N Ornek","year":"2015","unstructured":"Ornek N, Inal M, Tulmac OB, Ozcan Dag Z, Ornek K (2015) Ocular blood flow in polycystic ovary syndrome. J Obstet Gynaecol Res 41(7):1080\u20131086","journal-title":"J Obstet Gynaecol Res"},{"issue":"5","key":"1787_CR20","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1016\/j.fertnstert.2014.08.001","volume":"102","author":"NM Daan","year":"2014","unstructured":"Daan NM, Louwers YV, Koster MP, Eijkemans MJ, de Rijke YB, Lentjes EW et al (2014) Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk? Fertil Steril 102(5):1444\u20131451","journal-title":"Fertil Steril"},{"issue":"8","key":"1787_CR21","doi-asserted-by":"publisher","first-page":"599","DOI":"10.3109\/00016349209006227","volume":"71","author":"E Dahlgren","year":"1992","unstructured":"Dahlgren E, Janson P, Johansson S, Lapidus L, Oden A (1992) Polycystic ovary syndrome and risk for myocardial infarction: evaluated from a risk factor model based on a prospective population study of women. Acta Obstet Gynecol Scand 71(8):599\u2013604","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"11","key":"1787_CR22","doi-asserted-by":"publisher","first-page":"5592","DOI":"10.1210\/jc.2004-0751","volume":"89","author":"I Tarkun","year":"2004","unstructured":"Tarkun I, Arslan BC, Canturk Z, Turemen\u015eah\u00ecn ET, Duman C (2004) Endothelial dysfunction in young women with polycystic ovary syndrome: relationship with insulin resistance and low-grade chronic inflammation. J Clin Endocrinol Metabol 89(11):5592\u20135596","journal-title":"J Clin Endocrinol Metabol"},{"key":"1787_CR23","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1152\/ajpendo.00343.2013","volume":"305","author":"MM Wenner","year":"2013","unstructured":"Wenner MM, Taylor HS, Stachenfeld NS (2013) Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors. Am J Physiol Endocrinol Metab 305:818\u2013825","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"8","key":"1787_CR24","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1177\/1933719114522523","volume":"21","author":"G Acmaz","year":"2014","unstructured":"Acmaz G, Atas M, Gulhan A, Acmaz B, Atas F, Aksoy H (2014) Evaluation of the macula, retinal nerve fiber layer, and choroid thickness in women with polycystic ovary syndrome using spectral-domain optical coherence tomography. Reprod Sci 21(8):1044\u20131049","journal-title":"Reprod Sci"},{"issue":"6","key":"1787_CR25","doi-asserted-by":"publisher","first-page":"684","DOI":"10.3928\/23258160-20150610-16","volume":"46","author":"MT Witmer","year":"2015","unstructured":"Witmer MT, Klufas MA, Kiss S (2015) Polycystic ovary syndrome and central serous chorioretinopathy. Ophthalmic Surg Lasers Imag Retina 46(6):684\u2013686","journal-title":"Ophthalmic Surg Lasers Imag Retina"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-021-01787-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-021-01787-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-021-01787-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T13:03:35Z","timestamp":1624885415000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-021-01787-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,16]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["1787"],"URL":"https:\/\/doi.org\/10.1007\/s10792-021-01787-0","relation":{},"ISSN":["0165-5701","1573-2630"],"issn-type":[{"value":"0165-5701","type":"print"},{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,16]]},"assertion":[{"value":"5 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no any competing financial interests in relation to the work described.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Additional informed consent was obtained from all individual participants for whom identifying information is included in this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of the Bakirkoy Dr Sadi Konuk Training and Research Hospital (Approval Number: 2019\/288).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}