{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T13:10:59Z","timestamp":1750079459215,"version":"3.37.3"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["No.81470637","No.81470637","No.81470637","No.81470637","No.81470637"],"award-info":[{"award-number":["No.81470637","No.81470637","No.81470637","No.81470637","No.81470637"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Natural Science Foundation of Xiamen","award":["3502Z20227277"],"award-info":[{"award-number":["3502Z20227277"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-023-02831-x","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T09:02:19Z","timestamp":1691658139000},"page":"3831-3839","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neuroprotective effects of idebenone on hydrogen peroxide-induced oxidative damage in retinal ganglion cells-5"],"prefix":"10.1007","volume":"43","author":[{"given":"Yuping","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanzhi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"2831_CR1","doi-asserted-by":"publisher","first-page":"478","DOI":"10.3389\/fnins.2017.00478","volume":"11","author":"G Chidlow","year":"2017","unstructured":"Chidlow G, Wood JPM, Casson RJ (2017) Investigations into Hypoxia and oxidative stress at the optic nerve head in a rat model of glaucoma. Front Neurosci 11:478","journal-title":"Front Neurosci"},{"issue":"5","key":"2831_CR2","doi-asserted-by":"publisher","first-page":"886","DOI":"10.3390\/antiox11050886","volume":"11","author":"DJ Hurley","year":"2022","unstructured":"Hurley DJ, Normile C, Irnaten M et al (2022) The intertwined roles of oxidative stress and endoplasmic reticulum stress in glaucoma. Antioxidants 11(5):886","journal-title":"Antioxidants"},{"key":"2831_CR3","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.mito.2020.01.002","volume":"51","author":"C Garza-Lomb\u00f3","year":"2020","unstructured":"Garza-Lomb\u00f3 C, Pappa A, Panayiotidis MI et al (2020) Redox homeostasis, oxidative stress and mitophagy. Mitochondrion 51:105\u2013117","journal-title":"Mitochondrion"},{"issue":"4","key":"2831_CR4","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.freeradbiomed.2008.04.026","volume":"45","author":"M Aslan","year":"2008","unstructured":"Aslan M, Cort A, Yucel I (2008) Oxidative and nitrative stress markers in glaucoma. Free Radic Biol Med 45(4):367\u2013376","journal-title":"Free Radic Biol Med"},{"issue":"1\u20132","key":"2831_CR5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s11010-008-9768-7","volume":"314","author":"RV Chertkova","year":"2008","unstructured":"Chertkova RV, Sharonov GV, Feofanov AV et al (2008) Proapoptotic activity of cytochrome c in living cells: effect of K72 substitutions and species differences. Mol Cell Biochem 314(1\u20132):85\u201393","journal-title":"Mol Cell Biochem"},{"issue":"5","key":"2831_CR6","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s10495-007-0756-2","volume":"12","author":"M Ott","year":"2007","unstructured":"Ott M, Gogvadze V, Orrenius S et al (2007) Mitochondria, oxidative stress and cell death. Apoptosis 12(5):913\u2013922","journal-title":"Apoptosis"},{"issue":"1","key":"2831_CR7","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.preteyeres.2003.10.003","volume":"23","author":"V Carelli","year":"2004","unstructured":"Carelli V, Ross-Cisneros FN, Sadun AA (2004) Mitochondrial dysfunction as a cause of optic neuropathies. Prog Retin Eye Res 23(1):53\u201389","journal-title":"Prog Retin Eye Res"},{"issue":"2","key":"2831_CR8","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.3390\/ijms15021865","volume":"15","author":"AJ Payne","year":"2014","unstructured":"Payne AJ, Kaja S, Naumchuk Y et al (2014) Antioxidant drug therapy approaches for neuroprotection in chronic diseases of the retina. Int J Mol Sci 15(2):1865\u20131886","journal-title":"Int J Mol Sci"},{"issue":"6","key":"2831_CR9","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.exer.2010.03.008","volume":"90","author":"NN Osborne","year":"2010","unstructured":"Osborne NN (2010) Mitochondria: their role in ganglion cell death and survival in primary open angle glaucoma. Exp Eye Res 90(6):750\u2013757","journal-title":"Exp Eye Res"},{"issue":"1","key":"2831_CR10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.coph.2012.09.002","volume":"13","author":"NN Osborne","year":"2013","unstructured":"Osborne NN, Del OS (2013) Maintenance of retinal ganglion cell mitochondrial functions as a neuroprotective strategy in glaucoma. Curr Opin Pharmacol 13(1):16\u201322","journal-title":"Curr Opin Pharmacol"},{"issue":"2","key":"2831_CR11","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.exer.2009.11.014","volume":"91","author":"H Levkovitch-Verbin","year":"2010","unstructured":"Levkovitch-Verbin H, Dardik R, Vander S et al (2010) Mechanism of retinal ganglion cells death in secondary degeneration of the optic nerve. Exp Eye Res 91(2):127\u2013134","journal-title":"Exp Eye Res"},{"issue":"3","key":"2831_CR12","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.bbrc.2016.11.088","volume":"482","author":"H Vakifahmetoglu-Norberg","year":"2017","unstructured":"Vakifahmetoglu-Norberg H, Ouchida AT, Norberg E (2017) The role of mitochondria in metabolism and cell death. Biochem Biophys Res Commun 482(3):426\u2013431","journal-title":"Biochem Biophys Res Commun"},{"issue":"22","key":"2831_CR13","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.3760\/cma.j.issn.0366-6999.20131956","volume":"126","author":"XJ Yang","year":"2013","unstructured":"Yang XJ, Ge J, Zhuo YH (2013) Role of mitochondria in the pathogenesis and treatment of glaucoma. Chin Med J 126(22):4358\u20134365","journal-title":"Chin Med J"},{"issue":"4","key":"2831_CR14","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1007\/s10517-022-05563-7","volume":"173","author":"NA Obanina","year":"2022","unstructured":"Obanina NA, Bgatova NP, Eremina AV et al (2022) Autophagy in human retinal neurons in glaucoma. Bull Exp Biol Med 173(4):468\u2013474","journal-title":"Bull Exp Biol Med"},{"issue":"1","key":"2831_CR15","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1080\/21505594.2020.1780088","volume":"11","author":"S Shojaei","year":"2020","unstructured":"Shojaei S, Suresh M, Klionsky DJ et al (2020) Autophagy and SARS-CoV-2 infection: apossible smart targeting of the autophagy pathway. Virulence 11(1):805\u2013810","journal-title":"Virulence"},{"issue":"5","key":"2831_CR16","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1111\/febs.15069","volume":"287","author":"S Shojaei","year":"2020","unstructured":"Shojaei S, Koleini N, Samiei E et al (2020) Simvastatin increases temozolomide-induced cell death by targeting the fusion of autophagosomes and lysosomes. FEBS J 287(5):1005\u20131034","journal-title":"FEBS J"},{"issue":"3","key":"2831_CR17","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","volume":"140","author":"N Mizushima","year":"2010","unstructured":"Mizushima N, Yoshimori T, Levine B (2010) Methods in mammalian autophagy research. Cell 140(3):313\u2013326","journal-title":"Cell"},{"issue":"21","key":"2831_CR18","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","volume":"19","author":"Y Kabeya","year":"2000","unstructured":"Kabeya Y, Mizushima N, Ueno T et al (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19(21):5720\u20135728","journal-title":"EMBO J"},{"issue":"4","key":"2831_CR19","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/cdd.2010.191","volume":"18","author":"R Kang","year":"2011","unstructured":"Kang R, Zeh HJ, Lotze MT et al (2011) The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 18(4):571\u2013580","journal-title":"Cell Death Differ"},{"issue":"4","key":"2831_CR20","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s10495-014-0967-2","volume":"19","author":"S Mukhopadhyay","year":"2014","unstructured":"Mukhopadhyay S, Panda PK, Sinha N et al (2014) Autophagy and apoptosis: where do they meet? Apoptosis 19(4):555\u2013566","journal-title":"Apoptosis"},{"issue":"2","key":"2831_CR21","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1167\/iovs.13-12564","volume":"55","author":"D Lee","year":"2014","unstructured":"Lee D, Shim MS, Kim KY et al (2014) Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma. Invest Ophthalmol Vis Sci 55(2):993\u20131005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"2831_CR22","doi-asserted-by":"publisher","first-page":"e17963","DOI":"10.1371\/journal.pone.0017963","volume":"6","author":"RH Haefeli","year":"2011","unstructured":"Haefeli RH, Erb M, Gemperli AC et al (2011) NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels[J]. PLoS One 6(3):e17963","journal-title":"PLoS One"},{"issue":"3","key":"2831_CR23","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0167-4943(89)90010-1","volume":"8","author":"M Suno","year":"1989","unstructured":"Suno M, Nagaoka A (1989) Inhibition of lipid peroxidation by idebenone in brain mitochondria in the presence of succinate. Arch Gerontol Geriatr 8(3):291\u2013297","journal-title":"Arch Gerontol Geriatr"},{"issue":"1","key":"2831_CR24","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.bbrc.2005.11.035","volume":"339","author":"H Rauchova","year":"2006","unstructured":"Rauchova H, Vrbacky M, Bergamini C et al (2006) Inhibition of glycerophosphate-dependent H2O2 generation in brown fat mitochondria by idebenone. Biochem Biophys Res Commun 339(1):362\u2013366","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"2831_CR25","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s11064-020-03186-w","volume":"46","author":"B Avc\u0131","year":"2021","unstructured":"Avc\u0131 B, G\u00fcnayd\u0131n C, G\u00fcven\u00e7 T et al (2021) Idebenone ameliorates rotenone-induced parkinson\u2019s disease in rats through decreasing lipid peroxidation. Neurochem Res 46(3):513\u2013522","journal-title":"Neurochem Res"},{"issue":"13","key":"2831_CR26","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1517\/14656566.9.13.2327","volume":"9","author":"C Tonon","year":"2008","unstructured":"Tonon C, Lodi R (2008) Idebenone in friedreich\u2019s ataxia. Expert Opin Pharmacother 9(13):2327\u20132337","journal-title":"Expert Opin Pharmacother"},{"issue":"2","key":"2831_CR27","doi-asserted-by":"publisher","first-page":"503","DOI":"10.3390\/biomedicines10020503","volume":"10","author":"ME Clementi","year":"2022","unstructured":"Clementi ME, Pizzoferrato M, Bianchetti G et al (2022) Cytoprotective effect of idebenone through modulation of the intrinsic mitochondrial pathway of apoptosis in human retinal pigment epithelial cells exposed to oxidative stress induced by hydrogen peroxide. Biomedicines 10(2):503","journal-title":"Biomedicines"},{"issue":"1","key":"2831_CR28","doi-asserted-by":"publisher","first-page":"213","DOI":"10.47162\/RJME.63.1.24","volume":"63","author":"MF Mercu\u0163","year":"2022","unstructured":"Mercu\u0163 MF, T\u0103nasie CA, Dan AO et al (2022) Retinal morphological and functional response to Idebenone therapy in Leber hereditary optic neuropathy[J]. Rom J Morphol Embryol 63(1):213\u2013219","journal-title":"Rom J Morphol Embryol"},{"issue":"6","key":"2831_CR29","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/aos.15153","volume":"100","author":"J van Everdingen","year":"2022","unstructured":"van Everdingen J, Pott J, Bauer N et al (2022) Clinical outcomes of treatment with idebenone in Leber\u2019s hereditary optic neuropathy in the Netherlands: a national cohort study[J]. Acta Ophthalmol 100(6):700\u2013706","journal-title":"Acta Ophthalmol"},{"key":"2831_CR30","doi-asserted-by":"publisher","first-page":"589114","DOI":"10.3389\/fphar.2020.589114","volume":"11","author":"HR Zhou","year":"2020","unstructured":"Zhou HR, Ma XF, Lin WJ et al (2020) Neuroprotective role of GLP-1 analog for retinal ganglion cells via PINK1\/Parkin-mediated mitophagy in diabetic retinopathy. Front Pharmacol 11:589114","journal-title":"Front Pharmacol"},{"key":"2831_CR31","doi-asserted-by":"publisher","first-page":"119693","DOI":"10.1016\/j.lfs.2021.119693","volume":"279","author":"S Pal","year":"2021","unstructured":"Pal S, Rao GN, Pal A (2021) Inflammation and apoptosis, two key events induced by hyperglycemia mediated reactive nitrogen species in RGC-5 cells. Life Sci 279:119693","journal-title":"Life Sci"},{"issue":"1","key":"2831_CR32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.5114\/ceji.2022.115710","volume":"47","author":"J Pan","year":"2022","unstructured":"Pan J, Liu H, Wu Q et al (2022) Scopoletin protects retinal ganglion cells 5 from high glucose-induced injury in a cellular model of diabetic retinopathy via ROS-dependent p38 and JNK signaling cascade. Cent Eur J Immunol 47(1):20\u201329","journal-title":"Cent Eur J Immunol"},{"key":"2831_CR33","doi-asserted-by":"publisher","first-page":"114886","DOI":"10.1016\/j.jep.2021.114886","volume":"288","author":"WH Hsu","year":"2022","unstructured":"Hsu WH, Chung CP, Wang YY et al (2022) Dendrobium nobile protects retinal cells from UV-induced oxidative stress damage via Nrf2\/HO-1 and MAPK pathways. J Ethnopharmacol 288:114886","journal-title":"J Ethnopharmacol"},{"key":"2831_CR34","doi-asserted-by":"publisher","first-page":"10533","DOI":"10.1038\/ncomms10533","volume":"7","author":"X Wu","year":"2016","unstructured":"Wu X, Fleming A, Ricketts T et al (2016) Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun 7:10533","journal-title":"Nat Commun"},{"key":"2831_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.03.002","volume":"47","author":"Y Munemasa","year":"2015","unstructured":"Munemasa Y, Kitaoka Y (2015) Autophagy in axonal degeneration in glaucomatous optic neuropathy. Prog Retin Eye Res 47:1\u201318","journal-title":"Prog Retin Eye Res"},{"issue":"3","key":"2831_CR36","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1358\/dot.2016.52.3.2463564","volume":"52","author":"N Gueven","year":"2016","unstructured":"Gueven N (2016) Idebenone for Leber\u2019s hereditary optic neuropathy. Drugs Today 52(3):173\u2013181","journal-title":"Drugs Today"},{"key":"2831_CR37","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ajo.2022.11.004","volume":"247","author":"E Borrelli","year":"2023","unstructured":"Borrelli E, Berni A, Cascavilla ML et al (2023) Visual outcomes and optical coherence tomography biomarkers of vision improvement in patients with leber hereditary optic neuropathy treated with idebenone. Am J Ophthalmol 247:35\u201341","journal-title":"Am J Ophthalmol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-023-02831-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-023-02831-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-023-02831-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T23:53:30Z","timestamp":1729900410000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-023-02831-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,10]]},"references-count":37,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["2831"],"URL":"https:\/\/doi.org\/10.1007\/s10792-023-02831-x","relation":{},"ISSN":["1573-2630"],"issn-type":[{"type":"electronic","value":"1573-2630"}],"subject":[],"published":{"date-parts":[[2023,8,10]]},"assertion":[{"value":"30 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors have no financial or competing interests concerning the present study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}