{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:57:06Z","timestamp":1789840626395,"version":"4.0.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873684"],"award-info":[{"award-number":["81873684"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-023-02716-z","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T10:03:18Z","timestamp":1682676198000},"page":"3165-3173","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Distribution of 50-layer corneal densitometry values and related factors"],"prefix":"10.1007","volume":"43","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"2716_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.clae.2011.07.001","volume":"35","author":"A Jinabhai","year":"2012","unstructured":"Jinabhai A, O\u2019Donnell C, Radhakrishnan H et al (2012) Forward light scatter and contrast sensitivity in keratoconic patients. Cont Lens Anterior Eye 35:22\u201327. https:\/\/doi.org\/10.1016\/j.clae.2011.07.001","journal-title":"Cont Lens Anterior Eye"},{"key":"2716_CR2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1167\/tvst.10.12.6","volume":"10","author":"AY Cheung","year":"2021","unstructured":"Cheung AY, Kalina A, Im A et al (2021) Region of interest densitometry analysis of descemet membrane endothelial keratoplasty dehiscence on anterior segment optical coherence tomography. Transl Vis Sci Technol 10:6. https:\/\/doi.org\/10.1167\/tvst.10.12.6","journal-title":"Transl Vis Sci Technol"},{"key":"2716_CR3","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1177\/016173460602800304","volume":"28","author":"RH Silverman","year":"2006","unstructured":"Silverman RH, Cannata J, Shung KK et al (2006) 75 MHz ultrasound biomicroscopy of anterior segment of eye. Ultrason Imaging 28:179\u2013188. https:\/\/doi.org\/10.1177\/016173460602800304","journal-title":"Ultrason Imaging"},{"key":"2716_CR4","doi-asserted-by":"publisher","first-page":"7274","DOI":"10.1167\/iovs.11-7747","volume":"52","author":"T Hillenaar","year":"2011","unstructured":"Hillenaar T, Cals RH, Eilers PH et al (2011) Normative database for corneal backscatter analysis by in vivo confocal microscopy. Invest Ophthalmol Vis Sci 52:7274\u20137281. https:\/\/doi.org\/10.1167\/iovs.11-7747","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2716_CR5","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1167\/iovs.13-13236","volume":"55","author":"S N\u00ed Dhubhghaill","year":"2014","unstructured":"N\u00ed Dhubhghaill S, Rozema JJ, Jongenelen S et al (2014) Normative values for corneal densitometry analysis by scheimpflug optical assessment. Invest Ophthalmol Vis Sci 55:162\u2013168. https:\/\/doi.org\/10.1167\/iovs.13-13236","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2716_CR6","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1016\/j.jcrs.2011.03.043","volume":"37","author":"JJ Rozema","year":"2011","unstructured":"Rozema JJ, Trau R, Verbruggen KHM, Tassignon MJ (2011) Backscattered light from the cornea before and after laser-assisted subepithelial keratectomy for myopia. J Cataract Refract Surg 37:1648\u20131654. https:\/\/doi.org\/10.1016\/j.jcrs.2011.03.043","journal-title":"J Cataract Refract Surg"},{"key":"2716_CR7","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1167\/iovs.15-17657","volume":"57","author":"JW McLaren","year":"2016","unstructured":"McLaren JW, Wacker K, Kane KM, Patel SV (2016) Measuring corneal haze by using scheimpflug photography and confocal microscopy. Invest Ophthalmol Vis Sci 57:227\u2013235. https:\/\/doi.org\/10.1167\/iovs.15-17657","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2716_CR8","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.ophtha.2011.08.024","volume":"119","author":"AM Otri","year":"2012","unstructured":"Otri AM, Fares U, Al-Aqaba MA, Dua HS (2012) Corneal densitometry as an indicator of corneal health. Ophthalmology 119:501\u2013508. https:\/\/doi.org\/10.1016\/j.ophtha.2011.08.024","journal-title":"Ophthalmology"},{"key":"2716_CR9","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1097\/ICO.0000000000000078","volume":"33","author":"S Chaurasia","year":"2014","unstructured":"Chaurasia S, Price MO, McKee Y, Price FW (2014) Descemet membrane endothelial keratoplasty combined with epithelial debridement and Mitomycin-C application for fuchs dystrophy with preoperative subepithelial fibrosis or anterior basement membrane dystrophy. Cornea 33:335\u2013339. https:\/\/doi.org\/10.1097\/ICO.0000000000000078","journal-title":"Cornea"},{"key":"2716_CR10","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12886-018-0851-x","volume":"18","author":"J Dong","year":"2018","unstructured":"Dong J, Zhang Y, Zhang H et al (2018) Corneal densitometry in high myopia. BMC Ophthalmol 18:182. https:\/\/doi.org\/10.1186\/s12886-018-0851-x","journal-title":"BMC Ophthalmol"},{"key":"2716_CR11","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1097\/ICO.0000000000000266","volume":"33","author":"B Lopes","year":"2014","unstructured":"Lopes B, Ramos I, Ambr\u00f3sio R (2014) Corneal densitometry in keratoconus. Cornea 33:1282\u20131286. https:\/\/doi.org\/10.1097\/ICO.0000000000000266","journal-title":"Cornea"},{"key":"2716_CR12","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1097\/ICO.0000000000002458","volume":"40","author":"M Jim\u00e9nez-Garc\u00eda","year":"2021","unstructured":"Jim\u00e9nez-Garc\u00eda M, N\u00ed Dhubhghaill S, Consejo A et al (2021) Scheimpflug densitometry in keratoconus: a new method of visualizing the cone. Cornea 40:194\u2013202. https:\/\/doi.org\/10.1097\/ICO.0000000000002458","journal-title":"Cornea"},{"key":"2716_CR13","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1111\/opo.12821","volume":"41","author":"M Jim\u00e9nez-Garc\u00eda","year":"2021","unstructured":"Jim\u00e9nez-Garc\u00eda M, N\u00ed Dhubhghaill S, Hershko S et al (2021) Densitometry marks delineating the affected area in keratoconus: clinical suitability of a new descriptive system based on its repeatability and reproducibility. Ophthalmic Physiol Opt 41:748\u2013756. https:\/\/doi.org\/10.1111\/opo.12821","journal-title":"Ophthalmic Physiol Opt"},{"key":"2716_CR14","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s10792-018-0876-4","volume":"39","author":"M B\u00f6hm","year":"2019","unstructured":"B\u00f6hm M, Shajari M, Remy M, Kohnen T (2019) Corneal densitometry after accelerated corneal collagen cross-linking in progressive keratoconus. Int Ophthalmol 39:765\u2013775. https:\/\/doi.org\/10.1007\/s10792-018-0876-4","journal-title":"Int Ophthalmol"},{"key":"2716_CR15","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1097\/ICO.0000000000002016","volume":"38","author":"B Agha","year":"2019","unstructured":"Agha B, Dawson DG, Kohnen T, Schmack I (2019) Corneal densitometry after secondary descemet membrane endothelial keratoplasty. Cornea 38:1083\u20131092. https:\/\/doi.org\/10.1097\/ICO.0000000000002016","journal-title":"Cornea"},{"key":"2716_CR16","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1097\/ICO.0000000000002468","volume":"39","author":"M Pakbin","year":"2020","unstructured":"Pakbin M, Khabazkhoob M, Pakravan M et al (2020) Corneal scheimpflug densitometry in photorefractive keratectomy candidates. Cornea 39:1381\u20131388. https:\/\/doi.org\/10.1097\/ICO.0000000000002468","journal-title":"Cornea"},{"key":"2716_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.07.001","volume":"49","author":"KM Meek","year":"2015","unstructured":"Meek KM, Knupp C (2015) Corneal structure and transparency. Prog Retin Eye Res 49:1\u201316. https:\/\/doi.org\/10.1016\/j.preteyeres.2015.07.001","journal-title":"Prog Retin Eye Res"},{"key":"2716_CR18","doi-asserted-by":"publisher","first-page":"521078","DOI":"10.3389\/fmed.2020.521078","volume":"7","author":"R Wei","year":"2020","unstructured":"Wei R, Li M, Yang W et al (2020) Corneal densitometry after small incision lenticule extraction (SMILE) and femtosecond laser-assisted LASIK (FS-LASIK): 5-year prospective comparative study. Front Med (Lausanne) 7:521078. https:\/\/doi.org\/10.3389\/fmed.2020.521078","journal-title":"Front Med (Lausanne)"},{"key":"2716_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09286586.2017.1320413","volume":"25","author":"GS Ying","year":"2018","unstructured":"Ying GS, Maguire MG, Glynn R, Rosner B (2018) Tutorial on biostatistics: statistical analysis for correlated binary eye data. Ophthal Epidemiol 25:1\u201312. https:\/\/doi.org\/10.1080\/09286586.2017.1320413","journal-title":"Ophthal Epidemiol"},{"key":"2716_CR20","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1167\/iovs.06-0767","volume":"48","author":"SV Patel","year":"2007","unstructured":"Patel SV, Winter EJ, McLaren JW, Bourne WM (2007) Objective measurement of backscattered light from the anterior and posterior cornea in vivo. Invest Ophthalmol Vis Sci 48:166\u2013172. https:\/\/doi.org\/10.1167\/iovs.06-0767","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2716_CR21","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1007\/s00417-013-2460-y","volume":"251","author":"F Arnalich-Montiel","year":"2013","unstructured":"Arnalich-Montiel F, Hern\u00e1ndez-Verdejo JL, Oblanca N, Mu\u00f1oz-Negrete FJ, De Miguel MP (2013) Comparison of corneal haze and visual outcome in primary DSAEK versus DSAEK following failed DMEK. Graefes Arch Clin Exp Ophthalmol 251:2575\u20132584. https:\/\/doi.org\/10.1007\/s00417-013-2460-y","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2716_CR22","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1097\/ICL.0b013e3181ee8992","volume":"36","author":"JV Jester","year":"2010","unstructured":"Jester JV, Winkler M, Jester BE et al (2010) Evaluating corneal collagen organization using high resolution non-linear optical (NLO) macroscopy. Eye Contact Lens 36:260\u2013264. https:\/\/doi.org\/10.1097\/ICL.0b013e3181ee8992","journal-title":"Eye Contact Lens"},{"key":"2716_CR23","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/eye.1990.81","volume":"4","author":"GT Smith","year":"1990","unstructured":"Smith GT, Brown NA, Shun-Shin GA (1990) Light scatter from the central human cornea. Eye (Lond) 4:584\u2013588. https:\/\/doi.org\/10.1038\/eye.1990.81","journal-title":"Eye (Lond)"},{"key":"2716_CR24","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1364\/josaa.3.001970","volume":"3","author":"DE Freund","year":"1986","unstructured":"Freund DE, McCally RL, Farrell RA (1986) Effects of fibril orientations on light scattering in the cornea. J Opt Soc Am A 3:1970\u20131982. https:\/\/doi.org\/10.1364\/josaa.3.001970","journal-title":"J Opt Soc Am A"},{"key":"2716_CR25","doi-asserted-by":"publisher","first-page":"20140717","DOI":"10.1098\/rsif.2014.0717","volume":"12","author":"A Abass","year":"2015","unstructured":"Abass A, Hayes S, White N, Sorensen T, Meek KM (2015) Transverse depth-dependent changes in corneal collagen lamellar orientation and distribution. J R Soc Interface 12:20140717. https:\/\/doi.org\/10.1098\/rsif.2014.0717","journal-title":"J R Soc Interface"},{"key":"2716_CR26","doi-asserted-by":"publisher","first-page":"5154","DOI":"10.1038\/s41598-017-05486-8","volume":"7","author":"M Lombardo","year":"2017","unstructured":"Lombardo M, Serrao S, Barbaro V, Di Iorio E, Lombardo G (2017) Multimodal imaging quality control of epithelia regenerated with cultured human donor corneal limbal epithelial stem cells. Sci Rep 7:5154. https:\/\/doi.org\/10.1038\/s41598-017-05486-8","journal-title":"Sci Rep"},{"key":"2716_CR27","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1016\/j.ophtha.2013.01.018","volume":"120","author":"HS Dua","year":"2013","unstructured":"Dua HS, Faraj LA, Said DG, Gray T, Lowe J (2013) Human corneal anatomy redefined a novel pre-descemet\u2019s layer (Dua\u2019s Layer). Ophthalmology 120:1778\u20131785. https:\/\/doi.org\/10.1016\/j.ophtha.2013.01.018","journal-title":"Ophthalmology"},{"key":"2716_CR28","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1167\/iovs.08-3309","volume":"50","author":"N Morishige","year":"2009","unstructured":"Morishige N, Yamada N, Teranishi S et al (2009) Detection of subepithelial fibrosis associated with corneal stromal edema by second harmonic generation imaging microscopy. Invest Ophthalmol Vis Sci 50:3145\u20133150. https:\/\/doi.org\/10.1167\/iovs.08-3309","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2716_CR29","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1167\/iovs.10-5657","volume":"52","author":"N Morishige","year":"2011","unstructured":"Morishige N, Takagi Y, Chikama T, Takahara A, Nishida T (2011) Three-dimensional analysis of collagen lamellae in the anterior stroma of the human cornea visualized by second harmonic generation imaging microscopy. Invest Ophthalmol Vis Sci 52:911\u2013915. https:\/\/doi.org\/10.1167\/iovs.10-5657","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2716_CR30","doi-asserted-by":"publisher","first-page":"e8563","DOI":"10.1097\/MD.0000000000008563","volume":"96","author":"K Alzahrani","year":"2017","unstructured":"Alzahrani K, Carley F, Brahma A, Morley D, Hillarby MC et al (2017) Corneal clarity measurements in healthy volunteers across different age groups: observational study. Med (Baltim) 96:e8563. https:\/\/doi.org\/10.1097\/MD.0000000000008563","journal-title":"Med (Baltim)"},{"key":"2716_CR31","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/ICO.0000000000002212","volume":"39","author":"A Bahar","year":"2020","unstructured":"Bahar A, Pekel G (2020) How does light intensity of the recording room affect the evaluation of lens and corneal clarity by scheimpflug tomography? Cornea 39:137\u2013139. https:\/\/doi.org\/10.1097\/ICO.0000000000002212","journal-title":"Cornea"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-023-02716-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-023-02716-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-023-02716-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T04:05:15Z","timestamp":1691035515000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-023-02716-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,28]]},"references-count":31,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["2716"],"URL":"https:\/\/doi.org\/10.1007\/s10792-023-02716-z","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,28]]},"assertion":[{"value":"24 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study adhered to the tenets of the Declaration of Helsinki and was approved by the medical ethics committee of Tianjin Eye Hospital (approval number TJYLL-2021\u201331).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study for use of their data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}