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This study investigates the features differentiating OC from IFOI on magnetic resonance imaging (MRI).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Retrospective study of adult patients with sinogenic OC and IFOI with pre-intervention MRI. Patients without post-septal involvement, non-sinogenic OC (e.g.: secondary to trauma) and poor-quality scans were excluded. Independent Sample\u2019s <jats:italic>t<\/jats:italic> test and Fisher\u2019s exact test were conducted with <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 deemed statistically significant.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Eleven cases each of OC (Mean age: 41.6\u2009\u00b1\u200918.4\u00a0years-old, Male: 10) and IFOI (Mean age: 65.0\u2009\u00b1\u200916.6\u00a0years-old, Male: 9) between 2006 and 2023. IFOI patients were older, more likely immunocompromised and had a lower mean white-cell count (<jats:italic>p<\/jats:italic> value\u2009=\u20090.005, 0.035 and 0.017, respectively). The ethmoid and maxillary sinuses were most commonly involved in both entities. Pre-septal and lacrimal gland involvement were more common in OC (<jats:italic>p<\/jats:italic>\u2009=\u20090.001 and 0.008, respectively). Infiltrative OC orbital lesions were poorly demarcated, whilst those in IFOI were expansile\/mass-like invading the orbit from the adjacent paranasal sinuses. Specific IFOI features included loss-of-contrast-enhancement (LoCE) of paranasal sinus tissues with orbital extension. Extra-orbital and -sinonasal extension indicative of IFOI included contiguous skull base or pterygopalatine fossa involvement, retro-antral and masticator space stranding and vasculitis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This study describes the key MRI features of IFOI including differentiating markers from OC. These specific features, such as LoCE of the paranasal and orbital soft tissues, the location and pattern of contiguous soft-tissue involvement, provide expedient identification of IFOI which necessitate early surgical intervention for microbiological confirmation of an invasive fungal pathology.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10792-024-03241-3","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T06:02:00Z","timestamp":1720418520000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Radiological differentiation between bacterial orbital cellulitis and invasive fungal sino-orbital infections"],"prefix":"10.1007","volume":"44","author":[{"given":"Terence","family":"Ang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanyin","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viraj","family":"Chaggar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh","family":"Selva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"issue":"7","key":"3241_CR1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3390\/medicina55070319","volume":"55","author":"PG Deutsch","year":"2019","unstructured":"Deutsch PG, Whittaker J, Prasad S (2019) Invasive and non-invasive fungal rhinosinusitis-a review and update of the evidence. 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