{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:15:25Z","timestamp":1770833725080,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-022-02432-0","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T13:03:11Z","timestamp":1658322191000},"page":"371-380","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinicopathological profile, management and clinical outcomes in recurrent cases of ocular surface squamous neoplasia at a tertiary care centre"],"prefix":"10.1007","volume":"43","author":[{"given":"Sonali Vinay","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay Kumar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alok","family":"Sati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"issue":"39","key":"2432_CR1","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0039-6257(05)80054-2","volume":"1995","author":"GA Lee","year":"1995","unstructured":"Lee GA, Hirst LW (1995) Ocular surface squamous neoplasia. Surv Ophthalmol 1995(39):429\u2013450","journal-title":"Surv Ophthalmol"},{"issue":"3","key":"2432_CR2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.mjafi.2017.01.006","volume":"74","author":"SV Kumar","year":"2018","unstructured":"Kumar SV, Joshi DK (2018) Ocular surface squamous neoplasia. Med J Armed Forces India 74(3):273\u2013275","journal-title":"Med J Armed Forces India"},{"key":"2432_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.survophthal.2003.10.008","volume":"49","author":"CL Shields","year":"2004","unstructured":"Shields CL, Shields JA (2004) Tumors of the conjunctiva and cornea. Surv Ophthalmol 49:3\u201324","journal-title":"Surv Ophthalmol"},{"issue":"2","key":"2432_CR4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.ophtha.2011.08.005","volume":"119","author":"YA Yousef","year":"2012","unstructured":"Yousef YA, Finger PT (2012) Squamous carcinoma and dysplasia of the conjunctiva and cornea: an analysis of 101 cases. Ophthalmology 119(2):233\u2013240","journal-title":"Ophthalmology"},{"key":"2432_CR5","first-page":"2131","volume":"118","author":"CL Shield","year":"2011","unstructured":"Shield CL, Ramasubramanium A, Mellen PL, Shield JA (2011) Conjunctival squamous cell carcinoma arising in immunosuppressed patients (organ transplant, humandeficiency virus infections). Ophthalmology 118:2131\u20132133","journal-title":"Ophthalmology"},{"key":"2432_CR6","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1136\/bjo.87.4.396","volume":"87","author":"W Tulvatana","year":"2003","unstructured":"Tulvatana W, Bhattarakosal P, Sansopha L et al (2003) Risk factors for conjunctival squamous cell neoplasia: a matched case control study. Br J Ophthalmol 87:396\u2013398","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"2432_CR7","first-page":"109","volume":"6","author":"CL Shields","year":"2017","unstructured":"Shields CL, Chien JL, Surakiatchanukul T, Sioufi K, Lally SE, Shields JA (2017) Conjunctival tumors: review of clinical features, risks, biomarkers, and outcomes. Asia Pac J Ophthalmol 6(2):109\u2013120","journal-title":"Asia Pac J Ophthalmol"},{"issue":"7","key":"2432_CR8","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1097\/00003226-200310000-00015","volume":"22","author":"S Basti","year":"2003","unstructured":"Basti S, Macsai MS (2003) Ocular surface squamous neoplasia: a review. Cornea 22(7):687\u2013704","journal-title":"Cornea"},{"issue":"3","key":"2432_CR9","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1097\/00003226-200005000-00004","volume":"19","author":"S Sudesh","year":"2000","unstructured":"Sudesh S, Rapuano CJ, Cohen EJ, Eagle RC Jr, Laibson PR (2000) Surgical management of ocular surface squamous neoplasms: the experience from a cornea center. Cornea 19(3):278\u2013283","journal-title":"Cornea"},{"key":"2432_CR10","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1097\/ICO.0b013e3182a6ea6c","volume":"32","author":"E Adler","year":"2013","unstructured":"Adler E, Turner JR, Stone DU (2013) Ocular surface squamous neoplasia:a survey of changes in the standard of care from 2003 to 2012. Cornea 32:1558\u20131561","journal-title":"Cornea"},{"issue":"3","key":"2432_CR11","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/01.ico.0000138834.42489.ba","volume":"24","author":"DU Stone","year":"2005","unstructured":"Stone DU, Butt AL, Chodosh J (2005) Ocular surface squamous neoplasia: a standard of care survey. Cornea 24(3):297\u2013300","journal-title":"Cornea"},{"key":"2432_CR12","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/S0161-6420(97)30287-5","volume":"104","author":"TGL Snibson","year":"1997","unstructured":"Snibson TGL, Loughnan M, Taylor H (1997) Late recurrences and the necessity for long- term follow-up in corneal and conjunctival intraepithelial neoplasia. Ophthalmology 104:485\u2013492","journal-title":"Ophthalmology"},{"issue":"2","key":"2432_CR13","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/S0161-6420(86)33764-3","volume":"93","author":"JC Erie","year":"1983","unstructured":"Erie JC, Campbell RJ, Liesegang TJ (1983) Conjunctival and corneal intraepithelial and invasive neoplasia. Ophthalmology 93(2):176\u2013183","journal-title":"Ophthalmology"},{"key":"2432_CR14","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1016\/j.ophtha.2012.04.022","volume":"119","author":"A Golar","year":"2012","unstructured":"Golar A, Karp CL, Oellers P, Kao AA, Abdelaziz A, Feuer W et al (2012) Predictors of ocular surface squamous neoplasia recurrence after excisional surgery. Ophthalmology 119:1974\u20131981","journal-title":"Ophthalmology"},{"issue":"2","key":"2432_CR15","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ajo.2015.04.027","volume":"160","author":"AS Li","year":"2015","unstructured":"Li AS, Shih CY, Rosen L, Steiner A, Milman T, Udell I (2015) Recurrence of ocular surface squamous neoplasia treated with excisional biopsy and cryotherapy. Am J Ophthalmol 160(2):213\u2013219","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"2432_CR16","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1097\/IOP.0b013e3181ac4c39","volume":"25","author":"PL Ballalai","year":"2009","unstructured":"Ballalai PL, Erwenne CM, Martins MC, Lowen MS, Barros JN (2009) Long-term results of topical mitomycin c 0.02% for primary and recurrent conjunctival-corneal intraepithelial neoplasia. Ophthal Plast Reconstr Surg 25(4):296\u2013299","journal-title":"Ophthal Plast Reconstr Surg"},{"issue":"1","key":"2432_CR17","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/ceo.12377","volume":"43","author":"AK Rudkin","year":"2015","unstructured":"Rudkin AK, Dempster L, Muecke JS (2015) Management of diffuse ocular surface squamous neoplasia: efficacy and complications of topical chemotherapy. Clin Exp Ophthalmol 43(1):20\u201325","journal-title":"Clin Exp Ophthalmol"},{"issue":"2","key":"2432_CR18","first-page":"131","volume":"80","author":"GA Viani","year":"2017","unstructured":"Viani GA, Fendi LI (2017) Adjuvant treatment or primary topical monotherapy for ocular surface squamous neoplasia:a systemic review. Arq Bras Oftalmos 80(2):131\u2013136","journal-title":"Arq Bras Oftalmos"},{"issue":"3","key":"2432_CR19","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1097\/ICO.0b013e3182523f61","volume":"32","author":"CL Shields","year":"2013","unstructured":"Shields CL, Kaliki S, Kim HJ, Al-Dahmash S, Shah SU, Lally SE, Shields JA (2013) Interferon for ocular surface squamous neoplasia in 81 cases: outcomes based on the American Joint Committee on Cancer Classification. Cornea 32(3):248\u2013256","journal-title":"Cornea"},{"issue":"8","key":"2432_CR20","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.ophtha.2008.01.006","volume":"115","author":"A Sturges","year":"2008","unstructured":"Sturges A, Butt AL, Lai JE, Chodosh J (2008) Topical interferon or surgical excision for the management of primary ocular surface squamous neoplasia. Ophthalmology 115(8):1297\u20131302","journal-title":"Ophthalmology"},{"issue":"1","key":"2432_CR21","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1097\/ICO.0b013e3181dee560","volume":"30","author":"ES Birkholz","year":"2011","unstructured":"Birkholz ES, Goins KM, Sutphin JE, Kitzmann AS, Wagoner MD (2011) Treatment of ocular surface squamous cell intraepithelial neoplasia with and without mitomycin C. Cornea 30(1):37\u201341","journal-title":"Cornea"},{"issue":"10","key":"2432_CR22","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1136\/bjo.2009.176099","volume":"94","author":"HC Russell","year":"2010","unstructured":"Russell HC, Chadha V, Lockington D, Kemp EG (2010) Topical mitomycin C chemotherapy in the management of ocular surface neoplasia: a 10-year review of treatment outcomes and complications. Br J Ophthalmol 94(10):1316\u20131321","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"2432_CR23","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1136\/bjo.2010.183244","volume":"95","author":"R Parrozini","year":"2011","unstructured":"Parrozini R, Lazzarini D, Alemony RE, Urban F, Midena E (2011) Topical 1% 5 Flurouracil in ocular squamous neoplasia: a long-term safety study. Br J Ophthalmol 95(3):355\u2013399","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"2432_CR24","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/ceo.12184","volume":"42","author":"B Bahrami","year":"2014","unstructured":"Bahrami B, Greenwell T, Muecke J (2014) Long-term outcomes after adjunctive topical 5-flurouracil or mitomycin C for the treatment of surgically excised, localized ocular surface squamous neoplasia. Clin Exp Ophthalmol 42(4):317\u2013322","journal-title":"Clin Exp Ophthalmol"},{"issue":"2","key":"2432_CR25","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3322\/caac.21388","volume":"67","author":"MB Amin","year":"2017","unstructured":"Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookeland RK, Meyer L, Gress DM, Byrd DR, Winchester DP (2017) The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging CA. Cancer J Clin 67(2):93\u201399","journal-title":"Cancer J Clin"},{"key":"2432_CR26","first-page":"787","volume-title":"Conjunctival carcinoma. AJCC cancer staging manual","author":"RM Conway","year":"2017","unstructured":"Conway RM, Graue GF, Pelayes DE et al (2017) Conjunctival carcinoma. AJCC cancer staging manual, 8th edn. Springer, New York, pp 787\u2013793","edition":"8"},{"issue":"2","key":"2432_CR27","first-page":"283","volume":"33","author":"CA Kiire","year":"2019","unstructured":"Kiire CA, Stewart RMK, Srinivasan S, Heimann H, Kaye SB, Dhillon B (2019) A prospective study of the incidence, associations and outcomes of ocular surface squamous neoplasia in the United Kingdom. Eye(Lond) 33(2):283\u2013294","journal-title":"Eye(Lond)"},{"key":"2432_CR28","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/S0002-9394(99)00286-X","volume":"129","author":"MS Sridhar","year":"2000","unstructured":"Sridhar MS, Honaver SG, Vemuganti G, Rao GN (2000) Conjunctival intraepithelial neoplasia presenting as corneal ulcer. Am J Ophthalmol 129:92\u201394","journal-title":"Am J Ophthalmol"},{"key":"2432_CR29","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/0039-6257(88)90072-0","volume":"33","author":"KA Lindenmuth","year":"1988","unstructured":"Lindenmuth KA, Sugar A, Kincaid MC, Nelson CC, Comstock CP (1988) Invasive squamous cell carcinoma of the conjunctiva presenting as necrotizing scleritis with scleral perforation and uveal prolapse. Surv Ophthalmol 33:50\u201354","journal-title":"Surv Ophthalmol"},{"key":"2432_CR30","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1097\/00003226-199905000-00007","volume":"18","author":"EK Akpek","year":"1999","unstructured":"Akpek EK, Polcharoen W, Chan R, Foster C (1999) Ocular surface neoplasia masquerading as chronic blepharoconjunctivitis. Cornea 18:282\u2013288","journal-title":"Cornea"},{"key":"2432_CR31","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1097\/ICL.0b013e31815700af","volume":"34","author":"E Mirza","year":"2008","unstructured":"Mirza E, Gumus K, Evereklioglu C, Arda H, Oner A, Canoz O et al (2008) Invasive squamous cell carcinoma of the conjunctiva first misdiagnosed as a pterygium: a clinicopathologic report. Eye Contact Lens 34:188\u2013190","journal-title":"Eye Contact Lens"},{"key":"2432_CR32","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/S0008-4182(02)80093-X","volume":"37","author":"G Cervantes","year":"2002","unstructured":"Cervantes G, Rodriguez AA, Leal AG (2002) Squamous cell carcinoma of the conjunctiva: clinicopathological features in 287 cases. Can J Ophthalmol 37:14\u201320","journal-title":"Can J Ophthalmol"},{"issue":"11","key":"2432_CR33","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1007\/s00417-013-2450-0","volume":"251","author":"BH Kim","year":"2013","unstructured":"Kim BH, Kim MK, Wee WR, Oh JY (2013) Clinical and pathological characteristics of ocular surface squamous neoplasia in an Asian population. Graefes Arch Clin Exp Ophthalmol 251(11):2569\u20132573","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"10","key":"2432_CR34","doi-asserted-by":"publisher","first-page":"936","DOI":"10.4103\/ijo.IJO_251_17","volume":"65","author":"R Meel","year":"2017","unstructured":"Meel R, Dhiman R, Vanathi M, Pushker N, Tandon R, Devi S (2017) Clinicodemographic profile and treatment outcome in patients of ocular surface squamous neoplasia. Indian J Ophthalmol 65(10):936\u2013941","journal-title":"Indian J Ophthalmol"},{"issue":"2","key":"2432_CR35","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1136\/bjo.86.2.168","volume":"86","author":"PA McKelvie","year":"2002","unstructured":"McKelvie PA, Daniell M, McNab A, Loughnan M, Santamaria JD (2002) Squamous cell carcinoma of the conjunctiva: a series of 26 cases. Br J Ophthalmol 86(2):168\u2013173","journal-title":"Br J Ophthalmol"},{"issue":"9","key":"2432_CR36","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.18240\/ijo.2019.09.09","volume":"12","author":"I Mirzayev","year":"2019","unstructured":"Mirzayev I, Gunduz AK, Ozalp Ates FS, Ozcan G, Isik MU (2019) Factors affecting recurrence after surgical treatment in cases with ocular surface squamous neoplasia. Int J Ophthalmol 12(9):1426\u20131431","journal-title":"Int J Ophthalmol"},{"issue":"9","key":"2432_CR37","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1016\/j.ophtha.2012.02.049","volume":"119","author":"AA Kao","year":"2012","unstructured":"Kao AA, Galor A, Karp CL, Abdelaziz A, Feuer WJ, Dubovy SR (2012) Clinicopathologic correlation of ocular surface squamous neoplasms at Bascom Palmer Eye Institute: 2001 to 2010. Ophthalmology 119(9):1773\u20131776","journal-title":"Ophthalmology"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-022-02432-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-022-02432-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-022-02432-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T02:04:07Z","timestamp":1677549847000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-022-02432-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,20]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["2432"],"URL":"https:\/\/doi.org\/10.1007\/s10792-022-02432-0","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,20]]},"assertion":[{"value":"12 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional reserch committee (Army Hospital Reserch & Referral) and with the 1964 Helsiniki Declaration and its amendments or comparable ethical standards. This manuscript did not involve any kind of animal research. All the authors consent to the publication of this manuscript in International Ophthalmology.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participant included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}