{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T12:48:29Z","timestamp":1748868509764,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670884","81873684"],"award-info":[{"award-number":["81670884","81873684"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s10792-021-02081-9","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T05:45:01Z","timestamp":1634103901000},"page":"981-988","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Understanding the role of corneal biomechanics-associated genetic variants by bioinformatic analyses"],"prefix":"10.1007","volume":"42","author":[{"given":"Xiao","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-kun","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1257-6635","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"issue":"11","key":"2081_CR1","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1016\/j.ophtha.2019.06.029","volume":"126","author":"B Zhang","year":"2019","unstructured":"Zhang B, Shweikh Y, Khawaja AP, Gallacher J, Bauermeister S, Foster PJ (2019) Associations with corneal hysteresis in a population cohort: results from 96 010 UK biobank participants. Ophthalmology 126(11):1500\u20131510","journal-title":"Ophthalmology"},{"issue":"4","key":"2081_CR2","doi-asserted-by":"publisher","first-page":"e258","DOI":"10.1111\/aos.12056","volume":"91","author":"G Labiris","year":"2013","unstructured":"Labiris G, Gatzioufas Z, Sideroudi H, Giarmoukakis A, Kozobolis V, Seitz B (2013) Biomechanical diagnosis of keratoconus: evaluation of the keratoconus match index and the keratoconus match probability. Acta Ophthalmol 91(4):e258\u2013e262","journal-title":"Acta Ophthalmol"},{"key":"2081_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-016-0048-4","author":"F Bao","year":"2016","unstructured":"Bao F, Geraghty B, Wang Q, Elsheikh A (2016) Consideration of corneal biomechanics in the diagnosis and management of keratoconus: is it important? Eye Vis. https:\/\/doi.org\/10.1186\/s40662-016-0048-4","journal-title":"Eye Vis"},{"key":"2081_CR4","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.2147\/OPTH.S236114","volume":"14","author":"L Zimprich","year":"2020","unstructured":"Zimprich L, Diedrich J, Bleeker A, Schweitzer JA (2020) Corneal hysteresis as a biomarker of glaucoma: current insights. Clin Ophthalmol 14:2255\u20132264","journal-title":"Clin Ophthalmol"},{"key":"2081_CR5","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.ajo.2019.07.007","volume":"207","author":"W Wu","year":"2019","unstructured":"Wu W, Dou R, Wang Y (2019) Comparison of corneal biomechanics between low and high myopic eyes-a meta-analysis. Am J Ophthalmol 207:419\u2013425","journal-title":"Am J Ophthalmol"},{"issue":"18","key":"2081_CR6","doi-asserted-by":"publisher","first-page":"3154","DOI":"10.1093\/hmg\/ddaa155","volume":"29","author":"MJ Simcoe","year":"2020","unstructured":"Simcoe MJ, Khawaja AP, Hysi PG, Hammond CJ (2020) Genome-wide association study of corneal biomechanical properties identifies over 200 loci providing insight into the genetic etiology of ocular diseases. Hum Mol Genet 29(18):3154\u20133164","journal-title":"Hum Mol Genet"},{"issue":"7","key":"2081_CR7","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.2174\/138920012802138561","volume":"13","author":"L Li","year":"2012","unstructured":"Li L, Chen Q, Wei DQ (2012) Prediction and functional analysis of single nucleotide polymorphisms. Curr Drug Metab 13(7):1012\u20131023","journal-title":"Curr Drug Metab"},{"key":"2081_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-6-S3-S16","author":"PJ Hale","year":"2012","unstructured":"Hale PJ, L\u00f3pez-Yunez AM, Chen JY (2012) Genome-wide meta-analysis of genetic susceptible genes for Type 2 Diabetes. Bmc Syst Biol. https:\/\/doi.org\/10.1186\/1752-0509-6-S3-S16","journal-title":"Bmc Syst Biol"},{"key":"2081_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s13040-018-0179-3","author":"J Zhang","year":"2018","unstructured":"Zhang J, Wu D, Dai Y, Xu J (2018) Functional relevance for central cornea thickness-associated genetic variants by using integrative analyses. Biodata Min. https:\/\/doi.org\/10.1186\/s13040-018-0179-3","journal-title":"Biodata Min"},{"issue":"D1","key":"2081_CR10","doi-asserted-by":"publisher","first-page":"D1005","DOI":"10.1093\/nar\/gky1120","volume":"47","author":"A Buniello","year":"2019","unstructured":"Buniello A, MacArthur J, Cerezo M, Harris LW, Hayhurst J, Malangone C, McMahon A, Morales J, Mountjoy E, Sollis E et al (2019) The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019. Nucl Acids Res 47(D1):D1005\u2013D1012","journal-title":"Nucl Acids Res"},{"issue":"D1","key":"2081_CR11","doi-asserted-by":"publisher","first-page":"D869","DOI":"10.1093\/nar\/gkv1317","volume":"44","author":"MJ Li","year":"2016","unstructured":"Li MJ, Liu Z, Wang P, Wong MP, Nelson MR, Kocher JP, Yeager M, Sham PC, Chanock SJ, Xia Z et al (2016) GWASdb v2: an update database for human genetic variants identified by genome-wide association studies. Nucl Acids Res 44(D1):D869\u2013D876","journal-title":"Nucl Acids Res"},{"issue":"D1","key":"2081_CR12","doi-asserted-by":"publisher","first-page":"D886","DOI":"10.1093\/nar\/gky1016","volume":"47","author":"P Rentzsch","year":"2019","unstructured":"Rentzsch P, Witten D, Cooper GM, Shendure J, Kircher M (2019) CADD: predicting the deleteriousness of variants throughout the human genome. Nucl Acids Res 47(D1):D886\u2013D894","journal-title":"Nucl Acids Res"},{"issue":"3","key":"2081_CR13","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/nmeth.2832","volume":"11","author":"GR Ritchie","year":"2014","unstructured":"Ritchie GR, Dunham I, Zeggini E, Flicek P (2014) Functional annotation of noncoding sequence variants. Nat Methods 11(3):294\u2013296","journal-title":"Nat Methods"},{"issue":"9","key":"2081_CR14","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1101\/gr.137323.112","volume":"22","author":"AP Boyle","year":"2012","unstructured":"Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, Kasowski M, Karczewski KJ, Park J, Hitz BC, Weng S et al (2012) Annotation of functional variation in personal genomes using RegulomeDB. Genome Res 22(9):1790\u20131797","journal-title":"Genome Res"},{"issue":"W1","key":"2081_CR15","doi-asserted-by":"publisher","first-page":"W90","DOI":"10.1093\/nar\/gkw377","volume":"44","author":"MV Kuleshov","year":"2016","unstructured":"Kuleshov MV, Jones MR, Rouillard AD, Fernandez NF, Duan Q, Wang Z, Koplev S, Jenkins SL, Jagodnik KM, Lachmann A et al (2016) Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucl Acids Res 44(W1):W90\u2013W97","journal-title":"Nucl Acids Res"},{"issue":"D1","key":"2081_CR16","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P et al (2019) STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucl Acids Res 47(D1):D607\u2013D613","journal-title":"Nucl Acids Res"},{"issue":"10","key":"2081_CR17","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1038\/nprot.2007.324","volume":"2","author":"MS Cline","year":"2007","unstructured":"Cline MS, Smoot M, Cerami E, Kuchinsky A, Landys N, Workman C, Christmas R, Avila-Campilo I, Creech M, Gross B et al (2007) Integration of biological networks and gene expression data using Cytoscape. Nat Protoc 2(10):2366\u20132382","journal-title":"Nat Protoc"},{"issue":"21","key":"2081_CR18","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1093\/bioinformatics\/btp517","volume":"25","author":"G Scardoni","year":"2009","unstructured":"Scardoni G, Petterlini M, Laudanna C (2009) Analyzing biological network parameters with CentiScaPe. Bioinformatics 25(21):2857\u20132859","journal-title":"Bioinformatics"},{"issue":"8","key":"2081_CR19","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1007\/s00439-020-02151-5","volume":"139","author":"Y Gautam","year":"2020","unstructured":"Gautam Y, Afanador Y, Ghandikota S, Mersha TB (2020) Comprehensive functional annotation of susceptibility variants associated with asthma. Hum Genet 139(8):1037\u20131053","journal-title":"Hum Genet"},{"issue":"4","key":"2081_CR20","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1111\/1753-0407.12421","volume":"9","author":"M Cheng","year":"2017","unstructured":"Cheng M, Liu X, Yang M, Han L, Xu A, Huang Q (2017) Computational analyses of type 2 diabetes-associated loci identified by genome-wide association studies. J Diabetes 9(4):362\u2013377","journal-title":"J Diabetes"},{"issue":"1","key":"2081_CR21","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jcrs.2004.10.044","volume":"31","author":"DA Luce","year":"2005","unstructured":"Luce DA (2005) Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg 31(1):156\u2013162","journal-title":"J Cataract Refract Surg"},{"issue":"9","key":"2081_CR22","doi-asserted-by":"publisher","first-page":"3852","DOI":"10.1167\/iovs.07-1670","volume":"49","author":"L Lim","year":"2008","unstructured":"Lim L, Gazzard G, Chan YH, Fong A, Kotecha A, Sim EL, Tan D, Tong L, Saw SM (2008) Cornea biomechanical characteristics and their correlates with refractive error in Singaporean children. Invest Ophthalmol Vis Sci 49(9):3852\u20133857","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2081_CR23","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.exer.2019.03.014","volume":"182","author":"L Hu","year":"2019","unstructured":"Hu L, Pu Q, Zhang Y, Ma Q, Li G, Li X (2019) Expansion and maintenance of primary corneal epithelial stem\/progenitor cells by inhibition of TGF\u03b2 receptor I-mediated signaling. Exp Eye Res 182:44\u201356","journal-title":"Exp Eye Res"},{"key":"2081_CR24","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1146\/annurev-biochem-013118-111829","volume":"88","author":"S Ma","year":"2019","unstructured":"Ma S, Meng Z, Chen R, Guan KL (2019) The hippo pathway: biology and pathophysiology. Annu Rev Biochem 88:577\u2013604","journal-title":"Annu Rev Biochem"},{"issue":"5","key":"2081_CR25","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/ejhg.2017.4","volume":"25","author":"M Kabza","year":"2017","unstructured":"Kabza M, Karolak JA, Rydzanicz M, Szcze\u015bniak MW, Nowak DM, Ginter-Matuszewska B, Polakowski P, Ploski R, Szaflik JP, Gajecka M (2017) Collagen synthesis disruption and downregulation of core elements of TGF-\u03b2, Hippo, and Wnt pathways in keratoconus corneas. Eur J Hum Genet 25(5):582\u2013590","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"2081_CR26","doi-asserted-by":"publisher","first-page":"6801","DOI":"10.1038\/s41598-017-06924-3","volume":"7","author":"N Okumura","year":"2017","unstructured":"Okumura N, Hashimoto K, Kitahara M, Okuda H, Ueda E, Watanabe K, Nakahara M, Sato T, Kinoshita S, Tourtas T et al (2017) Activation of TGF-\u03b2 signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy. Sci Rep 7(1):6801","journal-title":"Sci Rep"},{"issue":"6651","key":"2081_CR27","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/39369","volume":"389","author":"A Nakao","year":"1997","unstructured":"Nakao A, Afrakhte M, Mor\u00e9n A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH et al (1997) Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature 389(6651):631\u2013635","journal-title":"Nature"},{"key":"2081_CR28","first-page":"577","volume":"21","author":"S Priyadarsini","year":"2015","unstructured":"Priyadarsini S, McKay TB, Sarker-Nag A, Karamichos D (2015) Keratoconus in vitro and the key players of the TGF-\u03b2 pathway. Mol Vis 21:577\u2013588","journal-title":"Mol Vis"},{"issue":"8","key":"2081_CR29","doi-asserted-by":"publisher","first-page":"3420","DOI":"10.1074\/jbc.M116.764910","volume":"292","author":"H Yadav","year":"2017","unstructured":"Yadav H, Devalaraja S, Chung ST, Rane SG (2017) TGF-\u03b21\/Smad3 pathway targets PP2A-AMPK-FoxO1 signaling to regulate hepatic gluconeogenesis. J Biol Chem 292(8):3420\u20133432","journal-title":"J Biol Chem"},{"issue":"4","key":"2081_CR30","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1080\/08977190412331279890","volume":"22","author":"D Chen","year":"2004","unstructured":"Chen D, Zhao M, Mundy GR (2004) Bone morphogenetic proteins. Growth Factors 22(4):233\u2013241","journal-title":"Growth Factors"},{"key":"2081_CR31","first-page":"2480","volume":"15","author":"JE Lee","year":"2009","unstructured":"Lee JE, Oum BS, Choi HY, Lee SU, Lee JS (2009) Evaluation of differentially expressed genes identified in keratoconus. Mol Vis 15:2480\u20132487","journal-title":"Mol Vis"},{"issue":"7","key":"2081_CR32","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1167\/iovs.17-21423","volume":"58","author":"DD Chung","year":"2017","unstructured":"Chung DD, Frausto RF, Lin BR, Hanser EM, Cohen Z, Aldave AJ (2017) Transcriptomic profiling of posterior polymorphous corneal dystrophy. Invest Ophthalmol Vis Sci 58(7):3202\u20133214","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-021-02081-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-021-02081-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-021-02081-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T16:49:12Z","timestamp":1647017352000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-021-02081-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,12]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["2081"],"URL":"https:\/\/doi.org\/10.1007\/s10792-021-02081-9","relation":{},"ISSN":["0165-5701","1573-2630"],"issn-type":[{"type":"print","value":"0165-5701"},{"type":"electronic","value":"1573-2630"}],"subject":[],"published":{"date-parts":[[2021,10,12]]},"assertion":[{"value":"13 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}