{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:51:37Z","timestamp":1793173897550,"version":"4.5.0"},"reference-count":227,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-023-02767-2","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T01:01:49Z","timestamp":1687482109000},"page":"3891-3909","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Stages, pathogenesis, clinical management and advancements in therapies of age-related macular degeneration"],"prefix":"10.1007","volume":"43","author":[{"given":"Ishita","family":"Shome","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neethi C.","family":"Thathapudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindu Madhav Reddy","family":"Aramati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavani S.","family":"Kowtharapu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaganmohan R.","family":"Jangamreddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,22]]},"reference":[{"issue":"1","key":"2767_CR1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2147\/nano.2007.2.1.65","volume":"2","author":"DG Birch","year":"2007","unstructured":"Birch DG, Liang FQ (2007) Age-related macular degeneration: a target for nanotechnology derived medicines. Int J Nanomed 2(1):65\u201377","journal-title":"Int J Nanomed"},{"issue":"6","key":"2767_CR2","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1167\/iovs.10-6163","volume":"52","author":"H Lin","year":"2011","unstructured":"Lin H, Xu H, Liang FQ, Liang H, Gupta P et al (2011) Mitochondrial DNA damage and repair in rpe associated with aging and age-related macular degeneration. Invest Ophthalmol Vis Sci 52(6):3521\u20133529","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"2767_CR3","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.survophthal.2008.10.004","volume":"54","author":"S Schmitz-Valckenberg","year":"2009","unstructured":"Schmitz-Valckenberg S, Fleckenstein M, Scholl HP, Holz FG (2009) Fundus autofluorescence and progression of age-related macular degeneration. Surv Ophthalmol 54(1):96\u2013117","journal-title":"Surv Ophthalmol"},{"issue":"6","key":"2767_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038673","volume":"7","author":"X Gu","year":"2012","unstructured":"Gu X, Neric NJ, Crabb JS, Crabb JW, Bhattacharya SK et al (2012) Age-related changes in the retinal pigment epithelium (RPE). PLoS ONE 7(6):e38673","journal-title":"PLoS ONE"},{"key":"2767_CR5","first-page":"1","volume":"209","author":"M Dornonville de la Cour","year":"1993","unstructured":"Dornonville de la Cour M (1993) Ion transport in the retinal pigment epithelium. A study with double barrelled ion-selective microelectrodes. Acta Ophthalmol Suppl 209:1\u201332","journal-title":"Acta Ophthalmol Suppl"},{"key":"2767_CR6","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/S0074-7696(02)15016-9","volume":"215","author":"S Hamann","year":"2002","unstructured":"Hamann S (2002) Molecular mechanisms of water transport in the eye. Int Rev Cytol 215:395\u2013431","journal-title":"Int Rev Cytol"},{"issue":"3","key":"2767_CR7","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1152\/physrev.00021.2004","volume":"85","author":"O Strauss","year":"2005","unstructured":"Strauss O (2005) The retinal pigment epithelium in visual function. Physiol Rev 85(3):845\u2013881","journal-title":"Physiol Rev"},{"issue":"3","key":"2767_CR8","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1001\/archopht.1984.01040030359038","volume":"102","author":"A Negi","year":"1984","unstructured":"Negi A, Marmor MF (1984) Experimental serous retinal detachment and focal pigment epithelial damage. Arch Ophthalmol 102(3):445\u2013449","journal-title":"Arch Ophthalmol"},{"issue":"5720","key":"2767_CR9","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1126\/science.1109557","volume":"308","author":"RJ Klein","year":"2005","unstructured":"Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS et al (2005) Complement factor H polymorphism in age-related macular degeneration. Science 308(5720):385\u2013389","journal-title":"Science"},{"issue":"14","key":"2767_CR10","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1056\/NEJMoa0802437","volume":"359","author":"Z Yang","year":"2008","unstructured":"Yang Z, Stratton C, Francis PJ, Kleinman ME, Tan PL et al (2008) Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med 359(14):1456\u20131463","journal-title":"N Engl J Med"},{"issue":"5","key":"2767_CR11","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1016\/S0002-9440(10)65026-2","volume":"156","author":"CD Collard","year":"2000","unstructured":"Collard CD, Vakeva A, Morrissey MA, Agah A, Rollins SA et al (2000) Complement activation after oxidative stress: role of the lectin complement pathway. Am J Pathol 156(5):1549\u20131556","journal-title":"Am J Pathol"},{"issue":"2","key":"2767_CR12","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1167\/iovs.16-20692","volume":"58","author":"ML Gao","year":"2017","unstructured":"Gao ML, Wu KC, Deng WL, Lei XL, Xiang L et al (2017) Toll-like receptor 3 activation initiates photoreceptor cell death in vivo and in vitro. Invest Ophthalmol Vis Sci 58(2):801\u2013811","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"2767_CR13","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/cdd.2013.109","volume":"21","author":"Y Murakami","year":"2014","unstructured":"Murakami Y, Matsumoto H, Roh M, Giani A, Kataoka K et al (2014) Programmed necrosis, not apoptosis, is a key mediator of cell loss and damp-mediated inflammation in dsrna-induced retinal degeneration. Cell Death Differ 21(2):270\u2013277","journal-title":"Cell Death Differ"},{"issue":"14","key":"2767_CR14","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1056\/NEJMra062326","volume":"355","author":"PT de Jong","year":"2006","unstructured":"de Jong PT (2006) Age-related macular degeneration. N Engl J Med 355(14):1474\u20131485","journal-title":"N Engl J Med"},{"issue":"4","key":"2767_CR15","first-page":"532","volume":"122","author":"Group* TEDPR","year":"2004","unstructured":"Group* TEDPR (2004) Prevalence of open-angle glaucoma among adults in the united states. JAMA Ophthalmol 122(4):532\u2013538","journal-title":"JAMA Ophthalmol"},{"issue":"5","key":"2767_CR16","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1136\/bjophthalmol-2011-300539","volume":"96","author":"D Pascolini","year":"2012","unstructured":"Pascolini D, Mariotti SP (2012) Global estimates of visual impairment: 2010. Br J Ophthalmol 96(5):614\u2013618","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"2767_CR17","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1001\/archopht.122.4.532","volume":"122","author":"DS Friedman","year":"2004","unstructured":"Friedman DS, Wolfs RC, O\u2019Colmain BJ, Klein BE, Taylor HR et al (2004) Prevalence of open-angle glaucoma among adults in the united states. Arch Ophthalmol 122(4):532\u2013538","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"2767_CR18","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","volume":"2","author":"WL Wong","year":"2014","unstructured":"Wong WL, Su X, Li X, Cheung CM, Klein R et al (2014) Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health 2(2):e106-116","journal-title":"Lancet Glob Health"},{"issue":"14","key":"2767_CR19","doi-asserted-by":"publisher","first-page":"Orsf5","DOI":"10.1167\/iovs.13-12789","volume":"54","author":"R Klein","year":"2013","unstructured":"Klein R, Klein BE (2013) The prevalence of age-related eye diseases and visual impairment in aging: current estimates. Invest Ophthalmol Vis Sci 54(14):Orsf5\u2013Orsf13","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2767_CR20","doi-asserted-by":"publisher","first-page":"963","DOI":"10.2147\/OPTH.S132338","volume":"11","author":"R Thapa","year":"2017","unstructured":"Thapa R, Bajimaya S, Paudyal G, Khanal S, Tan S, Thapa SS, van Rens G (2017) Prevalence of and risk factors for age-related macular degeneration in Nepal: the Bhaktapur Retina Study. Clin Ophthalmol 11:963\u2013972","journal-title":"Clin Ophthalmol"},{"issue":"5","key":"2767_CR21","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1001\/archopht.1986.01050170092029","volume":"104","author":"DR Guyer","year":"1986","unstructured":"Guyer DR, Fine SL, Maguire MG, Hawkins BS, Owens SL et al (1986) Subfoveal choroidal neovascular membranes in age-related macular degeneration. Visual prognosis in eyes with relatively good initial visual acuity. Arch Ophthalmol 104(5):702\u2013705","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"2767_CR22","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.ophtha.2007.03.008","volume":"115","author":"TY Wong","year":"2008","unstructured":"Wong TY, Chakravarthy U, Klein R, Mitchell P, Zlateva G et al (2008) The natural history and prognosis of neovascular age-related macular degeneration: a systematic review of the literature and meta-analysis. Ophthalmology 115(1):116\u2013126","journal-title":"Ophthalmology"},{"issue":"7","key":"2767_CR23","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1111\/aos.12346","volume":"92","author":"MG Erke","year":"2014","unstructured":"Erke MG, Bertelsen G, Peto T, Sj\u00f8lie AK, Lindekleiv H, Nj\u00f8lstad I (2014) Cardiovascular risk factors associated with age-related macular degeneration: the troms\u00f8 study. Acta Ophthalmol 92(7):662\u2013669","journal-title":"Acta Ophthalmol"},{"issue":"3","key":"2767_CR24","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.ophtha.2011.09.027","volume":"119","author":"AR Rudnicka","year":"2012","unstructured":"Rudnicka AR, Jarrar Z, Wormald R, Cook DG, Fletcher A, Owen CG (2012) Age and gender variations in age-related macular degeneration prevalence in populations of European ancestry: a meta-analysis. Ophthalmology 119(3):571\u2013580","journal-title":"Ophthalmology"},{"issue":"2","key":"2767_CR25","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.ajo.2007.09.008","volume":"145","author":"R Klein","year":"2008","unstructured":"Klein R, Meuer SM, Knudtson MD, Iyengar SK, Klein BE (2008) The epidemiology of retinal reticular drusen. Am J Ophthalmol 145(2):317\u2013326","journal-title":"Am J Ophthalmol"},{"key":"2767_CR26","doi-asserted-by":"crossref","unstructured":"Klein ML, Ferris FL, 3rd, Francis PJ, Lindblad AS, Chew EY et al (2010) Progression of geographic atrophy and genotype in age-related macular degeneration. Ophthalmology 117(8):1554\u20131559, 1559.e1551","DOI":"10.1016\/j.ophtha.2009.12.012"},{"issue":"2","key":"2767_CR27","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1136\/bjophthalmol-2016-308422","volume":"101","author":"FG Schlanitz","year":"2017","unstructured":"Schlanitz FG, Baumann B, Kundi M, Sacu S, Baratsits M et al (2017) Drusen volume development over time and its relevance to the course of age-related macular degeneration. Br J Ophthalmol 101(2):198\u2013203","journal-title":"Br J Ophthalmol"},{"key":"2767_CR28","doi-asserted-by":"publisher","first-page":"2913612","DOI":"10.1155\/2016\/2913612","volume":"2016","author":"O Al Gwairi","year":"2016","unstructured":"Al Gwairi O, Thach L, Zheng W, Osman N, Little PJ (2016) Cellular and molecular pathology of age-related macular degeneration: potential role for proteoglycans. J Ophthalmol 2016:2913612","journal-title":"J Ophthalmol"},{"issue":"2","key":"2767_CR29","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/path.4266","volume":"232","author":"CM van Lookeren","year":"2014","unstructured":"van Lookeren CM, LeCouter J, Yaspan BL, Ye W (2014) Mechanisms of age-related macular degeneration and therapeutic opportunities. J Pathol 232(2):151\u2013164","journal-title":"J Pathol"},{"issue":"Pt 3","key":"2767_CR30","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/eye.2001.141","volume":"15","author":"M Boulton","year":"2001","unstructured":"Boulton M, Dayhaw-Barker P (2001) The role of the retinal pigment epithelium: topographical variation and ageing changes. Eye (Lond) 15(Pt 3):384\u2013389","journal-title":"Eye (Lond)"},{"issue":"5","key":"2767_CR31","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.compbiomed.2008.02.008","volume":"38","author":"C K\u00f6se","year":"2008","unstructured":"K\u00f6se C, Sevik U, Gen\u00e7alio\u011flu O (2008) Automatic segmentation of age-related macular degeneration in retinal fundus images. Comput Biol Med 38(5):611\u2013619","journal-title":"Comput Biol Med"},{"issue":"4","key":"2767_CR32","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1167\/iovs.12-11449","volume":"54","author":"MJ van Grinsven","year":"2013","unstructured":"van Grinsven MJ, Lechanteur YT, van de Ven JP, van Ginneken B, Hoyng CB et al (2013) Automatic drusen quantification and risk assessment of age-related macular degeneration on color fundus images. Invest Ophthalmol Vis Sci 54(4):3019\u20133027","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"2767_CR33","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.survophthal.2007.08.022","volume":"52","author":"H Bartlett","year":"2007","unstructured":"Bartlett H, Eperjesi F (2007) Use of fundus imaging in quantification of age-related macular change. Surv Ophthalmol 52(6):655\u2013671","journal-title":"Surv Ophthalmol"},{"issue":"4","key":"2767_CR34","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.mam.2012.04.006","volume":"33","author":"PS Mettu","year":"2012","unstructured":"Mettu PS, Wielgus AR, Ong SS, Cousins SW (2012) Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration. Mol Asp Med 33(4):376\u2013398","journal-title":"Mol Asp Med"},{"issue":"11","key":"2767_CR35","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1001\/jamaophthalmol.2016.3519","volume":"134","author":"JM Seddon","year":"2016","unstructured":"Seddon JM, McLeod DS, Bhutto IA, Villalonga MB, Silver RE et al (2016) Histopathological insights into choroidal vascular loss in clinically documented cases of age-related macular degeneration. JAMA Ophthalmol 134(11):1272\u20131280","journal-title":"JAMA Ophthalmol"},{"key":"2767_CR36","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.preteyeres.2018.07.002","volume":"67","author":"E Borrelli","year":"2018","unstructured":"Borrelli E, Sarraf D, Freund KB, Sadda SR (2018) Oct angiography and evaluation of the choroid and choroidal vascular disorders. Prog Retinal Eye Res 67:30\u201355","journal-title":"Prog Retinal Eye Res"},{"issue":"7","key":"2767_CR37","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1136\/bjo.2009.165563","volume":"94","author":"S Cherepanoff","year":"2010","unstructured":"Cherepanoff S, McMenamin P, Gillies MC, Kettle E, Sarks SH (2010) Bruch\u2019s membrane and choroidal macrophages in early and advanced age-related macular degeneration. Br J Ophthalmol 94(7):918\u2013925","journal-title":"Br J Ophthalmol"},{"issue":"11","key":"2767_CR38","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/eye.2017.81","volume":"31","author":"M Ashraf","year":"2017","unstructured":"Ashraf M, Souka AAR (2017) Aflibercept in age-related macular degeneration: evaluating its role as a primary therapeutic option. Eye (Lond) 31(11):1523\u20131536","journal-title":"Eye (Lond)"},{"issue":"4","key":"2767_CR39","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1167\/iovs.11-9338","volume":"53","author":"TR Friberg","year":"2012","unstructured":"Friberg TR, Bilonick RA, Brennen P (2012) Is drusen area really so important? An assessment of risk of conversion to neovascular amd based on computerized measurements of drusen. Invest Ophthalmol Vis Sci 53(4):1742\u20131751","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"2767_CR40","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1001\/jamaophthalmol.2020.0824","volume":"138","author":"S Vitale","year":"2020","unstructured":"Vitale S, Agr\u00f3n E, Clemons TE, Keenan TDL, Domalpally A et al (2020) Association of 2-year progression along the AREDS AMD scale and development of late age-related macular degeneration or loss of visual acuity: AREDS report 41. JAMA Ophthalmol 138(6):610\u2013617","journal-title":"JAMA Ophthalmol"},{"issue":"6","key":"2767_CR41","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/nri3459","volume":"13","author":"J Ambati","year":"2013","unstructured":"Ambati J, Atkinson JP, Gelfand BD (2013) Immunology of age-related macular degeneration. Nat Rev Immunol 13(6):438\u2013451","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"2767_CR42","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/eye.2017.298","volume":"32","author":"PTVM De Jong","year":"2018","unstructured":"De Jong PTVM (2018) Elusive drusen and changing terminology of amd. Eye 32(5):904\u2013914","journal-title":"Eye"},{"issue":"3","key":"2767_CR43","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S0002-9394(02)01624-0","volume":"134","author":"DH Anderson","year":"2002","unstructured":"Anderson DH, Mullins RF, Hageman GS, Johnson LV (2002) A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 134(3):411\u2013431","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"2767_CR44","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/S1350-9462(01)00010-6","volume":"20","author":"GS Hageman","year":"2001","unstructured":"Hageman GS, Luthert PJ, Victor Chong NH, Johnson LV, Anderson DH et al (2001) An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-bruch\u2019s membrane interface in aging and age-related macular degeneration. Prog Retinal Eye Res 20(6):705\u2013732","journal-title":"Prog Retinal Eye Res"},{"issue":"7","key":"2767_CR45","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1096\/fasebj.14.7.835","volume":"14","author":"RF Mullins","year":"2000","unstructured":"Mullins RF, Russell SR, Anderson DH, Hageman GS (2000) Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 14(7):835\u2013846","journal-title":"FASEB J"},{"issue":"43","key":"2767_CR46","doi-asserted-by":"publisher","first-page":"42027","DOI":"10.1074\/jbc.M305460200","volume":"278","author":"X Gu","year":"2003","unstructured":"Gu X, Meer SG, Miyagi M, Rayborn ME, Hollyfield JG et al (2003) Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration. J Biol Chem 278(43):42027\u201342035","journal-title":"J Biol Chem"},{"issue":"Pt 3","key":"2767_CR47","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/eye.2001.142","volume":"15","author":"RF Mullins","year":"2001","unstructured":"Mullins RF, Aptsiauri N, Hageman GS (2001) Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesis. Eye (Lond) 15(Pt 3):390\u2013395","journal-title":"Eye (Lond)"},{"issue":"2","key":"2767_CR48","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.preteyeres.2009.11.003","volume":"29","author":"DH Anderson","year":"2010","unstructured":"Anderson DH, Radeke MJ, Gallo NB, Chapin EA, Johnson PT et al (2010) The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retinal Eye Res 29(2):95\u2013112","journal-title":"Prog Retinal Eye Res"},{"issue":"20","key":"2767_CR49","doi-asserted-by":"publisher","first-page":"7227","DOI":"10.1073\/pnas.0501536102","volume":"102","author":"GS Hageman","year":"2005","unstructured":"Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ et al (2005) A common haplotype in the complement regulatory gene factor H (HF1\/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA 102(20):7227\u20137232","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"2767_CR50","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1006\/exer.2001.1094","volume":"73","author":"LV Johnson","year":"2001","unstructured":"Johnson LV, Leitner WP, Staples MK, Anderson DH (2001) Complement activation and inflammatory processes in drusen formation and age related macular degeneration. Exp Eye Res 73(6):887\u2013896","journal-title":"Exp Eye Res"},{"issue":"12","key":"2767_CR51","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1001\/archopht.116.12.1629","volume":"116","author":"T Ishibashi","year":"1998","unstructured":"Ishibashi T, Murata T, Hangai M, Nagai R, Horiuchi S et al (1998) Advanced glycation end products in age-related macular degeneration. Arch Ophthalmol 116(12):1629\u20131632","journal-title":"Arch Ophthalmol"},{"issue":"23","key":"2767_CR52","doi-asserted-by":"publisher","first-page":"14682","DOI":"10.1073\/pnas.222551899","volume":"99","author":"JW Crabb","year":"2002","unstructured":"Crabb JW, Miyagi M, Gu X, Shadrach K, West KA et al (2002) Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci USA 99(23):14682\u201314687","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"2767_CR53","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/ICU.0b013e32832af468","volume":"20","author":"NB Javitt","year":"2009","unstructured":"Javitt NB, Javitt JC (2009) The retinal oxysterol pathway: a unifying hypothesis for the cause of age-related macular degeneration. Curr Opin Ophthalmol 20(3):151\u2013157","journal-title":"Curr Opin Ophthalmol"},{"issue":"2","key":"2767_CR54","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/S0161-6420(97)30322-4","volume":"104","author":"RF Mullins","year":"1997","unstructured":"Mullins RF, Johnson LV, Anderson DH, Hageman GS (1997) Characterization of drusen-associated glycoconjugates. Ophthalmology 104(2):288\u2013294","journal-title":"Ophthalmology"},{"issue":"2","key":"2767_CR55","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s00109-008-0418-z","volume":"87","author":"K Kaarniranta","year":"2009","unstructured":"Kaarniranta K, Salminen A (2009) Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors. J Mol Med (Berl) 87(2):117\u2013123","journal-title":"J Mol Med (Berl)"},{"issue":"2","key":"2767_CR56","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S1350-9462(00)00027-6","volume":"20","author":"DY Yu","year":"2001","unstructured":"Yu DY, Cringle SJ (2001) Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease. Prog Retinal Eye Res 20(2):175\u2013208","journal-title":"Prog Retinal Eye Res"},{"issue":"5","key":"2767_CR57","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s10522-013-9463-2","volume":"14","author":"P Tokarz","year":"2013","unstructured":"Tokarz P, Kaarniranta K, Blasiak J (2013) Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD). Biogerontology 14(5):461\u2013482","journal-title":"Biogerontology"},{"issue":"4021","key":"2767_CR58","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1126\/science.175.4021.530","volume":"175","author":"AU Arstila","year":"1972","unstructured":"Arstila AU, Smith MA, Trump BF (1972) Microsomal lipid peroxidation: morphological characterization. Science 175(4021):530\u2013533","journal-title":"Science"},{"issue":"7","key":"2767_CR59","first-page":"2091","volume":"33","author":"MA De La Paz","year":"1992","unstructured":"De La Paz MA, Anderson RE (1992) Lipid peroxidation in rod outer segments. Role of hydroxyl radical and lipid hydroperoxides. Invest Ophthalmol Vis Sci 33(7):2091\u20132096","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"34","key":"2767_CR60","doi-asserted-by":"publisher","first-page":"13757","DOI":"10.1073\/pnas.1121309109","volume":"109","author":"PX Shaw","year":"2012","unstructured":"Shaw PX, Zhang L, Zhang M, Du H, Zhao L et al (2012) Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids. Proc Natl Acad Sci 109(34):13757\u201313762","journal-title":"Proc Natl Acad Sci"},{"issue":"12","key":"2767_CR61","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1172\/JCI8472","volume":"105","author":"PX Shaw","year":"2000","unstructured":"Shaw PX, H\u00f6rkk\u00f6 S, Chang M-K, Curtiss LK, Palinski W et al (2000) Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. J Clin Investig 105(12):1731\u20131740","journal-title":"J Clin Investig"},{"issue":"5","key":"2767_CR62","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.exer.2005.01.007","volume":"80","author":"JR Sparrow","year":"2005","unstructured":"Sparrow JR, Boulton M (2005) RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res 80(5):595\u2013606","journal-title":"Exp Eye Res"},{"issue":"16","key":"2767_CR63","doi-asserted-by":"publisher","first-page":"7275","DOI":"10.1073\/pnas.0913112107","volume":"107","author":"Y Wu","year":"2010","unstructured":"Wu Y, Yanase E, Feng X, Siegel MM, Sparrow JR (2010) Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration. Proc Natl Acad Sci USA 107(16):7275\u20137280","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"2767_CR64","first-page":"1981","volume":"41","author":"JR Sparrow","year":"2000","unstructured":"Sparrow JR, Nakanishi K, Parish CA (2000) The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 41(7):1981\u20131989","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"20","key":"2767_CR65","doi-asserted-by":"publisher","first-page":"18207","DOI":"10.1074\/jbc.M300457200","volume":"278","author":"JR Sparrow","year":"2003","unstructured":"Sparrow JR, Vollmer-Snarr HR, Zhou J, Jang YP, Jockusch S et al (2003) A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation. J Biol Chem 278(20):18207\u201318213","journal-title":"J Biol Chem"},{"issue":"6","key":"2767_CR66","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.coi.2007.09.002","volume":"19","author":"V P\u00e9trilli","year":"2007","unstructured":"P\u00e9trilli V, Dostert C, Muruve DA, Tschopp J (2007) The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol 19(6):615\u2013622","journal-title":"Curr Opin Immunol"},{"key":"2767_CR67","doi-asserted-by":"publisher","first-page":"v","DOI":"10.1016\/j.coi.2013.12.006","volume":"26","author":"SL Masters","year":"2014","unstructured":"Masters SL, De Nardo D (2014) Innate immunity. Curr Opin Immunol 26:v\u2013vi","journal-title":"Curr Opin Immunol"},{"issue":"5","key":"2767_CR68","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ni.1863","volume":"11","author":"T Kawai","year":"2010","unstructured":"Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat Immunol 11(5):373\u2013384","journal-title":"Nat Immunol"},{"key":"2767_CR69","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3109\/08830185.2010.529976","volume":"30","author":"H Kumar","year":"2011","unstructured":"Kumar H, Kawai T, Akira S (2011) Pathogen recognition by the innate immune system. Int Rev Immunol 30:16\u201334","journal-title":"Int Rev Immunol"},{"issue":"1","key":"2767_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1189\/jlb.0306164","volume":"81","author":"ME Bianchi","year":"2007","unstructured":"Bianchi ME (2007) Damps, pamps and alarmins: all we need to know about danger. J Leukoc Biol 81(1):1\u20135","journal-title":"J Leukoc Biol"},{"issue":"1","key":"2767_CR71","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.smim.2006.12.002","volume":"19","author":"K Miyake","year":"2007","unstructured":"Miyake K (2007) Innate immune sensing of pathogens and danger signals by cell surface toll-like receptors. Semin Immunol 19(1):3\u201310","journal-title":"Semin Immunol"},{"issue":"5","key":"2767_CR72","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.exer.2005.10.005","volume":"82","author":"Y Yamada","year":"2006","unstructured":"Yamada Y, Ishibashi K, Ishibashi K, Bhutto IA, Tian J et al (2006) The expression of advanced glycation endproduct receptors in RPE cells associated with basal deposits in human maculas. Exp Eye Res 82(5):840\u2013848","journal-title":"Exp Eye Res"},{"issue":"10","key":"2767_CR73","doi-asserted-by":"publisher","first-page":"3713","DOI":"10.1167\/iovs.04-0404","volume":"45","author":"KA Howes","year":"2004","unstructured":"Howes KA, Liu Y, Dunaief JL, Milam A, Frederick JM et al (2004) Receptor for advanced glycation end products and age-related macular degeneration. Invest Ophthalmol Vis Sci 45(10):3713\u20133720","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"2767_CR74","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S1350-9462(00)00017-3","volume":"20","author":"GM Holtkamp","year":"2001","unstructured":"Holtkamp GM, Kijlstra A, Peek R, de Vos AF (2001) Retinal pigment epithelium-immune system interactions: cytokine production and cytokine-induced changes. Prog Retinal Eye Res 20(1):29\u201348","journal-title":"Prog Retinal Eye Res"},{"issue":"4","key":"2767_CR75","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.exer.2007.06.013","volume":"85","author":"D Yang","year":"2007","unstructured":"Yang D, Elner SG, Bian ZM, Till GO, Petty HR et al (2007) Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells. Exp Eye Res 85(4):462\u2013472","journal-title":"Exp Eye Res"},{"key":"2767_CR76","first-page":"82","volume":"30","author":"M Boulton","year":"1989","unstructured":"Boulton M, McKechnie NM, Breda J et al (1989) The formation of autofluorescent granules in cultured human RPE. Invest Ophthalmol Vis Sci 30:82\u201389","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"2767_CR77","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/0891-5849(96)00175-X","volume":"21","author":"D Yin","year":"1996","unstructured":"Yin D (1996) Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores. Free Radic Biol Med 21(6):871\u2013888","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"2767_CR78","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.tcm.2005.12.001","volume":"16","author":"RS Vohra","year":"2006","unstructured":"Vohra RS, Murphy JE, Walker JH, Ponnambalam S, Homer-Vanniasinkam S (2006) Atherosclerosis and the lectin-like oxidized low-density lipoprotein scavenger receptor. Trends Cardiovasc Med 16(2):60\u201364","journal-title":"Trends Cardiovasc Med"},{"issue":"4","key":"2767_CR79","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1006\/bbrc.2002.6756","volume":"292","author":"KG Duncan","year":"2002","unstructured":"Duncan KG, Bailey KR, Kane JP, Schwartz DM (2002) Human retinal pigment epithelial cells express scavenger receptors BI and BII. Biochem Biophys Res Commun 292(4):1017\u20131022","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"2767_CR80","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1474-9726.2007.00351.x","volume":"7","author":"H Xu","year":"2008","unstructured":"Xu H, Chen M, Manivannan A, Lois N, Forrester JV (2008) Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice. Aging Cell 7(1):58\u201368","journal-title":"Aging Cell"},{"issue":"3","key":"2767_CR81","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0304-3940(97)00266-8","volume":"226","author":"YM Li","year":"1997","unstructured":"Li YM, Dickson DW (1997) Enhanced binding of advanced glycation endproducts (AGE) by the ApoE4 isoform links the mechanism of plaque deposition in Alzheimer\u2019s disease. Neurosci Lett 226(3):155\u2013158","journal-title":"Neurosci Lett"},{"issue":"4","key":"2767_CR82","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1097\/00001756-199703030-00018","volume":"8","author":"M Tabaton","year":"1997","unstructured":"Tabaton M, Perry G, Smith M, Vitek M, Angelini G et al (1997) Is amyloid beta-protein glycated in Alzheimer\u2019s disease? NeuroReport 8(4):907\u2013909","journal-title":"NeuroReport"},{"issue":"3","key":"2767_CR83","first-page":"325","volume":"75","author":"HP Hammes","year":"1996","unstructured":"Hammes HP, Weiss A, Hess S, Araki N, Horiuchi S et al (1996) Modification of vitronectin by advanced glycation alters functional properties in vitro and in the diabetic retina. Lab Invest 75(3):325\u2013338","journal-title":"Lab Invest"},{"issue":"3","key":"2767_CR84","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.cyto.2013.03.027","volume":"62","author":"T Lin","year":"2013","unstructured":"Lin T, Walker GB, Kurji K, Fang E, Law G et al (2013) Parainflammation associated with advanced glycation endproduct stimulation of RPE in vitro: implications for age-related degenerative diseases of the eye. Cytokine 62(3):369\u2013381","journal-title":"Cytokine"},{"issue":"5","key":"2767_CR85","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1074\/jbc.M006545200","volume":"276","author":"N Ohgami","year":"2001","unstructured":"Ohgami N, Nagai R, Ikemoto M, Arai H, Kuniyasu A et al (2001) Cd36, a member of the class b scavenger receptor family, as a receptor for advanced glycation end products. J Biol Chem 276(5):3195\u20133202","journal-title":"J Biol Chem"},{"key":"2767_CR86","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/978-1-4615-0067-4_26","volume":"533","author":"JR Sparrow","year":"2003","unstructured":"Sparrow JR, Cai B, Fishkin N, Jang YP, Krane S et al (2003) A2E, a fluorophore of RPE lipofuscin: can it cause rpe degeneration? Adv Exp Med Biol 533:205\u2013211","journal-title":"Adv Exp Med Biol"},{"issue":"8","key":"2767_CR87","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1016\/j.biocel.2003.08.009","volume":"36","author":"A Terman","year":"2004","unstructured":"Terman A, Brunk UT (2004) Lipofuscin. Int J Biochem Cell Biol 36(8):1400\u20131404","journal-title":"Int J Biochem Cell Biol"},{"issue":"7","key":"2767_CR88","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1167\/iovs.07-1352","volume":"49","author":"CL Nordgaard","year":"2008","unstructured":"Nordgaard CL, Karunadharma PP, Feng X, Olsen TW, Ferrington DA (2008) Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration. Invest Ophthalmol Vis Sci 49(7):2848\u20132855","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"2767_CR89","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1034\/j.1600-0420.2002.800204.x","volume":"80","author":"PV Algvere","year":"2002","unstructured":"Algvere PV, Seregard S (2002) Age-related maculopathy: pathogenetic features and new treatment modalities. Acta Ophthalmol Scand 80(2):136\u2013143","journal-title":"Acta Ophthalmol Scand"},{"issue":"1","key":"2767_CR90","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1600-0420.2005.00627.x","volume":"84","author":"PV Algvere","year":"2006","unstructured":"Algvere PV, Marshall J, Seregard S (2006) Age-related maculopathy and the impact of blue light hazard. Acta Ophthalmol Scand 84(1):4\u201315","journal-title":"Acta Ophthalmol Scand"},{"key":"2767_CR91","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.preteyeres.2015.09.002","volume":"51","author":"DA Ferrington","year":"2016","unstructured":"Ferrington DA, Sinha D, Kaarniranta K (2016) Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration. Prog Retinal Eye Res 51:69\u201389","journal-title":"Prog Retinal Eye Res"},{"issue":"9b","key":"2767_CR92","doi-asserted-by":"publisher","first-page":"3616","DOI":"10.1111\/j.1582-4934.2008.00577.x","volume":"13","author":"T Ryh\u00e4nen","year":"2009","unstructured":"Ryh\u00e4nen T, Hyttinen JM, Kopitz J, Rilla K, Kuusisto E et al (2009) Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells. J Cell Mol Med 13(9b):3616\u20133631","journal-title":"J Cell Mol Med"},{"issue":"2","key":"2767_CR93","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.arr.2009.01.001","volume":"8","author":"K Kaarniranta","year":"2009","unstructured":"Kaarniranta K, Salminen A, Eskelinen EL, Kopitz J (2009) Heat shock proteins as gatekeepers of proteolytic pathways-implications for age-related macular degeneration (AMD). Ageing Res Rev 8(2):128\u2013139","journal-title":"Ageing Res Rev"},{"issue":"2","key":"2767_CR94","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.3390\/ijms14022996","volume":"14","author":"J Blasiak","year":"2013","unstructured":"Blasiak J, Glowacki S, Kauppinen A, Kaarniranta K (2013) Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration. Int J Mol Sci 14(2):2996\u20133010","journal-title":"Int J Mol Sci"},{"issue":"12","key":"2767_CR95","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s00417-002-0558-8","volume":"240","author":"F Sch\u00fctt","year":"2002","unstructured":"Sch\u00fctt F, Bergmann M, Holz FG, Kopitz J (2002) Isolation of intact lysosomes from human RPE cells and effects of A2-E on the integrity of the lysosomal and other cellular membranes. Graefes Arch Clin Exp Ophthalmol 240(12):983\u2013988","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"3","key":"2767_CR96","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1096\/fj.03-0289fje","volume":"18","author":"M Bergmann","year":"2004","unstructured":"Bergmann M, Sch\u00fctt F, Holz FG, Kopitz J (2004) Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration. FASEB J 18(3):562\u2013564","journal-title":"FASEB J"},{"issue":"36","key":"2767_CR97","doi-asserted-by":"publisher","first-page":"24770","DOI":"10.1074\/jbc.M800706200","volume":"283","author":"C Vives-Bauza","year":"2008","unstructured":"Vives-Bauza C, Anand M, Shiraz AK, Magrane J, Gao J et al (2008) The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells. J Biol Chem 283(36):24770\u201324780","journal-title":"J Biol Chem"},{"issue":"3","key":"2767_CR98","doi-asserted-by":"publisher","first-page":"480","DOI":"10.4161\/auto.27292","volume":"10","author":"M Valapala","year":"2014","unstructured":"Valapala M, Wilson C, Hose S, Bhutto IA, Grebe R et al (2014) Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1\/\u03b2A3\/A1-crystallin via V-ATPase-MTORC1 signaling. Autophagy 10(3):480\u2013496","journal-title":"Autophagy"},{"key":"2767_CR99","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.arr.2014.07.002","volume":"18","author":"JM Hyttinen","year":"2014","unstructured":"Hyttinen JM, Amadio M, Viiri J, Pascale A, Salminen A et al (2014) Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases. Ageing Res Rev 18:16\u201328","journal-title":"Ageing Res Rev"},{"issue":"1","key":"2767_CR100","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","volume":"132","author":"B Levine","year":"2008","unstructured":"Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132(1):27\u201342","journal-title":"Cell"},{"issue":"4","key":"2767_CR101","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.arr.2009.06.002","volume":"8","author":"O Arjamaa","year":"2009","unstructured":"Arjamaa O, Nikinmaa M, Salminen A, Kaarniranta K (2009) Regulatory role of HIF-1\u03b1 in the pathogenesis of age-related macular degeneration (AMD). Ageing Res Rev 8(4):349\u2013358","journal-title":"Ageing Res Rev"},{"issue":"3","key":"2767_CR102","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.bbamcr.2012.11.018","volume":"1833","author":"JM Hyttinen","year":"2013","unstructured":"Hyttinen JM, Niittykoski M, Salminen A, Kaarniranta K (2013) Maturation of autophagosomes and endosomes: a key role for Rab7. Biochim Biophys Acta 1833(3):503\u2013510","journal-title":"Biochim Biophys Acta"},{"issue":"23","key":"2767_CR103","doi-asserted-by":"publisher","first-page":"4635","DOI":"10.1091\/mbc.e11-08-0680","volume":"22","author":"PC Zucchi","year":"2011","unstructured":"Zucchi PC, Zick M (2011) Membrane fusion catalyzed by a Rab, SNAREs, and SNARE chaperones is accompanied by enhanced permeability to small molecules and by lysis. Mol Biol Cell 22(23):4635\u20134646","journal-title":"Mol Biol Cell"},{"issue":"7302","key":"2767_CR104","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature09204","volume":"466","author":"C Behrends","year":"2010","unstructured":"Behrends C, Sowa ME, Gygi SP, Harper JW (2010) Network organization of the human autophagy system. Nature 466(7302):68\u201376","journal-title":"Nature"},{"key":"2767_CR105","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1756-6606-2-5","volume":"2","author":"V Cullen","year":"2009","unstructured":"Cullen V, Lindfors M, Ng J, Paetau A, Swinton E et al (2009) Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo. Mol Brain 2:5","journal-title":"Mol Brain"},{"issue":"2","key":"2767_CR106","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0891-5849(96)00612-0","volume":"23","author":"J O'Neil","year":"1997","unstructured":"O\u2019Neil J, Hoppe G, Sayre LM, Hoff HF (1997) Inactivation of cathepsin B by oxidized LDL involves complex formation induced by binding of putative reactive sites exposed at low PH to thiols on the enzyme. Free Radic Biol Med 23(2):215\u2013225","journal-title":"Free Radic Biol Med"},{"issue":"7","key":"2767_CR107","doi-asserted-by":"publisher","first-page":"973","DOI":"10.4161\/auto.24546","volume":"9","author":"K Kaarniranta","year":"2013","unstructured":"Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Ver\u00e9b Z et al (2013) Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy 9(7):973\u2013984","journal-title":"Autophagy"},{"issue":"2","key":"2767_CR108","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.exer.2009.10.014","volume":"90","author":"TU Krohne","year":"2010","unstructured":"Krohne TU, Kaemmerer E, Holz FG, Kopitz J (2010) Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action. Exp Eye Res 90(2):261\u2013266","journal-title":"Exp Eye Res"},{"issue":"48","key":"2767_CR109","first-page":"29035","volume":"290","author":"L Perusek","year":"2015","unstructured":"Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le YZ, Subauste CS, Chen Y, Palczewski K, Maeda A (2015) Di-retinoid-pyridinium-ethanolamine (A2E) accumulation and the maintenance of the visual cycle are independent of Atg7-mediated autophagy in the retinal pigmented epithelium. Mol Bases Dis Cell Biol 290(48):29035\u201329044","journal-title":"Mol Bases Dis Cell Biol"},{"issue":"6","key":"2767_CR110","doi-asserted-by":"publisher","first-page":"3842","DOI":"10.1073\/pnas.052025899","volume":"99","author":"SC Finnemann","year":"2002","unstructured":"Finnemann SC, Leung LW, Rodriguez-Boulan E (2002) The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium. Proc Natl Acad Sci USA 99(6):3842\u20133847","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"2767_CR111","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1562\/0031-8655(2004)079<0127:AACOOL>2.0.CO;2","volume":"79","author":"LE Lamb","year":"2004","unstructured":"Lamb LE, Simon JD (2004) A2e: a component of ocular lipofuscin. Photochem Photobiol 79(2):127\u2013136","journal-title":"Photochem Photobiol"},{"issue":"1","key":"2767_CR112","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.453","volume":"8","author":"N Golestaneh","year":"2017","unstructured":"Golestaneh N, Chu Y, Xiao YY, Stoleru GL, Theos AC (2017) Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration. Cell Death Dis 8(1):e2537","journal-title":"Cell Death Dis"},{"issue":"6","key":"2767_CR113","doi-asserted-by":"publisher","first-page":"542","DOI":"10.4161\/auto.4600","volume":"3","author":"N Mizushima","year":"2007","unstructured":"Mizushima N, Yoshimori T (2007) How to interpret LC3 immunoblotting. Autophagy 3(6):542\u2013545","journal-title":"Autophagy"},{"issue":"12","key":"2767_CR114","doi-asserted-by":"publisher","first-page":"3961","DOI":"10.1096\/fj.201600698R","volume":"30","author":"MB Schaaf","year":"2016","unstructured":"Schaaf MB, Keulers TG, Vooijs MA, Rouschop KM (2016) LC3\/gabarap family proteins: autophagy-(un)related functions. FASEB J 30(12):3961\u20133978","journal-title":"FASEB J"},{"key":"2767_CR115","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/978-1-4614-3209-8_10","volume":"801","author":"EF Nandrot","year":"2014","unstructured":"Nandrot EF (2014) Animal models, in \u201cthe quest to decipher RPE phagocytosis.\u201d Adv Exp Med Biol 801:77\u201383","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"2767_CR116","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.ajo.2004.11.050","volume":"139","author":"SL Fine","year":"2005","unstructured":"Fine SL (2005) Age-related macular degeneration 1969\u20132004: a 35-year personal perspective. Am J Ophthalmol 139(3):405\u2013420","journal-title":"Am J Ophthalmol"},{"issue":"11","key":"2767_CR117","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.biochi.2004.09.029","volume":"86","author":"J Kopitz","year":"2004","unstructured":"Kopitz J, Holz FG, Kaemmerer E, Schutt F (2004) Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration. Biochimie 86(11):825\u2013831","journal-title":"Biochimie"},{"issue":"4","key":"2767_CR118","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1755-3768.2011.02179.x","volume":"90","author":"K Kinnunen","year":"2012","unstructured":"Kinnunen K, Petrovski G, Moe MC, Berta A, Kaarniranta K (2012) Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration. Acta Ophthalmol 90(4):299\u2013309","journal-title":"Acta Ophthalmol"},{"issue":"10","key":"2767_CR119","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1301\/nr.2003.oct.342-346","volume":"61","author":"G Wolf","year":"2003","unstructured":"Wolf G (2003) Lipofuscin and macular degeneration. Nutr Rev 61(10):342\u2013346","journal-title":"Nutr Rev"},{"issue":"7","key":"2767_CR120","first-page":"1271","volume":"36","author":"DJ Tate Jr","year":"1995","unstructured":"Tate DJ Jr, Miceli MV, Newsome DA (1995) Phagocytosis and H2O2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 36(7):1271\u20131279","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"2767_CR121","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exer.2003.10.003","volume":"78","author":"F Shang","year":"2004","unstructured":"Shang F, Taylor A (2004) Function of the ubiquitin proteolytic pathway in the eye. Exp Eye Res 78(1):1\u201314","journal-title":"Exp Eye Res"},{"key":"2767_CR122","first-page":"35","volume":"5","author":"G Lutty","year":"1999","unstructured":"Lutty G, Grunwald J, Majji AB, Uyama M, Yoneya S (1999) Changes in choriocapillaris and retinal pigment epithelium in age-related macular degeneration. Mol Vis 5:35","journal-title":"Mol Vis"},{"issue":"1","key":"2767_CR123","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.exer.2005.05.007","volume":"82","author":"IA Bhutto","year":"2006","unstructured":"Bhutto IA, McLeod DS, Hasegawa T, Kim SY, Merges C et al (2006) Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration. Exp Eye Res 82(1):99\u2013110","journal-title":"Exp Eye Res"},{"issue":"2","key":"2767_CR124","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/S0002-9394(02)01549-0","volume":"134","author":"NM Holekamp","year":"2002","unstructured":"Holekamp NM, Bouck N, Volpert O (2002) Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration. Am J Ophthalmol 134(2):220\u2013227","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"2767_CR125","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.3390\/jcm3041542","volume":"3","author":"CP Ardeljan","year":"2014","unstructured":"Ardeljan CP, Ardeljan D, Abu-Asab M, Chan CC (2014) Inflammation and cell death in age-related macular degeneration: an immunopathological and ultrastructural model. J Clin Med 3(4):1542\u20131560","journal-title":"J Clin Med"},{"issue":"9","key":"2767_CR126","doi-asserted-by":"publisher","first-page":"5048","DOI":"10.1167\/iovs.15-16401","volume":"56","author":"J Hanus","year":"2015","unstructured":"Hanus J, Kolkin A, Chimienti J, Botsay S, Wang S (2015) 4-acetoxyphenol prevents rpe oxidative stress-induced necrosis by functioning as an NRF2 stabilizer. Invest Ophthalmol Vis Sci 56(9):5048\u20135059","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"2767_CR127","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1167\/iovs.12-10655","volume":"54","author":"WA Tseng","year":"2013","unstructured":"Tseng WA, Thein T, Kinnunen K, Lashkari K, Gregory MS et al (2013) NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci 54(1):110\u2013120","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"2767_CR128","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.celrep.2015.05.023","volume":"11","author":"BD Gelfand","year":"2015","unstructured":"Gelfand BD, Wright CB, Kim Y, Yasuma T, Yasuma R et al (2015) Iron toxicity in the retina requires Alu RNA and the NLRP3 inflammasome. Cell Rep 11(11):1686\u20131693","journal-title":"Cell Rep"},{"issue":"12","key":"2767_CR129","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.478","volume":"4","author":"J Hanus","year":"2013","unstructured":"Hanus J, Zhang H, Wang Z, Liu Q, Zhou Q et al (2013) Induction of necrotic cell death by oxidative stress in retinal pigment epithelial cells. Cell Death Dis 4(12):e965","journal-title":"Cell Death Dis"},{"key":"2767_CR130","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jphotobiol.2016.05.018","volume":"161","author":"C Brandstetter","year":"2016","unstructured":"Brandstetter C, Patt J, Holz FG, Krohne TU (2016) Inflammasome priming increases retinal pigment epithelial cell susceptibility to lipofuscin phototoxicity by changing the cell death mechanism from apoptosis to pyroptosis. J Photochem Photobiol B 161:177\u2013183","journal-title":"J Photochem Photobiol B"},{"issue":"3","key":"2767_CR131","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1083\/jcb.119.3.493","volume":"119","author":"Y Gavrieli","year":"1992","unstructured":"Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119(3):493\u2013501","journal-title":"J Cell Biol"},{"key":"2767_CR132","unstructured":"Xu GZ, Li WW, Tso MO (1996) Apoptosis in human retinal degenerations. Trans Am Ophthalmol Soc 94:411\u2013430; discussion 430\u2013411"},{"issue":"11","key":"2767_CR133","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1001\/archopht.120.11.1435","volume":"120","author":"JL Dunaief","year":"2002","unstructured":"Dunaief JL, Dentchev T, Ying GS, Milam AH (2002) The role of apoptosis in age-related macular degeneration. Arch Ophthalmol 120(11):1435\u20131442","journal-title":"Arch Ophthalmol"},{"issue":"3","key":"2767_CR134","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1167\/iovs.02-0492","volume":"44","author":"DN Zacks","year":"2003","unstructured":"Zacks DN, Hanninen V, Pantcheva M, Ezra E, Grosskreutz C et al (2003) Caspase activation in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci 44(3):1262\u20131267","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"2767_CR135","doi-asserted-by":"publisher","first-page":"4563","DOI":"10.1167\/iovs.04-0598","volume":"45","author":"DN Zacks","year":"2004","unstructured":"Zacks DN, Zheng QD, Han Y, Bakhru R, Miller JW (2004) Fas-mediated apoptosis and its relation to intrinsic pathway activation in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci 45(12):4563\u20134569","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"2767_CR136","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1167\/iovs.10-6509","volume":"52","author":"T Nakazawa","year":"2011","unstructured":"Nakazawa T, Kayama M, Ryu M, Kunikata H, Watanabe R et al (2011) Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment. Invest Ophthalmol Vis Sci 52(3):1384\u20131391","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2767_CR137","first-page":"867","volume":"12","author":"T Nakazawa","year":"2006","unstructured":"Nakazawa T, Matsubara A, Noda K, Hisatomi T, She H et al (2006) Characterization of cytokine responses to retinal detachment in rats. Mol Vis 12:867\u2013878","journal-title":"Mol Vis"},{"issue":"4","key":"2767_CR138","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/S0002-9440(10)64078-3","volume":"158","author":"T Hisatomi","year":"2001","unstructured":"Hisatomi T, Sakamoto T, Murata T, Yamanaka I, Oshima Y et al (2001) Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo. Am J Pathol 158(4):1271\u20131278","journal-title":"Am J Pathol"},{"issue":"50","key":"2767_CR139","doi-asserted-by":"publisher","first-page":"21695","DOI":"10.1073\/pnas.1009179107","volume":"107","author":"G Trichonas","year":"2010","unstructured":"Trichonas G, Murakami Y, Thanos A, Morizane Y, Kayama M et al (2010) Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proc Natl Acad Sci USA 107(50):21695\u201321700","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"2767_CR140","first-page":"2025","volume":"118","author":"T Hisatomi","year":"2008","unstructured":"Hisatomi T, Nakazawa T, Noda K, Almulki L, Miyahara S et al (2008) HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice. J Clin Invest 118(6):2025\u20132038","journal-title":"J Clin Invest"},{"key":"2767_CR141","doi-asserted-by":"publisher","first-page":"26322","DOI":"10.1038\/srep26322","volume":"6","author":"Y Zhu","year":"2016","unstructured":"Zhu Y, Zhao KK, Tong Y, Zhou YL, Wang YX et al (2016) Exogenous nad(+) decreases oxidative stress and protects H2O2-treated RPE cells against necrotic death through the up-regulation of autophagy. Sci Rep 6:26322","journal-title":"Sci Rep"},{"issue":"10","key":"2767_CR142","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/nrm2970","volume":"11","author":"P Vandenabeele","year":"2010","unstructured":"Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G (2010) Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol 11(10):700\u2013714","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"2767_CR143","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/labinvest.2008.165","volume":"89","author":"N Arimura","year":"2009","unstructured":"Arimura N, Ki-i Y, Hashiguchi T, Kawahara K, Biswas KK et al (2009) Intraocular expression and release of high-mobility group box 1 protein in retinal detachment. Lab Invest 89(3):278\u2013289","journal-title":"Lab Invest"},{"issue":"17","key":"2767_CR144","doi-asserted-by":"publisher","first-page":"6617","DOI":"10.1073\/pnas.0401529101","volume":"101","author":"G Rebello","year":"2004","unstructured":"Rebello G, Ramesar R, Vorster A, Roberts L, Ehrenreich L et al (2004) Apoptosis-inducing signal sequence mutation in carbonic anhydrase IV identified in patients with the RP17 form of retinitis pigmentosa. Proc Natl Acad Sci USA 101(17):6617\u20136622","journal-title":"Proc Natl Acad Sci USA"},{"issue":"13","key":"2767_CR145","doi-asserted-by":"publisher","first-page":"5961","DOI":"10.1073\/pnas.0911991107","volume":"107","author":"MS Gorbatyuk","year":"2010","unstructured":"Gorbatyuk MS, Knox T, LaVail MM, Gorbatyuk OS, Noorwez SM et al (2010) Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP\/Grp78. Proc Natl Acad Sci USA 107(13):5961\u20135966","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"2767_CR146","doi-asserted-by":"publisher","first-page":"3234","DOI":"10.1167\/iovs.06-0213","volume":"47","author":"BM Tam","year":"2006","unstructured":"Tam BM, Moritz OL (2006) Characterization of rhodopsin P23H-induced retinal degeneration in a Xenopus laevis model of retinitis pigmentosa. Invest Ophthalmol Vis Sci 47(8):3234\u20133241","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"2767_CR147","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.mehy.2007.04.041","volume":"70","author":"T Shinohara","year":"2008","unstructured":"Shinohara T, Mulhern ML, Madson CJ (2008) Silencing gene therapy for mutant membrane, secretory, and lipid proteins in retinitis pigmentosa (RP). Med Hypotheses 70(2):378\u2013380","journal-title":"Med Hypotheses"},{"issue":"9","key":"2767_CR148","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1007\/s10495-006-9006-2","volume":"11","author":"D Sanges","year":"2006","unstructured":"Sanges D, Marigo V (2006) Cross-talk between two apoptotic pathways activated by endoplasmic reticulum stress: differential contribution of caspase-12 and AIF. Apoptosis 11(9):1629\u20131641","journal-title":"Apoptosis"},{"issue":"11","key":"2767_CR149","doi-asserted-by":"publisher","first-page":"5191","DOI":"10.1167\/iovs.07-0512","volume":"48","author":"LP Yang","year":"2007","unstructured":"Yang LP, Wu LM, Guo XJ, Tso MO (2007) Activation of endoplasmic reticulum stress in degenerating photoreceptors of the rd1 mouse. Invest Ophthalmol Vis Sci 48(11):5191\u20135198","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"2767_CR150","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1016\/j.ophtha.2013.03.046","volume":"120","author":"S Rofagha","year":"2013","unstructured":"Rofagha S, Bhisitkul RB, Boyer DS, Sadda SR, Zhang K (2013) Seven-year outcomes in ranibizumab-treated patients in anchor, marina, and horizon: a multicenter cohort study (seven-up). Ophthalmology 120(11):2292\u20132299","journal-title":"Ophthalmology"},{"issue":"2","key":"2767_CR151","first-page":"102","volume":"22","author":"GA Peyman","year":"1991","unstructured":"Peyman GA, Blinder KJ, Paris CL, Alturki W, Nelson NC Jr et al (1991) A technique for retinal pigment epithelium transplantation for age-related macular degeneration secondary to extensive subfoveal scarring. Ophthalmic Surg 22(2):102\u2013108","journal-title":"Ophthalmic Surg"},{"issue":"3","key":"2767_CR152","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1177\/112067219900900310","volume":"9","author":"PV Algvere","year":"1999","unstructured":"Algvere PV, Gouras P, Dafgard Kopp E (1999) Long-term outcome of RPE allografts in non-immunosuppressed patients with amd. Eur J Ophthalmol 9(3):217\u2013230","journal-title":"Eur J Ophthalmol"},{"issue":"1","key":"2767_CR153","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0169-409X(01)00195-8","volume":"52","author":"RZ Renno","year":"2001","unstructured":"Renno RZ, Miller JW (2001) Photosensitizer delivery for photodynamic therapy of choroidal neovascularization. Adv Drug Deliv Rev 52(1):63\u201378","journal-title":"Adv Drug Deliv Rev"},{"issue":"4","key":"2767_CR154","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/eye.2009.122","volume":"24","author":"DP Han","year":"2010","unstructured":"Han DP, McAllister JT, Weinberg DV, Kim JE, Wirostko WJ (2010) Combined intravitreal anti-VEGF and verteporfin photodynamic therapy for juxtafoveal and extrafoveal choroidal neovascularization as an alternative to laser photocoagulation. Eye (Lond) 24(4):713\u2013716","journal-title":"Eye (Lond)"},{"issue":"3","key":"2767_CR155","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1001\/jamaophthalmol.2013.6636","volume":"132","author":"EY Chew","year":"2014","unstructured":"Chew EY, Clemons TE, Agr\u00f3n E, Sperduto RD, SanGiovanni JP et al (2014) Ten-year follow-up of age-related macular degeneration in the age-related eye disease study: AREDS report no. 36. JAMA Ophthalmol 132(3):272\u2013277","journal-title":"JAMA Ophthalmol"},{"issue":"8","key":"2767_CR156","first-page":"1215","volume":"62","author":"EY Chew","year":"2021","unstructured":"Chew EY, Clemons TE, Keenan TDL, Agron E, Malley CE et al (2021) The results of the 10 year follow-on study of the age-related eye disease study 2 (AREDS2). Invest Ophthalmol Vis Sci 62(8):1215\u20131215","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"19","key":"2767_CR157","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1001\/jama.2013.4997","volume":"309","author":"Group* TA-REDSR","year":"2013","unstructured":"Group* TA-REDSR (2013) Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA 309(19):2005\u20132015","journal-title":"JAMA"},{"key":"2767_CR158","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1001\/jamaophthalmol.2022.1640","volume":"140","author":"EY Chew","year":"2022","unstructured":"Chew EY, Clemons TE, Agr\u00f3n E, Domalpally A, Keenan TDL et al (2022) Long-term outcomes of adding lutein\/zeaxanthin and \u03c9-3 fatty acids to the AREDS supplements on age-related macular degeneration progression: AREDS2 report. JAMA Ophthalmol 140:692\u2013698","journal-title":"JAMA Ophthalmol"},{"issue":"10","key":"2767_CR159","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1016\/j.ophtha.2016.06.049","volume":"123","author":"L da Cruz","year":"2016","unstructured":"da Cruz L, Dorn JD, Humayun MS, Dagnelie G, Handa J et al (2016) Five-year safety and performance results from the Argus II retinal prosthesis system clinical trial. Ophthalmology 123(10):2248\u20132254","journal-title":"Ophthalmology"},{"issue":"9","key":"2767_CR160","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1111\/ans.13616","volume":"86","author":"PM Lewis","year":"2016","unstructured":"Lewis PM, Ayton LN, Guymer RH, Lowery AJ, Blamey PJ et al (2016) Advances in implantable bionic devices for blindness: a review. ANZ J Surg 86(9):654\u2013659","journal-title":"ANZ J Surg"},{"issue":"Pt B","key":"2767_CR161","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.visres.2014.10.023","volume":"111","author":"JH Jung","year":"2015","unstructured":"Jung JH, Aloni D, Yitzhaky Y, Peli E (2015) Active confocal imaging for visual prostheses. Vis Res 111(Pt B):182\u2013196","journal-title":"Vis Res"},{"key":"2767_CR162","unstructured":"Luo G, Peli E (2011) Development and evaluation of vision rehabilitation devices. In: Conference proceedings: annual international conference of the IEEE engineering in medicine and biology society, pp 5228\u20135231"},{"issue":"3","key":"2767_CR163","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.stemcr.2017.07.022","volume":"9","author":"A Gonzalez-Cordero","year":"2017","unstructured":"Gonzalez-Cordero A, Kruczek K, Naeem A, Fernando M, Kloc M et al (2017) Recapitulation of human retinal development from human pluripotent stem cells generates transplantable populations of cone photoreceptors. Stem Cell Rep 9(3):820\u2013837","journal-title":"Stem Cell Rep"},{"issue":"6","key":"2767_CR164","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1016\/j.stemcr.2017.04.030","volume":"8","author":"K Kruczek","year":"2017","unstructured":"Kruczek K, Gonzalez-Cordero A, Goh D, Naeem A, Jonikas M et al (2017) Differentiation and transplantation of embryonic stem cell-derived cone photoreceptors into a mouse model of end-stage retinal degeneration. Stem Cell Rep 8(6):1659\u20131674","journal-title":"Stem Cell Rep"},{"issue":"6","key":"2767_CR165","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.stemcr.2014.04.010","volume":"2","author":"S Decembrini","year":"2014","unstructured":"Decembrini S, Koch U, Radtke F, Moulin A, Arsenijevic Y (2014) Derivation of traceable and transplantable photoreceptors from mouse embryonic stem cells. Stem Cell Rep 2(6):853\u2013865","journal-title":"Stem Cell Rep"},{"issue":"1","key":"2767_CR166","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/s41598-017-00774-9","volume":"7","author":"KJ Wahlin","year":"2017","unstructured":"Wahlin KJ, Maruotti JA, Sripathi SR, Ball J, Angueyra JM et al (2017) Photoreceptor outer segment-like structures in long-term 3D retinas from human pluripotent stem cells. Sci Rep 7(1):766","journal-title":"Sci Rep"},{"key":"2767_CR167","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.1038\/ncomms5047","volume":"5","author":"X Zhong","year":"2014","unstructured":"Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN et al (2014) Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs. Nat Commun 5:4047","journal-title":"Nat Commun"},{"issue":"11","key":"2767_CR168","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1001\/archopht.125.11.1460","volume":"125","author":"TS Chang","year":"2007","unstructured":"Chang TS, Bressler NM, Fine JT, Dolan CM, Ward J et al (2007) Improved vision-related function after ranibizumab treatment of neovascular age-related macular degeneration: results of a randomized clinical trial. Arch Ophthalmol 125(11):1460\u20131469","journal-title":"Arch Ophthalmol"},{"key":"2767_CR169","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/510285","volume":"2014","author":"P Fernandez-Robredo","year":"2014","unstructured":"Fernandez-Robredo P, Sancho A, Johnen S, Recalde S, Gama N et al (2014) Current treatment limitations in age-related macular degeneration and future approaches based on cell therapy and tissue engineering. J Ophthalmol 2014:510285","journal-title":"J Ophthalmol"},{"issue":"3","key":"2767_CR170","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.exer.2004.05.013","volume":"79","author":"S Arai","year":"2004","unstructured":"Arai S, Thomas BB, Seiler MJ, Aramant RB, Qiu G et al (2004) Restoration of visual responses following transplantation of intact retinal sheets in rd mice. Exp Eye Res 79(3):331\u2013341","journal-title":"Exp Eye Res"},{"issue":"1","key":"2767_CR171","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1097\/00006982-200402000-00014","volume":"24","author":"F Ghosh","year":"2004","unstructured":"Ghosh F, Wong F, Johansson K, Bruun A, Petters RM (2004) Transplantation of full-thickness retina in the rhodopsin transgenic pig. Retina 24(1):98\u2013109","journal-title":"Retina"},{"issue":"2","key":"2767_CR172","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1006\/exer.2002.2001","volume":"75","author":"RB Aramant","year":"2002","unstructured":"Aramant RB, Seiler MJ (2002) Transplanted sheets of human retina and retinal pigment epithelium develop normally in nude rats. Exp Eye Res 75(2):115\u2013125","journal-title":"Exp Eye Res"},{"key":"2767_CR173","volume":"84","author":"D Eberle","year":"2014","unstructured":"Eberle D, Santos-Ferreira T, Grahl S, Ader M (2014) Subretinal transplantation of macs purified photoreceptor precursor cells into the adult mouse retina. J Vis Exp 84:e50932","journal-title":"J Vis Exp"},{"issue":"7116","key":"2767_CR174","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nature05161","volume":"444","author":"RE MacLaren","year":"2006","unstructured":"MacLaren RE, Pearson RA, MacNeil A, Douglas RH, Salt TE et al (2006) Retinal repair by transplantation of photoreceptor precursors. Nature 444(7116):203\u2013207","journal-title":"Nature"},{"issue":"1","key":"2767_CR175","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s13287-017-0661-8","volume":"8","author":"Y Liu","year":"2017","unstructured":"Liu Y, Chen SJ, Li SY, Qu LH, Meng XH et al (2017) Long-term safety of human retinal progenitor cell transplantation in retinitis pigmentosa patients. Stem Cell Res Ther 8(1):209","journal-title":"Stem Cell Res Ther"},{"key":"2767_CR176","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/939801","volume":"2012","author":"H Klassen","year":"2012","unstructured":"Klassen H, Kiilgaard JF, Warfvinge K, Samuel MS, Prather RS et al (2012) Photoreceptor differentiation following transplantation of allogeneic retinal progenitor cells to the dystrophic rhodopsin Pro347Leu transgenic pig. Stem Cells Int 2012:939801","journal-title":"Stem Cells Int"},{"key":"2767_CR177","first-page":"472","volume":"22","author":"MK Jones","year":"2016","unstructured":"Jones MK, Lu B, Saghizadeh M, Wang S (2016) Gene expression changes in the retina following subretinal injection of human neural progenitor cells into a rodent model for retinal degeneration. Mol Vis 22:472\u2013490","journal-title":"Mol Vis"},{"issue":"3","key":"2767_CR178","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/j.1460-9568.2011.07970.x","volume":"35","author":"TJ McGill","year":"2012","unstructured":"McGill TJ, Cottam B, Lu B, Wang S, Girman S et al (2012) Transplantation of human central nervous system stem cells-neuroprotection in retinal degeneration. Eur J Neurosci 35(3):468\u2013477","journal-title":"Eur J Neurosci"},{"issue":"11","key":"2767_CR179","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","volume":"121","author":"YC Tham","year":"2014","unstructured":"Tham YC, Li X, Wong TY, Quigley HA, Aung T et al (2014) Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology 121(11):2081\u20132090","journal-title":"Ophthalmology"},{"issue":"11","key":"2767_CR180","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1056\/NEJMoa1608368","volume":"376","author":"M Mandai","year":"2017","unstructured":"Mandai M, Watanabe A, Kurimoto Y, Hirami Y, Morinaga C et al (2017) Autologous induced stem-cell-derived retinal cells for macular degeneration. N Engl J Med 376(11):1038\u20131046","journal-title":"N Engl J Med"},{"issue":"1","key":"2767_CR181","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1167\/iovs.16-19778","volume":"58","author":"H Kamao","year":"2017","unstructured":"Kamao H, Mandai M, Ohashi W, Hirami Y, Kurimoto Y et al (2017) Evaluation of the surgical device and procedure for extracellular matrix-scaffold-supported human iPSC-derived retinal pigment epithelium cell sheet transplantation. Invest Ophthalmol Vis Sci 58(1):211\u2013220","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"2767_CR182","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.stemcr.2014.03.011","volume":"2","author":"J Assawachananont","year":"2014","unstructured":"Assawachananont J, Mandai M, Okamoto S, Yamada C, Eiraku M et al (2014) Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice. Stem Cell Rep 2(5):662\u2013674","journal-title":"Stem Cell Rep"},{"issue":"6","key":"2767_CR183","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1167\/iovs.16-19238","volume":"57","author":"BB Thomas","year":"2016","unstructured":"Thomas BB, Zhu D, Zhang L, Thomas PB, Hu Y et al (2016) Survival and functionality of hESC-derived retinal pigment epithelium cells cultured as a monolayer on polymer substrates transplanted in RCS rats. Invest Ophthalmol Vis Sci 57(6):2877\u20132887","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2767_CR184","first-page":"20150376","volume":"374","author":"J Wang","year":"2016","unstructured":"Wang J, Westenskow PD, Fang M, Friedlander M, Siuzdak G (2016) Quantitative metabolomics of photoreceptor degeneration and the effects of stem cell-derived retinal pigment epithelium transplantation. Philos Trans R Soc Math Phys Eng Sci 374:20150376","journal-title":"Philos Trans R Soc Math Phys Eng Sci"},{"issue":"12","key":"2767_CR185","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008152","volume":"4","author":"AJ Carr","year":"2009","unstructured":"Carr AJ, Vugler AA, Hikita ST, Lawrence JM, Gias C et al (2009) Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat. PLoS ONE 4(12):e8152","journal-title":"PLoS ONE"},{"issue":"2","key":"2767_CR186","doi-asserted-by":"publisher","first-page":"192","DOI":"10.5966\/sctm.2015-0125","volume":"5","author":"S Becker","year":"2016","unstructured":"Becker S, Eastlake K, Jayaram H, Jones MF, Brown RA et al (2016) Allogeneic transplantation of muller-derived retinal ganglion cells improves retinal function in a feline model of ganglion cell depletion. Stem Cells Transl Med 5(2):192\u2013205","journal-title":"Stem Cells Transl Med"},{"issue":"3","key":"2767_CR187","doi-asserted-by":"publisher","first-page":"188","DOI":"10.5966\/sctm.2011-0005","volume":"1","author":"S Singhal","year":"2012","unstructured":"Singhal S, Bhatia B, Jayaram H, Becker S, Jones MF et al (2012) Human muller glia with stem cell characteristics differentiate into retinal ganglion cell (RGC) precursors in vitro and partially restore RGC function in vivo following transplantation. Stem Cells Transl Med 1(3):188\u2013199","journal-title":"Stem Cells Transl Med"},{"issue":"8","key":"2767_CR188","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1517\/14712598.2010.495218","volume":"10","author":"SZ Wang","year":"2010","unstructured":"Wang SZ, Ma W, Yan RT, Mao W (2010) Generating retinal neurons by reprogramming retinal pigment epithelial cells. Expert Opin Biol Ther 10(8):1227\u20131239","journal-title":"Expert Opin Biol Ther"},{"issue":"3","key":"2767_CR189","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.exer.2009.03.025","volume":"89","author":"U Aftab","year":"2009","unstructured":"Aftab U, Jiang C, Tucker B, Kim JY, Klassen H et al (2009) Growth kinetics and transplantation of human retinal progenitor cells. Exp Eye Res 89(3):301\u2013310","journal-title":"Exp Eye Res"},{"issue":"296","key":"2767_CR190","doi-asserted-by":"publisher","first-page":"296ra110","DOI":"10.1126\/scitranslmed.aaa8791","volume":"7","author":"M Ashtari","year":"2015","unstructured":"Ashtari M, Zhang H, Cook PA, Cyckowski LL, Shindler KS et al (2015) Plasticity of the human visual system after retinal gene therapy in patients with Leber\u2019s congenital amaurosis. Sci Transl Med 7(296):296ra110","journal-title":"Sci Transl Med"},{"issue":"21","key":"2767_CR191","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1056\/NEJMoa0802315","volume":"358","author":"AM Maguire","year":"2008","unstructured":"Maguire AM, Simonelli F, Pierce EA, Pugh EN Jr, Mingozzi F et al (2008) Safety and efficacy of gene transfer for Leber\u2019s congenital amaurosis. N Engl J Med 358(21):2240\u20132248","journal-title":"N Engl J Med"},{"key":"2767_CR192","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.preteyeres.2014.06.002","volume":"42","author":"E Bertolotti","year":"2014","unstructured":"Bertolotti E, Neri A, Camparini M, Macaluso C, Marigo V (2014) Stem cells as source for retinal pigment epithelium transplantation. Prog Retinal Eye Res 42:130\u2013144","journal-title":"Prog Retinal Eye Res"},{"issue":"9817","key":"2767_CR193","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/S0140-6736(12)60028-2","volume":"379","author":"SD Schwartz","year":"2012","unstructured":"Schwartz SD, Hubschman JP, Heilwell G, Franco-Cardenas V, Pan CK et al (2012) Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet 379(9817):713\u2013720","journal-title":"Lancet"},{"issue":"5","key":"2767_CR194","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.stemcr.2015.04.005","volume":"4","author":"WK Song","year":"2015","unstructured":"Song WK, Park KM, Kim HJ, Lee JH, Choi J et al (2015) Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: preliminary results in Asian patients. Stem Cell Rep 4(5):860\u2013872","journal-title":"Stem Cell Rep"},{"issue":"7","key":"2767_CR195","doi-asserted-by":"publisher","first-page":"4956","DOI":"10.1167\/iovs.13-11957","volume":"54","author":"L Han","year":"2013","unstructured":"Han L, Ma Z, Wang C, Dou H, Hu Y et al (2013) Autologous transplantation of simple retinal pigment epithelium sheet for massive submacular hemorrhage associated with pigment epithelium detachment. Invest Ophthalmol Vis Sci 54(7):4956\u20134963","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"2767_CR196","first-page":"1280","volume":"36","author":"MW Kelley","year":"1995","unstructured":"Kelley MW, Turner JK, Reh TA (1995) Regulation of proliferation and photoreceptor differentiation in fetal human retinal cell cultures. Invest Ophthalmol Vis Sci 36(7):1280\u20131289","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"2767_CR197","doi-asserted-by":"publisher","first-page":"ORSFf1","DOI":"10.1167\/iovs.15-18160","volume":"57","author":"D Sinha","year":"2016","unstructured":"Sinha D, Phillips J, Joseph Phillips M, Gamm DM (2016) Mimicking retinal development and disease with human pluripotent stem cells. Invest Ophthalmol Vis Sci 57(5):ORSFf1\u2013ORSFf9","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2767_CR198","doi-asserted-by":"publisher","first-page":"1h.8.1","DOI":"10.1002\/9780470151808.sc01h08s32","volume":"32","author":"SK Ohlemacher","year":"2015","unstructured":"Ohlemacher SK, Iglesias CL, Sridhar A, Gamm DM, Meyer JS (2015) Generation of highly enriched populations of optic vesicle-like retinal cells from human pluripotent stem cells. Curr Protoc Stem Cell Biol 32:1h.8.1-1h.8.20","journal-title":"Curr Protoc Stem Cell Biol"},{"key":"2767_CR199","doi-asserted-by":"publisher","first-page":"5087","DOI":"10.1167\/iovs.12-11239","volume":"54","author":"B Diniz","year":"2013","unstructured":"Diniz B, Thomas P, Thomas B, Ribeiro R, Hu Y, Brant R, Ahuja A, Zhu D, Liu L, Koss M et al (2013) Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer. Invest Ophthalmol Vis Sci 54:5087\u20135096","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"2767_CR200","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.stemcr.2013.12.007","volume":"2","author":"H Kamao","year":"2014","unstructured":"Kamao H, Mandai M, Okamoto S, Sakai N, Suga A et al (2014) Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application. Stem Cell Rep 2(2):205\u2013218","journal-title":"Stem Cell Rep"},{"issue":"9967","key":"2767_CR201","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S0140-6736(14)61376-3","volume":"385","author":"SD Schwartz","year":"2015","unstructured":"Schwartz SD, Regillo CD, Lam BL, Eliott D, Rosenfeld PJ et al (2015) Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and stargardt\u2019s macular dystrophy: follow-up of two open-label phase 1\/2 studies. Lancet 385(9967):509\u2013516","journal-title":"Lancet"},{"key":"2767_CR202","doi-asserted-by":"crossref","unstructured":"Cyranoski D (2014) Japanese woman is first recipient of next-generation stem cells. Nature 12","DOI":"10.1038\/nature.2014.15915"},{"issue":"8","key":"2767_CR203","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1002\/term.1458","volume":"7","author":"TJ Rowland","year":"2013","unstructured":"Rowland TJ, Blaschke AJ, Buchholz DE, Hikita ST, Johnson LV et al (2013) Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins. J Tissue Eng Regen Med 7(8):642\u2013653","journal-title":"J Tissue Eng Regen Med"},{"key":"2767_CR204","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1242\/dev.086603","volume":"140","author":"IO Nasonkin","year":"2013","unstructured":"Nasonkin IO, Merbs SL, Lazo K, Oliver VF, Brooks M, Patel K, Enke RA, Nellissery J, Jamrich M, Le YZ et al (2013) Conditional knockdown of DNA methyltransferase 1 reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis. Development 140:1330\u20131341","journal-title":"Development"},{"issue":"16","key":"2767_CR205","doi-asserted-by":"publisher","first-page":"4110","DOI":"10.1016\/j.biomaterials.2012.02.040","volume":"33","author":"AM Shadforth","year":"2012","unstructured":"Shadforth AM, George KA, Kwan AS, Chirila TV, Harkin DG (2012) The cultivation of human retinal pigment epithelial cells on Bombyx mori silk fibroin. Biomaterials 33(16):4110\u20134117","journal-title":"Biomaterials"},{"key":"2767_CR206","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1167\/iovs.13-12833","volume":"55","author":"KJ McHugh","year":"2014","unstructured":"McHugh KJ, Tao SL, Saint-Geniez M (2014) Porous poly(\u03b5-caprolactone) scaffolds for retinal pigment epithelium transplantation. Invest Ophthamol Vis Sci 55:1754\u20131762","journal-title":"Invest Ophthamol Vis Sci"},{"key":"2767_CR207","first-page":"81","volume":"53","author":"RH Croze","year":"2014","unstructured":"Croze RH, Clegg DO (2014) Differentiation of pluripotent stem cells into retinal pigmented epithelium. Dev Opthalmol 53:81\u201396","journal-title":"Dev Opthalmol"},{"issue":"4","key":"2767_CR208","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s10544-012-9645-8","volume":"14","author":"B Lu","year":"2012","unstructured":"Lu B, Zhu D, Hinton D, Humayun MS, Tai YC (2012) Mesh-supported submicron parylene-c membranes for culturing retinal pigment epithelial cells. Biomed Microdevices 14(4):659\u2013667","journal-title":"Biomed Microdevices"},{"issue":"4","key":"2767_CR209","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000338749","volume":"48","author":"Y Hu","year":"2012","unstructured":"Hu Y, Liu L, Lu B, Zhu D, Ribeiro R et al (2012) A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer. Ophthalmic Res 48(4):186\u2013191","journal-title":"Ophthalmic Res"},{"issue":"9","key":"2767_CR210","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1016\/j.biomaterials.2013.12.069","volume":"35","author":"Z Liu","year":"2014","unstructured":"Liu Z, Yu N, Holz FG, Yang F, Stanzel BV (2014) Enhancement of retinal pigment epithelial culture characteristics and subretinal space tolerance of scaffolds with 200\u00a0nm fiber topography. Biomaterials 35(9):2837\u20132850","journal-title":"Biomaterials"},{"issue":"7","key":"2767_CR211","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1016\/S0142-9612(01)00284-8","volume":"23","author":"M Merodio","year":"2002","unstructured":"Merodio M, Irache JM, Valamanesh F, Mirshahi M (2002) Ocular disposition and tolerance of ganciclovir-loaded albumin nanoparticles after intravitreal injection in rats. Biomaterials 23(7):1587\u20131594","journal-title":"Biomaterials"},{"issue":"7","key":"2767_CR212","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1016\/j.biomaterials.2010.11.030","volume":"32","author":"JH Kim","year":"2011","unstructured":"Kim JH, Kim MH, Jo DH, Yu YS, Lee TG et al (2011) The inhibition of retinal neovascularization by gold nanoparticles via suppression of VEGFR-2 activation. Biomaterials 32(7):1865\u20131871","journal-title":"Biomaterials"},{"issue":"5","key":"2767_CR213","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.nano.2011.09.003","volume":"8","author":"DH Jo","year":"2012","unstructured":"Jo DH, Kim JH, Yu YS, Lee TG, Kim JH (2012) Antiangiogenic effect of silicate nanoparticle on retinal neovascularization induced by vascular endothelial growth factor. Nanomedicine 8(5):784\u2013791","journal-title":"Nanomedicine"},{"key":"2767_CR214","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.freeradbiomed.2014.07.013","volume":"75","author":"RN Mitra","year":"2014","unstructured":"Mitra RN, Merwin MJ, Han Z, Conley SM, Al-Ubaidi MR et al (2014) Yttrium oxide nanoparticles prevent photoreceptor death in a light-damage model of retinal degeneration. Free Radic Biol Med 75:140\u2013148","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"2767_CR215","first-page":"390","volume":"6","author":"HY Zhou","year":"2013","unstructured":"Zhou HY, Hao JL, Wang S, Zheng Y, Zhang WS (2013) Nanoparticles in the ocular drug delivery. Int J Ophthalmol 6(3):390\u2013396","journal-title":"Int J Ophthalmol"},{"issue":"35","key":"2767_CR216","doi-asserted-by":"publisher","first-page":"9483","DOI":"10.1016\/j.biomaterials.2011.08.062","volume":"32","author":"A Koirala","year":"2011","unstructured":"Koirala A, Makkia RS, Cooper MJ, Naash MI (2011) Nanoparticle-mediated gene transfer specific to retinal pigment epithelial cells. Biomaterials 32(35):9483\u20139493","journal-title":"Biomaterials"},{"issue":"9","key":"2767_CR217","doi-asserted-by":"publisher","first-page":"5257","DOI":"10.1021\/nl502275s","volume":"14","author":"A Rajala","year":"2014","unstructured":"Rajala A, Wang Y, Zhu Y, Ranjo-Bishop M, Ma JX et al (2014) Nanoparticle-assisted targeted delivery of eye-specific genes to eyes significantly improves the vision of blind mice in vivo. Nano Lett 14(9):5257\u20135263","journal-title":"Nano Lett"},{"issue":"9","key":"2767_CR218","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1211\/0022357021701","volume":"55","author":"JV Aukunuru","year":"2003","unstructured":"Aukunuru JV, Ayalasomayajula SP, Kompella UB (2003) Nanoparticle formulation enhances the delivery and activity of a vascular endothelial growth factor antisense oligonucleotide in human retinal pigment epithelial cells. J Pharm Pharmacol 55(9):1199\u20131206","journal-title":"J Pharm Pharmacol"},{"issue":"8","key":"2767_CR219","doi-asserted-by":"publisher","first-page":"3562","DOI":"10.1167\/iovs.02-1068","volume":"44","author":"JL Bourges","year":"2003","unstructured":"Bourges JL, Gautier SE, Delie F, Bejjani RA, Jeanny JC et al (2003) Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles. Invest Ophthalmol Vis Sci 44(8):3562\u20133569","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2767_CR220","first-page":"124","volume":"11","author":"RA Bejjani","year":"2005","unstructured":"Bejjani RA, BenEzra D, Cohen H, Rieger J, Andrieu C et al (2005) Nanoparticles for gene delivery to retinal pigment epithelial cells. Mol Vis 11:124\u2013132","journal-title":"Mol Vis"},{"issue":"14","key":"2767_CR221","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1016\/j.addr.2005.09.006","volume":"57","author":"AA Moshfeghi","year":"2005","unstructured":"Moshfeghi AA, Peyman GA (2005) Micro- and nanoparticulates. Adv Drug Deliv Rev 57(14):2047\u20132052","journal-title":"Adv Drug Deliv Rev"},{"key":"2767_CR222","first-page":"53","volume":"2006","author":"M Naash","year":"2006","unstructured":"Naash M (2006) Applications of nanotechnology to gene delivery in ophthalmology. Invest Ophthalmol Vis Sci 2006:53","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"13","key":"2767_CR223","first-page":"844","volume":"47","author":"J Liu","year":"2006","unstructured":"Liu J, Min SH, Chiodo V, Boye SL, Alexander J et al (2006) Linear polyethylenimine-based DNA nanoparticle delivery into mouse retinas. Invest Ophthalmol Vis Sci 47(13):844\u2013844","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"2767_CR224","doi-asserted-by":"publisher","first-page":"26","DOI":"10.4103\/0974-9233.106384","volume":"20","author":"Q Xu","year":"2013","unstructured":"Xu Q, Kambhampati SP, Kannan RM (2013) Nanotechnology approaches for ocular drug delivery. Middle East Afr J Ophthalmol 20(1):26\u201337","journal-title":"Middle East Afr J Ophthalmol"},{"issue":"1","key":"2767_CR225","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1159\/000055638","volume":"33","author":"E Sakurai","year":"2001","unstructured":"Sakurai E, Ozeki H, Kunou N, Ogura Y (2001) Effect of particle size of polymeric nanospheres on intravitreal kinetics. Ophthalmic Res 33(1):31\u201336","journal-title":"Ophthalmic Res"},{"issue":"7","key":"2767_CR226","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1167\/iovs.06-1242","volume":"48","author":"T Sakai","year":"2007","unstructured":"Sakai T, Kuno N, Takamatsu F, Kimura E, Kohno H et al (2007) Prolonged protective effect of basic fibroblast growth factor-impregnated nanoparticles in royal college of surgeons rats. Invest Ophthalmol Vis Sci 48(7):3381\u20133387","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"2767_CR227","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1021\/nl051679d","volume":"5","author":"R Ideta","year":"2005","unstructured":"Ideta R, Tasaka F, Jang WD, Nishiyama N, Zhang GD et al (2005) Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. Nano Lett 5(12):2426\u20132431","journal-title":"Nano Lett"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-023-02767-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-023-02767-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-023-02767-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T11:24:45Z","timestamp":1694777085000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-023-02767-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,22]]},"references-count":227,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["2767"],"URL":"https:\/\/doi.org\/10.1007\/s10792-023-02767-2","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,22]]},"assertion":[{"value":"16 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No conflicts of interest. All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria, educational grants, participation in speakers\u2019 bureaus, membership, employment, consultancies, stock ownership\u00a0 or other equity interest and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}