{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:59:41Z","timestamp":1780577981437,"version":"3.54.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-022-02613-x","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T14:05:12Z","timestamp":1671199512000},"page":"2171-2181","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of retinal and optic disc vascular structures in patients with familial Mediterranean fever (FMF) via optical coherence tomography angiography"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8619-8078","authenticated-orcid":false,"given":"Mehmet","family":"Bulut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1037-7381","authenticated-orcid":false,"given":"Oznur","family":"Kutluk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-1187","authenticated-orcid":false,"given":"Birumut","family":"Ged\u0131k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4838-1650","authenticated-orcid":false,"given":"Ulku","family":"Ucar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2590-4009","authenticated-orcid":false,"given":"Yigit Caglar","family":"Bozdogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1325-8081","authenticated-orcid":false,"given":"Muhammet Huseyin","family":"Sari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5466-7482","authenticated-orcid":false,"given":"Hasan Fatih","family":"Cay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"issue":"1","key":"2613_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00296-017-3796-0","volume":"38","author":"K Barut","year":"2018","unstructured":"Barut K, Sahin S, Adrovic A et al (2018) Familial mediterranean fever in childhood: a single-center experience. Rheumatol Int 38(1):67\u201374. https:\/\/doi.org\/10.1007\/s00296-017-3796-0","journal-title":"Rheumatol Int"},{"key":"2613_CR2","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/sj.ejhg.5200674","volume":"9","author":"E Y\u0131lmaz","year":"2011","unstructured":"Y\u0131lmaz E, Ozen S, Balci B et al (2011) Mutation frequency of familial Mediterranean fever and evidence for a high carrier rate in the Turkish population. Eur J Hum Genet 9:553\u2013555. https:\/\/doi.org\/10.1038\/sj.ejhg.5200674","journal-title":"Eur J Hum Genet"},{"key":"2613_CR3","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/ni.3457","volume":"17","author":"YH Park","year":"2016","unstructured":"Park YH, Wood G, Kastner DL, Chae JJ (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17:914\u2013921. https:\/\/doi.org\/10.1038\/ni.3457","journal-title":"Nat Immunol"},{"key":"2613_CR4","first-page":"103","volume":"28","author":"T Akalin","year":"2010","unstructured":"Akalin T, Demirag MD, Tezcan ME et al (2010) Scleritis and sudden hearing loss associated with familial Mediterranean fever. Clin Exp Rheumatol 28:103\u2013104","journal-title":"Clin Exp Rheumatol"},{"key":"2613_CR5","doi-asserted-by":"publisher","first-page":"593","DOI":"10.5301\/ejo.5000398","volume":"24","author":"A Yazici","year":"2014","unstructured":"Yazici A, Ozdal P, Yuksekkaya P et al (2014) Ophthalmic manifestations in familial Mediterranean fever: a case series of 6 patients. Eur J Ophthalmol 24:593\u2013598. https:\/\/doi.org\/10.5301\/ejo.5000398","journal-title":"Eur J Ophthalmol"},{"key":"2613_CR6","first-page":"621","volume":"114","author":"S Satoh","year":"2010","unstructured":"Satoh S, Itoh C, Nakamura N (2010) A case of frosted branch angiitis associated with retinal vein occlusion as a complication of familial Mediterranean fever. Nippon Ganka Gakkai Zasshi 114:621\u2013628","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"2613_CR7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1755-3768.2008.01437.x","volume":"87","author":"A Karalezli","year":"2009","unstructured":"Karalezli A, Borazan M, Yilmaz S et al (2009) Conjunctival impression cytology and tear-film changes in patients with familial Mediterranean fever. Acta Ophthalmol 87:39\u201343. https:\/\/doi.org\/10.1111\/j.1755-3768.2008.01437.x","journal-title":"Acta Ophthalmol"},{"key":"2613_CR8","doi-asserted-by":"publisher","first-page":"102428","DOI":"10.1016\/j.pdpdt.2021.102428","volume":"35","author":"B Gedik","year":"2021","unstructured":"Gedik B, Suren S, Bulut M et al (2021) Changes in choroidal blood flow in patients with macular hole after surgery. Photodiagn Photodyn Ther 35:102428. https:\/\/doi.org\/10.1016\/j.pdpdt.2021.102428","journal-title":"Photodiagn Photodyn Ther"},{"issue":"3","key":"2613_CR9","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1080\/09273948.2019.1695857","volume":"29","author":"AU Yener","year":"2019","unstructured":"Yener AU, Tayfur AC (2019) Posterior segment ocular parameters in children with familial Mediterranean fever. Ocul Immunol Inflamm 29(3):615\u2013620. https:\/\/doi.org\/10.1080\/09273948.2019.1695857","journal-title":"Ocul Immunol Inflamm"},{"key":"2613_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/2515841419892056","volume":"11","author":"EE Karaca","year":"2019","unstructured":"Karaca EE, Ozek D, Omma A, Kemer OE (2019) Comparison of optical coherence tomography angiography results of adult patients with familial Mediterranean fever and healthy individuals. Therap Adv Ophthalmol 11:1\u20138. https:\/\/doi.org\/10.1177\/2515841419892056","journal-title":"Therap Adv Ophthalmol"},{"key":"2613_CR11","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1002\/art.1780401023","volume":"40","author":"A Livneh","year":"1997","unstructured":"Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T et al (1997) Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 40:1879\u20131885. https:\/\/doi.org\/10.1002\/art.1780401023","journal-title":"Arthritis Rheum"},{"issue":"3","key":"2613_CR12","doi-asserted-by":"publisher","first-page":"282","DOI":"10.5606\/ArchRheumatol.2018.6488","volume":"33","author":"RMK Kisla Ekinci","year":"2019","unstructured":"Kisla Ekinci RMK, Balci S, Altintas DU et al (2019) The influence of concomitant disorders on disease severity of familial Mediterranean fever in children. Arch Rheumatol 33(3):282\u2013287. https:\/\/doi.org\/10.5606\/ArchRheumatol.2018.6488","journal-title":"Arch Rheumatol"},{"key":"2613_CR13","doi-asserted-by":"publisher","first-page":"144","DOI":"10.5222\/buchd.2018.144","volume":"8","author":"A Caglar","year":"2018","unstructured":"Caglar A, Ozcel\u0131\u0307kAkinci GN (2018) Genotype-phenotype correlation in pediatric patients with familial mediterrenean fever. J Dr Behcet Uz Child Hosp 8:144\u2013150. https:\/\/doi.org\/10.5222\/buchd.2018.144","journal-title":"J Dr Behcet Uz Child Hosp"},{"issue":"4","key":"2613_CR14","doi-asserted-by":"publisher","first-page":"422","DOI":"10.3109\/09273948.2015.1010012","volume":"24","author":"H Petrushkin","year":"2016","unstructured":"Petrushkin H, Stanford M, Fortune F et al (2016) Clinical review: familial Mediterranean fever: an overview of pathogenesis, symptoms, ocular manifestations, and treatment clinical review: familial Mediterranean fever. Ocul Immunol Inflamm 24(4):422\u2013430. https:\/\/doi.org\/10.3109\/09273948.2015.1010012","journal-title":"Ocul Immunol Inflamm"},{"key":"2613_CR15","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13023-015-0252-7","volume":"10","author":"I Ben-Zvi","year":"2015","unstructured":"Ben-Zvi I, Herskovizh C, Kukuy O, Kassel Y, Grossman C, Livneh A (2015) Familial mediterranean fever without MEFV mutations: a case\u2013control study. Orphanet J Rare Dis 10:34. https:\/\/doi.org\/10.1186\/s13023-015-0252-7","journal-title":"Orphanet J Rare Dis"},{"issue":"6","key":"2613_CR16","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1136\/jmedgenet-2013-101577","volume":"50","author":"I Touitou","year":"2013","unstructured":"Touitou I (2013) Inheritance of autoinflammatory diseases: shifting paradigms and nomenclature. J Med Genet 50(6):349\u2013359. https:\/\/doi.org\/10.1136\/jmedgenet-2013-101577","journal-title":"J Med Genet"},{"key":"2613_CR17","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2147\/JIR.S91352","volume":"9","author":"HE Sonmez","year":"2016","unstructured":"Sonmez HE, Batu ED, Ozen S (2016) Familial Mediterranean fever: current perspectives. J Inflamm Res 9:13\u201320. https:\/\/doi.org\/10.2147\/JIR.S91352","journal-title":"J Inflamm Res"},{"key":"2613_CR18","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/13816810.2020.1759108","volume":"41","author":"C Cavdarli","year":"2020","unstructured":"Cavdarli C, Cavdarli B, Yilmaz PT, Gultekin BP (2020) Optical coherence tomography-angiographic vascular densities in familial Mediterranean fever (FMF) patients with M694V mutations. Ophthalmic Genet 41:257\u2013262. https:\/\/doi.org\/10.1080\/13816810.2020.1759108","journal-title":"Ophthalmic Genet"},{"key":"2613_CR19","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1136\/annrheumdis-2018-eular.3419","volume":"36","author":"E Ozer","year":"2018","unstructured":"Ozer E, Seker D, Taner E et al (2018) The frequency of juvenile spondyloarthropathies in childhood familial Mediterranean fever. Clin Exp Rheumatol 36:141\u2013145. https:\/\/doi.org\/10.1136\/annrheumdis-2018-eular.3419","journal-title":"Clin Exp Rheumatol"},{"key":"2613_CR20","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1111\/j.1365-2249.2004.02632.x","volume":"138","author":"U Musabak","year":"2004","unstructured":"Musabak U, Sengul A, Oktenli C et al (2004) Does immune activation continue during an attack-free period in familial Mediterranean fever? Clin Exp Immunol 138:526\u2013533. https:\/\/doi.org\/10.1111\/j.1365-2249.2004.02632.x","journal-title":"Clin Exp Immunol"},{"key":"2613_CR21","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/cge.13070","volume":"93","author":"R Koshy","year":"2018","unstructured":"Koshy R, Sivadas A, Scaria V (2018) Genetic epidemiology of familial Mediterranean fever through integrative analysis of whole genome and exome sequences from middle east and north Africa. Clin Genet 93:92\u2013102. https:\/\/doi.org\/10.1111\/cge.13070","journal-title":"Clin Genet"},{"key":"2613_CR22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00296-019-04391-9.ien","volume":"40","author":"M Yildiz","year":"2020","unstructured":"Yildiz M, Adrovic A, Tasdemir E et al (2020) Evaluation of co-existing diseases in children with familial Mediterranean fever. Rheumatol Int 40:57\u201364. https:\/\/doi.org\/10.1007\/s00296-019-04391-9.ien","journal-title":"Rheumatol Int"},{"key":"2613_CR23","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/s41590-020-0705-6","volume":"21","author":"YH Park","year":"2020","unstructured":"Park YH, Remmers EF, Lee W et al (2020) Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis. Nat Immunol 21:857\u2013867. https:\/\/doi.org\/10.1038\/s41590-020-0705-6","journal-title":"Nat Immunol"},{"key":"2613_CR24","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1007\/s10067-017-3715-5","volume":"36","author":"M Alghamdi","year":"2017","unstructured":"Alghamdi M (2017) Familial Mediterranean fever, review of the literature. Clin Rheumatol 36:1707\u20131713. https:\/\/doi.org\/10.1007\/s10067-017-3715-5","journal-title":"Clin Rheumatol"},{"key":"2613_CR25","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1093\/rheumatology\/kep131","volume":"48","author":"S Ugurlu","year":"2009","unstructured":"Ugurlu S, Seyahi E, Cetinkaya F et al (2009) Intima-media thickening in patients with familial Mediterranean fever. Rheumatology 48:911\u2013915. https:\/\/doi.org\/10.1093\/rheumatology\/kep131","journal-title":"Rheumatology"},{"key":"2613_CR26","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1007\/s00296-008-0605-9","volume":"28","author":"Y Bilginer","year":"2008","unstructured":"Bilginer Y, Ozaltin F, Basaran C et al (2008) Evaluation of intima media thickness of the common and internal carotid arteries with inflammatory markers in familial Mediterranean fever as possible predictors for atherosclerosis. Rheumatol Int 28:1211\u20131216. https:\/\/doi.org\/10.1007\/s00296-008-0605-9","journal-title":"Rheumatol Int"},{"key":"2613_CR27","doi-asserted-by":"publisher","first-page":"158","DOI":"10.4103\/ajm.AJM_78_17","volume":"7","author":"A Alsarah","year":"2017","unstructured":"Alsarah A, Alsara O, Laird-Fick HS (2017) Cardiac manifestations of familial Mediterranean fever. Avicenna J Med 7:158\u2013163. https:\/\/doi.org\/10.4103\/ajm.AJM_78_17","journal-title":"Avicenna J Med"},{"key":"2613_CR28","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s10792-017-0446-1","volume":"38","author":"S Alim","year":"2018","unstructured":"Alim S, Esen M, Demir AK et al (2018) Peripapillary retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in adult-onset familial Mediterranean fever. Int Ophthalmol 38:183\u2013190. https:\/\/doi.org\/10.1007\/s10792-017-0446-1","journal-title":"Int Ophthalmol"},{"key":"2613_CR29","doi-asserted-by":"publisher","first-page":"444","DOI":"10.3109\/09273948.2014.916309","volume":"22","author":"M Erdurmus","year":"2014","unstructured":"Erdurmus M, Bekdas M, Demircioglu F et al (2014) Retinal and choroidal thickness in children with familial Mediterranean fever. Ocul Immunol Inflamm 22:444\u2013448. https:\/\/doi.org\/10.3109\/09273948.2014.916309","journal-title":"Ocul Immunol Inflamm"},{"key":"2613_CR30","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1080\/09286586.2017.1294697","volume":"24","author":"T Bicer","year":"2017","unstructured":"Bicer T, Celikay O, Kosker M et al (2017) Retinal and choroidal thickness in adult patients with familial Mediterranean fever. Ophthalmic Epidemiol 24:346\u2013351. https:\/\/doi.org\/10.1080\/09286586.2017.1294697","journal-title":"Ophthalmic Epidemiol"},{"key":"2613_CR31","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1159\/000442216","volume":"235","author":"FC Gundogan","year":"2016","unstructured":"Gundogan FC, Akay F, Uzun S et al (2016) Choroidal thickness changes in the acute attack period in patients with familial Mediterranean fever. Ophthalmologica 235:72\u201377. https:\/\/doi.org\/10.1159\/000442216","journal-title":"Ophthalmologica"},{"key":"2613_CR32","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3389\/fimmu.2017.00253","volume":"8","author":"S Ozen","year":"2017","unstructured":"Ozen S, Batu ED, Demir S (2017) Familial Mediterranean fever: recent developments in pathogenesis and new recommendations for management. Front Immunol 8:253. https:\/\/doi.org\/10.3389\/fimmu.2017.00253","journal-title":"Front Immunol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-022-02613-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-022-02613-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-022-02613-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T15:05:24Z","timestamp":1688137524000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-022-02613-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,16]]},"references-count":32,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["2613"],"URL":"https:\/\/doi.org\/10.1007\/s10792-022-02613-x","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,16]]},"assertion":[{"value":"17 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no funding was received and no conflict of interest\/competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the Health Sciences University Antalya Training And Research Hospital (Date: 18.03.21 No:3\/17).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written consent was acquired by all participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Written consent was acquired by all participants.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}