{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T19:07:40Z","timestamp":1781896060741,"version":"3.54.5"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100009092","name":"Universidad de Alicante","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009092","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To analyze and report the long-term outcomes in terms of efficacy and safety of eyes implanted with the spherical version of a foldable iris-fixated phakic intraocular lens (pIOL) for the correction of myopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of the results of 56 eyes of 32 patients (age, 19\u201345\u00a0years) who underwent implantation of the spherical model of the Artiflex pIOL (Ophtec B.V., Groningen, The Netherlands) for the correction of myopia. Visual, refractive, biometric, intraocular pressure (IOP) and corneal endothelial changes were evaluated during a long-term follow-up: 2, 7, 10 and 12\u00a0years for more than 50, 30, 20 and 10 eyes, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 4\u00a0weeks postoperatively, a significant reduction of manifest sphere and spherical equivalent (SE), with a significant improvement of uncorrected distance visual acuity  were found (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No significant changes were found during the rest of follow-up in sphere (\n                      <jats:italic>p\u2009<\/jats:italic>\n                      \u2265\u20090.072). The percentage of eyes with SE within\u2009\u00b1\u20091.00 D was over 83% during the whole follow-up. A non-significant trend to IOP increase was observed at 4\u00a0weeks postoperatively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.530), with a significant reduction at 1\u00a0year after (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039) and no significant changes during the rest of follow-up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.180). There was a significant reduction of anterior chamber depth at 4\u00a0weeks after surgery (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with no significant changes during the following 9\u00a0years of follow-up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.118). However, an additional significant decrease of this parameter was observed between 10 and 13\u00a0years after surgery (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027). Mean endothelial cell loss changed from 2.01\u2009\u00b1\u20094.49% at 4\u00a0weeks after surgery to 9.11\u2009\u00b1\u20092.24% at the end of the follow-up. No complications were reported during the follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Myopia correction with the Artiflex pIOL is an effective and safe procedure in the long term.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10792-023-02850-8","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T04:02:41Z","timestamp":1692244961000},"page":"4491-4502","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long-term safety and efficacy of a foldable iris-fixated phakic intraocular lens for the correction of myopia"],"prefix":"10.1007","volume":"43","author":[{"given":"Mariano","family":"Royo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Pi\u00f1ero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"2850_CR1","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1097\/j.jcrs.0000000000000914","volume":"48","author":"A Marta","year":"2022","unstructured":"Marta A, Leite J, Abreu AC, Monteiro S, Pinto C (2022) Long-term results in patients with iris fixated foldable phakic intraocular lens for myopia and astigmatism. J Cataract Refract Surg 48:993\u2013998","journal-title":"J Cataract Refract Surg"},{"key":"2850_CR2","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1097\/j.jcrs.0000000000000937","volume":"48","author":"MR Papa-Vettorazzi","year":"2022","unstructured":"Papa-Vettorazzi MR, Moura-Coelho N, Manero F, Cruz-Rodriguez JB, Elies D, G\u00fcell JL (2022) Long-term efficacy and safety profiles of iris fixated foldable anterior chamber phakic intraocular lens implantation in eyes with \u2265 10-year follow-up. J Cataract Refract Surg 48:987\u2013992","journal-title":"J Cataract Refract Surg"},{"key":"2850_CR3","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1097\/j.jcrs.0000000000000532","volume":"47","author":"GA van Rijn","year":"2021","unstructured":"van Rijn GA, Gaurisankar ZS, Saxena R, Gibbes D, Jongman HP, Haasnoot GW, Cheng YYY, Beenakker JM, Luyten GPM (2021) Implantation of an iris-fixated phakic intraocular lens for the correction of hyperopia: 15-year follow-up. J Cataract Refract Surg 47:748\u2013758","journal-title":"J Cataract Refract Surg"},{"key":"2850_CR4","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/j.jcrs.0000000000000419","volume":"47","author":"T Monteiro","year":"2021","unstructured":"Monteiro T, Correia FF, Franqueira N, Mendes JC, Pinto C, Vaz F (2021) Long-term efficacy and safety results after iris fixated foldable phakic intraocular lens for myopia and astigmatism: 6-year follow-up. J Cataract Refract Surg 47:211\u2013220","journal-title":"J Cataract Refract Surg"},{"key":"2850_CR5","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/j.jcrs.0000000000000002","volume":"46","author":"GA van Rijn","year":"2020","unstructured":"van Rijn GA, Gaurisankar ZS, Ilgenfritz AP, Lima JEE, Haasnoot GW, Beenakker JWM, Cheng YYY, Luyten GPM (2020) Middle-and long-term results after iris-fixated phakic intraocular lens implantation in myopic and hyperopic patients: a meta-analysis. J Cataract Refract Surg 46:125\u2013137","journal-title":"J Cataract Refract Surg"},{"key":"2850_CR6","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ajo.2018.07.015","volume":"194","author":"SMR Jonker","year":"2018","unstructured":"Jonker SMR, Berendschot TTJM, Ronden AE, Saelens IEY, Bauer NJC, Nuijts RMMA (2018) Five-year endothelial cell loss after implantation with Artiflex Myopia and Artiflex Toric phakic intraocular lenses. Am J Ophthalmol 194:110\u2013119","journal-title":"Am J Ophthalmol"},{"key":"2850_CR7","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1167\/iovs.11-8868","volume":"53","author":"N Visser","year":"2012","unstructured":"Visser N, Berendschot TTJM, Bauer NJC, Nuijts RMMA (2012) Vector analysis of corneal and refractive astigmatism changes following toric pseudophakic and toric phakic IOL implantation. Invest Ophthalmol Vis Sci 53:1865\u20131873","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2850_CR8","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1177\/11206721211035617","volume":"32","author":"M Royo","year":"2022","unstructured":"Royo M, Jim\u00e9nez A, Mart\u00ednez-Alberquilla I, Alfonso JF (2022) Eight-year follow up of Artiflex and Artiflex Toric phakic intraocular lens. Eur J Ophthalmol 32:2051\u20132058","journal-title":"Eur J Ophthalmol"},{"key":"2850_CR9","first-page":"284","volume":"12","author":"IM Rizk","year":"2019","unstructured":"Rizk IM, Al Hessy AA, El Khouly SE, Sewelam AM (2019) Visual performance after implantation of two types of phakic foldable intraocular lenses for correction of high myopia. Int J Ophthalmol 12:284\u2013290","journal-title":"Int J Ophthalmol"},{"key":"2850_CR10","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1016\/j.jcrs.2015.10.039","volume":"41","author":"AA Aerts","year":"2015","unstructured":"Aerts AA, Jonker SM, Wielders LH, Berendschot TT, Doors M, De Brabander J, Nuijts RM (2015) Phakic intraocular lens: Two-year results and comparison of endothelial cell loss with iris fixated intraocular lenses. J Cataract Refract Surg 41:2258\u20132265","journal-title":"J Cataract Refract Surg"},{"key":"2850_CR11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.5301\/ejo.5000298","volume":"24","author":"MB Guerin","year":"2014","unstructured":"Guerin MB, Treacy MP, O\u2019Keeffe M (2014) Twelve month follow up of the Artiflex toric phakic intraocular lens. Eur J Ophthalmol 24:10\u201313","journal-title":"Eur J Ophthalmol"},{"key":"2850_CR12","first-page":"174","volume":"9","author":"M Ghoreishi","year":"2014","unstructured":"Ghoreishi M, Agherian R, Peyman AR, Feshareki H, Mohammadinia M (2014) Flexible toric iris claw phakic intraocular lens implantation for myopia and astigmatism. J Ophthalmic Vis Res 9:174\u2013180","journal-title":"J Ophthalmic Vis Res"},{"issue":"23","key":"2850_CR13","first-page":"8","volume":"60","author":"Y Ozert\u00fcrk","year":"2012","unstructured":"Ozert\u00fcrk Y, Kubaloglu A, Sari ES, Koytak A, Capkin M, Ak\u00e7ay L, Evcili PS (2012) Foldable iris fixated phakic intraocular lens implantation for the correction of myopia: two years of follow-up. Indian J Ophthalmol 60(23):8","journal-title":"Indian J Ophthalmol"},{"key":"2850_CR14","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3928\/1081597X-20090710-05","volume":"26","author":"LA van Philips","year":"2010","unstructured":"van Philips LA (2010) High and low contrast visual acuity after artiflex phakic intraocular lens implantation for the correction of myopia. J Refract Surg 26:423\u2013429","journal-title":"J Refract Surg"},{"key":"2850_CR15","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.ophtha.2008.12.059","volume":"116","author":"HB Dick","year":"2009","unstructured":"Dick HB, Budo C, Malecaze F, G\u00fcell JL, Marinho AA, Nuijts RM, Luyten GP, Menezo JL, Kohnen T (2009) Foldable Artiflex phakic intraocular lens for the correction of myopia: two-year follow-up results of a prospective European multicenter study. Ophthalmology 116:671\u2013677","journal-title":"Ophthalmology"},{"key":"2850_CR16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1055\/s-2008-1050231","volume":"193","author":"G Van der Heijde","year":"1988","unstructured":"Van der Heijde G, Fechner P, Worst J (1988) Optical consequences of implantation of a negative intraocular lens in myopic patients. Klin Monbl Augenheilkd 193:99\u2013102","journal-title":"Klin Monbl Augenheilkd"},{"key":"2850_CR17","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/S0886-3350(00)00797-5","volume":"27","author":"LN Thibos","year":"2001","unstructured":"Thibos LN, Horner D (2001) Power vector analysis of the optical outcomes of refractive surgery. J Cataract Refract Surg 27:80\u201385","journal-title":"J Cataract Refract Surg"},{"key":"2850_CR18","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3928\/1081597X-20170302-01","volume":"33","author":"DZ Reinstein","year":"2017","unstructured":"Reinstein DZ, Archer TJ, Srinivasan S, Mamalis N, Kohnen T, Dupps WJ Jr, Randleman B (2017) Standard for reporting refractive outcomes of intraocular lens-based refractive surgery. J Refract Surg 33:218\u2013222","journal-title":"J Refract Surg"},{"key":"2850_CR19","first-page":"376","volume":"7","author":"IBS Muslubas","year":"2014","unstructured":"Muslubas IBS, Kandemir B, Oral AYA, Kugu S, Dastan M (2014) Long-term vision threatening complications of phakic intraocular lens implantation for high myopia. Int J Ophthalmol 7:376\u2013380","journal-title":"Int J Ophthalmol"},{"key":"2850_CR20","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1001\/jamaophthalmol.2021.5067","volume":"140","author":"SSY Lee","year":"2022","unstructured":"Lee SSY, Lingham G, Sanfilippo PG, Hammond CJ, Saw SM, Guggenheim JA, Yazar S, Mackey DA (2022) Incidence and progression of myopia in early adulthood. JAMA Ophthalmol 140:162\u2013169","journal-title":"JAMA Ophthalmol"},{"key":"2850_CR21","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1097\/ICO.0000000000002507","volume":"39","author":"H Namba","year":"2020","unstructured":"Namba H, Sugano A, Murakami T, Utsunomiya H, Nishitsuka K, Ishizawa K, Kayama T, Yamashita H (2020) Age-related changes in astigmatism and potential causes. Cornea 39:S34\u2013S38","journal-title":"Cornea"},{"key":"2850_CR22","first-page":"779","volume":"38","author":"WM Bourne","year":"1997","unstructured":"Bourne WM, Nelson LIL, Hodge DO (1997) Central corneal endothelial cell changes over a ten-year period. Invest Ophthalmol Vis Sci 38:779\u2013782","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-023-02850-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-023-02850-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-023-02850-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T10:04:39Z","timestamp":1702634679000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-023-02850-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,17]]},"references-count":22,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["2850"],"URL":"https:\/\/doi.org\/10.1007\/s10792-023-02850-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2404782\/v1","asserted-by":"object"}]},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,17]]},"assertion":[{"value":"22 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the ethics committee of San Rafael Hospital (Madrid, Spain) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}