{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T04:40:52Z","timestamp":1772340052914,"version":"3.50.1"},"reference-count":123,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-024-03071-3","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T13:01:55Z","timestamp":1718974915000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of hub genes and molecular pathways in keratoconus by integrating bioinformatics and literature mining at the RNA level"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5167-3318","authenticated-orcid":false,"given":"Feiying","family":"Meng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-1102","authenticated-orcid":false,"given":"Shengwei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"issue":"4","key":"3071_CR1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","volume":"42","author":"YS Rabinowitz","year":"1998","unstructured":"Rabinowitz YS (1998) Keratoconus. Surv Ophthalmol 42(4):297\u2013319","journal-title":"Surv Ophthalmol"},{"issue":"2","key":"3071_CR2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/ICO.0000000000002150","volume":"39","author":"H Hashemi","year":"2020","unstructured":"Hashemi H, Heydarian S, Hooshmand E, Saatchi M, Yekta A, Aghamirsalim M et al (2020) The prevalence and risk factors for keratoconus: a systematic review and meta-analysis. Cornea 39(2):263\u2013270","journal-title":"Cornea"},{"key":"3071_CR3","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108328","volume":"202","author":"YS Rabinowitz","year":"2021","unstructured":"Rabinowitz YS, Galvis V, Tello A, Rueda D, Garc\u00eda JD (2021) Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus. Exp Eye Res 202:108328","journal-title":"Exp Eye Res"},{"issue":"12","key":"3071_CR4","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/s41433-020-1065-z","volume":"34","author":"L Lim","year":"2020","unstructured":"Lim L, Lim EWL (2020) Current perspectives in the management of keratoconus with contact lenses. Eye (Lond) 34(12):2175\u20132196","journal-title":"Eye (Lond)"},{"issue":"8","key":"3071_CR5","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s10792-018-0994-z","volume":"39","author":"V Galvis","year":"2019","unstructured":"Galvis V, Tello A, Laiton AN, Salcedo SLL (2019) Indications and techniques of corneal transplantation in a referral center in Colombia, South America (2012\u20132016). Int Ophthalmol 39(8):1723\u20131733","journal-title":"Int Ophthalmol"},{"key":"3071_CR6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ajo.2021.05.013","volume":"231","author":"C Thanitcul","year":"2021","unstructured":"Thanitcul C, Varadaraj V, Canner JK, Woreta FA, Soiberman US, Srikumaran D (2021) Predictors of receiving keratoplasty for keratoconus. Am J Ophthalmol 231:11\u201318","journal-title":"Am J Ophthalmol"},{"issue":"8","key":"3071_CR7","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1097\/ICO.0000000000000499","volume":"34","author":"V Galvis","year":"2015","unstructured":"Galvis V, Tello A, Barrera R, Ni\u00f1o CA (2015) Inflammation in keratoconus. Cornea 34(8):e22\u2013e23","journal-title":"Cornea"},{"issue":"1","key":"3071_CR8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/11206721221125013","volume":"33","author":"PAH Nichani","year":"2023","unstructured":"Nichani PAH, Solomon B, Trinh T, Mimouni M, Rootman D, Singal N et al (2023) Investigating the role of inflammation in keratoconus: a retrospective analysis of 551 eyes. Eur J Ophthalmol 33(1):35\u201343","journal-title":"Eur J Ophthalmol"},{"issue":"8","key":"3071_CR9","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1007\/s00417-021-05081-8","volume":"259","author":"S Sahebjada","year":"2021","unstructured":"Sahebjada S, Al-Mahrouqi HH, Moshegov S, Panchatcharam SM, Chan E, Daniell M et al (2021) Eye rubbing in the aetiology of keratoconus: a systematic review and meta-analysis. Graefe\u2019s Arch Clin Exp Ophthalmol 259(8):2057\u20132067","journal-title":"Graefe's Arch Clin Exp Ophthalmol"},{"issue":"11","key":"3071_CR10","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1097\/ICO.0000000000000935","volume":"35","author":"M Shajari","year":"2016","unstructured":"Shajari M, Eberhardt E, M\u00fcller M, Al Khateeb G, Friderich S, Remy M et al (2016) Effects of atopic syndrome on keratoconus. Cornea 35(11):1416\u20131420","journal-title":"Cornea"},{"issue":"6","key":"3071_CR11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/APO.0000000000000334","volume":"9","author":"AZ Crawford","year":"2020","unstructured":"Crawford AZ, Zhang J, Gokul A, McGhee CNJ, Ormonde SE (2020) The enigma of environmental factors in keratoconus. Asia-Pac J Ophthalmol (Philadelphia, PA) 9(6):549\u2013556","journal-title":"Asia-Pac J Ophthalmol (Philadelphia, PA)"},{"issue":"8","key":"3071_CR12","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/ICL.0000000000000899","volume":"48","author":"C Cagliari","year":"2022","unstructured":"Cagliari C, Schor P, Formentin L, Lipener C, Dos Santos MS, Oliveira H et al (2022) Corneal response to scleral contact lens wear in keratoconus. Eye Contact Lens 48(8):322\u2013327","journal-title":"Eye Contact Lens"},{"issue":"4","key":"3071_CR13","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1097\/ICO.0000000000002219","volume":"39","author":"D Gatinel","year":"2020","unstructured":"Gatinel D, Galvis V, Tello A, Ni\u00f1o CA, Rey JJ, Camacho PA et al (2020) Obstructive sleep Apnea-Hypopnea syndrome and keratoconus: an epiphenomenon related to sleep position? Cornea 39(4):e11\u2013e12","journal-title":"Cornea"},{"issue":"1","key":"3071_CR14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000524116","volume":"13","author":"K Bitton","year":"2022","unstructured":"Bitton K, Dubois M, Moran S, Gatinel D (2022) Discordant keratoconus in monozygotic twins. Case Rep Ophthalmol 13(1):313\u2013317","journal-title":"Case Rep Ophthalmol"},{"key":"3071_CR15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.exer.2019.03.016","volume":"182","author":"E di Martino","year":"2019","unstructured":"di Martino E, Ali M, Inglehearn CF (2019) Matrix metalloproteinases in keratoconus\u2014too much of a good thing? Exp Eye Res 182:137\u2013143","journal-title":"Exp Eye Res"},{"issue":"2","key":"3071_CR16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10792-012-9651-0","volume":"33","author":"EA Hasby","year":"2013","unstructured":"Hasby EA, Saad HA (2013) Immunohistochemical expression of Fas ligand (FasL) and neprilysin (neutral endopeptidase\/CD10) in keratoconus. Int Ophthalmol 33(2):125\u2013131","journal-title":"Int Ophthalmol"},{"issue":"7","key":"3071_CR17","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.4103\/ijo.IJO_3011_20","volume":"69","author":"A Elbeyli","year":"2021","unstructured":"Elbeyli A, Kurtul BE (2021) Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio levels are associated with keratoconus. Indian J Ophthalmol 69(7):1725\u20131729","journal-title":"Indian J Ophthalmol"},{"issue":"1","key":"3071_CR18","doi-asserted-by":"crossref","first-page":"17141","DOI":"10.1038\/s41598-022-21109-3","volume":"12","author":"S Hazra","year":"2022","unstructured":"Hazra S, Chaudhuri AG, Tiwary BK, Chakrabarti N (2022) Integrated network-based multiple computational analyses for identification of co-expressed candidate genes associated with neurological manifestations of COVID-19. Sci Rep 12(1):17141","journal-title":"Sci Rep"},{"key":"3071_CR19","volume":"8","author":"XD Hao","year":"2021","unstructured":"Hao XD, Gao H, Xu WH, Shan C, Liu Y, Zhou ZX et al (2021) Systematically displaying the pathogenesis of keratoconus via multi-level related gene enrichment-based review. Front Med 8:770138","journal-title":"Front Med"},{"key":"3071_CR20","doi-asserted-by":"crossref","first-page":"4740141","DOI":"10.1155\/2022\/4740141","volume":"2022","author":"D Hu","year":"2022","unstructured":"Hu D, Lin Z, Jiang J, Li P, Zhang Z, Yang C (2022) Identification of key genes and molecular pathways in keratoconus: integrating text mining and bioinformatics analysis. Biomed Res Int 2022:4740141","journal-title":"Biomed Res Int"},{"issue":"1","key":"3071_CR21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41421-022-00397-z","volume":"8","author":"S Dou","year":"2022","unstructured":"Dou S, Wang Q, Zhang B, Wei C, Wang H, Liu T et al (2022) Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis. Cell Discov 8(1):66","journal-title":"Cell Discov"},{"issue":"9","key":"3071_CR22","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1167\/iovs.16-21400","volume":"58","author":"M Arbab","year":"2017","unstructured":"Arbab M, Tahir S, Niazi MK, Ishaq M, Hussain A, Siddique PM et al (2017) TNF-\u03b1 genetic predisposition and higher expression of inflammatory pathway components in keratoconus. Invest Ophthalmol Vis Sci 58(9):3481\u20133487","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"3071_CR23","doi-asserted-by":"crossref","first-page":"5844","DOI":"10.1038\/s41598-020-62572-0","volume":"10","author":"X Xu","year":"2020","unstructured":"Xu X, Zhang X, Cui Y, Yang H, Ping X, Wu J et al (2020) Three novel variants identified within ECM-related genes in Chinese Han keratoconus patients. Sci Rep 10(1):5844","journal-title":"Sci Rep"},{"issue":"2","key":"3071_CR24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.5005\/jp-journals-10025-1123","volume":"5","author":"Y Bykhovskaya","year":"2016","unstructured":"Bykhovskaya Y, Gromova A, Makarenkova HP, Rabinowitz YS (2016) Abnormal regulation of extracellular matrix and adhesion molecules in corneas of patients with keratoconus. Int J Keratoconus Ectatic Corneal Dis 5(2):63\u201370","journal-title":"Int J Keratoconus Ectatic Corneal Dis"},{"issue":"2","key":"3071_CR25","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1167\/iovs.05-0551","volume":"47","author":"F Chiambaretta","year":"2006","unstructured":"Chiambaretta F, Nakamura H, De Graeve F, Sakai H, Marceau G, Maruyama Y et al (2006) Kruppel-like factor 6 (KLF6) affects the promoter activity of the alpha1-proteinase inhibitor gene. Invest Ophthalmol Vis Sci 47(2):582\u2013590","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"3071_CR26","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3109\/02713683.2013.774421","volume":"38","author":"ES Chung","year":"2013","unstructured":"Chung ES, Lee KH, Kim M, Chang EJ, Chung TY, Kim EK et al (2013) Expression of neurotrophic factors and their receptors in keratoconic cornea. Curr Eye Res 38(7):743\u2013750","journal-title":"Curr Eye Res"},{"issue":"5","key":"3071_CR27","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ajo.2010.11.008","volume":"151","author":"C Engler","year":"2011","unstructured":"Engler C, Chakravarti S, Doyle J, Eberhart CG, Meng H, Stark WJ et al (2011) Transforming growth factor-\u03b2 signaling pathway activation in Keratoconus. Am J Ophthalmol 151(5):752\u20139.e2","journal-title":"Am J Ophthalmol"},{"issue":"10","key":"3071_CR28","volume":"11","author":"XD Hao","year":"2016","unstructured":"Hao XD, Chen ZL, Qu ML, Zhao XW, Li SX, Chen P (2016) Decreased integrity, content, and increased transcript level of mitochondrial DNA are associated with keratoconus. PLoS ONE 11(10):e0165580","journal-title":"PLoS ONE"},{"issue":"3","key":"3071_CR29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1167\/iovs.04-0549","volume":"46","author":"MC Kenney","year":"2005","unstructured":"Kenney MC, Chwa M, Atilano SR, Tran A, Carballo M, Saghizadeh M et al (2005) Increased levels of catalase and cathepsin V\/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder. Invest Ophthalmol Vis Sci 46(3):823\u2013832","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"3071_CR30","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1167\/iovs.18-24267","volume":"59","author":"ML Khaled","year":"2018","unstructured":"Khaled ML, Bykhovskaya Y, Yablonski SER, Li H, Drewry MD, Aboobakar IF et al (2018) Differential expression of coding and long noncoding RNAs in keratoconus-affected corneas. Invest Ophthalmol Vis Sci 59(7):2717\u20132728","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"3071_CR31","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1167\/iovs.10-70981","volume":"52","author":"M Mac\u00e9","year":"2011","unstructured":"Mac\u00e9 M, Galiacy SD, Erraud A, Mej\u00eda JE, Etchevers H, Allouche M et al (2011) Comparative transcriptome and network biology analyses demonstrate antiproliferative and hyperapoptotic phenotypes in human keratoconus corneas. Invest Ophthalmol Vis Sci 52(9):6181\u20136191","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"3071_CR32","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/ejhg.2017.4","volume":"25","author":"M Kabza","year":"2017","unstructured":"Kabza M, Karolak JA, Rydzanicz M, Szcze\u015bniak MW, Nowak DM, Ginter-Matuszewska B et al (2017) Collagen synthesis disruption and downregulation of core elements of TGF-\u03b2, Hippo, and Wnt pathways in keratoconus corneas. Eur J Hum Genet EJHG 25(5):582\u2013590","journal-title":"Eur J Hum Genet EJHG"},{"issue":"4","key":"3071_CR33","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1167\/iovs.04-1148","volume":"46","author":"YS Rabinowitz","year":"2005","unstructured":"Rabinowitz YS, Dong L, Wistow G (2005) Gene expression profile studies of human keratoconus cornea for NEIBank: a novel cornea-expressed gene and the absence of transcripts for aquaporin 5. Invest Ophthalmol Vis Sci 46(4):1239\u20131246","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"3071_CR34","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/exer.2001.1028","volume":"73","author":"M Saghizadeh","year":"2001","unstructured":"Saghizadeh M, Chwa M, Aoki A, Lin B, Pirouzmanesh A, Brown DJ et al (2001) Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas. Exp Eye Res 73(2):179\u2013189","journal-title":"Exp Eye Res"},{"issue":"1","key":"3071_CR35","doi-asserted-by":"crossref","first-page":"9907","DOI":"10.1038\/s41598-020-66735-x","volume":"10","author":"V Shinde","year":"2020","unstructured":"Shinde V, Hu N, Mahale A, Maiti G, Daoud Y, Eberhart CG et al (2020) RNA sequencing of corneas from two keratoconus patient groups identifies potential biomarkers and decreased NRF2-antioxidant responses. Sci Rep 10(1):9907","journal-title":"Sci Rep"},{"issue":"2","key":"3071_CR36","first-page":"201","volume":"12","author":"YN Wang","year":"2019","unstructured":"Wang YN, Liu XN, Wang XD, Yin Y, Chen Y, Xiao XH et al (2019) Expression of visual system homeobox 1 in human keratoconus. Int J Ophthalmol 12(2):201\u2013206","journal-title":"Int J Ophthalmol"},{"issue":"2","key":"3071_CR37","first-page":"529","volume":"38","author":"RB Whitelock","year":"1997","unstructured":"Whitelock RB, Fukuchi T, Zhou L, Twining SS, Sugar J, Feder RS et al (1997) Cathepsin G, acid phosphatase, and alpha 1-proteinase inhibitor messenger RNA levels in keratoconus corneas. Invest Ophthalmol Vis Sci 38(2):529\u2013534","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"3071_CR38","first-page":"419","volume":"38","author":"G Zhao","year":"2002","unstructured":"Zhao G, Wang C, Sun W, Zhang W, Li Y, Sheng H et al (2002) The expression of protein betaig-h3 inducible by transforming growth factor-beta in keratoconus and normal cornea. Chin J Ophthalmol 38(7):419\u2013421","journal-title":"Chin J Ophthalmol"},{"issue":"11","key":"3071_CR39","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/tvst.10.11.6","volume":"10","author":"DM Nowak-Malczewska","year":"2021","unstructured":"Nowak-Malczewska DM, Karolak JA, Swierkowska J, Jaworska MM, Kulinska KI, Polakowski P et al (2021) Changes in nuclear gene expression related to mitochondrial function affect extracellular matrix, collagens, and focal adhesion in keratoconus. Transl Vis Sci Technol 10(11):6","journal-title":"Transl Vis Sci Technol"},{"key":"3071_CR40","doi-asserted-by":"crossref","first-page":"e9793","DOI":"10.7717\/peerj.9793","volume":"8","author":"JA Karolak","year":"2020","unstructured":"Karolak JA, Ginter-Matuszewska B, Tomela K, Kabza M, Nowak-Malczewska DM, Rydzanicz M et al (2020) Further evaluation of differential expression of keratoconus candidate genes in human corneas. PeerJ 8:e9793","journal-title":"PeerJ"},{"issue":"7","key":"3071_CR41","doi-asserted-by":"crossref","first-page":"900","DOI":"10.3109\/02713683.2015.1078361","volume":"41","author":"A Sarker-Nag","year":"2016","unstructured":"Sarker-Nag A, Hutcheon AE, Karamichos D (2016) Mitochondrial profile and responses to TGF-\u03b2 ligands in keratoconus. Curr Eye Res 41(7):900\u2013907","journal-title":"Curr Eye Res"},{"issue":"1","key":"3071_CR42","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/jovr.jovr_80_18","volume":"14","author":"SR Atilano","year":"2019","unstructured":"Atilano SR, Lee DH, Fukuhara PS, Chwa M, Nesburn AB, Udar N et al (2019) Corneal oxidative damage in keratoconus cells due to decreased oxidant elimination from modified expression levels of SOD enzymes, PRDX6, SCARA3, CPSF3, and FOXM1. J Ophthalmic Vis Res 14(1):62\u201370","journal-title":"J Ophthalmic Vis Res"},{"issue":"3","key":"3071_CR43","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/exer.1998.0604","volume":"68","author":"S Chiplunkar","year":"1999","unstructured":"Chiplunkar S, Chamblis K, Chwa M, Rosenberg S, Kenney MC, Brown DJ (1999) Enhanced expression of a transmembrane phosphotyrosine phosphatase (LAR) in keratoconus cultures and corneas. Exp Eye Res 68(3):283\u2013293","journal-title":"Exp Eye Res"},{"issue":"18","key":"3071_CR44","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1177\/1535370216650940","volume":"241","author":"G Du","year":"2016","unstructured":"Du G, Liu C, Li X, Chen W, He R, Wang X et al (2016) Induction of matrix metalloproteinase-1 by tumor necrosis factor-\u03b1 is mediated by interleukin-6 in cultured fibroblasts of keratoconus. Exp Biol Med (Maywood) 241(18):2033\u20132041","journal-title":"Exp Biol Med (Maywood)"},{"issue":"6","key":"3071_CR45","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1167\/iovs.15-16692","volume":"57","author":"B Garc\u00eda","year":"2016","unstructured":"Garc\u00eda B, Garc\u00eda-Su\u00e1rez O, Merayo-Lloves J, Alcalde I, Alfonso JF, Fern\u00e1ndez-Vega Cueto L et al (2016) Differential expression of proteoglycans by corneal stromal cells in keratoconus. Invest Ophthalmol Vis Sci 57(6):2618\u20132628","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3071_CR46","doi-asserted-by":"crossref","first-page":"3502386","DOI":"10.1155\/2017\/3502386","volume":"2017","author":"B Garc\u00eda","year":"2017","unstructured":"Garc\u00eda B, Garc\u00eda-Su\u00e1rez O, Merayo-Lloves J, Ferrara G, Alcalde I, Gonz\u00e1lez J et al (2017) Heparanase overexpresses in keratoconic cornea and tears depending on the pathologic grade. Dis Markers 2017:3502386","journal-title":"Dis Markers"},{"issue":"6","key":"3071_CR47","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/02713680490502201","volume":"28","author":"NT Ha","year":"2004","unstructured":"Ha NT, Nakayasu K, Murakami A, Ishidoh K, Kanai A (2004) Microarray analysis identified differentially expressed genes in keratocytes from keratoconus patients. Curr Eye Res 28(6):373\u2013379","journal-title":"Curr Eye Res"},{"issue":"7","key":"3071_CR48","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1167\/iovs.11-9062","volume":"53","author":"R Joseph","year":"2012","unstructured":"Joseph R, Srivastava OP, Pfister RR (2012) Downregulation of \u03b2-actin gene and human antigen R in human keratoconus. Invest Ophthalmol Vis Sci 53(7):4032\u20134041","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3071_CR49","first-page":"2480","volume":"15","author":"JE Lee","year":"2009","unstructured":"Lee JE, Oum BS, Choi HY, Lee SU, Lee JS (2009) Evaluation of differentially expressed genes identified in keratoconus. Mol Vis 15:2480\u20132487","journal-title":"Mol Vis"},{"key":"3071_CR50","first-page":"706","volume":"15","author":"VV Mootha","year":"2009","unstructured":"Mootha VV, Kanoff JM, Shankardas J, Dimitrijevich S (2009) Marked reduction of alcohol dehydrogenase in keratoconus corneal fibroblasts. Mol Vis 15:706\u2013712","journal-title":"Mol Vis"},{"issue":"5","key":"3071_CR51","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000267325","volume":"25","author":"DP Peters","year":"1993","unstructured":"Peters DP, Harrison DA, Brandt CR (1993) Heterogeneity of type I collagen expression in human corneal keratoconus fibroblasts. Ophthalmic Res 25(5):273\u2013279","journal-title":"Ophthalmic Res"},{"key":"3071_CR52","first-page":"577","volume":"21","author":"S Priyadarsini","year":"2015","unstructured":"Priyadarsini S, McKay TB, Sarker-Nag A, Karamichos D (2015) Keratoconus in vitro and the key players of the TGF-\u03b2 pathway. Mol Vis 21:577\u2013588","journal-title":"Mol Vis"},{"key":"3071_CR53","first-page":"2501","volume":"19","author":"S Saee-Rad","year":"2013","unstructured":"Saee-Rad S, Raoofian R, Mahbod M, Miraftab M, Mojarrad M, Asgari S et al (2013) Analysis of superoxide dismutase 1, dual-specificity phosphatase 1, and transforming growth factor, beta 1 genes expression in keratoconic and non-keratoconic corneas. Mol Vis 19:2501\u20132507","journal-title":"Mol Vis"},{"issue":"1","key":"3071_CR54","doi-asserted-by":"crossref","first-page":"12567","DOI":"10.1038\/s41598-019-48983-8","volume":"9","author":"R Sharif","year":"2019","unstructured":"Sharif R, Khaled ML, McKay TB, Liu Y, Karamichos D (2019) Transcriptional profiling of corneal stromal cells derived from patients with keratoconus. Sci Rep 9(1):12567","journal-title":"Sci Rep"},{"issue":"7","key":"3071_CR55","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/BF03401852","volume":"7","author":"K Wentz-Hunter","year":"2001","unstructured":"Wentz-Hunter K, Cheng EL, Ueda J, Sugar J, Yue BY (2001) Keratocan expression is increased in the stroma of keratoconus corneas. Mol Med (Cambridge, Mass) 7(7):470\u2013477","journal-title":"Mol Med (Cambridge, Mass)"},{"issue":"8","key":"3071_CR56","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1167\/iovs.63.8.7","volume":"63","author":"T Stachon","year":"2022","unstructured":"Stachon T, Nastaranpour M, Seitz B, Meese E, Latta L, Taneri S et al (2022) Altered regulation of mRNA and miRNA expression in epithelial and stromal tissue of keratoconus corneas. Invest Ophthalmol Vis Sci 63(8):7","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"3071_CR57","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.clae.2018.11.015","volume":"42","author":"B Ayan","year":"2019","unstructured":"Ayan B, Yuksel N, Carhan A, Gumu\u015fkaya Ocal B, Akcay E, Cagil N et al (2019) Evaluation estrogen, progesteron and androgen receptor expressions in corneal epithelium in keratoconus. Contact Lens Anterior Eye 42(5):492\u2013496","journal-title":"Contact Lens Anterior Eye"},{"issue":"6","key":"3071_CR58","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1167\/iovs.02-0671","volume":"44","author":"K Nielsen","year":"2003","unstructured":"Nielsen K, Birkenkamp-Demtr\u00f6der K, Ehlers N, Orntoft TF (2003) Identification of differentially expressed genes in keratoconus epithelium analyzed on microarrays. Invest Ophthalmol Vis Sci 44(6):2466\u20132476","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"13","key":"3071_CR59","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1167\/iovs.16-19677","volume":"57","author":"N Pahuja","year":"2016","unstructured":"Pahuja N, Kumar NR, Shroff R, Shetty R, Nuijts RM, Ghosh A et al (2016) Differential molecular expression of extracellular matrix and inflammatory genes at the corneal cone apex drives focal weakening in keratoconus. Invest Ophthalmol Vis Sci 57(13):5372\u20135382","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"3071_CR60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184628","volume":"12","author":"R Shetty","year":"2017","unstructured":"Shetty R, Sharma A, Pahuja N, Chevour P, Padmajan N, Dhamodaran K et al (2017) Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients. PLoS ONE 12(9):e0184628","journal-title":"PLoS ONE"},{"key":"3071_CR61","first-page":"12","volume":"21","author":"R Shetty","year":"2015","unstructured":"Shetty R, Sathyanarayanamoorthy A, Ramachandra RA, Arora V, Ghosh A, Srivatsa PR et al (2015) Attenuation of lysyl oxidase and collagen gene expression in keratoconus patient corneal epithelium corresponds to disease severity. Mol Vis 21:12\u201325","journal-title":"Mol Vis"},{"issue":"1","key":"3071_CR62","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/tvst.8.1.2","volume":"8","author":"R Shetty","year":"2019","unstructured":"Shetty R, Vunnava KP, Dhamodaran K, Matalia H, Murali S, Jayadev C et al (2019) Characterization of corneal epithelial cells in keratoconus. Transl Vis Sci Technol 8(1):2","journal-title":"Transl Vis Sci Technol"},{"issue":"1","key":"3071_CR63","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1442-9071.2009.02216.x","volume":"38","author":"G Sutton","year":"2010","unstructured":"Sutton G, Madigan M, Roufas A, McAvoy J (2010) Secreted frizzled-related protein 1 (SFRP1) is highly upregulated in keratoconus epithelium: a novel finding highlighting a new potential focus for keratoconus research and treatment. Clin Exp Ophthalmol 38(1):43\u201348","journal-title":"Clin Exp Ophthalmol"},{"issue":"1","key":"3071_CR64","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41598-017-18480-x","volume":"8","author":"J You","year":"2018","unstructured":"You J, Corley SM, Wen L, Hodge C, H\u00f6llhumer R, Madigan MC et al (2018) RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients. Sci Rep 8(1):389","journal-title":"Sci Rep"},{"issue":"6","key":"3071_CR65","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/iovs.62.6.16","volume":"62","author":"JW Foster","year":"2021","unstructured":"Foster JW, Parikh RN, Wang J, Bower KS, Matthaei M, Chakravarti S et al (2021) Transcriptomic and immunohistochemical analysis of progressive keratoconus reveal altered WNT10A in epithelium and Bowman\u2019s layer. Invest Ophthalmol Vis Sci 62(6):16","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"3071_CR66","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1167\/iovs.14-14831","volume":"56","author":"R Shetty","year":"2015","unstructured":"Shetty R, Ghosh A, Lim RR, Subramani M, Mihir K, Reshma AR et al (2015) Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients is inhibited by cyclosporine A. Invest Ophthalmol Vis Sci 56(2):738\u2013750","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3071_CR67","volume":"13","author":"X Sun","year":"2022","unstructured":"Sun X, Zhang H, Shan M, Dong Y, Zhang L, Chen L et al (2022) Comprehensive transcriptome analysis of patients with keratoconus highlights the regulation of immune responses and inflammatory processes. Front Genet 13:782709","journal-title":"Front Genet"},{"key":"3071_CR68","doi-asserted-by":"crossref","unstructured":"Regueiro U, L\u00f3pez-L\u00f3pez M, Hervella P, Sobrino T, Lema I 2021 Corneal and conjunctival alteration of innate immune expression in first-degree relatives of keratoconus patients. Graefe's Arch Clin Exp Ophthalmol 259(2):459\u201367.","DOI":"10.1007\/s00417-020-04929-9"},{"issue":"10","key":"3071_CR69","doi-asserted-by":"crossref","first-page":"e0273807","DOI":"10.1371\/journal.pone.0273807","volume":"17","author":"T Lupasco","year":"2022","unstructured":"Lupasco T, He Z, Cassagne M, Sagnial T, Brion L, Fourni\u00e9 P et al (2022) Corneal epithelium in keratoconus underexpresses active NRF2 and a subset of oxidative stress-related genes. PLoS ONE 17(10):e0273807","journal-title":"PLoS ONE"},{"key":"3071_CR70","doi-asserted-by":"crossref","first-page":"1543742","DOI":"10.1155\/2022\/1543742","volume":"2022","author":"V Navel","year":"2022","unstructured":"Navel V, Malecaze J, Belville C, Choltus H, Henrioux F, Dutheil F et al (2022) Dysregulation of receptor for advanced glycation end products (RAGE) expression as a biomarker of keratoconus. Dis Markers 2022:1543742","journal-title":"Dis Markers"},{"issue":"5","key":"3071_CR71","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1080\/02713683.2022.2025846","volume":"47","author":"E Y\u0131ld\u0131z","year":"2022","unstructured":"Y\u0131ld\u0131z E, Aydemir D, Zibandeh N, Ku\u015fan E, G\u00fcm\u00fc\u015f K, \u0130lhan Sara\u00e7 \u00d6 et al (2022) Investigation of mitophagy biomarkers in corneal epithelium of keratoconus patients. Curr Eye Res 47(5):661\u2013669","journal-title":"Curr Eye Res"},{"issue":"6","key":"3071_CR72","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.survophthal.2017.06.009","volume":"62","author":"V Mas Tur","year":"2017","unstructured":"Mas Tur V, MacGregor C, Jayaswal R, O\u2019Brart D, Maycock N (2017) A review of keratoconus: diagnosis, pathophysiology, and genetics. Surv Ophthalmol 62(6):770\u2013783","journal-title":"Surv Ophthalmol"},{"key":"3071_CR73","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108398","volume":"202","author":"Y Bykhovskaya","year":"2021","unstructured":"Bykhovskaya Y, Rabinowitz YS (2021) Update on the genetics of keratoconus. Exp Eye Res 202:108398","journal-title":"Exp Eye Res"},{"key":"3071_CR74","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-vision-121219-081723","volume":"6","author":"SEM Lucas","year":"2020","unstructured":"Lucas SEM, Burdon KP (2020) Genetic and environmental risk factors for keratoconus. Ann Rev Vis Sci 6:25\u201346","journal-title":"Ann Rev Vis Sci"},{"issue":"1","key":"3071_CR75","first-page":"109","volume":"37","author":"Y Bykhovskaya","year":"2016","unstructured":"Bykhovskaya Y, Li X, Taylor KD, Haritunians T, Rotter JI, Rabinowitz YS (2016) Linkage analysis of high-density SNPs confirms keratoconus locus at 5q chromosomal region. Ophthalmic Genet 37(1):109\u2013110","journal-title":"Ophthalmic Genet"},{"issue":"3","key":"3071_CR76","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1167\/iovs.08-2382","volume":"50","author":"L Bisceglia","year":"2009","unstructured":"Bisceglia L, De Bonis P, Pizzicoli C, Fischetti L, Laborante A, Di Perna M et al (2009) Linkage analysis in keratoconus: replication of locus 5q21.2 and identification of other suggestive Loci. Investig Ophthalmol Vis Sci 50(3):1081\u20131086","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"6","key":"3071_CR77","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1001\/jamaophthalmol.2022.0891","volume":"140","author":"W He","year":"2022","unstructured":"He W, Han X, Ong JS, Hewitt AW, Mackey DA, Gharahkhani P et al (2022) Association of novel loci with keratoconus susceptibility in a multitrait genome-wide association study of the UK Biobank database and Canadian longitudinal study on aging. JAMA Ophthalmol 140(6):568\u2013576","journal-title":"JAMA Ophthalmol"},{"issue":"1","key":"3071_CR78","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s42003-021-01784-0","volume":"4","author":"AJ Hardcastle","year":"2021","unstructured":"Hardcastle AJ, Liskova P, Bykhovskaya Y, McComish BJ, Davidson AE, Inglehearn CF et al (2021) A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus. Commun Biol 4(1):266","journal-title":"Commun Biol"},{"key":"3071_CR79","first-page":"270","volume":"27","author":"L Xu","year":"2021","unstructured":"Xu L, Yang K, Fan Q, Zhao D, Pang C, Ren S (2021) Whole mitochondrial genome analysis in Chinese patients with keratoconus. Mol Vis 27:270\u2013282","journal-title":"Mol Vis"},{"issue":"1","key":"3071_CR80","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s12886-017-0567-3","volume":"17","author":"T Guan","year":"2017","unstructured":"Guan T, Wang X, Zheng LB, Wu HJ, Yao YF (2017) Analysis of the VSX1 gene in sporadic keratoconus patients from China. BMC Ophthalmol 17(1):173","journal-title":"BMC Ophthalmol"},{"issue":"6","key":"3071_CR81","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/09286586.2021.1879173","volume":"28","author":"T Jurkiewicz","year":"2021","unstructured":"Jurkiewicz T, Marty AS (2021) Correlation between keratoconus and pollution. Ophthalmic Epidemiol 28(6):495\u2013501","journal-title":"Ophthalmic Epidemiol"},{"issue":"3","key":"3071_CR82","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jtos.2020.03.006","volume":"18","author":"G Ferrari","year":"2020","unstructured":"Ferrari G, Rama P (2020) The keratoconus enigma: A review with emphasis on pathogenesis. Ocul Surf 18(3):363\u2013373","journal-title":"Ocul Surf"},{"issue":"2","key":"3071_CR83","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cyto.2013.07.022","volume":"64","author":"C Gu","year":"2013","unstructured":"Gu C, Wu L, Li X (2013) IL-17 family: cytokines, receptors and signaling. Cytokine 64(2):477\u2013485","journal-title":"Cytokine"},{"issue":"10","key":"3071_CR84","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.4049\/jimmunol.169.10.5897","volume":"169","author":"J Maertzdorf","year":"2002","unstructured":"Maertzdorf J, Osterhaus AD, Verjans GM (2002) IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. J Immunol (Baltimore, Md: 1950) 169(10):5897\u20135903","journal-title":"J Immunol (Baltimore, Md: 1950)"},{"issue":"12","key":"3071_CR85","first-page":"2795","volume":"42","author":"JW Hong","year":"2001","unstructured":"Hong JW, Liu JJ, Lee JS, Mohan RR, Mohan RR, Woods DJ et al (2001) Proinflammatory chemokine induction in keratocytes and inflammatory cell infiltration into the cornea. Invest Ophthalmol Vis Sci 42(12):2795\u20132803","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"3071_CR86","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1080\/09273948.2017.1316411","volume":"26","author":"A Hou","year":"2018","unstructured":"Hou A, Tong L (2018) Expression, regulation, and effects of Interleukin-17f in the human ocular surface. Ocul Immunol Inflamm 26(7):1069\u20131077","journal-title":"Ocul Immunol Inflamm"},{"issue":"1","key":"3071_CR87","doi-asserted-by":"crossref","first-page":"55","DOI":"10.18388\/abp.2014_1923","volume":"61","author":"KA Wojcik","year":"2014","unstructured":"Wojcik KA, Blasiak J, Szaflik J, Szaflik JP (2014) Role of biochemical factors in the pathogenesis of keratoconus. Acta Biochim Pol 61(1):55\u201362","journal-title":"Acta Biochim Pol"},{"key":"3071_CR88","doi-asserted-by":"crossref","first-page":"1243819","DOI":"10.1155\/2016\/1243819","volume":"2016","author":"C Ionescu","year":"2016","unstructured":"Ionescu C, Corbu CG, Tanase C, Jonescu-Cuypers C, Nicula C, Dascalescu D et al (2016) Inflammatory biomarkers profile as microenvironmental expression in keratoconus. Dis Markers 2016:1243819","journal-title":"Dis Markers"},{"issue":"1","key":"3071_CR89","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ejhg.2016.130","volume":"25","author":"JA Karolak","year":"2017","unstructured":"Karolak JA, Gambin T, Pitarque JA, Molinari A, Jhangiani S, Stankiewicz P et al (2017) Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing. Eur J Hum Genet 25(1):73\u201378","journal-title":"Eur J Hum Genet"},{"issue":"11","key":"3071_CR90","doi-asserted-by":"crossref","first-page":"7165","DOI":"10.1007\/s11033-021-06708-z","volume":"48","author":"IB Gomes","year":"2021","unstructured":"Gomes IB, Ayo CM, Lopes AG, Kumano LS, de Faria Junior GM, de Almeida Jr GC et al (2021) Mol Biol Rep 48(11):7165\u20137170","journal-title":"Mol Biol Rep"},{"issue":"1","key":"3071_CR91","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.molmed.2017.11.002","volume":"24","author":"A Annibaldi","year":"2018","unstructured":"Annibaldi A, Meier P (2018) Checkpoints in TNF-induced cell death: implications in inflammation and cancer. Trends Mol Med 24(1):49\u201365","journal-title":"Trends Mol Med"},{"issue":"17","key":"3071_CR92","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1016\/j.cell.2021.07.026","volume":"184","author":"J Taft","year":"2021","unstructured":"Taft J, Markson M, Legarda D, Patel R, Chan M, Malle L et al (2021) Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death. Cell 184(17):4447\u201363.e20","journal-title":"Cell"},{"issue":"2","key":"3071_CR93","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41590-021-01110-0","volume":"23","author":"L Zhou","year":"2022","unstructured":"Zhou L, Zhou W, Joseph AM, Chu C, Putzel GG, Fang B et al (2022) Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation. Nat Immunol 23(2):251\u2013261","journal-title":"Nat Immunol"},{"issue":"4","key":"3071_CR94","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ophtha.2004.11.050","volume":"112","author":"I Lema","year":"2005","unstructured":"Lema I, Dur\u00e1n JA (2005) Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology 112(4):654\u2013659","journal-title":"Ophthalmology"},{"issue":"13","key":"3071_CR95","first-page":"1314","volume":"44","author":"JA Duran","year":"2003","unstructured":"Duran JA, Lema I (2003) Inflammatory markers in keratoconus. Investig Ophthalmol Vis Sci 44(13):1314","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"1","key":"3071_CR96","doi-asserted-by":"crossref","first-page":"e16437","DOI":"10.1371\/journal.pone.0016437","volume":"6","author":"AS Jun","year":"2011","unstructured":"Jun AS, Cope L, Speck C, Feng X, Lee S, Meng H et al (2011) Subnormal cytokine profile in the tear fluid of keratoconus patients. PLoS ONE 6(1):e16437","journal-title":"PLoS ONE"},{"key":"3071_CR97","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4103\/jrms.jrms_35_21","volume":"26","author":"A Peyman","year":"2021","unstructured":"Peyman A, Namgar M, Feizi A, Hakemi MG, Nasab FH, Pourazizi M (2021) Interleukin-6 and tumor necrosis factor-\u03b1 levels in tear film of Keratoconus patients. J Res Med Sci 26:75","journal-title":"J Res Med Sci"},{"issue":"2","key":"3071_CR98","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/cxo.12025","volume":"96","author":"IM Cheung","year":"2013","unstructured":"Cheung IM, McGhee CN, Sherwin T (2013) A new perspective on the pathobiology of keratoconus: interplay of stromal wound healing and reactive species-associated processes. Clin Exp Optom 96(2):188\u2013196","journal-title":"Clin Exp Optom"},{"issue":"4","key":"3071_CR99","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/00003226-199907000-00011","volume":"18","author":"M Nakamura","year":"1999","unstructured":"Nakamura M, Nishida T (1999) Differential effects of epidermal growth factor and interleukin 6 on corneal epithelial cells and vascular endothelial cells. Cornea 18(4):452\u2013458","journal-title":"Cornea"},{"issue":"12","key":"3071_CR100","doi-asserted-by":"crossref","first-page":"8549","DOI":"10.1167\/iovs.11-7956","volume":"52","author":"N Ebihara","year":"2011","unstructured":"Ebihara N, Matsuda A, Nakamura S, Matsuda H, Murakami A (2011) Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing. Invest Ophthalmol Vis Sci 52(12):8549\u20138557","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"3071_CR101","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00003226-200203000-00017","volume":"21","author":"RM Kaldawy","year":"2002","unstructured":"Kaldawy RM, Wagner J, Ching S, Seigel GM (2002) Evidence of apoptotic cell death in keratoconus. Cornea 21(2):206\u2013209","journal-title":"Cornea"},{"issue":"4","key":"3071_CR102","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1006\/exer.1996.0038","volume":"62","author":"SE Wilson","year":"1996","unstructured":"Wilson SE, He YG, Weng J, Li Q, McDowall AW, Vital M et al (1996) Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing. Exp Eye Res 62(4):325\u2013327","journal-title":"Exp Eye Res"},{"issue":"8","key":"3071_CR103","first-page":"1582","volume":"37","author":"SE Wilson","year":"1996","unstructured":"Wilson SE, Li Q, Weng J, Barry-Lane PA, Jester JV, Liang Q et al (1996) The Fas-Fas ligand system and other modulators of apoptosis in the cornea. Invest Ophthalmol Vis Sci 37(8):1582\u20131592","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3071_CR104","first-page":"656","volume":"27","author":"GS Moura","year":"2021","unstructured":"Moura GS, Santos A, Cenedeze MA, Hiyane MI, Camara NOS, Barbosa de Sousa L et al (2021) Increased lacrimal inflammatory mediators in patients with keratoconus. Mol Vis 27:656\u2013665","journal-title":"Mol Vis"},{"issue":"11","key":"3071_CR105","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.4103\/ijo.IJO_838_17","volume":"65","author":"P Garg","year":"2017","unstructured":"Garg P (2017) Altered tear inflammatory profile in Indian keratoconus patients. Indian J Ophthalmol 65(11):1073\u20131074","journal-title":"Indian J Ophthalmol"},{"issue":"3","key":"3071_CR106","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10384-011-0002-x","volume":"55","author":"S Sugaya","year":"2011","unstructured":"Sugaya S, Sakimoto T, Shoji J, Sawa M (2011) Regulation of soluble interleukin-6 (IL-6) receptor release from corneal epithelial cells and its role in the ocular surface. Jpn J Ophthalmol 55(3):277\u2013282","journal-title":"Jpn J Ophthalmol"},{"issue":"2","key":"3071_CR107","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/bjo.85.2.147","volume":"85","author":"VA Smith","year":"2001","unstructured":"Smith VA, Rishmawi H, Hussein H, Easty DL (2001) Tear film MMP accumulation and corneal disease. Br J Ophthalmol 85(2):147\u2013153","journal-title":"Br J Ophthalmol"},{"issue":"12","key":"3071_CR108","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1093\/rheumatology\/keh369","volume":"43","author":"J Hulkkonen","year":"2004","unstructured":"Hulkkonen J, Pertovaara M, Antonen J, Pasternack A, Hurme M, P\u00f6ll\u00e4nen P et al (2004) Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren\u2019s syndrome. Rheumatology (Oxford) 43(12):1476\u20131479","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"3071_CR109","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10792-019-01149-x","volume":"40","author":"M Mutlu","year":"2020","unstructured":"Mutlu M, Sarac O, Ca\u011f\u0131l N, Avc\u0131o\u011flu G (2020) Relationship between tear eotaxin-2 and MMP-9 with ocular allergy and corneal topography in keratoconus patients. Int Ophthalmol 40(1):51\u201357","journal-title":"Int Ophthalmol"},{"issue":"4","key":"3071_CR110","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1006\/exer.2001.1054","volume":"73","author":"DQ Li","year":"2001","unstructured":"Li DQ, Lokeshwar BL, Solomon A, Monroy D, Ji Z, Pflugfelder SC (2001) Regulation of MMP-9 production by human corneal epithelial cells. Exp Eye Res 73(4):449\u2013459","journal-title":"Exp Eye Res"},{"issue":"4","key":"3071_CR111","doi-asserted-by":"crossref","first-page":"e303","DOI":"10.1111\/j.1755-3768.2011.02369.x","volume":"90","author":"SA Balasubramanian","year":"2012","unstructured":"Balasubramanian SA, Mohan S, Pye DC, Willcox MD (2012) Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus. Acta Ophthalmol 90(4):e303\u2013e309","journal-title":"Acta Ophthalmol"},{"key":"3071_CR112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pmbts.2017.02.005","volume":"147","author":"N Cui","year":"2017","unstructured":"Cui N, Hu M, Khalil RA (2017) Biochemical and biological attributes of matrix metalloproteinases. Prog Mol Biol Transl Sci 147:1\u201373","journal-title":"Prog Mol Biol Transl Sci"},{"key":"3071_CR113","first-page":"20","volume":"270","author":"A Zilfyan","year":"2017","unstructured":"Zilfyan A, Abovyan A (2017) A new approach to keratoconus diagnostics using matrix metalloproteinase-9 marker. Georgian Med News 270:20\u201324","journal-title":"Georgian Med News"},{"issue":"1","key":"3071_CR114","doi-asserted-by":"crossref","first-page":"12975","DOI":"10.1038\/s41598-017-13525-7","volume":"7","author":"T Sobrino","year":"2017","unstructured":"Sobrino T, Regueiro U, Malfeito M, Vieites-Prado A, P\u00e9rez-Mato M, Campos F et al (2017) Higher expression of toll-like receptors 2 and 4 in blood cells of keratoconus patiens. Sci Rep 7(1):12975","journal-title":"Sci Rep"},{"issue":"6","key":"3071_CR115","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1136\/bjo.2008.144253","volume":"93","author":"I Lema","year":"2009","unstructured":"Lema I, Sobrino T, Dur\u00e1n JA, Brea D, D\u00edez-Feijoo E (2009) Subclinical keratoconus and inflammatory molecules from tears. Br J Ophthalmol 93(6):820\u2013824","journal-title":"Br J Ophthalmol"},{"key":"3071_CR116","doi-asserted-by":"crossref","first-page":"108734","DOI":"10.1016\/j.exer.2021.108734","volume":"211","author":"AL Daphne Teh","year":"2021","unstructured":"Daphne Teh AL, Jayapalan JJ, Loke MF, Wan Abdul Kadir AJ, Subrayan V (2021) Identification of potential serum metabolic biomarkers for patient with keratoconus using untargeted metabolomics approach. Exp Eye Res 211:108734","journal-title":"Exp Eye Res"},{"issue":"2","key":"3071_CR117","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3390\/cells11020224","volume":"11","author":"TB McKay","year":"2022","unstructured":"McKay TB, Priyadarsini S, Karamichos D (2022) Sex hormones, growth hormone, and the cornea. Cells 11(2):224","journal-title":"Cells"},{"issue":"1","key":"3071_CR118","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1076\/ceyr.22.1.28.6980","volume":"22","author":"T Suzuki","year":"2001","unstructured":"Suzuki T, Kinoshita Y, Tachibana M, Matsushima Y, Kobayashi Y, Adachi W et al (2001) Expression of sex steroid hormone receptors in human cornea. Curr Eye Res 22(1):28\u201333","journal-title":"Curr Eye Res"},{"issue":"2","key":"3071_CR119","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3390\/ijms23020916","volume":"23","author":"P Escandon","year":"2022","unstructured":"Escandon P, Nicholas SE, Cunningham RL, Murphy DA, Riaz KM, Karamichos D (2022) The role of estriol and estrone in keratoconic stromal sex hormone receptors. Int J Mol Sci 23(2):916","journal-title":"Int J Mol Sci"},{"key":"3071_CR120","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.101016","volume":"88","author":"D Karamichos","year":"2022","unstructured":"Karamichos D, Escandon P, Vasini B, Nicholas SE, Van L, Dang DH et al (2022) Anterior pituitary, sex hormones, and keratoconus: beyond traditional targets. Prog Retin Eye Res 88:101016","journal-title":"Prog Retin Eye Res"},{"key":"3071_CR121","volume":"9","author":"X Zhao","year":"2022","unstructured":"Zhao X, Yuan Y, Sun T, Zhang Y, Chen Y (2022) Associations between keratoconus and the level of sex hormones: a cross-sectional study. Front Med 9:828233","journal-title":"Front Med"},{"issue":"1","key":"3071_CR122","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/ICO.0b013e3181ac0518","volume":"29","author":"BA Fink","year":"2010","unstructured":"Fink BA, Sinnott LT, Wagner H, Friedman C, Zadnik K (2010) The influence of gender and hormone status on the severity and progression of keratoconus. Cornea 29(1):65\u201372","journal-title":"Cornea"},{"key":"3071_CR123","doi-asserted-by":"crossref","first-page":"42896","DOI":"10.1038\/srep42896","volume":"7","author":"TB McKay","year":"2017","unstructured":"McKay TB, Hjortdal J, Sejersen H, Karamichos D (2017) Differential effects of hormones on cellular metabolism in keratoconus in vitro. Sci Rep 7:42896","journal-title":"Sci Rep"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-024-03071-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-024-03071-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-024-03071-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T15:38:35Z","timestamp":1741880315000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-024-03071-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,21]]},"references-count":123,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3071"],"URL":"https:\/\/doi.org\/10.1007\/s10792-024-03071-3","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,21]]},"assertion":[{"value":"11 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Need for approval from ethics was waived.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"244"}}