{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:35:30Z","timestamp":1773282930630,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s10792-021-01814-0","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T17:05:00Z","timestamp":1616605500000},"page":"2555-2563","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Can dynamic and static pupillary responses be used as an indicator of autonomic dysfunction in patients with obstructive sleep apnea syndrome?"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-1293","authenticated-orcid":false,"given":"Seyfettin","family":"Erdem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sureyya","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mine","family":"Karahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Emin","family":"Dursun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sedat","family":"Ava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Fuat","family":"Alakus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Keklikci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"issue":"2","key":"1814_CR1","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/s11325-014-1051-4","volume":"19","author":"OK Basoglu","year":"2015","unstructured":"Basoglu OK, Vardar R, Tasbakan MS et al (2015) Obstructive sleep apnea syndrome and gastroesophageal reflux disease: the importance of obesity and gender. Sleep Breath 19(2):585\u2013592","journal-title":"Sleep Breath"},{"issue":"1","key":"1814_CR2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1152\/physrev.00043.2008","volume":"90","author":"JA Dempsey","year":"2010","unstructured":"Dempsey JA, Veasey SC, Morgan BJ et al (2010) Pathophysiology of sleep apnea. Physiol Rev 90(1):47\u2013112","journal-title":"Physiol Rev"},{"issue":"9657","key":"1814_CR3","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/S0140-6736(08)61622-0","volume":"373","author":"TD Bradley","year":"2009","unstructured":"Bradley TD, Floras JS (2009) Obstructive sleep apnoea and its cardiovascular consequences. Lancet 373(9657):82\u201393","journal-title":"Lancet"},{"issue":"10","key":"1814_CR4","doi-asserted-by":"publisher","first-page":"e022752","DOI":"10.1136\/bmjopen-2018-022752","volume":"8","author":"S Strausz","year":"2018","unstructured":"Strausz S, Havulinna AS, Tuomi T et al (2018) Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes: A longitudinal population-based study in Finland. BMJ Open 8(10):e022752","journal-title":"BMJ Open"},{"issue":"19","key":"1814_CR5","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1161\/CIRCULATIONAHA.117.029400","volume":"136","author":"LF Drager","year":"2017","unstructured":"Drager LF, McEvoy RD, Barbe F et al (2017) Sleep apnea and cardiovascular disease: Lessons from recent trials and need for team science. Circulation 136(19):1840\u20131850","journal-title":"Circulation"},{"issue":"9","key":"1814_CR6","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1016\/S0735-1097(03)00184-0","volume":"41","author":"JDL Lattimore","year":"2003","unstructured":"Lattimore JDL, Celermajer DS, Wilcox I (2003) Obstructive sleep apnea and cardiovascular disease. J Am Coll Cardiol 41(9):1429\u20131437","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"1814_CR7","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1097\/MLG.0b013e318123ee56","volume":"117","author":"RB Mitchell","year":"2007","unstructured":"Mitchell RB (2007) Adenotonsillectomy for obstructive sleep apnea in children: outcome evaluated by pre- and postoperative polysomnography. Laryngoscope 117(10):1844\u20131854","journal-title":"Laryngoscope"},{"issue":"8","key":"1814_CR8","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1001\/archinte.162.8.893","volume":"162","author":"T Young","year":"2002","unstructured":"Young T, Shahar E, Nieto FJ et al (2002) Predictors of sleep-disordered breathing in community-dwelling adults: The Sleep Heart Health Study. Arch Intern Med 162(8):893\u2013900","journal-title":"Arch Intern Med"},{"issue":"5","key":"1814_CR9","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1093\/sleep\/22.5.667","volume":"22","author":"WW Flemons","year":"1999","unstructured":"Flemons WW, Buysse D, Redline S et al (1999) Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep 22(5):667\u2013689","journal-title":"Sleep"},{"issue":"6","key":"1814_CR10","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1378\/chest.103.6.1763","volume":"103","author":"JT Carlson","year":"1993","unstructured":"Carlson JT, Hedner J, Elam M et al (1993) Augmented resting sympathetic activity in awake patients with obstructive sleep apnea. Chest 103(6):1763\u20131768","journal-title":"Chest"},{"issue":"4","key":"1814_CR11","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1172\/JCI118235","volume":"96","author":"VK Somers","year":"1995","unstructured":"Somers VK, Dyken ME, Clary MP et al (1995) Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96(4):1897\u20131904","journal-title":"J Clin Invest"},{"issue":"3","key":"1814_CR12","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1046\/j.1365-201X.2003.01091.x","volume":"177","author":"K Narkiewicz","year":"2003","unstructured":"Narkiewicz K, Somers VK (2003) Sympathetic nerve activity in obstructive sleep apnoea. Acta Physiol Scand 177(3):385\u2013390","journal-title":"Acta Physiol Scand"},{"issue":"5","key":"1814_CR13","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1046\/j.1365-2281.2000.00259.x","volume":"20","author":"F Fotiou","year":"2000","unstructured":"Fotiou F, Fountoulakis KN, Goulas A et al (2000) Automated standardized pupillometry with optical method for purposes of clinical practice and research. Clin Physiol 20(5):336\u2013347","journal-title":"Clin Physiol"},{"issue":"1","key":"1814_CR14","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/01376517-200502000-00006","volume":"37","author":"M Meeker","year":"2005","unstructured":"Meeker M, Du R, Bacchetti P et al (2005) Pupil examination: validity and clinical utility of an automated pupillometer. J Neurosci Nurs 37(1):34\u201340","journal-title":"J Neurosci Nurs"},{"issue":"11","key":"1814_CR15","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1080\/02699052.2016.1192220","volume":"30","author":"JQ Truong","year":"2016","unstructured":"Truong JQ, Ciuffreda KJ (2016) Quantifying pupillary asymmetry through objective binocular pupillometry in the normal and mild traumatic brain injury (mTBI) populations. Brain Inj 30(11):1372\u20131377","journal-title":"Brain Inj"},{"issue":"1","key":"1814_CR16","doi-asserted-by":"publisher","first-page":"33373","DOI":"10.1038\/srep33373","volume":"6","author":"P Adhikari","year":"2016","unstructured":"Adhikari P, Zele AJ, Thomas R et al (2016) Quadrant field pupillometry detects melanopsin dysfunction in glaucoma suspects and early glaucoma. Sci Rep 6(1):33373","journal-title":"Sci Rep"},{"issue":"2","key":"1814_CR17","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.ophtha.2010.06.033","volume":"118","author":"R Kardon","year":"2011","unstructured":"Kardon R, Anderson SC, Damarjian TG et al (2011) Chromatic pupillometry in patients with retinitis pigmentosa. Ophthalmology 118(2):376\u2013381","journal-title":"Ophthalmology"},{"issue":"4","key":"1814_CR18","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.jcrc.2014.01.012","volume":"29","author":"SF Zafar","year":"2014","unstructured":"Zafar SF, Suarez JI (2014) Automated pupillometer for monitoring the critically ill patient: a critical appraisal. J Crit Care 29(4):599\u2013603","journal-title":"J Crit Care"},{"issue":"8","key":"1814_CR19","doi-asserted-by":"publisher","first-page":"789","DOI":"10.3928\/1081-597X-20071001-08","volume":"23","author":"YT Hsieh","year":"2007","unstructured":"Hsieh YT, Hu FR (2007) The correlation of pupil size measured by colvard pupillometer and orbscan II. J Refract Surg 23(8):789\u2013795","journal-title":"J Refract Surg"},{"issue":"10","key":"1814_CR20","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1093\/sleep\/33.10.1349","volume":"33","author":"M Montesano","year":"2010","unstructured":"Montesano M, Miano S, Paolino MC et al (2010) Autonomic cardiovascular tests in children with obstructive sleep apnea syndrome. Sleep 33(10):1349\u20131355","journal-title":"Sleep"},{"key":"1814_CR21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/B978-0-444-52902-2.00007-2","volume":"115","author":"R Freeman","year":"2013","unstructured":"Freeman R, Chapleau MW (2013) Testing the autonomic nervous system. Handb Clin Neurol 115:115\u2013136","journal-title":"Handb Clin Neurol"},{"issue":"6","key":"1814_CR22","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.2337\/diacare.24.6.1093","volume":"24","author":"M Nakayama","year":"2001","unstructured":"Nakayama M, Nakamura J, Hamada Y et al (2001) Aldose reductase inhibition ameliorates pupillary light reflex and F-wave latency in patients with mild diabetic neuropathy. Diabetes Care 24(6):1093\u20131098","journal-title":"Diabetes Care"},{"issue":"3","key":"1814_CR23","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1046\/j.1463-1326.1999.00025.x","volume":"1","author":"PG McNally","year":"1999","unstructured":"McNally PG, Lawrence IG, Panerai RB et al (1999) Sudden death in type 1 diabetes. Diabetes Obes Metab 1(3):151\u2013158","journal-title":"Diabetes Obes Metab"},{"issue":"2","key":"1814_CR24","doi-asserted-by":"publisher","first-page":"313","DOI":"10.2337\/diab.43.2.313","volume":"43","author":"P Reichard","year":"1994","unstructured":"Reichard P, Pihl M (1994) Mortality and treatment side-effects during long-term intensified conventional insulin treatment in the Stockholm Diabetes Intervention Study. Diabetes 43(2):313\u2013317","journal-title":"Diabetes"},{"issue":"9","key":"1814_CR25","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1111\/j.1464-5491.1989.tb01278.x","volume":"6","author":"CF Clarke","year":"1989","unstructured":"Clarke CF, Piesowicz AT, Spathis GS (1989) Pupillary size in children and adolescents with type 1 diabetes. Diabet Med 6(9):780\u2013783","journal-title":"Diabet Med"},{"issue":"6","key":"1814_CR26","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/s11892-006-0074-z","volume":"6","author":"AI Vinik","year":"2006","unstructured":"Vinik AI, Erbas T (2006) Cardiovascular autonomic neuropathy: diagnosis and management. Curr Diab Rep 6(6):424\u2013430","journal-title":"Curr Diab Rep"},{"issue":"10","key":"1814_CR27","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1111\/j.1464-5491.1995.tb00388.x","volume":"12","author":"KC Donaghue","year":"1995","unstructured":"Donaghue KC, Pena MM, Fung ATW et al (1995) The prospective assessment of autonomic nerve function by pupillometry in adolescents with type 1 diabetes mellitus. Diabet Med 12(10):868\u2013873","journal-title":"Diabet Med"},{"issue":"6","key":"1814_CR28","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.mehy.2003.11.014","volume":"62","author":"AJ Yun","year":"2004","unstructured":"Yun AJ, Lee PY, Bazar KA (2004) Autonomic dysregulation as a basis of cardiovascular, endocrine, and inflammatory disturbances associated with obstructive sleep apnea and other conditions of chronic hypoxia, hypercapnia, and acidosis. Med Hypotheses 62(6):852\u2013856","journal-title":"Med Hypotheses"},{"issue":"5","key":"1814_CR29","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.sleep.2005.03.014","volume":"6","author":"C Guilleminault","year":"2005","unstructured":"Guilleminault C, Poyares D, Rosa A et al (2005) Heart rate variability, sympathetic and vagal balance and EEG arousals in upper airway resistance and mild obstructive sleep apnea syndromes. Sleep Med 6(5):451\u2013457","journal-title":"Sleep Med"},{"issue":"9","key":"1814_CR30","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.2337\/diacare.25.9.1545","volume":"25","author":"D Pittasch","year":"2002","unstructured":"Pittasch D, Lobmann R, Behrens-Baumann W et al (2002) Pupil signs of sympathetic autonomic neuropathy in patients with type 1 diabetes. Diabetes Care 25(9):1545\u20131550","journal-title":"Diabetes Care"},{"key":"1814_CR31","first-page":"379","volume":"5","author":"BSI Katz","year":"1992","unstructured":"Katz BSI (1992) Pupillary changes of diabetic eye. Ophthalmol Clin North Am 5:379\u2013388","journal-title":"Ophthalmol Clin North Am"},{"issue":"2","key":"1814_CR32","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1136\/bjo.67.2.89","volume":"67","author":"SA Smith","year":"1983","unstructured":"Smith SA, Smith SE (1983) Evidence for a neuropathic aetiology in the small pupil of diabetes mellitus. Br J Ophthalmol 67(2):89\u201393","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"1814_CR33","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1093\/sleep\/28.6.747","volume":"28","author":"LM O\u2019Brien","year":"2005","unstructured":"O\u2019Brien LM, Gozal D (2005) Autonomic dysfunction in children with sleep-disordered breathing. Sleep 28(6):747\u2013752","journal-title":"Sleep"},{"issue":"2","key":"1814_CR34","first-page":"139","volume":"32","author":"A Monaco","year":"2014","unstructured":"Monaco A, Cattaneo R, Mesin L et al (2014) Evaluation of autonomic nervous system in sleep apnea patients using pupillometry under occlusal stress: a pilot study. Cranio J Craniomandib Pract 32(2):139\u2013147","journal-title":"Cranio J Craniomandib Pract"},{"issue":"10","key":"1814_CR35","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.sleep.2015.06.001","volume":"16","author":"MF Philby","year":"2015","unstructured":"Philby MF, Aydinoz S, Gozal D et al (2015) Pupillometric findings in children with obstructive sleep apnea. Sleep Med 16(10):1187\u20131191","journal-title":"Sleep Med"},{"issue":"2","key":"1814_CR36","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.pediatrneurol.2014.05.003","volume":"51","author":"K Chaidas","year":"2014","unstructured":"Chaidas K, Tsaoussoglou M, Theodorou E et al (2014) Poincar\u00e9 plot width, morning urine norepinephrine levels, and autonomic imbalance in children with obstructive sleep Apnea. Pediatr Neurol 51(2):246\u2013251","journal-title":"Pediatr Neurol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-021-01814-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-021-01814-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-021-01814-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T13:05:18Z","timestamp":1624885518000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-021-01814-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,24]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["1814"],"URL":"https:\/\/doi.org\/10.1007\/s10792-021-01814-0","relation":{},"ISSN":["0165-5701","1573-2630"],"issn-type":[{"value":"0165-5701","type":"print"},{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,24]]},"assertion":[{"value":"5 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers\u2019 bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent\u2013licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.<b>Informed consent<\/b> Written informed consent was obtained from the participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}