{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:28:20Z","timestamp":1772119700024,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10792-021-02097-1","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T03:02:49Z","timestamp":1636081369000},"page":"1111-1119","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of parasympathetic cardiovascular activity in primary open-angle glaucoma"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8701-707X","authenticated-orcid":false,"given":"Oluwaseun O.","family":"Awe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwadare","family":"Ogundare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernice O.","family":"Adegbehingbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"2097_CR1","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","volume":"121","author":"YC Tham","year":"2014","unstructured":"Tham YC, Li X, Wong TY et al (2014) Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology 121:2081\u20132090. https:\/\/doi.org\/10.1016\/j.ophtha.2014.05.013","journal-title":"Ophthalmology"},{"issue":"Suppl 1","key":"2097_CR2","doi-asserted-by":"publisher","first-page":"S97","DOI":"10.4103\/0301-4738.73695","volume":"59","author":"DR Anderson","year":"2011","unstructured":"Anderson DR (2011) Normal-tension glaucoma (Low-tension glaucoma). Indian J Ophthalmol 59(Suppl 1):S97\u2013S101. https:\/\/doi.org\/10.4103\/0301-4738.73695","journal-title":"Indian J Ophthalmol"},{"key":"2097_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.06.003","author":"TCW Chan","year":"2017","unstructured":"Chan TCW, Bala C, Siu A et al (2017) Risk factors for rapid glaucoma disease progression. Am J Ophthalmol. https:\/\/doi.org\/10.1016\/j.ajo.2017.06.003","journal-title":"Am J Ophthalmol"},{"key":"2097_CR4","unstructured":"Gibbons CH, Cheshire WP, Fife TD (2014) Model coverage policy: autonomic testing. American Academy of Neurology"},{"key":"2097_CR5","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1002\/cphy.c140014.Autonomic","volume":"5","author":"DH McDougal","year":"2015","unstructured":"McDougal DH, Gamlin PD (2015) Autonomic control of the eye. Compr Physiol 5:439\u2013473. https:\/\/doi.org\/10.1002\/cphy.c140014.Autonomic","journal-title":"Compr Physiol"},{"key":"2097_CR6","first-page":"2338","volume":"38","author":"CE Riva","year":"1997","unstructured":"Riva CE, Titze P, Hero M et al (1997) Choroidal blood flow during isometric exercises. Investig Ophthalmol Vis Sci 38:2338\u20132343","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"2097_CR7","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1167\/iovs.05-1053","volume":"47","author":"J Choi","year":"2006","unstructured":"Choi J, Jeong J, Cho HS, Kook MS (2006) Effect of nocturnal blood pressure reduction on circadian fluctuation of mean ocular perfusion pressure: a risk factor for normal tension glaucoma. Investig Ophthalmol Vis Sci 47:831\u2013836. https:\/\/doi.org\/10.1167\/iovs.05-1053","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"2097_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/418159","volume":"2015","author":"B Quill","year":"2015","unstructured":"Quill B, Henry E, Simon E, Brien CJO (2015) Evaluation of the effect of hypercapnia on vascular function in normal tension glaucoma. Biomed Res Int 2015:1\u201311","journal-title":"Biomed Res Int"},{"key":"2097_CR9","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1001\/archopht.117.10.1359","volume":"117","author":"D Gherghel","year":"1999","unstructured":"Gherghel D, Org\u00fcl S, Dubler B et al (1999) Is vascular regulation in the central retinal artery altered in persons with vasospasm? Arch Ophthalmol 117:1359\u20131362","journal-title":"Arch Ophthalmol"},{"key":"2097_CR10","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1136\/bjo.2003.032110","volume":"88","author":"M Emre","year":"2004","unstructured":"Emre M, Org\u00fcl S, Gugleta K, Flammer J (2004) Ocular blood flow alteration in glaucoma is related to systemic vascular dysregulation. Br J Ophthalmol 88:662\u2013666. https:\/\/doi.org\/10.1136\/bjo.2003.032110","journal-title":"Br J Ophthalmol"},{"key":"2097_CR11","first-page":"6","volume":"10","author":"A Banerjee","year":"2017","unstructured":"Banerjee A, Khurana I (2017) Altered autonomic balance in normal tension glaucoma. Asian J Pharm Clin Res 10:6\u20138","journal-title":"Asian J Pharm Clin Res"},{"key":"2097_CR12","doi-asserted-by":"publisher","first-page":"e9744","DOI":"10.1097\/MD.0000000000009744","volume":"97","author":"NI Kurysheva","year":"2018","unstructured":"Kurysheva NI, Shlapak VN, Ryabova TY (2018) Heart rate variability in normal tension glaucoma. Medicine (Baltimore) 97:e9744. https:\/\/doi.org\/10.1097\/MD.0000000000009744","journal-title":"Medicine (Baltimore)"},{"key":"2097_CR13","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S0002-9394(14)73703-1","volume":"111","author":"P Gasser","year":"1991","unstructured":"Gasser P, Flammer J (1991) Blood-cell velocity in the nailfold capillaries of patients with normal-tension and high-tension glaucoma. Am J Ophthalmol 111:585\u2013588. https:\/\/doi.org\/10.1016\/S0002-9394(14)73703-1","journal-title":"Am J Ophthalmol"},{"key":"2097_CR14","doi-asserted-by":"publisher","first-page":"308","DOI":"10.7326\/0003-4819-92-2-308","volume":"92","author":"D Ewing","year":"1980","unstructured":"Ewing D, Campbell I, Clarke B (1980) Assessment of cardiovascular effects in diabetic autonomic neuropathy and prognostic implications. Ann Intern Med 92:308\u2013311","journal-title":"Ann Intern Med"},{"key":"2097_CR15","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1080\/09286580500180572","volume":"12","author":"M Mafwiri","year":"2005","unstructured":"Mafwiri M, Bowman RJC, Wood M, Kabiru J (2005) Primary open-angle glaucoma presentation at a tertiary unit in Africa: intraocular pressure levels and visual status. Ophthalmic Epidemiol 12:299\u2013302. https:\/\/doi.org\/10.1080\/09286580500180572","journal-title":"Ophthalmic Epidemiol"},{"key":"2097_CR16","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12886-015-0097-9","volume":"15","author":"MM Abdull","year":"2015","unstructured":"Abdull MM, Gilbert CC, Evans J (2015) Primary open angle glaucoma in northern Nigeria: stage at presentation and acceptance of treatment. BMC Ophthalmol 15:111. https:\/\/doi.org\/10.1186\/s12886-015-0097-9","journal-title":"BMC Ophthalmol"},{"key":"2097_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21767\/1791-809X.1000466","volume":"10","author":"O Olajide","year":"2017","unstructured":"Olajide O, Onabolu O, Jagun O et al (2017) Spectrum of glaucoma presentation in a suburban teaching hospital in South Western Nigeria. Heal Sci J 10:1\u20134. https:\/\/doi.org\/10.21767\/1791-809X.1000466","journal-title":"Heal Sci J"},{"key":"2097_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/0189-9171.142747","volume":"22","author":"O Olawoye","year":"2018","unstructured":"Olawoye O, Tarella S (2018) Spectrum of glaucoma presentation in a Nigerian Tertiary Hospital. Niger J Ophthalmol 22:1\u201315. https:\/\/doi.org\/10.4103\/0189-9171.142747","journal-title":"Niger J Ophthalmol"},{"key":"2097_CR19","doi-asserted-by":"publisher","first-page":"215","DOI":"10.19070\/2332-290X-1600044","volume":"4","author":"KO Ajite","year":"2016","unstructured":"Ajite KO, Fadamiro CO, Ajayi IA et al (2016) Demographic characteristics of normal tension glaucoma seen in a suburban tertiary hospital. Int J Ophthalmol Eye Sci 4:215\u2013219. https:\/\/doi.org\/10.19070\/2332-290X-1600044","journal-title":"Int J Ophthalmol Eye Sci"},{"key":"2097_CR20","first-page":"192","volume":"23","author":"F Majeed","year":"2007","unstructured":"Majeed F, Tauheed S, Aamir IS et al (2007) Frequency of normal-tension glaucoma in suspected cases of primary open angle glaucoma. Pak J Ophthalmol 23:192\u2013197","journal-title":"Pak J Ophthalmol"},{"key":"2097_CR21","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1097\/00061198-200304000-00011","volume":"12","author":"M Riccadonna","year":"2003","unstructured":"Riccadonna M, Covi G, Pancera P et al (2003) Autonomic system activity and 24-hour blood pressure variations in subjects with normal- and high-tension glaucoma. J Glaucoma 12:156\u2013163. https:\/\/doi.org\/10.1097\/00061198-200304000-00011","journal-title":"J Glaucoma"},{"key":"2097_CR22","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1080\/00365510601034736","volume":"67","author":"T Nieminen","year":"2007","unstructured":"Nieminen T, Lehtim\u00e4ki T, M\u00e4enp\u00e4\u00e4 J et al (2007) Ophthalmic timolol: plasma concentration and systemic cardiopulmonary effects. Scand J Clin Lab Invest 67:237\u2013245. https:\/\/doi.org\/10.1080\/00365510601034736","journal-title":"Scand J Clin Lab Invest"},{"key":"2097_CR23","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.2147\/OPTH.S118409","volume":"10","author":"A Farkouh","year":"2016","unstructured":"Farkouh A, Frigo P, Czejka M (2016) Systemic side effects of eye drops: a pharmacokinetic perspective. Clin Ophthalmol 10:2433\u20132441. https:\/\/doi.org\/10.2147\/OPTH.S118409","journal-title":"Clin Ophthalmol"},{"key":"2097_CR24","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1034\/j.1600-0420.2002.800309.x","volume":"80","author":"WC Stewart","year":"2002","unstructured":"Stewart WC, Stewart JA, Jackson AL (2002) Cardiovascular effects of timolol maleate, brimonidine or brimonidine\/timolol maleate in concomitant therapy. Acta Ophthalmol Scand 80:277\u2013281. https:\/\/doi.org\/10.1034\/j.1600-0420.2002.800309.x","journal-title":"Acta Ophthalmol Scand"},{"key":"2097_CR25","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1161\/CIRCRESAHA.114.302524","volume":"114","author":"G Mancia","year":"2014","unstructured":"Mancia G, Grassi G (2014) The autonomic nervous system and hypertension. Circ Res 114:1804\u20131814. https:\/\/doi.org\/10.1161\/CIRCRESAHA.114.302524","journal-title":"Circ Res"},{"key":"2097_CR26","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/j.1475-1313.2007.00485.x","volume":"27","author":"D Gherghel","year":"2007","unstructured":"Gherghel D, Hosking SL, Armstrong R, Cunliffe IA (2007) Autonomic dysfunction in unselected and untreated primary open angle glaucoma patients: a pilot study. Ophthalmic Physiol Opt 27:336\u2013341. https:\/\/doi.org\/10.1111\/j.1475-1313.2007.00485.x","journal-title":"Ophthalmic Physiol Opt"},{"key":"2097_CR27","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1136\/bjophthalmol-2011-300945","volume":"96","author":"J Wierzbowska","year":"2012","unstructured":"Wierzbowska J, Wierzbowski R, Wierzbowska J et al (2012) Cardiac autonomic dysfunction in patients with normal tension glaucoma: 24-h heart rate and blood pressure variability analysis. Br J Ophthalmol 96:624\u2013628. https:\/\/doi.org\/10.1136\/bjophthalmol-2011-300945","journal-title":"Br J Ophthalmol"},{"key":"2097_CR28","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1001\/2013.jamaophthalmol.1","volume":"131","author":"S Mroczkowska","year":"2013","unstructured":"Mroczkowska S, Benavente-Perez A, Negi A et al (2013) Primary open-angle glaucoma vs normal-tension glaucoma: the vascular perspective. JAMA Ophthalmol 131:36\u201343. https:\/\/doi.org\/10.1001\/2013.jamaophthalmol.1","journal-title":"JAMA Ophthalmol"},{"key":"2097_CR29","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1093\/ajh\/hpw012","volume":"29","author":"G Grassi","year":"2016","unstructured":"Grassi G (2016) Sympathomodulatory effects of antihypertensive drug treatment. Am J Hypertens 29:665\u2013675. https:\/\/doi.org\/10.1093\/ajh\/hpw012","journal-title":"Am J Hypertens"},{"key":"2097_CR30","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0895-7061(99)00150-8","volume":"13","author":"G Grassi","year":"2000","unstructured":"Grassi G (2000) Sympathoexcitatory responses to the acute blood pressure fall induced by central or peripheral antihypertensive drugs. Am J Hypertens 13:29\u201334. https:\/\/doi.org\/10.1016\/S0895-7061(99)00150-8","journal-title":"Am J Hypertens"},{"key":"2097_CR31","first-page":"265","volume":"104","author":"R Mapstone","year":"1985","unstructured":"Mapstone R, Clark CV (1985) The prevalence of autonomic neuropathy in glaucoma. Trans Ophthalmol Soc U K 104:265\u2013269","journal-title":"Trans Ophthalmol Soc U K"},{"key":"2097_CR32","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1159\/000310383","volume":"206","author":"L Boji\u0107","year":"1993","unstructured":"Boji\u0107 L, \u010cagalj S, Ra\u010di\u0107 G, Karaman-Kraljevi\u0107 K (1993) Cardiovascular reflex testing and pupil cycle time in open-angle glaucoma. Ophthalmologica 206:158\u2013161. https:\/\/doi.org\/10.1159\/000310383","journal-title":"Ophthalmologica"},{"key":"2097_CR33","doi-asserted-by":"publisher","first-page":"16865","DOI":"10.14260\/jemds\/2015\/2536","volume":"4","author":"MM Khan","year":"2015","unstructured":"Khan MM, Ghosh S, Bera C (2015) Study of autonomic activities in primary open angle glaucoma. J Evol Med Dent Sci 4:16865\u201316870. https:\/\/doi.org\/10.14260\/jemds\/2015\/2536","journal-title":"J Evol Med Dent Sci"},{"key":"2097_CR34","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/S0140-6736(73)93323-0","volume":"302","author":"DJ Ewing","year":"1973","unstructured":"Ewing DJ, Burt AA, Campbell IW, Clarke BF (1973) Vascular reflexes in diabetic autonomic neuropathy. Lancet 302:1354\u20131356. https:\/\/doi.org\/10.1016\/S0140-6736(73)93323-0","journal-title":"Lancet"},{"key":"2097_CR35","doi-asserted-by":"publisher","first-page":"036","DOI":"10.23937\/2378-2951\/1410036","volume":"2","author":"O Ogunlade","year":"2015","unstructured":"Ogunlade O, Ayoka AO, Akintomide A et al (2015) Non-invasive assessment of cardiac autonomic functions in healthy young adults in Ile-Ife, South-Western Nigeria. Int J Clin Cardiol 2:036","journal-title":"Int J Clin Cardiol"},{"key":"2097_CR36","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1136\/bjo.86.10.1089","volume":"86","author":"JC Khan","year":"2002","unstructured":"Khan JC (2002) Pulsatile ocular blood flow: the effect of the Valsalva manoeuvre in open angle and normal tension glaucoma: a case report and prospective study. Br J Ophthalmol 86:1089\u20131092. https:\/\/doi.org\/10.1136\/bjo.86.10.1089","journal-title":"Br J Ophthalmol"},{"key":"2097_CR37","first-page":"1599","volume":"3","author":"S Begum","year":"2015","unstructured":"Begum S, Razak A (2015) Valsalva ratio: a measure of stress in first year medical students. Int J Res Med Sci 3:1599\u20131604","journal-title":"Int J Res Med Sci"},{"key":"2097_CR38","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0161-6420(99)00015-9","volume":"107","author":"JS Schuman","year":"2000","unstructured":"Schuman JS, Massicotte EC, Connolly S et al (2000) Increased intraocular pressure and visual field defects in high resistance wind instrument players. Ophthalmology 107:127\u2013133","journal-title":"Ophthalmology"},{"key":"2097_CR39","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1177\/2040622314530181","volume":"5","author":"II Bussel","year":"2014","unstructured":"Bussel II, Aref AA (2014) Dietary factors and the risk of glaucoma: a review. Ther Adv Chronic Dis 5:188\u2013194. https:\/\/doi.org\/10.1177\/2040622314530181","journal-title":"Ther Adv Chronic Dis"},{"key":"2097_CR40","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1055\/s-2001-14915","volume":"218","author":"D Krist","year":"2001","unstructured":"Krist D, Cursiefen C, J\u00fcnemann A (2001) Transient intrathoracic and abdominal pressure elevation in the history of 64 patients with normal-tension glaucoma. Klin Monbl Augenheilkd 218:209\u2013213. https:\/\/doi.org\/10.1055\/s-2001-14915","journal-title":"Klin Monbl Augenheilkd"},{"key":"2097_CR41","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2147\/EB.S9078","volume":"2","author":"M Wong-Riley","year":"2010","unstructured":"Wong-Riley M (2010) Energy metabolism of the visual system. Eye Brain 2:99\u2013116","journal-title":"Eye Brain"},{"key":"2097_CR42","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/sj.eye.6701574","volume":"18","author":"JE Morgan","year":"2004","unstructured":"Morgan JE (2004) Circulation and axonal transport in the optic nerve. Eye 18:1089\u20131095. https:\/\/doi.org\/10.1038\/sj.eye.6701574","journal-title":"Eye"},{"key":"2097_CR43","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/cxo.12303","volume":"98","author":"M Palamar","year":"2015","unstructured":"Palamar M, Dag MY, Yagci A (2015) The effects of valsalva manoeuvre on ocular response analyzer measurements. Clin Exp Optom 98:447\u2013450. https:\/\/doi.org\/10.1111\/cxo.12303","journal-title":"Clin Exp Optom"},{"key":"2097_CR44","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1001\/archopht.1993.01090080021008","volume":"111","author":"JC van Meurs","year":"1993","unstructured":"van Meurs JC, van den Bosch WA (1993) Suprachoroidal hemorrhage following a valsalva maneuver. Arch Ophthalmol 111:1025\u20131026","journal-title":"Arch Ophthalmol"},{"key":"2097_CR45","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1001\/archopht.124.9.1251","volume":"124","author":"GM Vieira","year":"2006","unstructured":"Vieira GM, Oliveira HB, De Andrade DT et al (2006) Intraocular pressure variation during weight lifting. Arch Ophthalmol 124:1251\u20131254. https:\/\/doi.org\/10.1001\/archopht.124.9.1251","journal-title":"Arch Ophthalmol"},{"key":"2097_CR46","doi-asserted-by":"publisher","first-page":"e76631","DOI":"10.1371\/journal.pone.0076631","volume":"8","author":"PM Macey","year":"2013","unstructured":"Macey PM, Kumar R, Woo MA et al (2013) Heart rate responses to autonomic challenges in obstructive sleep apnea. PLoS ONE 8:e76631. https:\/\/doi.org\/10.1371\/journal.pone.0076631","journal-title":"PLoS ONE"},{"key":"2097_CR47","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3129\/i08-056","volume":"43","author":"J Flammer","year":"2008","unstructured":"Flammer J, Mozaffarieh M (2008) Autoregulation, a balancing act between supply and demand. Can J Ophthalmol 43:317\u2013321. https:\/\/doi.org\/10.3129\/i08-056","journal-title":"Can J Ophthalmol"},{"key":"2097_CR48","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1023\/A:1006113109864","volume":"22","author":"N Collignon","year":"1998","unstructured":"Collignon N, Dewe W, Guillaume S, Collignon-Brach J (1998) Ambulatory blood pressure monitoring in glaucoma patients. The nocturnal systolic dip and its relationship with disease progression. Int Ophthalmol 22:19\u201325. https:\/\/doi.org\/10.1023\/A:1006113109864","journal-title":"Int Ophthalmol"},{"key":"2097_CR49","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1540-8167.1994.tb01109.x","volume":"5","author":"CT Leffler","year":"1994","unstructured":"Leffler CT, Saul JP, Cohen RJ (1994) Rate-related and autonomic effects on atrioventricular conduction assessed through beat-to-beat PR interval and cycle length variahility. J Cardivascular Electrophysiol 5:2\u201315","journal-title":"J Cardivascular Electrophysiol"},{"key":"2097_CR50","doi-asserted-by":"crossref","unstructured":"Sheridan E, Heneghan C, O\u2019Malley MO, et al (2001) Characterization of autonomic nervous influences on PR and RR intervals in the electrocardiogram. In: 23rd Annual international conference of the IEEE engineering in medicine and biology society, pp 540\u2013543","DOI":"10.1109\/IEMBS.2001.1018989"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-021-02097-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-021-02097-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-021-02097-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T02:23:18Z","timestamp":1649384598000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-021-02097-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,5]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["2097"],"URL":"https:\/\/doi.org\/10.1007\/s10792-021-02097-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-772258\/v1","asserted-by":"object"}]},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,5]]},"assertion":[{"value":"31 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Approval was obtained from the Ethics and Research Committee of Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria (OAUTHC\/ERC\/2017\/12\/01), and the study was therefore performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All participants gave their informed consent prior to their inclusion in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}