{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:18:16Z","timestamp":1790036296450,"version":"4.0.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005743","name":"Universit\u00e0 Cattolica del Sacro Cuore","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005743","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The aim of this study is to investigate changes in choroidal and optic nerve morphological parameters following MicroShunt PreserFlo implantation. The secondary aim is to investigate how the structural changes relate to the decrease in intraocular pressure (IOP).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Prospective observational study on 15 eyes with glaucoma requiring MicroShunt implantation. Optical coherence tomography was used to measure macular choroidal thickness (MCT), peripapillary choroidal thickness (PCT), lamina cribrosa depth (LCD), cup depth and prelaminar tissue thickness (PLT), before and one day after surgery. Results were expressed in median and interquartile range (IQR) and correlated with IOP results.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The IOP decreased from a median of 25 (IQR\u2009=\u200911) mmHg to 8 (IQR\u2009=\u20092) mmHg the day after surgery. Median MCT increased after MicroShunt implantation from 252.1 (IQR\u2009=\u2009156.4) \u00b5m to a postoperative value of 318.1 (IQR\u2009=\u2009166.6) \u00b5m (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with a median increase of\u2009+\u200987.7\u00a0\u00b5m (+\u200926.4%). PCT increased from 157.2 (IQR\u2009=\u2009109.1) \u00b5m before surgery to 206.0 (IQR\u2009=\u2009136.1) \u00b5m after surgery (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Moreover, we found a significant post-operative decrease in cup depth (median reduction of \u2212\u200929.3\u00a0\u00b5m, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and an increase in PLT (median increase of 27.3\u00a0\u00b5m, <jats:italic>p<\/jats:italic>\u2009=\u20090.028). On the other side, LCD reduction 24\u00a0h after surgery didn\u2019t reach any statistical significance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>PreserFlo implantation determines retinal structural changes which appear similar to those caused by traditional filtering surgery, confirming the effectiveness of this device, meantime carrying a much smaller complications rate when compared to trabeculectomy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10792-022-02519-8","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T10:05:57Z","timestamp":1663754757000},"page":"1207-1214","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early evaluation of optic nerve head morphology and choroidal thickness after PreserFlo MicroShunt implantation"],"prefix":"10.1007","volume":"43","author":[{"given":"Gloria","family":"Gambini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-1638","authenticated-orcid":false,"given":"Matteo Mario","family":"Carl\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomaso","family":"Caporossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Baldascino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Crincoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"De Vico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Savastano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Caporossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislao","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"2519_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ajo.2011.01.024","volume":"152","author":"EJ Lee","year":"2011","unstructured":"Lee EJ, Kim T-W, Weinreb RN, Park KH, Kim SH, Kim DM (2011) Visualization of the lamina cribrosa using enhanced depth imaging spectral-domain optical coherence tomography. 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