{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:11:00Z","timestamp":1791897060965,"version":"4.3.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Evaluate effectiveness and safety outcomes for patients treated with canaloplasty and trabeculotomy previously treated with a trabecular microbypass stent (TBS).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Retrospective, multicenter, IRB approved study. Patients treated with TBS (iStent\/iStent inject, Glaukos) and subsequently with OMNI surgical system (OSS) (Sight Sciences). From 5 practices in 5 US states. Open-angle glaucoma (OAG), minimum 3\u00a0months follow-up after OSS surgery, Pre-OSS IOP\u2009\u2265\u200917\u00a0mmHg on\u2009\u2265\u20091 medication. No glaucoma procedures between TBS and OSS. Endpoints: proportion with\u2009\u2265\u200920% reduction in IOP, IOP between 6 and 18\u00a0mmHg, mean IOP, change in IOP, mean number of medications. Adverse events and secondary surgical interventions (SSI). Mann\u2013Whitney rank sum test compared pre-OSS IOP and medications with follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Twenty seven patients. Average age (SD) 72.2 (10.8), 22\/27 primary OAG (82%), mean MD\u2009\u2212\u20096.2 (7.0) dB. Mean IOP before OSS 22.3 (4.3) mmHg on 2.2 (1.3) medications. At last follow-up (mean 11\u00a0months) IOP was 17.2\u00a0mmHg on 1.8 medications,\u2009\u2212\u20095.1\u00a0mmHg (\u2212\u200923%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001),\u2009\u2212\u20090.4 meds (\u2212\u200918%, <jats:italic>p<\/jats:italic>\u2009=\u2009.193);\u2009\u2265\u200920% IOP reduction (41%), IOP\u2009\u2264\u200918 (56%). Adverse events were non-serious. Hyphema\u2009&gt;\u20091\u00a0mm (3, 11%), BCVA decrease (4, 15%), IOP spike (2, 7%). SSI (4, 15%) had higher pre-OSS IOP (23.4\u00a0mmHg) and worse MD (\u2212\u20099.6\u00a0dB).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Patients uncontrolled by medication and a prior TBS would once have been candidates for trabeculectomy and tube shunts. OSS offered a minimally invasive option that provided IOP control and avoidance of traditional surgery for the majority over follow-up averaging 11\u00a0months and up to 42\u00a0months.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10792-022-02553-6","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T16:02:30Z","timestamp":1665676950000},"page":"1647-1656","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Canaloplasty and trabeculotomy with the OMNI\u00ae surgical system in OAG with prior trabecular microbypass stenting"],"prefix":"10.1007","volume":"43","author":[{"given":"Daniel C.","family":"Terveen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Steven R.","family":"Sarkisian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Vold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepan","family":"Selvadurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake K.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah G.","family":"Ristvedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam R.","family":"Bleeker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita","family":"Dhamdhere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Jaime E.","family":"Dickerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"2553_CR1","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.ophtha.2021.02.012","volume":"128","author":"MMG Olivier","year":"2021","unstructured":"Olivier MMG, Smith OU, Croteau-Chonka CC, VanderBeek BL, Maguire MG, Lum F et al (2021) Demographic and clinical characteristics associated with minimally invasive glaucoma surgery use: an intelligent research in sight (IRIS\u00ae) registry retrospective cohort analysis. 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Ristvedt, Sarkisian, Vold, and Williamson are consultants and speakers for Sight Sciences and Glaukos. Dr. Sarkisian has an equity interest in Sight Sciences. Drs. Dickerson and Dhamdhere are employees of Sight Sciences, Inc. The other authors have no financial interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was reviewed by the Institutional Review Board (WCG IRB, Puyallup, WA, USA; IRB Protocol No: 20213289). All patient data was treated with confidentiality, in accordance with the Declaration of Helsinki. This study is not considered an \u201cApplicable Clinical Trial\u201d under 42 CFR 11.22(b) and is exempt from listing on clinicaltrials.gov.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Waiver of consent was granted by the WCG IRB due to the retrospective non-interventional nature of the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}