{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T18:09:14Z","timestamp":1766167754032,"version":"3.48.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-025-03455-z","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T08:34:05Z","timestamp":1741941245000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of choroidal thickness and vascularity in patients with subretinal drusenoid deposits and large drusen using swept-source optical coherence tomography"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1474-9237","authenticated-orcid":false,"given":"Erkut","family":"K\u00fc\u00e7\u00fck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00fcge","family":"\u00c7oban Karata\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"issue":"9","key":"3455_CR1","doi-asserted-by":"publisher","first-page":"e29583","DOI":"10.7759\/cureus.29583","volume":"14","author":"H Vyawahare","year":"2022","unstructured":"Vyawahare H, Shinde P (2022) Age-related macular degeneration: epidemiology, pathophysiology, diagnosis, and treatment. Cureus 14(9):e29583. https:\/\/doi.org\/10.7759\/cureus.29583","journal-title":"Cureus"},{"issue":"6","key":"3455_CR2","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1159\/000517520","volume":"244","author":"R Flores","year":"2021","unstructured":"Flores R, Carneiro \u00c2, Vieira M, Tenreiro S, Seabra MC (2021) Age-related macular degeneration: pathophysiology, management, and future perspectives. Ophthalmologica 244(6):495\u2013511. https:\/\/doi.org\/10.1159\/000517520","journal-title":"Ophthalmologica"},{"issue":"1","key":"3455_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41572-021-00265-2","volume":"7","author":"M Fleckenstein","year":"2021","unstructured":"Fleckenstein M, Keenan TDL, Guymer RH, Chakravarthy U, Schmitz-Valckenberg S, Klaver CC, Wong WT, Chew EY (2021) Age-related macular degeneration. Nat Rev Dis Primers 7(1):31. https:\/\/doi.org\/10.1038\/s41572-021-00265-2","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"3455_CR4","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1159\/000524942","volume":"65","author":"J Garcia-Garcia","year":"2022","unstructured":"Garcia-Garcia J, Usategui-Martin R, Sanabria MR, Fernandez-Perez E, Telleria JJ, Coco-Martin RM (2022) Pathophysiology of age-related macular degeneration: implications for treatment. Ophthalmic Res 65(6):615\u2013636. https:\/\/doi.org\/10.1159\/000524942","journal-title":"Ophthalmic Res"},{"issue":"1","key":"3455_CR5","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/eye.2016.216","volume":"31","author":"KR Chirco","year":"2017","unstructured":"Chirco KR, Sohn EH, Stone EM, Tucker BA, Mullins RF (2017) Structural and molecular changes in the aging choroid: implications for age-related macular degeneration. Eye (Lond) 31(1):10\u201325. https:\/\/doi.org\/10.1038\/eye.2016.216","journal-title":"Eye (Lond)"},{"issue":"6","key":"3455_CR6","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1056\/NEJMcp2102061","volume":"385","author":"RS Apte","year":"2021","unstructured":"Apte RS (2021) Age-related macular degeneration. N Engl J Med 385(6):539\u2013547. https:\/\/doi.org\/10.1056\/NEJMcp2102061","journal-title":"N Engl J Med"},{"issue":"3","key":"3455_CR7","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.mcna.2021.01.003","volume":"105","author":"CJ Thomas","year":"2021","unstructured":"Thomas CJ, Mirza RG, Gill MK (2021) Age-related macular degeneration. Med Clin North Am 105(3):473\u2013491. https:\/\/doi.org\/10.1016\/j.mcna.2021.01.003","journal-title":"Med Clin North Am"},{"issue":"6","key":"3455_CR8","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.ophtha.2007.08.030","volume":"115","author":"ML Klein","year":"2008","unstructured":"Klein ML, Ferris FL, Armstrong J, Hwang TS, Chew EY, Bressler SB, Chandra SR (2008) Retinal precursors and the development of geographic atrophy in age-related macular degeneration. Ophthalmol 115(6):1026\u20131031. https:\/\/doi.org\/10.1016\/j.ophtha.2007.08.030","journal-title":"Ophthalmol"},{"issue":"6","key":"3455_CR9","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.survophthal.2018.05.005","volume":"63","author":"RF Spaide","year":"2018","unstructured":"Spaide RF, Ooto S, Curcio CA (2018) Subretinal drusenoid deposits AKA pseudodrusen. Surv Ophthalmol 63(6):782\u2013815. https:\/\/doi.org\/10.1016\/j.survophthal.2018.05.005","journal-title":"Surv Ophthalmol"},{"issue":"2","key":"3455_CR10","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1097\/IAE.0b013e31827e25e0","volume":"33","author":"CA Curcio","year":"2013","unstructured":"Curcio CA, Messinger JD, Sloan KR, McGwin G, Medeiros NE, Spaide RF (2013) Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model. Retina 33(2):265\u2013276. https:\/\/doi.org\/10.1097\/IAE.0b013e31827e25e0","journal-title":"Retina"},{"issue":"7","key":"3455_CR11","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1097\/iae.0000000000003460","volume":"42","author":"RJ Thomson","year":"2022","unstructured":"Thomson RJ, Chazaro J, Otero-Marquez O, Ledesma-Gil G, Tong Y, Coughlin AC, Teibel ZR, Alauddin S, Tai K, Lloyd H, Scolaro M, Govindaiah A, Bhuiyan A, Dhamoon MS, Deobhakta A, Narula J, Rosen RB, Yannuzzi LA, Freund KB, Smith RT (2022) Subretinal drusenoid deposits and soft drusen: Are They Markers for Distinct Retinal Diseases? Retina 42(7):1311\u20131318. https:\/\/doi.org\/10.1097\/iae.0000000000003460","journal-title":"Retina"},{"key":"3455_CR12","doi-asserted-by":"publisher","first-page":"100951","DOI":"10.1016\/j.preteyeres.2021.100951","volume":"84","author":"I La\u00edns","year":"2021","unstructured":"La\u00edns I, Wang JC, Cui Y, Katz R, Vingopoulos F, Staurenghi G, Vavvas DG, Miller JW, Miller JB (2021) Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Prog Retin Eye Res 84:100951. https:\/\/doi.org\/10.1016\/j.preteyeres.2021.100951","journal-title":"Prog Retin Eye Res"},{"issue":"6","key":"3455_CR13","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.ajo.2015.03.005","volume":"159","author":"S Sonoda","year":"2015","unstructured":"Sonoda S, Sakamoto T, Yamashita T, Uchino E, Kawano H, Yoshihara N, Terasaki H, Shirasawa M, Tomita M, Ishibashi T (2015) Luminal and stromal areas of choroid determined by binarization method of optical coherence tomographic images. Am J Ophthalmol 159(6):1123-1131.e1121. https:\/\/doi.org\/10.1016\/j.ajo.2015.03.005","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"3455_CR14","doi-asserted-by":"publisher","first-page":"e0146344","DOI":"10.1371\/journal.pone.0146344","volume":"11","author":"R Agrawal","year":"2016","unstructured":"Agrawal R, Salman M, Tan K-A, Karampelas M, Sim DA, Keane PA, Pavesio C (2016) Choroidal vascularity index (CVI)-a novel optical coherence tomography parameter for monitoring patients with panuveitis? PLoS ONE 11(1):e0146344","journal-title":"PLoS ONE"},{"key":"3455_CR15","doi-asserted-by":"publisher","first-page":"21090","DOI":"10.1038\/srep21090","volume":"6","author":"R Agrawal","year":"2016","unstructured":"Agrawal R, Gupta P, Tan KA, Cheung CM, Wong TY, Cheng CY (2016) Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study. Sci Rep 6:21090. https:\/\/doi.org\/10.1038\/srep21090","journal-title":"Sci Rep"},{"issue":"4","key":"3455_CR16","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1097\/iae.0000000000002434","volume":"40","author":"TD Keenan","year":"2020","unstructured":"Keenan TD, Klein B, Agr\u00f3n E, Chew EY, Cukras CA, Wong WT (2020) Choroidal thickness and vascularity vary with disease severity and subretinal drusenoid deposit presence in nonadvanced age-related macular degeneration. Retina 40(4):632\u2013642. https:\/\/doi.org\/10.1097\/iae.0000000000002434","journal-title":"Retina"},{"issue":"9","key":"3455_CR17","doi-asserted-by":"publisher","first-page":"6307","DOI":"10.1167\/iovs.13-12653","volume":"54","author":"EJ Sigler","year":"2013","unstructured":"Sigler EJ, Randolph JC (2013) Comparison of macular choroidal thickness among patients older than age 65 with early atrophic age-related macular degeneration and normals. Invest Ophthalmol Vis Sci 54(9):6307\u20136313. https:\/\/doi.org\/10.1167\/iovs.13-12653","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"3455_CR18","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1136\/bjophthalmol-2016-309281","volume":"101","author":"A Govetto","year":"2017","unstructured":"Govetto A, Sarraf D, Figueroa MS, Pierro L, Ippolito M, Risser G, Bandello F, Hubschman JP (2017) Choroidal thickness in non-neovascular versus neovascular age-related macular degeneration: a fellow eye comparative study. Br J Ophthalmol 101(6):764\u2013769. https:\/\/doi.org\/10.1136\/bjophthalmol-2016-309281","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"3455_CR19","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.ajo.2014.01.018","volume":"157","author":"N Ueda-Arakawa","year":"2014","unstructured":"Ueda-Arakawa N, Ooto S, Ellabban AA, Takahashi A, Oishi A, Tamura H, Yamashiro K, Tsujikawa A, Yoshimura N (2014) Macular choroidal thickness and volume of eyes with reticular pseudodrusen using swept-source optical coherence tomography. Am J Ophthalmol 157(5):994\u20131004. https:\/\/doi.org\/10.1016\/j.ajo.2014.01.018","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"3455_CR20","doi-asserted-by":"publisher","first-page":"3250","DOI":"10.1167\/iovs.13-11923","volume":"54","author":"F Alten","year":"2013","unstructured":"Alten F, Clemens CR, Heiduschka P, Eter N (2013) Localized Reticular pseudodrusen and their topographic relation to choroidal watershed zones and changes in choroidal volumes. Invest Ophthalmol Vis Sci 54(5):3250\u20133257. https:\/\/doi.org\/10.1167\/iovs.13-11923","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3455_CR21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ajo.2017.05.021","volume":"180","author":"I La\u00edns","year":"2017","unstructured":"La\u00edns I, Wang J, Provid\u00eancia J, Mach S, Gil P, Gil J, Marques M, Armstrong G, Garas S, Barreto P, Kim IK, Vavvas DG, Miller JW, Husain D, Silva R, Miller JB (2017) Choroidal changes associated with subretinal drusenoid deposits in age-related macular degeneration using swept-source optical coherence tomography. Am J Ophthalmol 180:55\u201363. https:\/\/doi.org\/10.1016\/j.ajo.2017.05.021","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"3455_CR22","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1097\/iae.0000000000002667","volume":"40","author":"SB Velaga","year":"2020","unstructured":"Velaga SB, Nittala MG, Vupparaboina KK, Jana S, Chhablani J, Haines J, Pericak-Vance MA, Stambolian D, Sadda SR (2020) Choroidal vascularity index and choroidal thickness in eyes with reticular pseudodrusen. Retina 40(4):612\u2013617. https:\/\/doi.org\/10.1097\/iae.0000000000002667","journal-title":"Retina"},{"issue":"7","key":"3455_CR23","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1038\/s41433-022-02134-y","volume":"37","author":"S Abdolrahimzadeh","year":"2023","unstructured":"Abdolrahimzadeh S, Di Pippo M, Sordi E, Cusato M, Lotery AJ (2023) Subretinal drusenoid deposits as a biomarker of age-related macular degeneration progression via reduction of the choroidal vascularity index. Eye 37(7):1365\u20131370. https:\/\/doi.org\/10.1038\/s41433-022-02134-y","journal-title":"Eye"},{"issue":"2","key":"3455_CR24","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.3928\/23258160-20190129-15","volume":"50","author":"R Agrawal","year":"2019","unstructured":"Agrawal R, Seen S, Vaishnavi S, Vupparaboina KK, Goud A, Rasheed MA, Chhablani J (2019) Choroidal vascularity index using swept-source and spectral-domain optical coherence tomography: a comparative study. Ophthalmic Surg Lasers Imaging Retina 50(2):e26\u2013e32. https:\/\/doi.org\/10.3928\/23258160-20190129-15","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"issue":"10","key":"3455_CR25","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1097\/iae.0000000000003547","volume":"42","author":"S Chen","year":"2022","unstructured":"Chen S, Zheng G, Yu X, Jiang Y, Lin Z, Lin G, Chen W, Shen M, Lu F (2022) Impact of penetration and image analysis in optical coherence tomography on the measurement of choroidal vascularity parameters. Retina 42(10):1965\u20131974. https:\/\/doi.org\/10.1097\/iae.0000000000003547","journal-title":"Retina"},{"issue":"12","key":"3455_CR26","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1167\/tvst.10.12.26","volume":"10","author":"R Sacconi","year":"2021","unstructured":"Sacconi R, Vella G, Battista M, Borrelli E, Balasubramanian S, Querques L, Bandello F, Querques G (2021) Choroidal vascularity index in different cohorts of dry age-related macular degeneration. Transl Vis Sci Technol 10(12):26\u201326. https:\/\/doi.org\/10.1167\/tvst.10.12.26","journal-title":"Transl Vis Sci Technol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-025-03455-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-025-03455-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-025-03455-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T18:05:08Z","timestamp":1766167508000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-025-03455-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,14]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3455"],"URL":"https:\/\/doi.org\/10.1007\/s10792-025-03455-z","relation":{},"ISSN":["1573-2630"],"issn-type":[{"type":"electronic","value":"1573-2630"}],"subject":[],"published":{"date-parts":[[2025,3,14]]},"assertion":[{"value":"16 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Clinical Research Ethics Committee of Ni\u011fde \u00d6mer Halisdemir University (26.10.2023 \/ 2023\/83).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication of the images in figures.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"94"}}