{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:27:28Z","timestamp":1772119648594,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-024-03020-0","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T06:02:39Z","timestamp":1708063359000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A comparison of conventional and accelerated corneal crosslinking: corneal epithelial remodeling and in vivo confocal microscopy analysis"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3634-5433","authenticated-orcid":false,"given":"Sezer","family":"Hac\u0131a\u011fao\u011flu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8322-1842","authenticated-orcid":false,"given":"Semra","family":"Akkaya Turhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1352-3025","authenticated-orcid":false,"given":"Ebru","family":"Toker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"issue":"8","key":"3020_CR1","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s00417-018-3966-0","volume":"256","author":"SK Subasinghe","year":"2018","unstructured":"Subasinghe SK, Ogbuehi KC, Dias GJ (2018) Current perspectives on corneal collagen crosslinking (CXL). Graefes Arch Clin Exp Ophthalmol 256(8):1363\u20131384. https:\/\/doi.org\/10.1007\/s00417-018-3966-0","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"8","key":"3020_CR2","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1016\/j.jcrs.2009.03.035","volume":"35","author":"T Koller","year":"2009","unstructured":"Koller T, Mrochen M, Seiler T (2009) Complication and failure rates after corneal crosslinking. J Cataract Refract Surg 35(8):1358\u20131362. https:\/\/doi.org\/10.1016\/j.jcrs.2009.03.035","journal-title":"J Cataract Refract Surg"},{"issue":"8","key":"3020_CR3","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1097\/ICO.0000000000000154","volume":"33","author":"U Elbaz","year":"2014","unstructured":"Elbaz U, Shen C, Lichtinger A, Zauberman NA, Goldich Y, Chan CC, Slomovic AR, Rootman DS (2014) Accelerated (9-mW\/cm2) corneal collagen crosslinking for keratoconus-A 1-year follow-up. Cornea 33(8):769\u2013773. https:\/\/doi.org\/10.1097\/ICO.0000000000000154","journal-title":"Cornea"},{"issue":"3","key":"3020_CR4","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.jcrs.2017.12.021","volume":"44","author":"ID Haberman","year":"2018","unstructured":"Haberman ID, Lang PZ, Broncano AF, Kim SW, Hafezi F, Randleman JB (2018) Epithelial remodeling after corneal crosslinking using higher fluence and accelerated treatment time. J Cataract Refract Surg 44(3):306\u2013312. https:\/\/doi.org\/10.1016\/j.jcrs.2017.12.021","journal-title":"J Cataract Refract Surg"},{"issue":"2","key":"3020_CR5","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ophtha.2013.09.014","volume":"121","author":"C Jordan","year":"2014","unstructured":"Jordan C, Patel DV, Abeysekera N, McGhee CN (2014) In vivo confocal microscopy analyses of corneal microstructural changes in a prospective study of collagen cross-linking in keratoconus. Ophthalmology 121(2):469\u2013474. https:\/\/doi.org\/10.1016\/j.ophtha.2013.09.014","journal-title":"Ophthalmology"},{"issue":"1","key":"3020_CR6","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1001\/jamaophthalmol.2015.4518","volume":"134","author":"M Parissi","year":"2016","unstructured":"Parissi M, Randjelovic S, Poletti E, Guimar\u00e3es P, Ruggeri A, Fragkiskou S, Wihlmark TB, Utheim TP, Lagali N (2016) Corneal nerve regeneration after collagen cross-linking treatment of keratoconus: a 5-year longitudinal study. JAMA Ophthalmol 134(1):70\u201378. https:\/\/doi.org\/10.1001\/jamaophthalmol.2015.4518","journal-title":"JAMA Ophthalmol"},{"issue":"3","key":"3020_CR7","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/eye.2008.52","volume":"23","author":"DV Patel","year":"2009","unstructured":"Patel DV, Ku JY, Johnson R, McGhee CN (2009) Laser scanning in vivo confocal microscopy and quantitative aesthesiometry reveal decreased corneal innervation and sensation in keratoconus. Eye (Lond) 23(3):586\u2013592. https:\/\/doi.org\/10.1038\/eye.2008.52","journal-title":"Eye (Lond)"},{"issue":"Pt 1","key":"3020_CR8","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/978-3-642-15705-9_37","volume":"13","author":"MA Dabbah","year":"2010","unstructured":"Dabbah MA, Graham J, Petropoulos I, Tavakoli M, Malik RA (2010) Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images. Med Image Comput Comput Assist Interv 13(Pt 1):300\u2013307. https:\/\/doi.org\/10.1007\/978-3-642-15705-9_37","journal-title":"Med Image Comput Comput Assist Interv"},{"issue":"10","key":"3020_CR9","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1016\/j.jcrs.2014.02.036","volume":"40","author":"AJ Kanellopoulos","year":"2014","unstructured":"Kanellopoulos AJ, Asimellis G (2014) Epithelial remodeling after partial topography-guided normalization and high-fluence short-duration crosslinking (Athens protocol): results up to 1 year. J Cataract Refract Surg 40(10):1597\u20131602. https:\/\/doi.org\/10.1016\/j.jcrs.2014.02.036","journal-title":"J Cataract Refract Surg"},{"issue":"3","key":"3020_CR10","doi-asserted-by":"publisher","first-page":"534","DOI":"10.3980\/j.issn.2222-3959.2015.03.17","volume":"8","author":"G Bitirgen","year":"2015","unstructured":"Bitirgen G, Ozkagnici A, Bozkurt B, Malik RA (2015) In vivo corneal confocal microscopic analysis in patients with keratoconus. Int J Ophthalmol 8(3):534\u2013539. https:\/\/doi.org\/10.3980\/j.issn.2222-3959.2015.03.17","journal-title":"Int J Ophthalmol"},{"issue":"1","key":"3020_CR11","doi-asserted-by":"publisher","first-page":"e22","DOI":"10.1111\/aos.13814","volume":"97","author":"M Shajari","year":"2019","unstructured":"Shajari M, Kolb CM, Agha B, Steinwender G, M\u00fcller M, Herrmann E, Schmack I, Mayer WJ, Kohnen T (2019) Comparison of standard and accelerated corneal cross-linking for the treatment of keratoconus: a meta-analysis. Acta Ophthalmol 97(1):e22\u2013e35. https:\/\/doi.org\/10.1111\/aos.13814","journal-title":"Acta Ophthalmol"},{"issue":"2","key":"3020_CR12","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1097\/ICO.0000000000002092","volume":"39","author":"H Kobashi","year":"2020","unstructured":"Kobashi H, Tsubota K (2020) Accelerated versus standard corneal cross-linking for progressive keratoconus: a meta-analysis of randomized controlled trials. Cornea 39(2):172\u2013180. https:\/\/doi.org\/10.1097\/ICO.0000000000002092","journal-title":"Cornea"},{"key":"3020_CR13","doi-asserted-by":"publisher","unstructured":"Wen D, Song B, Li Q, Tu R, Huang Y, Wang Q, McAlinden C, O\u02bcBrart D, Huang J (2018) Comparison of Epithelium-off versus transepithelial corneal collagen cross-linking for keratoconus: a systematic review and meta-analysis. Cornea 37(8):1018\u20131024. https:\/\/doi.org\/10.1097\/ICO.0000000000001632","DOI":"10.1097\/ICO.0000000000001632"},{"key":"3020_CR14","doi-asserted-by":"publisher","unstructured":"Mazzotta C, Raiskup F, Hafezi F, Torres-Netto EA, Armia Balamoun A, Giannaccare G, Bagaglia SA (2021) Long term results of accelerated 9\u2009mW corneal crosslinking for early progressive keratoconus: the Siena Eye-Cross Study 2. Eye Vis (Lond).8(1):16. https:\/\/doi.org\/10.1186\/s40662-021-00240-8","DOI":"10.1186\/s40662-021-00240-8"},{"issue":"4","key":"3020_CR15","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3928\/1081597X-20100218-01","volume":"26","author":"DZ Reinstein","year":"2010","unstructured":"Reinstein DZ, Gobbe M, Archer TJ, Silverman RH, Coleman DJ (2010) Epithelial, stromal, and total corneal thickness in keratoconus: three-dimensional display with artemis very-high frequency digital ultrasound. J Refract Surg 26(4):259\u2013271. https:\/\/doi.org\/10.3928\/1081597X-20100218-01","journal-title":"J Refract Surg"},{"issue":"10","key":"3020_CR16","doi-asserted-by":"publisher","first-page":"E963","DOI":"10.1097\/OPX.0b013e318188892c","volume":"85","author":"S Haque","year":"2008","unstructured":"Haque S, Jones L, Simpson T (2008) Thickness mapping of the cornea and epithelium using optical coherence tomography. Optom Vis Sci 85(10):E963\u2013E976. https:\/\/doi.org\/10.1097\/OPX.0b013e318188892c","journal-title":"Optom Vis Sci"},{"issue":"12","key":"3020_CR17","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1016\/j.ophtha.2012.06.023","volume":"119","author":"Y Li","year":"2012","unstructured":"Li Y, Tan O, Brass R, Weiss JL, Huang D (2012) Corneal epithelial thickness mapping by Fourier-domain optical coherence tomography in normal and keratoconic eyes. Ophthalmology 119(12):2425\u20132433. https:\/\/doi.org\/10.1016\/j.ophtha.2012.06.023","journal-title":"Ophthalmology"},{"issue":"7","key":"3020_CR18","doi-asserted-by":"publisher","first-page":"604","DOI":"10.3928\/1081597X-20090610-06","volume":"25","author":"DZ Reinstein","year":"2009","unstructured":"Reinstein DZ, Archer TJ, Gobbe M (2009) Corneal epithelial thickness profile in the diagnosis of keratoconus. J Refract Surg 25(7):604\u2013610. https:\/\/doi.org\/10.3928\/1081597X-20090610-06","journal-title":"J Refract Surg"},{"issue":"6","key":"3020_CR19","doi-asserted-by":"publisher","first-page":"571","DOI":"10.3928\/1081597X-20080601-05","volume":"24","author":"DZ Reinstein","year":"2008","unstructured":"Reinstein DZ, Archer TJ, Gobbe M, Silverman RH, Coleman DJ (2008) Epithelial thickness in the normal cornea: three-dimensional display with Artemis very high-frequency digital ultrasound. J Refract Surg 24(6):571\u2013581. https:\/\/doi.org\/10.3928\/1081597X-20080601-05","journal-title":"J Refract Surg"},{"issue":"5","key":"3020_CR20","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3928\/1081597X-20100930-01","volume":"27","author":"DZ Reinstein","year":"2011","unstructured":"Reinstein DZ, Gobbe M, Archer TJ, Couch D (2011) Epithelial thickness profile as a method to evaluate the effectiveness of collagen cross-linking treatment after corneal ectasia. J Refract Surg 27(5):356\u2013363. https:\/\/doi.org\/10.3928\/1081597X-20100930-01","journal-title":"J Refract Surg"},{"issue":"2","key":"3020_CR21","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3928\/1081597X-20140120-08","volume":"30","author":"KM Rocha","year":"2014","unstructured":"Rocha KM, Perez-Straziota CE, Stulting RD, Randleman JB (2014) Epithelial and stromal remodeling after corneal collagen cross-linking evaluated by spectral-domain OCT. J Refract Surg 30(2):122\u2013127. https:\/\/doi.org\/10.3928\/1081597X-20140120-08","journal-title":"J Refract Surg"},{"issue":"6","key":"3020_CR22","doi-asserted-by":"publisher","first-page":"408","DOI":"10.3928\/1081597X-20180402-03","volume":"34","author":"J Lautert","year":"2018","unstructured":"Lautert J, Doshi D, Price FW Jr, Price MO (2018) Corneal epithelial remodeling after standard epithelium-off corneal cross-linking in keratoconic eyes. J Refract Surg 34(6):408\u2013412. https:\/\/doi.org\/10.3928\/1081597X-20180402-03","journal-title":"J Refract Surg"},{"issue":"9","key":"3020_CR23","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3928\/1081597X-20160531-02","volume":"32","author":"X Chen","year":"2016","unstructured":"Chen X, Stojanovic A, Wang X, Liang J, Hu D, Utheim TP (2016) Epithelial thickness profile change after combined topography-guided transepithelial photorefractive keratectomy and corneal cross-linking in treatment of keratoconus. J Refract Surg 32(9):626\u2013634. https:\/\/doi.org\/10.3928\/1081597X-20160531-02","journal-title":"J Refract Surg"},{"key":"3020_CR24","doi-asserted-by":"publisher","first-page":"32692","DOI":"10.1038\/srep32692","volume":"6","author":"X Zhang","year":"2016","unstructured":"Zhang X, Sun L, Chen Y, Li M, Tian M, Zhou X (2016) One-year outcomes of pachymetry and epithelium thicknesses after accelerated (45 mW\/cm2) transepithelial corneal collagen cross-linking for keratoconus patients. Sci Rep 6:32692. https:\/\/doi.org\/10.1038\/srep32692","journal-title":"Sci Rep"},{"issue":"2","key":"3020_CR25","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/ceo.13108","volume":"46","author":"A Gokul","year":"2018","unstructured":"Gokul A, Vellara HR, Patel DV (2018) Advanced anterior segment imaging in keratoconus: a review. Clin Exp Ophthalmol 46(2):122\u2013132. https:\/\/doi.org\/10.1111\/ceo.13108","journal-title":"Clin Exp Ophthalmol"},{"issue":"4","key":"3020_CR26","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1167\/iovs.05-1217","volume":"47","author":"DV Patel","year":"2006","unstructured":"Patel DV, McGhee CN (2006) Mapping the corneal sub-basal nerve plexus in keratoconus by in vivo laser scanning confocal microscopy. Invest Ophthalmol Vis Sci 47(4):1348\u20131351. https:\/\/doi.org\/10.1167\/iovs.05-1217","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"3020_CR27","doi-asserted-by":"publisher","first-page":"484","DOI":"10.3109\/02713683.2014.932387","volume":"40","author":"EB Ozgurhan","year":"2015","unstructured":"Ozgurhan EB, Celik U, Bozkurt E, Demirok A (2015) Evaluation of subbasal nerve morphology and corneal sensation after accelerated corneal collagen cross-linking treatment on keratoconus. Curr Eye Res 40(5):484\u2013489. https:\/\/doi.org\/10.3109\/02713683.2014.932387","journal-title":"Curr Eye Res"},{"issue":"11","key":"3020_CR28","doi-asserted-by":"publisher","first-page":"7601","DOI":"10.1167\/iovs.14-15662","volume":"55","author":"N Bouheraoua","year":"2014","unstructured":"Bouheraoua N, Jouve L, El Sanharawi M, Sandali O, Temstet C, Loriaut P, Basli E, Borderie V, Laroche L (2014) Optical coherence tomography and confocal microscopy following three different protocols of corneal collagen-crosslinking in keratoconus. Invest Ophthalmol Vis Sci 55(11):7601\u20137609. https:\/\/doi.org\/10.1167\/iovs.14-15662","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"3020_CR29","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3928\/1081597X-20121016-01","volume":"28","author":"D Touboul","year":"2012","unstructured":"Touboul D, Efron N, Smadja D, Praud D, Malet F, Colin J (2012) Corneal confocal microscopy following conventional, transepithelial, and accelerated corneal collagen cross-linking procedures for keratoconus. J Refract Surg 28(11):769\u2013776. https:\/\/doi.org\/10.3928\/1081597X-20121016-01","journal-title":"J Refract Surg"},{"issue":"4","key":"3020_CR30","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.jtos.2015.04.007","volume":"13","author":"C Mazzotta","year":"2015","unstructured":"Mazzotta C, Hafezi F, Kymionis G, Caragiuli S, Jacob S, Traversi C, Barabino S, Randleman JB (2015) In vivo confocal microscopy after corneal collagen crosslinking. Ocul Surf 13(4):298\u2013314. https:\/\/doi.org\/10.1016\/j.jtos.2015.04.007","journal-title":"Ocul Surf"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-024-03020-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-024-03020-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-024-03020-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T11:41:18Z","timestamp":1741866078000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-024-03020-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,16]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3020"],"URL":"https:\/\/doi.org\/10.1007\/s10792-024-03020-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2766183\/v1","asserted-by":"object"}]},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,16]]},"assertion":[{"value":"1 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"87"}}