{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:55:27Z","timestamp":1785365727954,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To analyze the choroidal thickness between patients with keratoconus undergoing cross-linking treatment and a healthy population, as well as to determine the factors that influence choroidal thickness.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This was an observational, analytical, case\u2013control study that was conducted from February 2021 to June 2021. Choroidal thickness was measured at different locations, including the subfoveal, nasal (1000\u00a0\u03bcm), temporal (1000\u00a0\u03bcm), superior (1000\u00a0\u03bcm) and inferior (1000\u00a0\u03bcm) locations using a Spectral-domain optical coherence tomography with enhanced depth imaging, which allowed us to obtain horizontal and vertical B-scans centered on the fovea.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>This study included 21 patients with keratoconus (mean age, 21.86\u2009\u00b1\u20095.28\u00a0years) and 28 healthy patients (mean age, 24.21\u2009\u00b1\u20094.71\u00a0years). Choroidal thickness was significantly greater in patients with keratoconus than in healthy patients in each of the following measured locations: subfoveal (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001); nasal (1000\u00a0\u03bcm) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), temporal (1000\u00a0\u03bcm) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), superior (1000\u00a0\u03bcm) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and inferior (1000\u00a0\u03bcm) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) locations. Variables such as age (<jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u2212\u20090.09; <jats:italic>P<\/jats:italic>\u2009=\u20090.50) and refraction (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.14; <jats:italic>P<\/jats:italic>\u2009=\u20090.34) were not found to be associated with choroidal thickness. In a stepwise multiple linear regression, the group was the single variable correlated with choroidal thickness (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.88; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Choroidal thickness is thicker in keratoconus patients treated with cross-linking than in the healthy population. This finding could be associated with inflammatory choroidal mechanisms in keratoconus patients, but more studies are needed. Age and refractive error do not seem to influence choroidal thickness.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10792-022-02517-w","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T03:30:46Z","timestamp":1663903846000},"page":"1185-1192","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Choroidal thickness assessment in keratoconus patients treated with cross-linking compared to healthy population"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9248-8685","authenticated-orcid":false,"given":"Antonio","family":"Ballesteros-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0382-2053","authenticated-orcid":false,"given":"Concepci\u00f3n","family":"De-Hita-Cantalejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9453-8615","authenticated-orcid":false,"given":"Mar\u00eda Carmen","family":"S\u00e1nchez-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-5014","authenticated-orcid":false,"given":"Mar\u00eda-Jos\u00e9","family":"Bautista-Llamas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0450-7717","authenticated-orcid":false,"given":"Jos\u00e9-Mar\u00eda","family":"S\u00e1nchez-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4618-6675","authenticated-orcid":false,"given":"Beatriz","family":"Gargallo-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"2517_CR1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/ICO.0000000000000408","volume":"34","author":"JAP Gomes","year":"2015","unstructured":"Gomes JAP, Tan D, Rapuano CJ et al (2015) Global consensus on keratoconus and ectatic diseases. 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The study was approved by the research ethics committee of the University of Murcia (CEIC).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standard"}},{"value":"All subjects from this research read, signed, and gave the researcher their informed consent prior to their inclusion in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication of the images in Fig.\u00a0","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}