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Progression criteria based on the ABCD system, changes in asphericity (Q), demographic factors and keratoconus phenotypes were evaluated. Subjects were followed for 24\u00a0months after procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty percent of participants were male. The mean age at the time of treatment was 21.0\u2009\u00b1\u20096.0\u00a0years. All tomographical values showed progression after 2\u00a0years of follow-up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), particularly during the first 6\u00a0months, except for anterior curvature. Within the ABCD grading system, we observed: A) an increase in anterior curvature, more evident with lower initial values; B) an increase in posterior curvature, more pronounced with higher initial values. Two years after I-CXL, 20% of subjects met progression criteria in two or more parameters, with 62.5% being under 19\u00a0years of age. Patients with a family history of corneal ectasia exhibited a mean KMax progression of 1.94D\u2009\u00b1\u20091.88, (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046). Only phenotypes 3 and 4 showed progression. Although patients under 19\u00a0years showed greater progression in all tomographical variables at the end of the study, this difference was not statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment with I-CXL did not stop progression in the variables studied two years after the procedure in an effective manner, especially in patients younger than 19\u00a0years. A family history of corneal ectasia and subtype 4 keratoconus predicted a less favourable response to I-CXL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10792-025-03421-9","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T01:57:07Z","timestamp":1739152627000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Demographic and topographic findings suggesting poor response to crosslinking-iontophoresis in patients with progressive keratoconus"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0386-2362","authenticated-orcid":false,"given":"Rosario","family":"Touri\u00f1o-Peralba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Rodr\u00edguez-Lago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lamas-Francis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Mart\u00ednez-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Rodr\u00edguez-Ares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"issue":"4","key":"3421_CR1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0039-6257(84)90094-8","volume":"28","author":"JH Krachmer","year":"1984","unstructured":"Krachmer JH, Feder RS, Belin MW (1984) Keratoconus and related noninflammatory corneal thinning disorders. 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This work has not been previously published and is not under consideration for publication in another journal. All authors, as well as the entity where this study was carried out approve its publication. If the manuscript is accepted, it will not be published elsewhere without the written consent of the copyright holder.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"69"}}