{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T14:09:09Z","timestamp":1768745349666,"version":"3.49.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Dublin, Trinity College"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Selective laser trabeculoplasty (SLT) is an effective treatment option in open-angle glaucoma (OAG) and ocular hypertension (OHT). The purpose of this study was to evaluate the real-world treatment outcomes of SLT in a tertiary referral glaucoma service.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed the medical records of consecutive patients who had undergone SLT in the glaucoma service at the Royal Victoria Eye and Ear Hospital, Dublin. All patients in this study were using topical IOP-lowering medications prior to SLT. The primary outcome measure was the mean change in intraocular pressure (IOP) at 6 to 8\u00a0weeks following the procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>71 eyes of 44 patients were included in this study. There was a mean reduction in IOP of 4.0\u00a0mmHg (SD 3.6), from 19.1\u00a0mmHg (SD 3.6) at baseline to 15.1\u00a0mmHg (SD 4.0) at 6 to 8\u00a0weeks post-SLT (p\u2009&lt;\u20090.001). The diagnosis was primary open-angle glaucoma (POAG) in 69.0% of eyes, pseudoexfoliation glaucoma (PXFG) in 5.6%, pigment dispersion glaucoma (PDG) in 2.8%, normal tension glaucoma (NTG) in 5.6%, ocular hypertension (OHT) in 15.5%, and pseudoexfoliation OHT in 1.4%. 100% of eyes were on topical IOP-lowering medication (mean number of agents 2.7). In addition, 8.5% had one previous SLT procedure. No immediate (&lt;\u20091\u00a0h) post-SLT IOP spikes occurred in this study. Pearson correlation analysis revealed a moderate correlation (r\u2009=\u2009-0.4021, p\u2009&lt;\u20090.001) between higher baseline IOP and greater IOP reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SLT is an effective IOP-lowering treatment in open-angle glaucoma and ocular hypertension in a real-world setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10792-025-03702-3","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T05:21:12Z","timestamp":1753939272000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real-world outcomes of selective laser trabeculoplasty in a tertiary referral glaucoma service"],"prefix":"10.1007","volume":"45","author":[{"given":"David","family":"Gildea","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoife","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"3702_CR1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.10.1268","author":"A Heijl","year":"2002","unstructured":"Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M (2002) Early manifest glaucoma trial group reduction of intraocular pressure and glaucoma progression: results from the early manifest glaucoma trial. 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Arch Ophthalmol. https:\/\/doi.org\/10.1001\/archopht.120.6.701","journal-title":"Arch Ophthalmol"},{"issue":"10180","key":"3702_CR3","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/S0140-6736(18)32213-X","volume":"393","author":"G Gazzard","year":"2019","unstructured":"Gazzard G, Konstantakopoulou E, Garway-Heath D, Garg A, Vickerstaff V, Hunter R, Ambler G, Bunce C, Wormald R, Nathwani N, Barton K (2019) Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial. Lancet 393(10180):1505\u20131516. https:\/\/doi.org\/10.1016\/S0140-6736(18)32213-X","journal-title":"Lancet"},{"issue":"9","key":"3702_CR4","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/j.ophtha.2019.04.012","volume":"126","author":"A Garg","year":"2019","unstructured":"Garg A, Vickerstaff V, Nathwani N, Garway-Heath D, Konstantakopoulou E, Ambler G, Bunce C, Wormald R, Barton K, Gazzard G, Bourne R (2019) Primary selective laser trabeculoplasty for open-angle glaucoma and ocular hypertension: clinical outcomes, predictors of success, and safety from the laser in glaucoma and ocular hypertension trial. 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Ophthalmology 127(6):748\u2013757. https:\/\/doi.org\/10.1016\/j.ophtha.2019.11.017","journal-title":"Ophthalmology"},{"issue":"1","key":"3702_CR6","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1038\/s41598-022-05699-6.PMID:35121762;PMCID:PMC8817042","volume":"12","author":"RY Abe","year":"2022","unstructured":"Abe RY, Maestrini HA, Guedes GB, Nascimento MM, Iguma CI, de Miranda Santos HD, Nasr MG, Lucena-Junior RP, Prata TS (2022) Real-world data from selective laser trabeculoplasty in Brazil. Sci Rep 12(1):1923. https:\/\/doi.org\/10.1038\/s41598-022-05699-6.PMID:35121762;PMCID:PMC8817042","journal-title":"Sci Rep"},{"key":"3702_CR7","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-310877","author":"G Gazzard","year":"2018","unstructured":"Gazzard G, Konstantakopoulou E, Garway-Heath D, Barton K, Wormald R, Morris S, Hunter R, Rubin G, Buszewicz M, Ambler G, Bunce C (2018) LiGHT trial study group laser in glaucoma and ocular hypertension (LiGHT) trial a multicentre, randomised controlled trial design and methodology. Br J Ophthalmol. https:\/\/doi.org\/10.1136\/bjophthalmol-2017-310877","journal-title":"Br J Ophthalmol"},{"issue":"9","key":"3702_CR8","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1136\/bjophthalmol-2017-311529","volume":"102","author":"HG Zhang","year":"2018","unstructured":"Zhang HG, Ying GS (2018) Statistical approaches in published ophthalmic clinical science papers: a comparison to statistical practice two decades ago. 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