{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:20:36Z","timestamp":1777044036912,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-025-03617-z","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T01:57:56Z","timestamp":1751075876000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Corneal biomechanical property changes following corneal collagen cross-linking in keratoconus: a systematic review and meta-regression analysis"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0806-8264","authenticated-orcid":false,"given":"Luksanaporn","family":"Krungkraipetch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angkhana","family":"Assawaboonyadech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dutdao","family":"Supajitgulchai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"issue":"4","key":"3617_CR1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","volume":"42","author":"YS Rabinowitz","year":"1998","unstructured":"Rabinowitz YS (1998) Keratoconus. Surv Ophthalmol 42(4):297\u2013319","journal-title":"Surv Ophthalmol"},{"issue":"6","key":"3617_CR2","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.survophthal.2017.06.009","volume":"62","author":"V Mas Tur","year":"2017","unstructured":"Mas Tur V, MacGregor C, Jayaswal R, O\u2019Brart D, Maycock N (2017) A review of keratoconus: diagnosis, pathophysiology, and genetics. Surv Ophthalmol 62(6):770\u2013783","journal-title":"Surv Ophthalmol"},{"issue":"7","key":"3617_CR3","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.ophtha.2019.02.029","volume":"126","author":"AC Ferdi","year":"2019","unstructured":"Ferdi AC, Nguyen V, Gore DM, Allan BD, Rozema JJ, Watson SL (2019) Keratoconus natural progression: a systematic review and meta-analysis of 11,529 eyes. Ophthalmology 126(7):935\u2013945","journal-title":"Ophthalmology"},{"key":"3617_CR4","doi-asserted-by":"publisher","first-page":"108398","DOI":"10.1016\/j.exer.2020.108398","volume":"202","author":"Y Bykhovskaya","year":"2021","unstructured":"Bykhovskaya Y, Rabinowitz YS (2021) Update on the genetics of keratoconus. Exp Eye Res 202:108398","journal-title":"Exp Eye Res"},{"key":"3617_CR5","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3389\/fbioe.2019.00066","volume":"7","author":"BJ Blackburn","year":"2019","unstructured":"Blackburn BJ, Jenkins MW, Rollins AM, Dupps WJ (2019) A review of structural and biomechanical changes in the cornea in aging, disease, and photochemical crosslinking. Front Bioeng Biotechnol 7:66","journal-title":"Front Bioeng Biotechnol"},{"issue":"4","key":"3617_CR6","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/cxo.12300","volume":"98","author":"LE Downie","year":"2015","unstructured":"Downie LE, Lindsay RG (2015) Contact lens management of keratoconus. Clin Exp Optom 98(4):299\u2013311","journal-title":"Clin Exp Optom"},{"issue":"5","key":"3617_CR7","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","volume":"135","author":"G Wollensak","year":"2003","unstructured":"Wollensak G, Spoerl E, Seiler T (2003) Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 135(5):620\u2013627","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"3617_CR8","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1167\/iovs.11-9385","volume":"53","author":"P Kamaev","year":"2012","unstructured":"Kamaev P, Friedman MD, Sherr E, Muller D (2012) Photochemical kinetics of corneal cross-linking with riboflavin. Invest Ophthalmol Vis Sci 53(4):2360\u20132367","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"3617_CR9","doi-asserted-by":"publisher","first-page":"264","DOI":"10.3928\/1081597X-20180220-01","volume":"34","author":"SH Chang","year":"2018","unstructured":"Chang SH, Mohammadvali A, Chen KJ, Ji YR, Young TH, Wang TJ et al (2018) The relationship between mechanical properties, ultrastructural changes, and intrafibrillar bond formation in corneal UVA\/riboflavin cross-linking treatment for keratoconus. J Refract Surg 34(4):264\u2013272. https:\/\/doi.org\/10.3928\/1081597X-20180220-01","journal-title":"J Refract Surg"},{"issue":"2","key":"3617_CR10","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jtos.2013.01.002","volume":"11","author":"F Raiskup","year":"2013","unstructured":"Raiskup F, Spoerl E (2013) Corneal crosslinking with riboflavin and ultraviolet A. I. Principles. Ocul Surf 11(2):65\u201374","journal-title":"Ocul Surf"},{"issue":"5","key":"3617_CR11","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.1167\/iovs.13-13748","volume":"55","author":"A Hammer","year":"2014","unstructured":"Hammer A, Richoz O, Arba Mosquera S, Tabibian D, Hoogewoud F, Hafezi F (2014) Corneal biomechanical properties at different corneal cross-linking (CXL) irradiances. Invest Ophthalmol Vis Sci 55(5):2881\u20132884","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"3617_CR12","doi-asserted-by":"publisher","first-page":"e22","DOI":"10.1111\/aos.13814","volume":"97","author":"M Shajari","year":"2019","unstructured":"Shajari M, Kolb CM, Agha B, Steinwender G, M\u00fcller M, Herrmann E et al (2019) Comparison of standard and accelerated corneal cross-linking for the treatment of keratoconus: a meta-analysis. Acta Ophthalmol 97(1):e22\u2013e35","journal-title":"Acta Ophthalmol"},{"issue":"8","key":"3617_CR13","doi-asserted-by":"publisher","first-page":"416","DOI":"10.4103\/0301-4738.116069","volume":"61","author":"R McQuaid","year":"2013","unstructured":"McQuaid R, Cummings AB, Mrochen M (2013) The theory and art of corneal cross-linking. Indian J Ophthalmol 61(8):416\u2013419","journal-title":"Indian J Ophthalmol"},{"issue":"1","key":"3617_CR14","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3928\/1081597X-20171025-01","volume":"34","author":"FJ Bao","year":"2018","unstructured":"Bao FJ, Zheng YR, Liu C, Zheng XB, Zhao YP, Wang Y et al (2018) Changes in corneal biomechanical properties with different corneal cross-linking irradiances. J Refract Surg 34(1):51\u201358. https:\/\/doi.org\/10.3928\/1081597X-20171025-01","journal-title":"J Refract Surg"},{"key":"3617_CR15","doi-asserted-by":"crossref","unstructured":"Yeh CY, Chen KC, Chen YJ, Cheng SF (2024) Accelerated versus conventional corneal collagen cross-linking for keratoconus: a meta-analysis of randomized controlled trials. Eur J Ophthalmol 2024:11206721241298317","DOI":"10.1177\/11206721241298317"},{"key":"3617_CR16","doi-asserted-by":"publisher","first-page":"8145651","DOI":"10.1155\/2017\/8145651","volume":"2017","author":"H Kobashi","year":"2017","unstructured":"Kobashi H, Rong SS (2017) Corneal collagen cross-linking for keratoconus: systematic review. Biomed Res Int 2017:8145651","journal-title":"Biomed Res Int"},{"issue":"3","key":"3617_CR17","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1097\/ICO.0000000000000723","volume":"35","author":"Z Meiri","year":"2016","unstructured":"Meiri Z, Keren S, Rosenblatt A, Sarig T, Shenhav L, Varssano D (2016) Efficacy of corneal collagen cross-linking for the treatment of keratoconus: a systematic review and meta-analysis. Cornea 35(3):417\u2013428","journal-title":"Cornea"},{"issue":"4","key":"3617_CR18","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/ICO.0000000000000408","volume":"34","author":"JAP Gomes","year":"2015","unstructured":"Gomes JAP, Tan D, Rapuano CJ, Belin MW, Ambr\u00f3sio R Jr, Guell JL et al (2015) Global consensus on keratoconus and ectatic diseases. Cornea 34(4):359\u2013369","journal-title":"Cornea"},{"issue":"7","key":"3617_CR19","doi-asserted-by":"publisher","first-page":"553","DOI":"10.3109\/02713683.2012.669007","volume":"37","author":"N Terai","year":"2012","unstructured":"Terai N, Raiskup F, Haustein M, Pillunat LE, Spoerl E (2012) Identification of biomechanical properties of the cornea: the ocular response analyzer. Curr Eye Res 37(7):553\u2013562","journal-title":"Curr Eye Res"},{"issue":"1","key":"3617_CR20","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3928\/1081597X-20151207-09","volume":"32","author":"J Steinberg","year":"2016","unstructured":"Steinberg J, Frings A, Mousli A, Casagrande MK, Druchkiv V, Katz T et al (2016) New Scheimpflug dynamic in vivo curve analyses to characterize biomechanical changes of the cornea after cross-linking for progressive keratoconus. J Refract Surg 32(1):34\u201339. https:\/\/doi.org\/10.3928\/1081597X-20151207-09","journal-title":"J Refract Surg"},{"issue":"5","key":"3617_CR21","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1364\/BOE.5.001419","volume":"5","author":"MD Twa","year":"2014","unstructured":"Twa MD, Li J, Vantipalli S, Singh M, Aglyamov S, Emelianov S et al (2014) Spatial characterization of corneal biomechanical properties with optical coherence elastography after UV cross-linking. Biomed Opt Express 5(5):1419\u20131427","journal-title":"Biomed Opt Express"},{"issue":"12","key":"3617_CR22","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1001\/jamaophthalmol.2014.3029","volume":"132","author":"J Beckman Rehnman","year":"2014","unstructured":"Beckman Rehnman J, Behndig A, Hallberg P, Lind\u00e9n C (2014) Increased corneal hysteresis after corneal collagen crosslinking: a study based on applanation resonance technology. JAMA Ophthalmol 132(12):1426\u20131432. https:\/\/doi.org\/10.1001\/jamaophthalmol.2014.3029","journal-title":"JAMA Ophthalmol"},{"issue":"4","key":"3617_CR23","doi-asserted-by":"publisher","first-page":"409","DOI":"10.4103\/joco.joco_177_21","volume":"34","author":"A Hamid","year":"2023","unstructured":"Hamid A, Jahadi-Hosseini H, Khalili MR, Jahanbani-Ardakani H (2023) Corneal biomechanical changes after corneal cross-linking in patients with keratoconus. J Curr Ophthalmol 34(4):409\u2013413. https:\/\/doi.org\/10.4103\/joco.joco_177_21","journal-title":"J Curr Ophthalmol"},{"key":"3617_CR24","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.actbio.2020.06.005","volume":"113","author":"T Liu","year":"2020","unstructured":"Liu T, Shen M, Li H, Zhang Y, Mu B, Zhao X et al (2020) Changes and quantitative characterization of hyper-viscoelastic biomechanical properties for young corneal stroma after standard corneal cross-linking treatment with different ultraviolet\u2014a energies. Acta Biomater 113:438\u2013451. https:\/\/doi.org\/10.1016\/j.actbio.2020.06.005. (Epub 2020 Jun 7)","journal-title":"Acta Biomater"},{"issue":"6","key":"3617_CR25","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3928\/1081597X-20220425-01","volume":"38","author":"X Zheng","year":"2022","unstructured":"Zheng X, Weng Y, Wang Y, Xin Y, Wu J, Ziad Masoud Abu Said A et al (2022) Long-term effects of riboflavin ultraviolet-A-induced CXL with different irradiances on the biomechanics of in vivo rabbit corneas. J Refract Surg 38(6):389\u2013397. https:\/\/doi.org\/10.3928\/1081597X-20220425-01","journal-title":"J Refract Surg"},{"issue":"3","key":"3617_CR26","first-page":"CD010621","volume":"2015","author":"E Sykakis","year":"2015","unstructured":"Sykakis E, Karim R, Evans JR et al (2015) Corneal collagen cross-linking for treating keratoconus. Cochrane Database Syst Rev 2015(3):CD010621","journal-title":"Cochrane Database Syst Rev"},{"key":"3617_CR27","doi-asserted-by":"publisher","first-page":"1212314","DOI":"10.3389\/fmed.2023.1212314","volume":"10","author":"R Deshmukh","year":"2023","unstructured":"Deshmukh R, Ong ZZ, Rampat R, Ali\u00f3 del Barrio JL, Barua A, Ang M et al (2023) Management of keratoconus: an updated review. Front Med (Lausanne) 10:1212314. https:\/\/doi.org\/10.3389\/fmed.2023.1212314","journal-title":"Front Med (Lausanne)"},{"key":"3617_CR28","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1136\/bmj.n71","volume":"2021","author":"MJ Page","year":"2020","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2020) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021:372. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"3617_CR29","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919","author":"JA Sterne","year":"2016","unstructured":"Sterne JA, Hern\u00e1n MA, Reeves BC, Savovi\u0107 J, Berkman ND, Viswanathan M et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. https:\/\/doi.org\/10.1136\/bmj.i4919","journal-title":"BMJ"},{"key":"3617_CR30","unstructured":"National Heart, Lung, and Blood Institute. Study Quality Assessment Tools [Internet]. Bethesda (MD): National Institutes of Health; [cited 2025 Mar 22]. https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools"},{"key":"3617_CR31","unstructured":"R Core Team (2023) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https:\/\/www.R-project.org\/"},{"issue":"12","key":"3617_CR32","doi-asserted-by":"publisher","first-page":"849","DOI":"10.3928\/1081597X-20181012-02","volume":"34","author":"MR Sedaghat","year":"2018","unstructured":"Sedaghat MR, Momeni-Moghaddam H, Ambr\u00f3sio R Jr, Roberts CJ, Yekta AA, Danesh Z et al (2018) Long-term evaluation of corneal biomechanical properties after corneal cross-linking for keratoconus: a 4-year longitudinal study. J Refract Surg 34(12):849\u2013856","journal-title":"J Refract Surg"},{"issue":"3","key":"3617_CR33","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.joco.2019.02.002","volume":"31","author":"R Salouti","year":"2019","unstructured":"Salouti R, Khalili MR, Zamani M, Ghoreyshi M, Nowroozzadeh MH (2019) Assessment of the changes in corneal biomechanical properties after collagen cross-linking in patients with keratoconus. J Curr Ophthalmol 31(3):262\u2013267. https:\/\/doi.org\/10.1016\/j.joco.2019.02.002","journal-title":"J Curr Ophthalmol"},{"issue":"11","key":"3617_CR34","doi-asserted-by":"publisher","first-page":"3635","DOI":"10.1007\/s00417-024-06549-z","volume":"262","author":"E Felter","year":"2024","unstructured":"Felter E, Khoramnia R, Friedrich M, Son HS, Auffarth GU, Augustin VA (2024) Biomechanical changes following corneal crosslinking in keratoconus patients. Graefes Arch Clin Exp Ophthalmol 262(11):3635\u20133642. https:\/\/doi.org\/10.1007\/s00417-024-06549-z. (Epub 2024 Jun 17)","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"3617_CR35","doi-asserted-by":"publisher","first-page":"579190","DOI":"10.1155\/2014\/579190","volume":"2014","author":"J Steinberg","year":"2014","unstructured":"Steinberg J, Katz T, Mousli A, Frings A, Casagrande MK, Druchkiv V et al (2014) Corneal biomechanical changes after crosslinking for progressive keratoconus with the corneal visualization Scheimpflug technology. J Ophthalmol 2014:579190. https:\/\/doi.org\/10.1155\/2014\/579190. (Epub 2014 Sep 22)","journal-title":"J Ophthalmol"},{"issue":"5","key":"3617_CR36","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1097\/ICO.0b013e318190734d","volume":"28","author":"Y Goldich","year":"2009","unstructured":"Goldich Y, Barkana Y, Morad Y, Hartstein M, Avni I, Zadok D (2009) Can we measure corneal biomechanical changes after collagen cross-linking in eyes with keratoconus?\u2014a pilot study. Cornea 28(5):498\u2013502. https:\/\/doi.org\/10.1097\/ICO.0b013e318190734d","journal-title":"Cornea"},{"issue":"7","key":"3617_CR37","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1097\/ICO.0000000000002572","volume":"40","author":"T Nishida","year":"2021","unstructured":"Nishida T, Kojima T, Kataoka T, Isogai N, Yoshida Y, Nakamura T (2021) Comparison of corneal biomechanical properties and corneal tomography between customized and accelerated corneal crosslinking in eyes with keratoconus. Cornea 40(7):851\u2013858. https:\/\/doi.org\/10.1097\/ICO.0000000000002572","journal-title":"Cornea"},{"issue":"6","key":"3617_CR38","doi-asserted-by":"publisher","first-page":"452","DOI":"10.3928\/1081597X-20110106-01","volume":"27","author":"E Spoerl","year":"2011","unstructured":"Spoerl E, Terai N, Scholz F, Raiskup F, Pillunat LE (2011) Detection of biomechanical changes after corneal cross-linking using ocular response analyzer software. J Refract Surg 27(6):452\u2013457. https:\/\/doi.org\/10.3928\/1081597X-20110106-01","journal-title":"J Refract Surg"},{"issue":"6","key":"3617_CR39","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1097\/ICL.0000000000000090","volume":"40","author":"KM Hallahan","year":"2014","unstructured":"Hallahan KM, Rocha K, Roy AS, Randleman JB, Stulting RD, Dupps WJ Jr (2014) Effects of corneal cross-linking on ocular response analyzer waveform-derived variables in keratoconus and postrefractive surgery ectasia. Eye Contact Lens 40(6):339\u2013344. https:\/\/doi.org\/10.1097\/ICL.0000000000000090","journal-title":"Eye Contact Lens"},{"issue":"4","key":"3617_CR40","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1177\/1120672120944798","volume":"31","author":"M Jabbarvand","year":"2021","unstructured":"Jabbarvand M, Moravvej Z, Shahraki K, Hashemian H, Ghasemi H, Berijani S et al (2021) Corneal biomechanical outcome of collagen cross-linking in keratoconic patients evaluated by Corvis ST. Eur J Ophthalmol 31(4):1577\u20131583. https:\/\/doi.org\/10.1177\/1120672120944798","journal-title":"Eur J Ophthalmol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-025-03617-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-025-03617-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-025-03617-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T18:05:11Z","timestamp":1766167511000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-025-03617-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3617"],"URL":"https:\/\/doi.org\/10.1007\/s10792-025-03617-z","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6309115\/v1","asserted-by":"object"}]},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,28]]},"assertion":[{"value":"26 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical Considerations: this systematic review involved data analysis from previously published studies and did not require ethical approval.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Since this study did not involve recruiting participants or collecting new data, obtaining informed consent was not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"270"}}