{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:38:34Z","timestamp":1786981114220,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-024-03389-y","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T05:12:36Z","timestamp":1737695556000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Classification and treatment approach of chemical burn associated Limbal stem cell deficiency: based on novel global consensus"],"prefix":"10.1007","volume":"45","author":[{"given":"Ilayda","family":"Korkmaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozer","family":"Sakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melis","family":"Palamar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sait","family":"Egrilmez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Yagci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Barut Selver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"3389_CR1","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/S0039-6257(00)00109-0","volume":"44","author":"HS Dua","year":"2000","unstructured":"Dua HS, Azuara-Blanco A (2000) Limbal stem cells of the corneal epithelium. Surv Ophthalmol 44:415\u2013425","journal-title":"Surv Ophthalmol"},{"key":"3389_CR2","first-page":"83","volume":"48","author":"HS Dua","year":"2000","unstructured":"Dua HS, Saini JS, Azuara-Blanco A, Gupta P (2000) Limbal stem cell deficiency: concept, aetiology, clinical presentation, diagnosis and management. Indian J Ophthalmol 48:83\u201392","journal-title":"Indian J Ophthalmol"},{"key":"3389_CR3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/sj.cr.7310137","volume":"17","author":"W Li","year":"2007","unstructured":"Li W, Hayashida Y, Chen Y-T, Tseng SC (2007) Niche regulation of corneal epithelial stem cells at the limbus. Cell Res 17:26\u201336","journal-title":"Cell Res"},{"key":"3389_CR4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jtos.2017.11.002","volume":"16","author":"Q Le","year":"2018","unstructured":"Le Q, Xu J, Deng SX (2018) The diagnosis of limbal stem cell deficiency. Ocul Surf 16:58\u201369","journal-title":"Ocul Surf"},{"key":"3389_CR5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.4103\/0974-9233.106381","volume":"20","author":"K Sejpal","year":"2013","unstructured":"Sejpal K, Bakhtiari P, Deng SX (2013) Presentation, diagnosis and management of limbal stem cell deficiency. Middle East Afr J Ophthalmol 20:5","journal-title":"Middle East Afr J Ophthalmol"},{"key":"3389_CR6","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/ICO.0000000000001820","volume":"38","author":"SX Deng","year":"2019","unstructured":"Deng SX, Borderie V, Chan CC, Dana R, Figueiredo FC, Gomes JAP et al (2019) Global consensus on definition, classification, diagnosis, and staging of limbal stem cell deficiency. Cornea 38:364\u2013375","journal-title":"Cornea"},{"key":"3389_CR7","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1097\/ICO.0000000000002358","volume":"39","author":"SX Deng","year":"2020","unstructured":"Deng SX, Kruse F, Gomes JAP, Chan CC, Daya S, Dana R et al (2020) Global consensus on the management of limbal stem cell deficiency. Cornea 39:1291\u20131302","journal-title":"Cornea"},{"key":"3389_CR8","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1097\/ICO.0000000000002249","volume":"39","author":"Y Sun","year":"2020","unstructured":"Sun Y, Yung M, Huang L, Tseng C, Deng SX (2020) Limbal stem cell deficiency after glaucoma surgery. Cornea 39:566","journal-title":"Cornea"},{"key":"3389_CR9","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.ophtha.2023.01.016","volume":"130","author":"Y Oie","year":"2023","unstructured":"Oie Y, Sugita S, Yokokura S, Nakazawa T, Tomida D, Satake Y et al (2023) Clinical trial of autologous cultivated limbal epithelial cell sheet transplantation for patients with limbal stem cell deficiency. Ophthalmology 130:608\u2013614","journal-title":"Ophthalmology"},{"key":"3389_CR10","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jtos.2020.04.007","volume":"19","author":"WW Binotti","year":"2021","unstructured":"Binotti WW, Nos\u00e9 RM, Koseoglu ND, Dieckmann GM, Kenyon K, Hamrah P (2021) The utility of anterior segment optical coherence tomography angiography for the assessment of limbal stem cell deficiency. Ocul Surf 19:94\u2013103","journal-title":"Ocul Surf"},{"key":"3389_CR11","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1136\/bjo.85.11.1379","volume":"85","author":"HS Dua","year":"2001","unstructured":"Dua HS, King AJ, Joseph A (2001) A new classification of ocular surface burns. Br J Ophthalmol 85:1379\u20131383","journal-title":"Br J Ophthalmol"},{"key":"3389_CR12","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.ajo.2008.03.028","volume":"146","author":"A Kheirkhah","year":"2008","unstructured":"Kheirkhah A, Blanco G, Casas V, Hayashida Y, Raju VK, Tseng SC (2008) Surgical strategies for fornix reconstruction based on symblepharon severity. Am J Ophthalmol 146:266\u2013275","journal-title":"Am J Ophthalmol"},{"key":"3389_CR13","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1023\/A:1017935624867","volume":"21","author":"VS Sangwan","year":"2001","unstructured":"Sangwan VS (2001) Limbal stem cells in health and disease. Biosci Rep 21:385\u2013405","journal-title":"Biosci Rep"},{"key":"3389_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1097\/ICO.0000000000000534","volume":"34","author":"EJ Holland","year":"2015","unstructured":"Holland EJ (2015) Management of limbal stem cell deficiency: a historical perspective, past, present, and future. Cornea 34:9\u201315","journal-title":"Cornea"},{"key":"3389_CR15","doi-asserted-by":"publisher","first-page":"8086269","DOI":"10.1155\/2018\/8086269","volume":"2018","author":"M Sacchetti","year":"2018","unstructured":"Sacchetti M, Rama P, Bruscolini A, Lambiase A (2018) Limbal stem cell transplantation: clinical results, limits, and perspectives. Stem Cells Int 2018:8086269","journal-title":"Stem Cells Int"},{"key":"3389_CR16","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.survophthal.2019.06.008","volume":"65","author":"Q Le","year":"2020","unstructured":"Le Q, Chauhan T, Deng SX (2020) Diagnostic criteria for limbal stem cell deficiency before surgical intervention\u2014a systematic literature review and analysis. Surv Ophthalmol 65:32\u201340","journal-title":"Surv Ophthalmol"},{"key":"3389_CR17","first-page":"684","volume":"21","author":"I Korkmaz","year":"2023","unstructured":"Korkmaz I, Palamar M, Egrilmez S, Gurdal M, Yagci A, Barut Selver O (2023) Evaluation of limbal stem cell transplant success in ocular chemical injury. Exp Clin Transplant 21:684\u2013690","journal-title":"Exp Clin Transplant"},{"key":"3389_CR18","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1097\/ICL.0000000000000858","volume":"48","author":"I Korkmaz","year":"2022","unstructured":"Korkmaz I, Palamar M, Egrilmez S, Yagci A, Barut Selver O (2022) Ten years of pediatric ocular chemical burn experience in a tertiary eye care center in Turkey. Eye Contact Lens 48:175\u2013179","journal-title":"Eye Contact Lens"},{"key":"3389_CR19","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1038\/s41433-022-02314-w","volume":"37","author":"M Kasikci","year":"2023","unstructured":"Kasikci M, Korkmaz I, Palamar M, Egrilmez S, Yagci A, Barut Selver O (2023) Evaluation of the factors that influence surgical outcome in conjunctival-limbal allograft transplantation. Eye 37:2192\u20132196","journal-title":"Eye"},{"key":"3389_CR20","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ajo.2018.01.020","volume":"188","author":"J Vazirani","year":"2018","unstructured":"Vazirani J, Nair D, Shanbhag S, Wurity S, Ranjan A, Sangwan V (2018) Limbal stem cell deficiency\u2014demography and underlying causes. Am J Ophthalmol 188:99\u2013103","journal-title":"Am J Ophthalmol"},{"key":"3389_CR21","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/IIO.0b013e3181924e54","volume":"49","author":"KM Hatch","year":"2009","unstructured":"Hatch KM, Dana R (2009) The structure and function of the limbal stem cell and the disease states associated with limbal stem cell deficiency. Int Ophthalmol Clin 49:43\u201352","journal-title":"Int Ophthalmol Clin"},{"key":"3389_CR22","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/sj.eye.6702895","volume":"22","author":"A Fatima","year":"2008","unstructured":"Fatima A, Iftekhar G, Sangwan VS, Vemuganti GK (2008) Ocular surface changes in limbal stem cell deficiency caused by chemical injury: a histologic study of excised pannus from recipients of cultured corneal epithelium. Eye 22:1161\u20131167","journal-title":"Eye"},{"key":"3389_CR23","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.2147\/OPTH.S235873","volume":"14","author":"M Soleimani","year":"2020","unstructured":"Soleimani M, Naderan M (2020) Management strategies of ocular chemical burns: current perspectives. Clin Ophthalmol 14:2687\u20132699","journal-title":"Clin Ophthalmol"},{"key":"3389_CR24","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1093\/stcltm\/szab028","volume":"11","author":"AM Elhusseiny","year":"2022","unstructured":"Elhusseiny AM, Soleimani M, Eleiwa TK, ElSheikh RH, Frank CR, Naderan M (2022) Current and emerging therapies for limbal stem cell deficiency. Stem Cells Transl Med 11:259\u2013268","journal-title":"Stem Cells Transl Med"},{"key":"3389_CR25","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1001\/jamaophthalmol.2020.1120","volume":"138","author":"Q Le","year":"2020","unstructured":"Le Q, Chauhan T, Yung M, Tseng CH, Deng SX (2020) Outcomes of limbal stem cell transplant: a meta-analysis. JAMA Ophthalmol 138:660\u2013670","journal-title":"JAMA Ophthalmol"},{"key":"3389_CR26","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/stem.1517","volume":"32","author":"G Pellegrini","year":"2014","unstructured":"Pellegrini G, Rama P, Di Rocco A, Panaras A, De Luca M (2014) Concise review: hurdles in a successful example of limbal stem cell-based regenerative medicine. Stem Cells 32:26\u201334","journal-title":"Stem Cells"},{"key":"3389_CR27","first-page":"31","volume":"1","author":"D \u00d6zek","year":"2021","unstructured":"\u00d6zek D, Karaca EE, Evren Kemer \u00d6 (2021) Simple limbal epithelial transplantation method in the treatment of unilateral limbal stem cell deficiency due to chemical burn. Eur Eye Res 1:31\u201336","journal-title":"Eur Eye Res"},{"key":"3389_CR28","first-page":"47","volume":"1","author":"BH Unlu","year":"2021","unstructured":"Unlu BH, Utine CA, Durak I (2021) Simple limbal epithelial transplantation in limbal stem cell deficiency after chemical eye injury. Eur Eye Res 1:47\u201352","journal-title":"Eur Eye Res"},{"key":"3389_CR29","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1177\/112067210801800605","volume":"18","author":"E Wylegala","year":"2008","unstructured":"Wylegala E, Dobrowolski D, Tarnawska D, Janiszewska D, Gabryel B, Malecki A et al (2008) Limbal stem cells transplantation in the reconstruction of the ocular surface: 6 years experience. Eur J Ophthalmol 18:886\u2013890","journal-title":"Eur J Ophthalmol"},{"key":"3389_CR30","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/j.1442-9071.2010.02229.x","volume":"38","author":"HS Dua","year":"2010","unstructured":"Dua HS, Miri A, Said DG (2010) Contemporary limbal stem cell transplantation - a review. Clin Experiment Ophthalmol 38:104\u2013117","journal-title":"Clin Experiment Ophthalmol"},{"key":"3389_CR31","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.ajo.2008.03.018","volume":"146","author":"PA Cauchi","year":"2008","unstructured":"Cauchi PA, Ang GS, Azuara-Blanco A, Burr JM (2008) A systematic literature review of surgical interventions for limbal stem cell deficiency in humans. Am J Ophthalmol 146:251\u2013259","journal-title":"Am J Ophthalmol"},{"key":"3389_CR32","doi-asserted-by":"publisher","first-page":"e000164","DOI":"10.1136\/bmjophth-2018-000164","volume":"3","author":"R Fernandez-Buenaga","year":"2018","unstructured":"Fernandez-Buenaga R, Aiello F, Zaher SS, Grixti A, Ahmad S (2018) Twenty years of limbal epithelial therapy: an update on managing limbal stem cell deficiency. BMJ Open Ophthalmol 3:e000164","journal-title":"BMJ Open Ophthalmol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-024-03389-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-024-03389-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-024-03389-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T18:06:00Z","timestamp":1766167560000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-024-03389-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3389"],"URL":"https:\/\/doi.org\/10.1007\/s10792-024-03389-y","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]},"assertion":[{"value":"20 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This retrospective study was carried out in accordance with the Declaration of Helsinki after approval by the Ege University Ethics Committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}],"article-number":"34"}}