{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:52:31Z","timestamp":1783475551728,"version":"3.55.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To evaluate the corneal epithelial thickness by anterior segment OCT in children with vernal keratoconjunctivitis (VKC) compared to normal participants.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Patient and methods<\/jats:title>\n                <jats:p>A cross-sectional case control observational study was conducted on children aged from 5 to 18\u00a0years with VKC. The study included 142 eyes divided into two groups: 71 eyes of VKC group and 71 eyes of age matched control group. Anterior segment OCT epithelial mapping for the central 5-mm was done to evaluate epithelial thickness-based variables.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Corneal epithelial thickness mapping showed significant superior thinning (51.07\u2009\u00b1\u20094.11)\u00a0\u03bcm in VKC group compared to controls (52.54\u2009\u00b1\u20092.01)\u00a0\u03bcm (<jats:italic>p<\/jats:italic>\u2009=\u20090.008), a decreased MIN epithelial thickness (45.99\u2009\u00b1\u20096.52)\u00a0\u03bcm compared to controls (50.11\u2009\u00b1\u20091.91)\u00a0\u03bcm (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and more negative (MIN\u2013MAX) value (\u2212\u200911.77\u2009\u00b1\u20099.38) indicating focal epithelial thinning compared to (\u2212\u20095.80\u2009\u00b1\u20091.88) in controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). In palpebral VKC, MIN epithelial thickness showed significant thinning (48. 38\u2009\u00b1\u20093.45)\u00a0\u03bcm compared to controls (50.11\u2009\u00b1\u20091.91)\u00a0\u03bcm (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Eyes with mixed VKC showed superior epithelial thinning (50.70\u2009\u00b1\u20094.59)\u00a0\u03bcm compared to (52.54\u2009\u00b1\u20092.01)\u00a0\u03bcm in controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.025) and significant decreased MIN epithelial thickness (43.78\u2009\u00b1\u20097.83)\u00a0\u03bcm compared to (50.11\u2009\u00b1\u20091.91)\u00a0\u03bcm in control group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>VKC is a disease primarily affecting the corneal epithelium. Corneal epithelial thickness mapping may be considered to assess the integrity of the ocular surface in eyes with VKC, and to detect corneal epithelial changes. Disease phenotype may influence the corneal epithelial changes, and the disease duration is another factor influencing these changes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10792-022-02596-9","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T16:02:37Z","timestamp":1670083357000},"page":"1967-1976","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of corneal epithelial thickness mapping using anterior segment OCT in children with vernal keratoconjunctivitis"],"prefix":"10.1007","volume":"43","author":[{"given":"Maha Alsayed","family":"Albadawi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada Azab","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2647-5883","authenticated-orcid":false,"given":"Heba A","family":"El Gendy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia AbdelFattah","family":"Ghalwash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,3]]},"reference":[{"issue":"4","key":"2596_CR1","first-page":"168","volume":"1","author":"AV Awargaonkar","year":"2014","unstructured":"Awargaonkar AV, Wagingard VD, Nandedkar V, Khaire BS (2014) Clinical profile of vernal kerato-conjunctivitis patients at tertiary eye care hospital Aurangabad district of Maharashtra, India. 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