{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:20:36Z","timestamp":1777044036947,"version":"3.51.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Alma Mater Studiorum - Universit\u00e0 di Bologna"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Idiopathic normal pressure hydrocephalus (iNPH) is associated with an increased prevalence of open-angle glaucoma, attributed to variations of the pressure gradient between intraocular and intracranial compartments at the level of the lamina cribrosa (LC). As ocular biomechanics influence the behavior of the LC, and a lower corneal hysteresis (CH) has been associated to a higher risk of glaucomatous optic nerve damage, in this study we compared ocular biomechanics of iNPH patients with healthy subjects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>\u00a0Twenty-four eyes of 24 non-shunted iNPH patients were prospectively recruited. Ocular biomechanical properties were investigated using the ocular response analyzer (Reichert Instruments) for the calculation of the CH, corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc). Results were compared with those of 25 eyes of 25 healthy subjects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>\u00a0In iNPH eyes, the median CH value and interquartile range (IQR) were 9.7\u00a0mmHg (7.8\u201310) and 10.6\u00a0mmHg (9.3\u201311.3) in healthy controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.015). No significant differences were found in IOPcc [18.1\u00a0mmHg (14.72\u201319.92) vs. 16.4\u00a0mmHg (13.05\u201319.6)], IOPg [15.4\u00a0mmHg (12.82\u201319.7) vs. 15.3\u00a0mmHg (12.55\u201317.35)], and CRF [9.65\u00a0mmHg (8.07\u201311.65) vs. 10.3\u00a0mmHg (9.3\u201311.5)] between iNPH patients and controls.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>\u00a0In iNPH patients, the CH was significantly lower compared to healthy subjects. This result suggests that ocular biomechanical properties may potentially contribute to the risk of development of glaucomatous optic nerve damage in iNPH patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10792-024-02922-3","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T09:02:18Z","timestamp":1707123738000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In vivo assessment of the ocular biomechanical properties in patients with idiopathic normal pressure hydrocephalus"],"prefix":"10.1007","volume":"44","author":[{"given":"Nicola","family":"Valsecchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Roda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Febbraro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Trolli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Palandri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Milletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costantino","family":"Schiavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"issue":"3","key":"2922_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1056\/NEJM196507152730301","volume":"273","author":"RD Adams","year":"1965","unstructured":"Adams RD, Fisher CM, Hakim S, Ojemann RG, Sweet WH (1965) Symptomatic occult hydrocephalus with normal cerebrospinal-fluid pressure. N Engl J Med 273(3):117\u2013126","journal-title":"N Engl J Med"},{"issue":"12","key":"2922_CR2","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1111\/cns.13526","volume":"26","author":"Z Wang","year":"2020","unstructured":"Wang Z, Zhang Y, Hu F, Ding J, Wang X (2020) Pathogenesis and pathophysiology of idiopathic normal pressure hydrocephalus. CNS Neurosci Ther 26(12):1230\u20131240","journal-title":"CNS Neurosci Ther"},{"issue":"14","key":"2922_CR3","doi-asserted-by":"publisher","first-page":"866313","DOI":"10.3389\/fnagi.2022.866313","volume":"28","author":"PA Bonney","year":"2022","unstructured":"Bonney PA, Briggs RG, Wu K, Choi W, Khahera A, Ojogho B et al (2022) Pathophysiological mechanisms underlying idiopathic normal pressure hydrocephalus: a review of recent insights. Front Aging Neurosci 28(14):866313","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"2922_CR4","first-page":"S2","volume":"57","author":"N Relkin","year":"2005","unstructured":"Relkin N, Marmarou A, Klinge P, Bergsneider M, Black PM (2005) Diagnosing idiopathic normal-pressure hydrocephalus. Neurosurgery 57(3):S2-4","journal-title":"Neurosurgery"},{"issue":"5","key":"2922_CR5","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1212\/CPJ.0b013e3182a78f6b","volume":"3","author":"MA Williams","year":"2013","unstructured":"Williams MA, Relkin NR (2013) Diagnosis and management of idiopathic normal-pressure hydrocephalus. Neurol Clin Pract 3(5):375\u2013385","journal-title":"Neurol Clin Pract"},{"issue":"11","key":"2922_CR6","doi-asserted-by":"publisher","first-page":"775","DOI":"10.2176\/nmc.52.775","volume":"52","author":"E Mori","year":"2012","unstructured":"Mori E, Ishikawa M, Kato T, Kazui H, Miyake H, Miyajima M et al (2012) Guidelines for management of idiopathic normal pressure hydrocephalus. Neurol Med Chir 52(11):775\u2013809","journal-title":"Neurol Med Chir"},{"key":"2922_CR7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jocn.2015.10.044","volume":"29","author":"R Shaw","year":"2016","unstructured":"Shaw R, Everingham E, Mahant N, Jacobson E, Owler B (2016) Clinical outcomes in the surgical treatment of idiopathic normal pressure hydrocephalus. J Clin Neurosci 29:81\u201386","journal-title":"J Clin Neurosci"},{"key":"2922_CR8","first-page":"1","volume":"1","author":"E Giordan","year":"2018","unstructured":"Giordan E, Palandri G, Lanzino G, Murad MH, Elder BD (2018) Outcomes and complications of different surgical treatments for idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis. J Neurosurg 1:1\u201313","journal-title":"J Neurosurg"},{"issue":"4","key":"2922_CR9","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.3171\/2017.5.JNS163062","volume":"129","author":"P Gallina","year":"2018","unstructured":"Gallina P, Savastano A, Becattini E, Orlandini S, Scollato A, Rizzo S et al (2018) Glaucoma in patients with shunt-treated normal pressure hydrocephalus. J Neurosurg 129(4):1078\u20131084","journal-title":"J Neurosurg"},{"issue":"3","key":"2922_CR10","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/IJG.0b013e31817eedf9","volume":"18","author":"TC Chang","year":"2009","unstructured":"Chang TC, Singh K (2009) Glaucomatous disease in patients with normal pressure hydrocephalus. J Glaucoma 18(3):243\u2013246","journal-title":"J Glaucoma"},{"issue":"1","key":"2922_CR11","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.1038\/s41598-019-39526-2","volume":"9","author":"N Igarashi","year":"2019","unstructured":"Igarashi N, Honjo M, Asano S, Takagi K, Aihara M (2019) Optic disc cupping characteristics of normal pressure hydrocephalus patients with normal-tension glaucoma. Sci Rep 9(1):3108","journal-title":"Sci Rep"},{"issue":"149","key":"2922_CR12","doi-asserted-by":"publisher","first-page":"e1061","DOI":"10.1016\/j.wneu.2021.01.003","volume":"1","author":"A Eleftheriou","year":"2021","unstructured":"Eleftheriou A, Huang-Link Y, Lundin F (2021) Optical coherence tomography revealing ganglion cell loss in idiopathic normal pressure hydrocephalus. World Neurosurgery 1(149):e1061\u2013e1066","journal-title":"World Neurosurgery"},{"issue":"8","key":"2922_CR13","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3389\/fneur.2017.00172","volume":"1","author":"JM Afonso","year":"2017","unstructured":"Afonso JM, Falc\u00e3o M, Schlichtenbrede F, Falc\u00e3o-Reis F, Silva SE, Schneider TM (2017) Spectral domain-optical coherence tomography as a new diagnostic marker for idiopathic normal pressure hydrocephalus. Front Neurol 1(8):172","journal-title":"Front Neurol"},{"issue":"4","key":"2922_CR14","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.mehy.2013.07.027","volume":"81","author":"RF Bokhari","year":"2013","unstructured":"Bokhari RF, Baeesa SS (2013) Does the treatment of normal pressure hydrocephalus put the retinal ganglion cells at risk? A brief literature review and novel hypothesis. Med Hypotheses 81(4):686\u2013689","journal-title":"Med Hypotheses"},{"key":"2922_CR15","first-page":"1","volume":"25","author":"P Gallina","year":"2022","unstructured":"Gallina P, Savastano A, Buzzi M, Angelini L, Miele A, Rizzo S et al (2022) Normal tension glaucoma in CSF-shunted normal pressure hydrocephalus patients. An extended follow-up Eye 25:1\u20132","journal-title":"An extended follow-up Eye"},{"issue":"1","key":"2922_CR16","doi-asserted-by":"publisher","first-page":"16379","DOI":"10.1038\/s41598-023-43518-8","volume":"13","author":"N Valsecchi","year":"2023","unstructured":"Valsecchi N, Roda M, Febbraro S, Wrona D, Marega G, Palandri G et al (2023) Choroidal morphology and microvascular structure in eyes of patients with idiopathic normal pressure hydrocephalus before and after ventriculo-peritoneal shunt surgery. Sci Rep 13(1):16379","journal-title":"Sci Rep"},{"issue":"2","key":"2922_CR17","first-page":"171","volume":"16","author":"NFS Cruz","year":"2021","unstructured":"Cruz NFS, Santos KS, Matuoka ML, Kasahara N (2021) Translaminar pressure difference and ocular perfusion pressure in glaucomatous eyes with different optic disc Sizes. J Ophthalmic Vis Res 16(2):171\u2013177","journal-title":"J Ophthalmic Vis Res"},{"issue":"5","key":"2922_CR18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11910-018-0831-9","volume":"18","author":"G J\u00f3hannesson","year":"2018","unstructured":"J\u00f3hannesson G, Eklund A, Lind\u00e9n C (2018) Intracranial and intraocular pressure at the lamina cribrosa: gradient effects. Curr Neurol Neurosci Rep 18(5):25","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"3","key":"2922_CR19","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1136\/bjo.84.3.311","volume":"84","author":"J Albon","year":"2000","unstructured":"Albon J, Karwatowski WS, Easty DL, Sims TJ, Duance VC (2000) Age related changes in the non-collagenous components of the extracellular matrix of the human lamina cribrosa. Br J Ophthalmol 84(3):311\u2013317","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"2922_CR20","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.ophtha.2022.11.009","volume":"130","author":"AJ Sit","year":"2023","unstructured":"Sit AJ, Chen TC, Takusagawa HL, Rosdahl JA, Hoguet A, Chopra V et al (2023) corneal hysteresis for the diagnosis of glaucoma and assessment of progression risk: a report by the american academy of ophthalmology. Ophthalmology 130(4):433\u2013442","journal-title":"Ophthalmology"},{"issue":"12","key":"2922_CR21","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1016\/j.ophtha.2019.07.023","volume":"126","author":"BN Susanna","year":"2019","unstructured":"Susanna BN, Ogata NG, Jammal AA, Susanna CN, Berchuck SI, Medeiros FA (2019) Corneal biomechanics and visual field progression in eyes with seemingly well-controlled intraocular pressure. Ophthalmology 126(12):1640\u20131646","journal-title":"Ophthalmology"},{"issue":"8","key":"2922_CR22","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/j.ophtha.2013.01.032","volume":"120","author":"FA Medeiros","year":"2013","unstructured":"Medeiros FA, Freitas D, Lisboa R, Kuang TM, Zangwill LM, Weinreb RN (2013) Corneal hysteresis as a risk factor for glaucoma progression: a prospective longitudinal study. Ophthalmology 120(8):1533\u20131540","journal-title":"Ophthalmology"},{"key":"2922_CR23","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.parkreldis.2019.07.021","volume":"66","author":"G Giannini","year":"2019","unstructured":"Giannini G, Palandri G, Ferrari A, Oppi F, Milletti D, Albini-Riccioli L et al (2019) A prospective evaluation of clinical and instrumental features before and after ventriculo-peritoneal shunt in patients with idiopathic Normal pressure hydrocephalus: the Bologna PRO-Hydro study. Parkinsonism Relat Disord 66:117\u2013124","journal-title":"Parkinsonism Relat Disord"},{"issue":"1","key":"2922_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12886-016-0396-9","volume":"17","author":"ML Murphy","year":"2017","unstructured":"Murphy ML, Pokrovskaya O, Galligan M, O\u2019Brien C (2017) Corneal hysteresis in patients with glaucoma-like optic discs, ocular hypertension and glaucoma. BMC Ophthalmol 17(1):1","journal-title":"BMC Ophthalmol"},{"issue":"1","key":"2922_CR25","doi-asserted-by":"publisher","first-page":"11677","DOI":"10.1038\/s41598-021-90588-7","volume":"11","author":"G Xu","year":"2021","unstructured":"Xu G, Chen Z (2021) Corneal hysteresis as a risk factor for optic nerve head surface depression and retinal nerve fiber layer thinning in glaucoma patients. Sci Rep 11(1):11677","journal-title":"Sci Rep"},{"key":"2922_CR26","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.ajo.2019.11.017","volume":"212","author":"BJ Wong","year":"2020","unstructured":"Wong BJ, Moghimi S, Zangwill LM, Christopher M, Belghith A, Ekici E et al (2020) Relationship of corneal hysteresis and anterior lamina cribrosa displacement in glaucoma. Am J Ophthalmol 212:134\u2013143","journal-title":"Am J Ophthalmol"},{"issue":"240","key":"2922_CR27","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ajo.2022.02.025","volume":"1","author":"A Kamalipour","year":"2022","unstructured":"Kamalipour A, Moghimi S, Eslani M, Nishida T, Mohammadzadeh V, Micheletti E et al (2022) A prospective longitudinal study to investigate corneal hysteresis as a risk factor of central visual field progression in glaucoma. Am J Ophthalmol 1(240):159\u2013169","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"2922_CR28","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1136\/jnnp.2004.039834","volume":"76","author":"H Stephensen","year":"2005","unstructured":"Stephensen H, Andersson N, Eklund A, Malm J, Tisell M, Wikkelso C (2005) Objective B wave analysis in 55 patients with non-communicating and communicating hydrocephalus. J Neurol Neurosurg Psychiatry 76(7):965\u2013970","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"2","key":"2922_CR29","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/00061198-200004000-00002","volume":"9","author":"S Asrani","year":"2000","unstructured":"Asrani S, Zeimer R, Wilensky J, Gieser D, Vitale S, Lindenmuth K (2000) Large diurnal fluctuations in intraocular pressure are an independent risk factor in patients with glaucoma. J Glaucoma 9(2):134\u2013142","journal-title":"J Glaucoma"},{"issue":"6","key":"2922_CR30","doi-asserted-by":"publisher","first-page":"e501","DOI":"10.1111\/aos.12947","volume":"94","author":"KR Pillunat","year":"2016","unstructured":"Pillunat KR, Spoerl E, Terai N, Pillunat LE (2016) Effect of selective laser trabeculoplasty on corneal biomechanics. Acta Ophthalmol 94(6):e501-504","journal-title":"Acta Ophthalmol"},{"issue":"1","key":"2922_CR31","first-page":"24","volume":"6","author":"GA Aydemir","year":"2021","unstructured":"Aydemir GA, Demirok G, Eksioglu U, Yakin M, Ornek F (2021) The effect of long-term usage of single-agent antiglaucomatous drops with different preservatives on cornea biomechanics. Beyoglu Eye J 6(1):24\u201330","journal-title":"Beyoglu Eye J"},{"issue":"1","key":"2922_CR32","first-page":"7","volume":"9","author":"M Pakravan","year":"2014","unstructured":"Pakravan M, Afroozifar M, Yazdani S (2014) Corneal biomechanical changes following trabeculectomy, phaco-trabeculectomy, ahmed glaucoma valve implantation and phacoemulsification. J Ophthalmic Vis Res 9(1):7\u201313","journal-title":"J Ophthalmic Vis Res"},{"issue":"2","key":"2922_CR33","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1136\/bjophthalmol-2016-308432","volume":"101","author":"R Meda","year":"2017","unstructured":"Meda R, Wang Q, Paoloni D, Harasymowycz P, Brunette I (2017) The impact of chronic use of prostaglandin analogues on the biomechanical properties of the cornea in patients with primary open-angle glaucoma. Br J Ophthalmol 101(2):120\u2013125","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"2922_CR34","doi-asserted-by":"publisher","first-page":"e0155527","DOI":"10.1371\/journal.pone.0155527","volume":"11","author":"N Wu","year":"2016","unstructured":"Wu N, Chen Y, Yu X, Li M, Wen W, Sun X (2016) Changes in corneal biomechanical properties after long-term topical prostaglandin therapy. PLoS ONE 11(5):e0155527","journal-title":"PLoS ONE"},{"issue":"5","key":"2922_CR35","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1136\/bjo.76.5.280","volume":"76","author":"R David","year":"1992","unstructured":"David R, Zangwill L, Briscoe D, Dagan M, Yagev R, Yassur Y (1992) Diurnal intraocular pressure variations: an analysis of 690 diurnal curves. Br J Ophthalmol 76(5):280\u2013283","journal-title":"Br J Ophthalmol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-024-02922-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-024-02922-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-024-02922-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T15:21:04Z","timestamp":1741879264000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-024-02922-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,2]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2922"],"URL":"https:\/\/doi.org\/10.1007\/s10792-024-02922-3","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,2]]},"assertion":[{"value":"9 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was adherent to the tenets of the Declaration of Helsinki and was approved by the Institutional Review Board\/Ethics Committee of the local health service of Bologna, Italy (Cod CE: 809\/2021).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Patients gave their consent for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Written informed consent was obtained from all subjects included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"1"}}