{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:41:28Z","timestamp":1793248888857,"version":"4.5.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Manipal Academy of Higher Education - Kasturba Medical College, Mangalore"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The aim is to evaluate the aldose reductase (AR) and glutathione (GSH) activity in the nucleus of senile cataract in type 2 diabetes and non-diabetic group of patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 62 patients including 31 diabetics and 31 non- diabetics who were undergoing cataract surgery were included. Nucleus extracted was sent for analysis of AR and GSH activity while blood sample was taken for glycated haemoglobin (HbA1c) levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Statistical analysis<\/jats:title>\n                <jats:p>Data were analysed using IBM SPSS 25. Comparison was carried out by unpaired <jats:italic>T<\/jats:italic>-test and correlations were established by Pearson\u2019s correlation. The <jats:italic>p<\/jats:italic> value less than 0.05 was considered significant for all analyses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Study design<\/jats:title>\n                <jats:p>This is a prospective cross-sectional comparative study.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In this study, diabetic group patients showed earlier progression of cataract as compared to the non-diabetic group (<jats:italic>p<\/jats:italic>-value 0.0310). Mean HbA1c in the diabetic group was 7.34% compared to the non-diabetic group of 5.7% (<jats:italic>p<\/jats:italic> value\u2009&lt;\u20090.001). AR in the diabetic patients was 2.07\u00a0mU\/mg while the non-diabetic group was 0.22\u00a0mU\/mg (<jats:italic>p<\/jats:italic>-value\u2009&lt;\u20090.001). GSH in the diabetic group was 3.38 \u03bcMol\/g and the non-diabetic group was 7.47 \u03bcMol\/g (<jats:italic>p<\/jats:italic> value\u2009&lt;\u20090.001). HbA1c showed positive correlation with AR among the diabetic group (<jats:italic>p<\/jats:italic>-value 0.028).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Elevated oxidative stress can be strongly attributed to high AR and low GSH activity among the diabetic group as compared to the non-diabetic group and can lead to early cataract formation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10792-023-02776-1","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T07:02:09Z","timestamp":1688367729000},"page":"3673-3680","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Aldose reductase and glutathione in senile cataract nucleus of diabetics and non-diabetics"],"prefix":"10.1007","volume":"43","author":[{"given":"Kanishk","family":"Khare","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teena","family":"Mendonca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-8473","authenticated-orcid":false,"given":"Gladys","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjunath","family":"Kamath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupama","family":"Hegde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamala","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kamath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumana","family":"Kamath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"2776_CR1","unstructured":"Steinmetz JD, Bourne RRA, Briant PS, Flaxman SR, Taylor HRB, Jonas JB, et al (2021) Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study. 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