{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:28:41Z","timestamp":1781530121986,"version":"3.54.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100008255","name":"Mustafa Kemal \u00dcniversitesi","doi-asserted-by":"publisher","award":["18.D.013"],"award-info":[{"award-number":["18.D.013"]}],"id":[{"id":"10.13039\/501100008255","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-022-02523-y","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T14:04:04Z","timestamp":1666101844000},"page":"1249-1259","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prevalence of Demodex folliculorum and Demodex brevis in patients with blepharitis and chalazion"],"prefix":"10.1007","volume":"43","author":[{"given":"Serife","family":"Akkucuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem Makbule","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lokman","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talat","family":"Ozdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugur","family":"Uslu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"2523_CR1","doi-asserted-by":"publisher","first-page":"CD005556","DOI":"10.1002\/14651858.CD005556.pub2","volume":"5","author":"K Lindsley","year":"2012","unstructured":"Lindsley K, Matsumura S, Hatef E, Akpek EK (2012) Interventions for chronic blepharitis. Cochrane Database Syst Rev 5:CD005556. https:\/\/doi.org\/10.1002\/14651858.CD005556.pub2","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"2523_CR2","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.jtos.2019.06.004","volume":"17","author":"V Navel","year":"2019","unstructured":"Navel V, Mulliez A, Benoist d\u2019Azy C, Baker JS, Malecaze J, Chiambaretta F, Dutheil F (2019) Efficacy of treatments for Demodex blepharitis: a systematic review and meta-analysis. Ocul Surf 17(4):655\u2013669. https:\/\/doi.org\/10.1016\/j.jtos.2019.06.004","journal-title":"Ocul Surf"},{"issue":"2","key":"2523_CR3","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1139\/i08-016","volume":"43","author":"WB Jackson","year":"2008","unstructured":"Jackson WB (2008) Blepharitis: current strategies for diagnosis and management. Can J Ophthalmol 43(2):170\u2013179. https:\/\/doi.org\/10.1139\/i08-016","journal-title":"Can J Ophthalmol"},{"issue":"5","key":"2523_CR4","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1097\/00003226-200009000-00010","volume":"19","author":"JP McCulley","year":"2000","unstructured":"McCulley JP, Shine WE (2000) Changing concepts in the diagnosis and management of blepharitis. Cornea 19(5):650\u2013658. https:\/\/doi.org\/10.1097\/00003226-200009000-00010","journal-title":"Cornea"},{"key":"2523_CR5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2147\/OPTO.S142708","volume":"10","author":"SR Fromstein","year":"2018","unstructured":"Fromstein SR, Harthan JS, Patel J, Opitz DL (2018) Demodex blepharitis: clinical perspectives. Clin Optom (Auckl) 10:57\u201363. https:\/\/doi.org\/10.2147\/OPTO.S142708","journal-title":"Clin Optom (Auckl)"},{"issue":"4","key":"2523_CR6","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1515\/ap-2015-0110","volume":"60","author":"W Tarkowski","year":"2015","unstructured":"Tarkowski W, Owczynska M, Blaszczyk-Tyszka A, Mlocicki D (2015) Demodex mites as potential etiological factor in chalazion - a study in Poland. Acta Parasitol 60(4):777\u2013783. https:\/\/doi.org\/10.1515\/ap-2015-0110","journal-title":"Acta Parasitol"},{"key":"2523_CR7","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.ajo.2013.09.031","volume":"157","author":"L Liang","year":"2014","unstructured":"Liang L, Ding X, Tseng SC (2014) High prevalence of demodex brevis infestation in chalazia. Am J Ophthalmol 157:342-348e1","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"2523_CR8","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/sj.eye.6701816","volume":"20","author":"AM Mansour","year":"2006","unstructured":"Mansour AM, Chan CC, Crawford MA, Tabbarah ZA, Shen D, Haddad WF, Salti I, Ghazi NG (2006) Virus-induced chalazion. Eye (Lond) 20(2):242\u2013246. https:\/\/doi.org\/10.1038\/sj.eye.6701816","journal-title":"Eye (Lond)"},{"issue":"3","key":"2523_CR9","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1442-9071.2008.01714.x","volume":"36","author":"CG Burkhart","year":"2008","unstructured":"Burkhart CG, Burkhart CN (2008) Similar to acne vulgaris bacteria may produce the biological glue that causes plugging of the meibomian gland leading to chalazions. Clin Exp Ophthalmol 36(3):295\u2013296. https:\/\/doi.org\/10.1111\/j.1442-9071.2008.01714.x","journal-title":"Clin Exp Ophthalmol"},{"issue":"4","key":"2523_CR10","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1515\/ap-2016-0112","volume":"61","author":"A Sedzikowska","year":"2016","unstructured":"Sedzikowska A, Oseka M, Grytner-Ziecina B (2016) Ocular symptoms reported by patients infested with Demodex mites. Acta Parasitol 61(4):808\u2013814. https:\/\/doi.org\/10.1515\/ap-2016-0112","journal-title":"Acta Parasitol"},{"issue":"1","key":"2523_CR11","first-page":"12","volume":"12","author":"D Litwin","year":"2017","unstructured":"Litwin D, Chen W, Dzika E, Korycinska J (2017) Human permanent Ectoparasites; recent advances on biology and clinical significance of Demodex mites: narrative review article. Iran J Parasitol 12(1):12\u201321","journal-title":"Iran J Parasitol"},{"issue":"4","key":"2523_CR12","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/ICU.0000000000000168","volume":"26","author":"AM Cheng","year":"2015","unstructured":"Cheng AM, Sheha H, Tseng SC (2015) Recent advances on ocular Demodex infestation. Curr Opin Ophthalmol 26(4):295\u2013300. https:\/\/doi.org\/10.1097\/ICU.0000000000000168","journal-title":"Curr Opin Ophthalmol"},{"issue":"2","key":"2523_CR13","doi-asserted-by":"publisher","first-page":"159","DOI":"10.5301\/ejo.5000341","volume":"24","author":"JC Yam","year":"2014","unstructured":"Yam JC, Tang BS, Chan TM, Cheng AC (2014) Ocular demodicidosis as a risk factor of adult recurrent chalazion. Eur J Ophthalmol 24(2):159\u2013163. https:\/\/doi.org\/10.5301\/ejo.5000341","journal-title":"Eur J Ophthalmol"},{"key":"2523_CR14","doi-asserted-by":"publisher","first-page":"169","DOI":"10.2307\/3278267","volume":"58","author":"C Desch","year":"1972","unstructured":"Desch C, Nutting WB (1972) Demodex folliculorum (Simon) and D. brevis akbulatova of man: redescription and reevaluation. J Parasitol 58:169\u2013177","journal-title":"J Parasitol"},{"issue":"2","key":"2523_CR15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1365-4362.1976.tb00663.x","volume":"15","author":"WB Nutting","year":"1976","unstructured":"Nutting WB (1976) Hair follicle mites (Acari: demodicidae) of man. Int J Dermatol 15(2):79\u201398. https:\/\/doi.org\/10.1111\/j.1365-4362.1976.tb00663.x","journal-title":"Int J Dermatol"},{"key":"2523_CR16","doi-asserted-by":"publisher","first-page":"420","DOI":"10.5336\/medsci.2012-29698","volume":"33","author":"E Yula","year":"2013","unstructured":"Yula E, Kaya O, Atambay M, Doganay S, Daldal N, Tuzcu E (2013) What is the importance of Demodex folliculorum and D. brevis in the etiology of blepharitis? Turkiye Klinikleri J Med Sci 33:420\u2013424","journal-title":"Turkiye Klinikleri J Med Sci"},{"issue":"9","key":"2523_CR17","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.3346\/jkms.2011.26.9.1231","volume":"26","author":"JH Kim","year":"2011","unstructured":"Kim JH, Chun YS, Kim JC (2011) Clinical and immunological responses in ocular demodecosis. J Korean Med Sci 26(9):1231\u20131237. https:\/\/doi.org\/10.3346\/jkms.2011.26.9.1231","journal-title":"J Korean Med Sci"},{"issue":"2","key":"2523_CR18","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s10792-018-0826-1","volume":"39","author":"O Murphy","year":"2019","unstructured":"Murphy O, O\u2019Dwyer V, Lloyd-McKernan A (2019) Ocular Demodex folliculorum: prevalence and associated symptoms in an Irish population. Int Ophthalmol 39(2):405\u2013417. https:\/\/doi.org\/10.1007\/s10792-018-0826-1","journal-title":"Int Ophthalmol"},{"issue":"5","key":"2523_CR19","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1097\/ACI.0b013e32833df9f4","volume":"10","author":"J Liu","year":"2010","unstructured":"Liu J, Sheha H, Tseng SC (2010) Pathogenic role of Demodex mites in blepharitis. Curr Opin Allergy Clin Immunol 10(5):505\u2013510. https:\/\/doi.org\/10.1097\/ACI.0b013e32833df9f4","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"63","key":"2523_CR20","first-page":"67","volume":"53","author":"D Czepita","year":"2007","unstructured":"Czepita D, Kuzna-Grygiel W, Czepita M, Grobelny A (2007) Demodex folliculorum and Demodex brevis as a cause of chronic marginal blepharitis. Ann Acad Med Stetin 53(63):67","journal-title":"Ann Acad Med Stetin"},{"issue":"1","key":"2523_CR21","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1097\/ICL.0000000000000234","volume":"43","author":"N Kabatas","year":"2017","unstructured":"Kabatas N, Dogan AS, Kabatas EU, Acar M, Bicer T, Gurdal C (2017) The effect of Demodex infestation on blepharitis and the ocular symptoms. Eye Contact Lens 43(1):64\u201367. https:\/\/doi.org\/10.1097\/ICL.0000000000000234","journal-title":"Eye Contact Lens"},{"issue":"4","key":"2523_CR22","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1080\/092865805910057","volume":"12","author":"M Kemal","year":"2005","unstructured":"Kemal M, Sumer Z, Toker MI, Erdogan H, Topalkara A, Akbulut M (2005) The Prevalence of Demodex folliculorum in blepharitis patients and the normal population. Ophthalmic Epidemiol 12(4):287\u2013290. https:\/\/doi.org\/10.1080\/092865805910057","journal-title":"Ophthalmic Epidemiol"},{"issue":"12","key":"2523_CR23","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.3346\/jkms.2012.27.12.1574","volume":"27","author":"H Koo","year":"2012","unstructured":"Koo H, Kim TH, Kim KW, Wee SW, Chun YS, Kim JC (2012) Ocular surface discomfort and Demodex: effect of tea tree oil eyelid scrub in Demodex blepharitis. J Korean Med Sci 27(12):1574\u20131579. https:\/\/doi.org\/10.3346\/jkms.2012.27.12.1574","journal-title":"J Korean Med Sci"},{"issue":"4","key":"2523_CR24","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1097\/IOP.0000000000000500","volume":"32","author":"MJ Schear","year":"2016","unstructured":"Schear MJ, Milman T, Steiner T, Shih C, Udell IJ, Steiner A (2016) The Association of Demodex with Chalazia: a Histopathologic Study of the Eyelid. Ophthalmic Plast Reconstr Surg 32(4):275\u2013278. https:\/\/doi.org\/10.1097\/IOP.0000000000000500","journal-title":"Ophthalmic Plast Reconstr Surg"},{"issue":"4","key":"2523_CR25","first-page":"296","volume":"31","author":"M Turk","year":"2007","unstructured":"Turk M, Ozturk I, Sener AG, Kucukbay S, Afsar I, Maden A (2007) Comparison of incidence of Demodex folliculorum on the eyelash follicule in normal people and blepharitis patients. Turkiye Parazitol Derg 31(4):296\u2013297","journal-title":"Turkiye Parazitol Derg"},{"issue":"2","key":"2523_CR26","doi-asserted-by":"publisher","first-page":"319","DOI":"10.5114\/aoms.2014.42585","volume":"10","author":"M Wesolowska","year":"2014","unstructured":"Wesolowska M, Knysz B, Reich A, Blazejewska D, Czarnecki M, Gladysz A, Pozowski A, Misiuk-Hojlo M (2014) Prevalence of Demodex spp. in eyelash follicles in different populations. Arch Med Sci. 10(2):319\u2013324","journal-title":"Arch Med Sci."},{"key":"2523_CR27","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.3389\/fmicb.2018.01719","volume":"9","author":"M Zhu","year":"2018","unstructured":"Zhu M, Cheng C, Yi H, Lin L, Wu K (2018) Quantitative analysis of the bacteria in blepharitis with Demodex infestation. Front Microbiol 9:1719. https:\/\/doi.org\/10.3389\/fmicb.2018.01719","journal-title":"Front Microbiol"},{"issue":"3","key":"2523_CR28","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/cxo.13123","volume":"104","author":"E Bitton","year":"2021","unstructured":"Bitton E, Aumond S (2021) Demodex and eye disesae: a review. Clin Exp Optom 104(3):285\u2013294. https:\/\/doi.org\/10.1111\/cxo.13123","journal-title":"Clin Exp Optom"},{"issue":"1","key":"2523_CR29","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1093\/jme\/tjy143","volume":"56","author":"E Zeytun","year":"2019","unstructured":"Zeytun E, Karakurt Y (2019) Prevalence and load of Demodex folliculorum and Demodex brevis (Acari: demodicidae) in patients with chronic blepharitis in the province of Erzincan. Turkey J Med Entomol 56(1):2\u20139. https:\/\/doi.org\/10.1093\/jme\/tjy143","journal-title":"Turkey J Med Entomol"},{"key":"2523_CR30","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/ICO.0b013e31820ce56c","volume":"31","author":"YY Gao","year":"2012","unstructured":"Gao YY, Xu DL, Huang lJ, Wang R, Tseng SC (2012) Treatment of ocular itching associated with ocular demodicosis by 5% tea tree oil ointment. Cornea 31:14\u201317. https:\/\/doi.org\/10.1097\/ICO.0b013e31820ce56c","journal-title":"Cornea"},{"issue":"1","key":"2523_CR31","doi-asserted-by":"publisher","first-page":"122","DOI":"10.18240\/ijo.2017.01.20","volume":"10","author":"N Kasetsuwan","year":"2017","unstructured":"Kasetsuwan N, Kositphipat K, Busayarat M, Threekhan P, Preativatanyou K, Phumee A, Siriyasatien P (2017) Prevalence of ocular demodicosis among patients at tertiary care center, Bangkok Thailand. Int J Ophthalmol 10(1):122\u2013127. https:\/\/doi.org\/10.18240\/ijo.2017.01.20","journal-title":"Int J Ophthalmol"},{"issue":"4","key":"2523_CR32","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.ram.2017.09.002","volume":"50","author":"F Mongi","year":"2018","unstructured":"Mongi F, Laconte L, Casero RD (2018) Demodex genus: colonizing parasites of healthy people or mites associated with ocular pathology? Rev Argent Microbiol 50(4):369\u2013373. https:\/\/doi.org\/10.1016\/j.ram.2017.09.002","journal-title":"Rev Argent Microbiol"},{"issue":"4","key":"2523_CR33","doi-asserted-by":"publisher","first-page":"589","DOI":"10.18240\/ijo.2018.04.08","volume":"11","author":"XB Zhang","year":"2018","unstructured":"Zhang XB, Ding YH, He W (2018) The association between demodex infestation and ocular surface manifestations in meibomian gland dysfunction. Int J Ophthalmol 11(4):589\u2013592. https:\/\/doi.org\/10.18240\/ijo.2018.04.08","journal-title":"Int J Ophthalmol"},{"issue":"1","key":"2523_CR34","first-page":"32","volume":"33","author":"T Inceboz","year":"2009","unstructured":"Inceboz T, Yaman A, Over L, Ozturk AT, Akisu C (2009) Diagnosis and treatment of demodectic blepharitis. Turkiye Parazitol Derg 33(1):32\u201336","journal-title":"Turkiye Parazitol Derg"},{"issue":"3","key":"2523_CR35","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1093\/jme\/tjy225","volume":"56","author":"OA Kaya","year":"2019","unstructured":"Kaya OA, Akkucuk S, Ilhan G, Guneri CO, Mumcuoglu K (2019) The importance of Demodex Mites (Acari: demodicidae) in patients with sickle cell anemia. J Med Entomol 56(3):599\u2013602. https:\/\/doi.org\/10.1093\/jme\/tjy225","journal-title":"J Med Entomol"},{"issue":"6","key":"2523_CR36","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1590\/s0004-27492011000600008","volume":"74","author":"LS Yamashita","year":"2011","unstructured":"Yamashita LS, Cariello AJ, Geha NM, Yu MC, Hofling-Lima AL (2011) Demodex folliculorum on the eyelash follicle of diabetic patients. Arq Bras Oftalmol 74(6):422\u2013424. https:\/\/doi.org\/10.1590\/s0004-27492011000600008","journal-title":"Arq Bras Oftalmol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-022-02523-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-022-02523-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-022-02523-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T20:46:05Z","timestamp":1681850765000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-022-02523-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,18]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["2523"],"URL":"https:\/\/doi.org\/10.1007\/s10792-022-02523-y","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,18]]},"assertion":[{"value":"15 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We declare that there is no conflict of interest in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}