{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T12:38:43Z","timestamp":1751459923516,"version":"3.37.3"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s10792-021-01839-5","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T07:02:56Z","timestamp":1617606176000},"page":"2827-2835","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Topographic and specular microscopic evaluation of cornea and meibomian gland morphology in children with isolated growth hormone deficiency"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-5546","authenticated-orcid":false,"given":"\u00d6zlem","family":"Kara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamze","family":"Dereli Can","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,5]]},"reference":[{"key":"1839_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0168-9525(02)02696-3","volume":"18","author":"CS Carter","year":"2002","unstructured":"Carter CS, Ramsey MM, Sonntag WE (2002) A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends Genet 18:295\u2013301","journal-title":"Trends Genet"},{"key":"1839_CR2","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1242\/dev.107.1.123","volume":"107","author":"R Cuthbertson","year":"1989","unstructured":"Cuthbertson R, Beck F, Senior P, Haralambidis J, Penschow J, Coghlan J (1989) Insulin-like growth factor II may play a local role in the regulation of ocular size. Dev 107:123\u2013130","journal-title":"Dev"},{"key":"1839_CR3","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1515\/JPEM.1998.11.2.261","volume":"11","author":"PF Collett-Solberg","year":"1998","unstructured":"Collett-Solberg PF, Liu GT, Satin-Smith M, Katz LL, Moshang \u03a4 Jr (1998) Pseudopapilledema and congenital disc anomalies in growth hormone deficiency. J Pediatr Endocrinol Metab 11:261\u2013266","journal-title":"J Pediatr Endocrinol Metab"},{"key":"1839_CR4","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1210\/jcem.87.7.8629","volume":"87","author":"A Hellstr\u00f6m","year":"2002","unstructured":"Hellstr\u00f6m A, Br C, Niklasson A, Segnestam K, Boguszewski M, de Lacerda L, Savage M, Svensson E, Smith L, Weinberger D (2002) IGF-I is critical for normal vascularization of the human retina. J Clin Endocrinol Metab 87:3413\u20133416","journal-title":"J Clin Endocrinol Metab"},{"key":"1839_CR5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.4274\/jcrpe.4758","volume":"10","author":"\u00d6 Y\u00fcce","year":"2018","unstructured":"Y\u00fcce \u00d6, Yal\u00e7\u0131n NG, Bideci A, D\u00f6\u011fer E, Emeksiz HC, Hasanreiso\u011flu M, Akta\u015f Z, \u00c7amurdan O, Cinaz P (2018) Retinal neural and vascular structure in isolated growth hormone deficiency children and evaluation of growth hormone treatment effect. J Clin Res Pediatr Endocrinol 10:113\u2013118","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"1839_CR6","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/j.1755-3768.2009.01519.x","volume":"88","author":"F Parentin","year":"2010","unstructured":"Parentin F, Pensiero S (2010) Central corneal thickness in children with growth hormone deficiency. Acta Ophthalmol 88:692\u2013694","journal-title":"Acta Ophthalmol"},{"key":"1839_CR7","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1210\/edrv.21.4.0404","volume":"21","author":"D Deplewski","year":"2000","unstructured":"Deplewski D, Rosenfield RL (2000) Role of hormones in pilosebaceous unit development. Endocr Rev 21:363\u2013392","journal-title":"Endocr Rev"},{"key":"1839_CR8","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1001\/jamaophthalmol.2013.8295","volume":"132","author":"J Ding","year":"2014","unstructured":"Ding J, Sullivan DA (2014) The effects of insulin-like growth factor 1 and growth hormone on human meibomian gland epithelial cells. JAMA ophthalmol 132:593\u2013599","journal-title":"JAMA ophthalmol"},{"key":"1839_CR9","doi-asserted-by":"publisher","first-page":"5596","DOI":"10.1167\/iovs.14-14782","volume":"55","author":"Y Liu","year":"2014","unstructured":"Liu Y, Ding J (2014) The combined effect of azithromycin and insulin-like growth factor-1 on cultured human meibomian gland epithelial cells. Invest Ophthalmol Vis Sci 55:5596\u20135601","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1839_CR10","first-page":"5728071","volume":"2016","author":"Y Liu","year":"2016","unstructured":"Liu Y, Knop E, Knop N, Sullivan DA, List EO, Kopchick JJ, Kam WR, Ding J (2016) Growth hormone influence on the morphology and size of the mouse meibomian gland. J ophthalmol 2016:5728071","journal-title":"J ophthalmol"},{"key":"1839_CR11","first-page":"317","volume":"7","author":"P Nalcacioglu-Yuksekkaya","year":"2014","unstructured":"Nalcacioglu-Yuksekkaya P, Sen E, Elgin U, Hocaoglu M, Ozturk F, Yilmaz SA, Kendirci HN, Cetinkaya S, Aycan Z (2014) Corneal properties in children with congenital isolated growth hormone deficiency. Int J Ophthalmol 7:317\u2013320","journal-title":"Int J Ophthalmol"},{"key":"1839_CR12","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ghir.2014.05.001","volume":"24","author":"A Ciresi","year":"2014","unstructured":"Ciresi A, Morreale R, Radellini S, Cillino S, Giordano C (2014) Corneal thickness in children with growth hormone deficiency: the effect of GH treatment. Growth Hormon IGF Res 24:150\u2013154","journal-title":"Growth Hormon IGF Res"},{"key":"1839_CR13","unstructured":"Carrillo AA, Bao Y (2006) Hormonal dynamic tests and genetic tests used in pediatric endocrinologyPediatric Endocrinology, Fifth Edition: Volume 2 Growth, Adrenal, Sexual, Thyroid, Calcium, and Fluid Balance Disorders. CRC Press, pp. 737\u2013767."},{"key":"1839_CR14","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s10384-011-0103-6","volume":"56","author":"R Arita","year":"2012","unstructured":"Arita R, Itoh K, Maeda S, Maeda K, Tomidokoro A, Amano S (2012) Association of contact lens-related allergic conjunctivitis with changes in the morphology of meibomian glands. Jpn J Ophthalmol 56:14\u201319","journal-title":"Jpn J Ophthalmol"},{"key":"1839_CR15","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1076\/ceyr.28.1.11.23491","volume":"28","author":"F Parentin","year":"2004","unstructured":"Parentin F, Tonini G, Perissutti P (2004) Refractive evaluation in children with growth defect. Curr Eye Res 28:11\u201315","journal-title":"Curr Eye Res"},{"key":"1839_CR16","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1159\/000085732","volume":"219","author":"F Parentin","year":"2005","unstructured":"Parentin F, Perissutti P (2005) Congenital growth hormone deficiency and eye refraction: a longitudinal study. Ophthalmologica 219:226\u2013231","journal-title":"Ophthalmologica"},{"key":"1839_CR17","first-page":"1408","volume":"43","author":"S-M Saw","year":"2002","unstructured":"Saw S-M, Chua W-H, Hong C-Y, Wu H-M, Chia K-S, Stone RA, Tan D (2002) Height and its relationship to refraction and biometry parameters in Singapore Chinese children. Invest Ophthalmol Vis Sci 43:1408\u20131413","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1116\u20131119","key":"1839_CR18","first-page":"e1111","volume":"161","author":"I Youngster","year":"2012","unstructured":"Youngster I, Rachmiel R, Pinhas-Hamiel O, Bistritzer T, Zuckerman-Levin N, de Vries L, Naugolny L, Eyal O, Braunstein R, Rachmiel M (2012) Treatment with recombinant human growth hormone during childhood is associated with increased intraocular pressure. J Pediatr 161(1116\u20131119):e1111","journal-title":"J Pediatr"},{"key":"1839_CR19","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1097\/00006324-199209000-00007","volume":"69","author":"RH Duckman","year":"1992","unstructured":"Duckman RH, Fitzgerald DE (1992) Evaluation of intraocular pressure in a pediatric population. Optometry and vision science: official publication of the American Academy of Optometry 69:705\u2013709","journal-title":"Optometry and vision science: official publication of the American Academy of Optometry"},{"key":"1839_CR20","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40662-016-0038-6","volume":"3","author":"JK Duncan","year":"2016","unstructured":"Duncan JK, Belin MW, Borgstrom M (2016) Assessing progression of keratoconus: novel tomographic determinants. Eye and Vision 3:6","journal-title":"Eye and Vision"},{"key":"1839_CR21","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/eye.2013.15","volume":"27","author":"J Zavala","year":"2013","unstructured":"Zavala J, Jaime GL, Barrientos CR, Valdez-Garcia J (2013) Corneal endothelium: developmental strategies for regeneration. Eye 27:579\u2013588","journal-title":"Eye"},{"key":"1839_CR22","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/ICO.0000000000001476","volume":"37","author":"PK Gupta","year":"2018","unstructured":"Gupta PK, Stevens MN, Kashyap N, Priestley Y (2018) Prevalence of meibomian gland atrophy in a pediatric population. Cornea 37:426","journal-title":"Cornea"},{"key":"1839_CR23","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.jtos.2018.03.006","volume":"16","author":"Y Zhao","year":"2018","unstructured":"Zhao Y, Chen S, Wang S, Chen Y, Li J, Fu Y, Dai Q, Lin X, Wu Y, Zhao Y (2018) The significance of meibomian gland changes in asymptomatic children. Ocul Surf 16:301\u2013305","journal-title":"Ocul Surf"},{"key":"1839_CR24","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s00417-012-2097-2","volume":"251","author":"SB Han","year":"2013","unstructured":"Han SB, Yang HK, Hyon JY, Hwang J-M (2013) Children with dry eye type conditions may report less severe symptoms than adult patients. Graefes Arch Clin Exp Ophthalmol 251:791\u2013796","journal-title":"Graefes Arch Clin Exp Ophthalmol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-021-01839-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-021-01839-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-021-01839-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T16:36:57Z","timestamp":1626712617000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-021-01839-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,5]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["1839"],"URL":"https:\/\/doi.org\/10.1007\/s10792-021-01839-5","relation":{},"ISSN":["0165-5701","1573-2630"],"issn-type":[{"type":"print","value":"0165-5701"},{"type":"electronic","value":"1573-2630"}],"subject":[],"published":{"date-parts":[[2021,4,5]]},"assertion":[{"value":"5 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Board of University of Health Sciences Yuksek Ihtisas Training and Research Hospital and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Ozlem Kara, Gamze Dereli Can. The first draft of the manuscript was written by Ozlem Kara, Gamze Dereli Can and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}