{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T04:23:48Z","timestamp":1741926228273,"version":"3.38.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-024-03031-x","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T18:02:16Z","timestamp":1708106536000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of the effect of calcium ions on promoting the penetrability of riboflavin into the corneal stroma by iontophoresis"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-3637","authenticated-orcid":false,"given":"Na","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengjun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiujun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"3031_CR1","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1097\/ICO.0000000000001912","volume":"38","author":"RS Rubinfeld","year":"2019","unstructured":"Rubinfeld RS, Caruso C, Ostacolo C (2019) Corneal cross-linking: the science beyond the myths and misconceptions. Cornea 38:780\u2013790","journal-title":"Cornea"},{"key":"3031_CR2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjophth-2021-000878","volume":"6","author":"ES Van der Valk Bouman","year":"2021","unstructured":"Van der Valk Bouman ES, Pump H, Borsook D, Severinsky B, Wisse RP, Saeed HN, Moulton EA (2021) Pain mechanisms and management in corneal cross-linking: a review. BMJ Open Ophthalmol 6:e000878","journal-title":"BMJ Open Ophthalmol"},{"key":"3031_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1080\/08820538.2017.1353809","volume":"33","author":"CB Evangelista","year":"2018","unstructured":"Evangelista CB, Hatch KM (2018) Corneal collagen cross-linking complications. Semin Ophthalmol 33:29\u201335","journal-title":"Semin Ophthalmol"},{"key":"3031_CR4","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/j.ophtha.2020.12.023","volume":"128","author":"S Nath","year":"2021","unstructured":"Nath S, Shen C, Koziarz A, Banfield L, Nowrouzi-Kia B, Fava MA, Hodge WG (2021) Transepithelial versus epithelium-off corneal collagen cross-linking for corneal ectasia: a systematic review and meta-analysis. Ophthalmology 128:1150\u20131160","journal-title":"Ophthalmology"},{"key":"3031_CR5","doi-asserted-by":"crossref","unstructured":"Ng SM, Ren M, Lindsley KB, Hawkins BS, Kuo IC (2021) Transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus. Cochrane Database Syst Rev 3:CD013512.","DOI":"10.1002\/14651858.CD013512.pub2"},{"key":"3031_CR6","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1007\/s10792-021-01713-4","volume":"41","author":"P Vinciguerra","year":"2021","unstructured":"Vinciguerra P, Montericcio A, Catania F, Fossati G, Raimondi R, Legrottaglie EF, Vinciguerra R (2021) New perspectives in keratoconus treatment: an update on iontophoresis-assisted corneal collagen crosslinking. Int Ophthalmol 41:1909\u20131916","journal-title":"Int Ophthalmol"},{"key":"3031_CR7","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.ajo.2013.11.018","volume":"157","author":"L Mastropasqua","year":"2014","unstructured":"Mastropasqua L, Nubile M, Calienno R, Mattei PA, Pedrotti E, Salgari N, Mastropasqua R, Lanzini M (2014) Corneal cross-linking: intrastromal riboflavin concentration in iontophoresis-assisted imbibition versus traditional and transepithelial techniques. Am J Ophthalmol 157:623\u2013630","journal-title":"Am J Ophthalmol"},{"key":"3031_CR8","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s10792-016-0266-8","volume":"37","author":"M Lanzini","year":"2017","unstructured":"Lanzini M, Curcio C, Spoerl E, Calienno R, Mastropasqua A, Colasante M, Mastropasqua R, Nubile M, Mastropasqua L (2017) Confocal microscopy evaluation of stromal fluorescence intensity after standard and accelerated iontophoresis-assisted corneal cross-linking. Int Ophthalmol 37:235\u2013243","journal-title":"Int Ophthalmol"},{"key":"3031_CR9","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1097\/ICO.0000000000001062","volume":"36","author":"L Jouve","year":"2017","unstructured":"Jouve L, Borderie V, Sandali O, Temstet C, Basli E, Laroche L, Bouheraoua N (2017) Conventional and iontophoresis corneal cross-linking for keratoconus: efficacy and assessment by optical coherence tomography and confocal microscopy. Cornea 36:153\u2013162","journal-title":"Cornea"},{"key":"3031_CR10","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.ophtha.2017.01.040","volume":"124","author":"M Lombardo","year":"2017","unstructured":"Lombardo M, Giannini D, Lombardo G, Serrao S (2017) Randomized controlled trial comparing transepithelial corneal cross-linking using iontophoresis with the Dresden protocol in progressive keratoconus. Ophthalmology 124:804\u2013812","journal-title":"Ophthalmology"},{"key":"3031_CR11","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1080\/02713680600899655","volume":"31","author":"S Hariharan","year":"2006","unstructured":"Hariharan S, Janoria KG, Gunda S, Zhu X, Pal D, Mitra AK (2006) Identification and functional expression of a carrier-mediated riboflavin transport system on rabbit corneal epithelium. Curr Eye Res 31:811\u2013824","journal-title":"Curr Eye Res"},{"key":"3031_CR12","doi-asserted-by":"publisher","first-page":"861","DOI":"10.3389\/fcell.2020.00861","volume":"8","author":"T Sinha","year":"2020","unstructured":"Sinha T, Naash MI, Al-Ubaidi MR (2020) Flavins act as a critical liaison between metabolic homeostasis and oxidative stress in the retina. Front Cell Dev Biol 8:861","journal-title":"Front Cell Dev Biol"},{"key":"3031_CR13","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s00018-021-04074-4","volume":"79","author":"YTK Nguyen","year":"2021","unstructured":"Nguyen YTK, Ha HTT, Nguyen TH, Nguyen LN (2021) The role of SLC transporters for brain health and disease. Cell Mol Life Sci 79:20","journal-title":"Cell Mol Life Sci"},{"key":"3031_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s13346-021-00898-6","volume":"12","author":"Y Wang","year":"2022","unstructured":"Wang Y, Zeng L, Song W, Liu J (2022) Influencing factors and drug application of iontophoresis in transdermal drug delivery: an overview of recent progress. Drug Deliv Transl Res 12:15\u201326","journal-title":"Drug Deliv Transl Res"},{"key":"3031_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.3540","volume":"38","author":"S Lee","year":"2022","unstructured":"Lee S, Lee C, Kim E, Ko SA, Kim SN, Choy YB, Im CH (2022) In-vivo estimation of tissue electrical conductivities of a rabbit eye for precise simulation of electric field distributions during ocular iontophoresis. Int J Numer Method Biomed Eng 38:e3540","journal-title":"Int J Numer Method Biomed Eng"},{"key":"3031_CR16","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1097\/CM9.0000000000001579","volume":"135","author":"N Li","year":"2022","unstructured":"Li N, Fan ZJ, Peng XJ (2022) A histological examination of corneal epithelium after iontophoresis with different riboflavin solutions. Chin Med J (Engl) 135:753\u2013755","journal-title":"Chin Med J (Engl)"},{"key":"3031_CR17","doi-asserted-by":"publisher","first-page":"6548554","DOI":"10.1155\/2021\/6548554","volume":"2021","author":"F Sanie-Jahromi","year":"2021","unstructured":"Sanie-Jahromi F, Azizi A, Shariat S, Johari M (2021) Effect of electrical stimulation on ocular cells: a means for improving ocular tissue engineering and treatments of eye diseases. Biomed Res Int 2021:6548554","journal-title":"Biomed Res Int"},{"key":"3031_CR18","doi-asserted-by":"publisher","first-page":"473","DOI":"10.3390\/membranes11070473","volume":"11","author":"AR Ruiz-Fern\u00e1ndez","year":"2021","unstructured":"Ruiz-Fern\u00e1ndez AR, Campos L, Villanelo F, Guti\u00e9rrez-Maldonado SE, Perez-Acle T (2021) Exploring the conformational changes induced by nanosecond pulsed electric fields on the voltage sensing domain of a Ca2+ channel. Membranes (Basel) 11:473","journal-title":"Membranes (Basel)"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-024-03031-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-024-03031-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-024-03031-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T15:22:35Z","timestamp":1741879355000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-024-03031-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,16]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3031"],"URL":"https:\/\/doi.org\/10.1007\/s10792-024-03031-x","relation":{},"ISSN":["1573-2630"],"issn-type":[{"type":"electronic","value":"1573-2630"}],"subject":[],"published":{"date-parts":[[2024,2,16]]},"assertion":[{"value":"6 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the Chinese PLA General Hospital (Date 2022-02\u201306).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"89"}}