{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:54:09Z","timestamp":1789430049121,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s10792-021-02185-2","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:04:01Z","timestamp":1643328241000},"page":"1875-1884","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Changes in the macular choroidal thickness of children who have type-1 diabetes mellitus, with and without vitamin D deficiency"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5708-9283","authenticated-orcid":false,"given":"Gozde","family":"Aksoy Aydemir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esat","family":"Yetkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Aydemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semih","family":"Bolu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulvahit","family":"Asik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"2185_CR1","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3341\/kjo.2016.30.6.426","volume":"30","author":"HT Kim","year":"2016","unstructured":"Kim HT, Kim JM, Kim JH, Lee MY, Won YS, Lee JY et al (2016) The relationship between vitamin D and glaucoma: a Kangbuk Samsung Health study. Korean J Ophthalmol 30:426\u2013433","journal-title":"Korean J Ophthalmol"},{"key":"2185_CR2","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1542\/peds.111.4.908","volume":"111","author":"LM Gartner","year":"2003","unstructured":"Gartner LM, Greer FR (2003) Prevention of rickets and vitamin D deficiency: new guidelines for vitamin D intake. Pediatrics 111:908\u2013910","journal-title":"Pediatrics"},{"key":"2185_CR3","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.exer.2015.02.019","volume":"134","author":"RY Reins","year":"2015","unstructured":"Reins RY, Mc Dermott AM (2015) Vitamin D: implications for ocular disease and therapeutic potential. Exp Eye Res 134:101\u2013110","journal-title":"Exp Eye Res"},{"key":"2185_CR4","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1159\/000265436","volume":"18","author":"A Verstappen","year":"1986","unstructured":"Verstappen A, Parmentie M, Chirnoaga M, Lawson DE, Pasteels JL, Pochet R (1986) Vitamin D-dependent calcium binding protein immunoreactivity in human retina. Ophthalmic Res 18:209\u2013214","journal-title":"Ophthalmic Res"},{"key":"2185_CR5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3109\/02713689508999921","volume":"14","author":"JA Johnson","year":"1995","unstructured":"Johnson JA, Grande JP, Roche PC, Campbell RJ, Kumar R (1995) Immunolocalization of the calcitriol receptor, calbindin-D28k and the plasma membrane calcium pump in the human eye. Curr Eye Res 14:101\u2013108","journal-title":"Curr Eye Res"},{"key":"2185_CR6","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1167\/iovs.13-13019","volume":"55","author":"JA Alsalem","year":"2014","unstructured":"Alsalem JA, Patel D, Susarla R, Coca-Prados M, Bland R, Walker EA et al (2014) Characterization of vitamin D production by human ocular barrier cells. Investig Ophthalmol Vis Sci 55:2140\u20132147","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"2185_CR7","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/dmr.5610110104","volume":"11","author":"G Dahlquist","year":"1995","unstructured":"Dahlquist G (1995) Environmental risk factors in human type 1 diabetes\u2014an epidemiological perspective. Diabetes Metab Rev 11:37\u201346","journal-title":"Diabetes Metab Rev"},{"key":"2185_CR8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s001250051112","volume":"42","author":"The EURODIAB Substudy 2 Study Group","year":"1999","unstructured":"The EURODIAB Substudy 2 Study Group (1999) Vitamin D supplement in early childhood and risk for type I (insulindependent) diabetes mellitus. Diabetologia 42:51\u201354","journal-title":"Diabetologia"},{"key":"2185_CR9","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1007\/s00125-005-1802-7","volume":"48","author":"C Mathieu","year":"2005","unstructured":"Mathieu C, Gysemans C, Giulietti A, Bouillon R (2005) Vitamin D and diabetes. Diabetologia 48:1247\u20131257","journal-title":"Diabetologia"},{"key":"2185_CR10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2217\/14796678.5.1.15","volume":"5","author":"ED Michos","year":"2009","unstructured":"Michos ED (2009) Vitamin D deficiency and the risk of incident Type 2 diabetes. Fut Cardiol 5:15\u201318","journal-title":"Fut Cardiol"},{"key":"2185_CR11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s12020-008-9115-5","volume":"35","author":"LG Danescu","year":"2009","unstructured":"Danescu LG, Levy S, Levy J (2009) Vitamin D and diabetes mellitus. Endocrine 35:11\u201317","journal-title":"Endocrine"},{"key":"2185_CR12","doi-asserted-by":"publisher","first-page":"185","DOI":"10.4158\/EP11147.OR","volume":"18","author":"JF Payne","year":"2012","unstructured":"Payne JF, Ray R, Watson DG, Delille C, Rimler E, Cleveland J et al (2012) Vitamin D insufficiency in diabetic retinopathy. Endocr Pract 18:185\u2013193","journal-title":"Endocr Pract"},{"key":"2185_CR13","first-page":"112067212090202","volume":"3","author":"E Vural","year":"2020","unstructured":"Vural E, Hazar L, \u00c7a\u011flayan M, \u015eeker \u00d6, \u00c7elebi ARC (2020) Peripapillary choroidal thickness in patients with vitamin D deficiency. Eur J Ophthalmol 3:1120672120902025","journal-title":"Eur J Ophthalmol"},{"key":"2185_CR14","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.jcjo.2020.06.014","volume":"55","author":"H \u00d6nc\u00fcl","year":"2020","unstructured":"\u00d6nc\u00fcl H, Alakus MF, \u00c7a\u011flayan M, \u00d6nc\u00fcl FY, Dag U, Arac E (2020) Changes in choroidal thickness after vitamin D supplementation in patients with vitamin D deficiency. Can J Ophthalmol 55:486\u2013491","journal-title":"Can J Ophthalmol"},{"key":"2185_CR15","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1210\/jc.2011-0385","volume":"96","author":"MF Holick","year":"2011","unstructured":"Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP et al (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:1911\u20131930","journal-title":"J Clin Endocrinol Metab"},{"key":"2185_CR16","doi-asserted-by":"publisher","first-page":"280","DOI":"10.4274\/jcrpe.2183","volume":"7","author":"O Neyzi","year":"2015","unstructured":"Neyzi O, Bundak R, Gokcay G, G\u00fcn\u00f6z H, Furman A, Darendeliler F et al (2015) Reference values for weight, height, head circumference, and body mass index in Turkish children. J Clin Res Pediatr Endocrinol 7:280\u2013293","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"2185_CR17","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1097\/OPX.0000000000000229","volume":"91","author":"M Kim","year":"2014","unstructured":"Kim M, Kim SS, Koh HJ, Lee SC (2014) Choroidal thickness, age, and refractive error in healthy Korean subjects. Vis Sci 91:491\u2013496","journal-title":"Vis Sci"},{"key":"2185_CR18","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1167\/iovs.11-8782","volume":"53","author":"CS Tan","year":"2012","unstructured":"Tan CS, Ouyang Y, Ruiz H, Sadda SR (2012) Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci 53:261\u2013266","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2185_CR19","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1080\/10790268.2015.1114224","volume":"39","author":"B Aminmansour","year":"2016","unstructured":"Aminmansour B, Asnaashari A, Rezvani M (2016) Effects of progesterone and vitamin D on outcome of patients with acute traumatic spinal cord injury; a randomized, double-blind, placebo-controlled study. J Spinal Cord Med 39:272\u2013280","journal-title":"J Spinal Cord Med"},{"key":"2185_CR20","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s11481-016-9720-7","volume":"12","author":"R Calvello","year":"2016","unstructured":"Calvello R, Cianciulli A, Nicolardi G (2016) Vitamin D treatment attenuates neuroinflammation and dopaminergic neurodegeneration in an animal model of Parkinson\u2019s disease, shifting M1 to M2 microglia responses. J NeuroImmune Pharmacol 12:327\u2013339","journal-title":"J NeuroImmune Pharmacol"},{"key":"2185_CR21","doi-asserted-by":"publisher","first-page":"820","DOI":"10.2174\/1567205014666170207093455","volume":"14","author":"J Cheng","year":"2017","unstructured":"Cheng J, Rui Y, Qin L (2017) Vitamin D combined with resveratrol prevents cognitive decline in SAMP8 mice. Curr Alzheimer Res 14:820\u2013833","journal-title":"Curr Alzheimer Res"},{"key":"2185_CR22","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3389\/fpsyt.2017.00047","volume":"8","author":"E Kocovska","year":"2017","unstructured":"Kocovska E, Gaughran F, Krivoy A (2017) Vitamin-D deficiency as a potential environmental risk factor in multiple sclerosis, schizophrenia, and autism. Front Psychiatry 8:47","journal-title":"Front Psychiatry"},{"key":"2185_CR23","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ensci.2018.12.004","volume":"14","author":"R AlJohri","year":"2018","unstructured":"AlJohri R, AlOkail M, Haq SH (2018) Neuroprotective role of vitamin D in primary neuronal cortical culture. ENeurologicalSci 14:43\u201348","journal-title":"ENeurologicalSci"},{"key":"2185_CR24","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.3390\/nu9101120","volume":"9","author":"A Garcia Layana","year":"2017","unstructured":"Garcia Layana A, Minnella AM, Garhoefer G, Aslam T, Holz FG, Leys A et al (2017) Vitamin D and age-related macular degeneration. Nutrients 9:1120","journal-title":"Nutrients"},{"key":"2185_CR25","doi-asserted-by":"crossref","unstructured":"Bener A, Elia\u00e7\u0131k M, Cincik H, \u00d6zt\u00fcrk M, DeFronzo RA, Abdul-Ghani M (2018) The impact of vitamin D deficiency on retinopathy and hearing loss among Type 2 diabetic patients. BioMed Res Int, 2714590","DOI":"10.1155\/2018\/2714590"},{"key":"2185_CR26","doi-asserted-by":"publisher","first-page":"4023","DOI":"10.1210\/jc.2008-1212","volume":"94","author":"O Tarcin","year":"2009","unstructured":"Tarcin O, Yavuz DG, Ozben B, Telli A, Velioglu Ogunc A, Yuksel M et al (2009) Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab 94:4023\u20134030","journal-title":"J Clin Endocrinol Metab"},{"key":"2185_CR27","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1159\/000330075","volume":"27","author":"C Molinari","year":"2011","unstructured":"Molinari C, Uberti F, Grossini E, Vacca G, Carda S, Invernizzi M et al (2011) 1a,25-Dihydroxycholecalciferol induces nitric oxide production in cultured endothelial cells. Cell Physiol Biochem 27:661\u2013668","journal-title":"Cell Physiol Biochem"},{"key":"2185_CR28","doi-asserted-by":"crossref","unstructured":"Mutlu U, Ikram MA, Hofman A, de Jong PTVM, Uitterlinden AG, Klaver CCW et al\u00a0(2016) Vitamin D and retinal microvascular damage. Medicine (Baltimore) 95:e5477","DOI":"10.1097\/MD.0000000000005477"},{"key":"2185_CR29","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s00592-008-0071-6","volume":"46","author":"A Bener","year":"2009","unstructured":"Bener A, Alsaied A, Al-Ali M, Al-Kubaisi A, Basha B, Abraham A et al (2009) High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children. Acta Diabetol 46:183\u2013189","journal-title":"Acta Diabetol"},{"key":"2185_CR30","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0009-9120(99)00085-5","volume":"33","author":"H Aksoy","year":"2000","unstructured":"Aksoy H, Ak\u00e7ay F, Kurtul N, Baykal O, Avci B (2000) Serum 1,25 dihydroxy vitamin D (1,25(OH)2D3), 25 hydroxy vitamin D (25(OH)D) and parathormone levels in diabetic retinopathy. Clin Biochem 33:47\u201351","journal-title":"Clin Biochem"},{"key":"2185_CR31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.diabres.2014.08.005","volume":"106","author":"N Shimo","year":"2014","unstructured":"Shimo N, Yasuda T, Kaneto H, Katakami N, Kuroda A, Sakamoto F et al (2014) Vitamin D deficiency is significantly associated with retinopathy in young Japanese type 1 diabetic patients. Diabetes Res Clin Pract 106:41\u201343","journal-title":"Diabetes Res Clin Pract"},{"key":"2185_CR32","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1111\/dme.12581","volume":"31","author":"R He","year":"2014","unstructured":"He R, Shen J, Liu F, Zeng H, Li L, Yu H et al (2014) Vitamin D deficiency increases the risk of retinopathy in Chinese patients with type 2 diabetes. Diabet Med 31:1657\u20131664","journal-title":"Diabet Med"},{"key":"2185_CR33","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1080\/00325481.2016.1210475","volume":"128","author":"U Yolcu","year":"2016","unstructured":"Yolcu U, \u00c7a\u011f\u0131ltay E, Toyran S, Akay F, Uzun S, Gundogan FC (2016) Choroidal and macular thickness changes in type 1 diabetes mellitus patients without diabetic retinopathy. Postgrad Med 128:755\u2013760","journal-title":"Postgrad Med"},{"key":"2185_CR34","doi-asserted-by":"publisher","first-page":"6803","DOI":"10.1167\/iovs.12-10314","volume":"53","author":"M Esmaeelpour","year":"2012","unstructured":"Esmaeelpour M, Brunner S, Ansari-Shahrezaei S, Nemetz S, Povazay B, Kajic V et al (2012) Choroidal thinning in diabetes type 1 detected by 3-dimensional 1060 nm optical coherence tomography. Invest Ophthalmol Vis Sci 53:6803\u20136809","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2185_CR35","first-page":"203","volume":"98","author":"T Li","year":"2020","unstructured":"Li T, Jia Y, Wang S, Xu Y, Yin Y, Wang A et al (2020) Change in peripapillary and macular choroidal thickness change in children with type 1 diabetes mellitus without visual impairment or diabetic retinopathy. Acta Ophthalmol 98:203\u2013211","journal-title":"Acta Ophthalmol"},{"key":"2185_CR36","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3109\/08820538.2013.838279","volume":"29","author":"N Sayin","year":"2014","unstructured":"Sayin N, Kara N, Pirhan D, Vural A, Araz Ersan HB, Onal H et al (2014) Evaluation of subfoveal choroidal thickness in children with type 1 diabetes mellitus: an EDI-OCT study. Semin Ophthalmol 29:27\u201331","journal-title":"Semin Ophthalmol"},{"key":"2185_CR37","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1515\/jpem-2013-0499","volume":"28","author":"S Elhabashy","year":"2015","unstructured":"Elhabashy S, Elbarbary N, Nageb K, Mohammed M (2015) Can optical coherence tomography predict early retinal microvascular pathology in type 1 diabetic adolescents without minimal diabetic retinopathy? A single-centre study. J Pediatr Endocrinol Metab 28:139\u2013146","journal-title":"J Pediatr Endocrinol Metab"},{"key":"2185_CR38","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1097\/IAE.0000000000002420","volume":"40","author":"M Niestrata-Ortiz","year":"2020","unstructured":"Niestrata-Ortiz M, Fichna P, Stankiewicz W, Stopa M (2020) Determining the effect of diabetes duration on retinal and choroidal thicknesses in children with type 1 diabetes mellitus. Retina 40:421\u2013427","journal-title":"Retina"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-021-02185-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-021-02185-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-021-02185-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T13:15:34Z","timestamp":1654002934000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-021-02185-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,28]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["2185"],"URL":"https:\/\/doi.org\/10.1007\/s10792-021-02185-2","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,28]]},"assertion":[{"value":"4 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no financial conflicts of interest to disclose. All authors attest that they meet the current ICMJE requirements to qualify as authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Adiyaman University Ethics Committee (Approval date: 29.12.2020, Approval number: 2020-14-5).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}