{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:35:15Z","timestamp":1791264915694,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To analyse and quantify ocular surface parameters in patients with unilateral neurotrophic keratitis (NK) induced by trigeminal nerve injury post-neurosurgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The study included 26 unilateral NK patients who had undergone neurosurgery, and 20 matched normal controls. Demographic and clinical characteristics of all participants were collected and analysed. Slit-lamp examination, Cochet\u2013Bonnet aesthesiometry, Keratograph 5\u00a0M, and LipiView interferometer were performed on both eyes of 17 mild NK patients. For nine moderate\/severe NK patients, sub-basal nerve density was measured by in vivo confocal microscopy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of the 26 patients, nine had acoustic neuroma, nine had trigeminal neuralgia, and eight had neoplasms. Facial\u00a0nerve\u00a0paralysis was observed in one of the 17 mild NK eyes (5.9%) and seven of the nine moderate\/severe NK eyes (77.8%). Compared to contralateral and normal control eyes, 26 NK eyes showed significantly reduced sensitivity in five corneal regions (<jats:italic>P<\/jats:italic><jats:bold>\u2009&lt;\u2009<\/jats:bold>0.05). Corneal sensitivity in moderate\/severe NK eyes was significantly lower than in mild NK eyes (<jats:italic>P<\/jats:italic><jats:bold>\u2009&lt;\u2009<\/jats:bold>0.05). Moderate\/severe NK eyes had poor visual acuity, and their sub-basal nerve density was lower than that of the controls. The onset of the moderate\/severe NK was from 0.5 to 24\u00a0months (median [Q1, Q3], 1 [0.5, 2.5] months) after neurosurgery. For the mild NK eyes, the number of total blinks, the first non-invasive tear breakup time (NITBUT) and average NITBUT were significantly lower than contralateral and normal control eyes (<jats:italic>P<\/jats:italic><jats:bold>\u2009&lt;\u2009<\/jats:bold>0.05), and the number of partial blinks and partial blinking rate were significantly higher than the other two control groups (<jats:italic>P<\/jats:italic><jats:bold>\u2009&lt;\u2009<\/jats:bold>0.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Patients with NK induced by trigeminal nerve injury following neurosurgery had decreased corneal sensitivity to various degrees accompanied by increased partial blinks and shortened NITBUT. The severity of NK is related to the severity of the corneal sensory impairment. Facial nerve paralysis can worsen the clinical progression of NK.<\/jats:p>\n                <jats:p>Trial\u00a0registration\u00a0Chinese\u00a0Clinical\u00a0Trial\u00a0Registry (ChiCTR2100044068,\u00a0Date\u00a0of\u00a0Registration: March 9, 2021).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10792-022-02521-0","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T19:19:22Z","timestamp":1663442362000},"page":"1229-1240","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Characteristics of the ocular surface in neurotrophic keratitis induced by trigeminal nerve injury following neurosurgery"],"prefix":"10.1007","volume":"43","author":[{"given":"Caiyuan","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9708-0355","authenticated-orcid":false,"given":"Ruihua","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,17]]},"reference":[{"key":"2521_CR1","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.jtos.2020.09.007","volume":"19","author":"RE Ruiz-Lozano","year":"2021","unstructured":"Ruiz-Lozano RE, Hernandez-Camarena JC, Loya-Garcia D, Merayo-Lloves J, Rodriguez-Garcia A (2021) The molecular basis of neurotrophic keratopathy: diagnostic and therapeutic implications. 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