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Home-based active visual training was prescribed immediately after surgery to all of them (20 sessions, 30\u00a0min): 31 subjects using a serious game based on Gabor patches (study group) and 29 using a placebo software (placebo group). Visual acuity, contrast sensitivity (CS), and perception of visual disturbances (QoV questionnaire) were evaluated before and after training. Likewise, in a small subgroup, resting-state functional magnetic resonance imaging (rs-fMRI) analysis was performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>No significant differences were found between groups in compliance time (<jats:italic>p<\/jats:italic>\u2009=\u20090.70). After training, only significant improvements in monocular uncorrected intermediate visual acuity were found in the study group (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.01), although differences between groups did not reach statistical significance (<jats:italic>p<\/jats:italic>\u2009\u2265\u20090.11). Likewise, significantly better binocular far CS values were found in the study group for the spatial frequencies of 6 (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) and 12\u00a0cpd (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). More visual symptoms of the QoV questionnaire experienced a significant change in the level of bothersomeness in the study group. Rs-fMRI revealed the presence significant changes reflecting higher functional connectivity after the training with the serious game.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>A 3-week visual training program based on the use of Gabor patches after bilateral implantation of trifocal diffractive IOLs may be beneficial for optimising the visual function, with neural changes associated suggesting an acceleration of neuroadaptation.<\/jats:p>\n                <jats:p><jats:italic>Trial registration<\/jats:italic> ClinicalTrials.gov, NCT04985097. Registered 02 August 2021, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/(NCT04985097\">https:\/\/clinicaltrials.gov\/(NCT04985097<\/jats:ext-link>).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10792-023-02809-9","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T16:02:03Z","timestamp":1689696123000},"page":"4035-4053","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Randomised placebo-controlled clinical trial evaluating the impact of a new visual rehabilitation program on neuroadaptation in patients implanted with trifocal intraocular lenses"],"prefix":"10.1007","volume":"43","author":[{"given":"David P.","family":"Pi\u00f1ero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel J.","family":"Maldonado-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa","family":"Molina-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Garc\u00eda-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L.","family":"Ram\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Rinc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Holgueras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Arenillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Planchuelo-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Leal-Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Bego\u00f1a","family":"Coco-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"2809_CR1","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.survophthal.2019.02.012","volume":"64","author":"K Cao","year":"2019","unstructured":"Cao K, Friedman DS, Jin S, Yusufu M, Zhang J, Wang J, Hou S, Zhu G, Wang B, Xiong Y, Li J, Li X, He H, Chai L, Wan XH (2019) Multifocal versus monofocal intraocular lenses for age-related cataract patients: a system review and meta-analysis based on randomized controlled trials. 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