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Age-matched primary angle closure suspect (PACS) and healthy control groups were also recruited. The vessel density (VD) and foveal avascular zone (FAZ) in each macular superficial area were measured using OCTA. The retinal nerve fiber layer thickness (RNFLT) and ganglion cell complex thickness (GCCT) of the corresponding regions were measured using OCT.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All parameters in the control, PACS, and mild APACG groups differed significantly from those in the moderate and severe APACG groups (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). VD and RNFLT showed high and moderate diagnostic ability, respectively, to distinguish moderate APACG from PACS, with significant differences (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in areas under the receiver operating characteristic curve (AUCs) for VD and RNFLT in six macular areas. The diagnostic abilities of VD and RNFLT for distinguishing severe APACG from PACS were increased, with significant differences in the AUCs for VD and RNFLT in five macular areas (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). All macular VDs and GCCTs were similar among the three APACG groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Damage to the VD and FAZ in the macula increased with APACG severity. VD in the macular superficial layer showed a higher diagnostic ability than RNFLT, which was equivalent to that of GCCT.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10792-022-02399-y","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T13:02:53Z","timestamp":1656939773000},"page":"3789-3801","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Changes of macular blood flow and structure in acute primary angle closure glaucoma"],"prefix":"10.1007","volume":"42","author":[{"given":"Rui","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liukun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1052-4222","authenticated-orcid":false,"given":"Xuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"2399_CR1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjophth-2016-000032","volume":"1","author":"KKW Chan","year":"2017","unstructured":"Chan KKW, Tang F, Tham CCY, Young AL, Cheung CY (2017) Retinal vasculature in glaucoma: a review. 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