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Studies that reported on risks, visual and ocular biometric effects of OK in patients\u2009&gt;\u20095\u00a0years of age with myopia (\u2212\u20090.75 to \u2212\u20096.00D) were included. Main outcomes are change in axial length and any adverse event.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Fourty-five papers were included in this systematic review and meta-analysis. The quality of data was variable and of moderate certainty, and selection bias likely skewed the results towards a relative benefit for OK. The rate of axial elongation in children was lower for OK treatment compared to other treatment modalities at one year (MD \u2212\u20090.16\u00a0mm, 95% CI \u2212\u20090.25 to \u2212\u20090.07). Rate of change in axial length in children rebounded after OK discontinuation compared to participants who continued treatment (MD 0.10\u00a0mm, 95% CI 0.06 to 0.14). Adults and children wearing OK were up to 3.79 times more likely to experience an adverse event when compared with conventional contact lenses (OR 3.79, 95% CI 1.24 to ll.), though this evidence base is underdeveloped and requires additional well-designed studies for substantial conclusions to be drawn.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>OK arrests myopia progression while in use, however, there remain unanswered questions about the optimal duration of treatment, discontinuation effects and long-term risk for adverse events.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10792-024-03175-w","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T08:01:58Z","timestamp":1718956918000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Benefits and risks of orthokeratology treatment: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"44","author":[{"given":"Lauren","family":"Sartor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien S.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai Linh","family":"Vo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chameen","family":"Samarawickrama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"issue":"4","key":"3175_CR1","doi-asserted-by":"publisher","first-page":"455","DOI":"10.4103\/0975-2870.186048","volume":"9","author":"KR Bhatnagar","year":"2016","unstructured":"Bhatnagar KR (2016) Childhood blindness: a priority eye disease. 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