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Participants with high myopia (spherical equivalent [SE]\u2009\u2264\u2009\u2009\u2212\u20096.0 D) or emmetropia (\u2212 0.5 D\u2009&lt;\u2009SE\u2009&lt;\u2009\u2009+\u20091.0 D) were genotyped for 47 targeted SNPs using the MassARRAY platform. Logistic regression models, adjusting for age and sex, were used to evaluate SNP associations with high myopia. Linkage disequilibrium and haplotype analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with emmetropia, SNPs rs2857656, rs3760396 (\n                      <jats:italic>CCL2<\/jats:italic>\n                      ), rs2317130 (\n                      <jats:italic>TGF\u03b21<\/jats:italic>\n                      ), rs2071230 (\n                      <jats:italic>MMP1<\/jats:italic>\n                      ), rs315952 (\n                      <jats:italic>IL1RN<\/jats:italic>\n                      ), and rs1143627 (\n                      <jats:italic>IL1\u03b2<\/jats:italic>\n                      ) were significantly associated with high myopia. Haplotype analysis identified risk (C\u2013C\u2013T) and protective (G\u2013T, G\u2013T\u2013C) haplotypes in\n                      <jats:italic>CCL2<\/jats:italic>\n                      and\n                      <jats:italic>TGF\u03b21<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that inflammatory gene polymorphisms may contribute to the development of high myopia in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10792-025-03791-0","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T04:44:27Z","timestamp":1761367467000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of inflammatory susceptibility genes with myopia in Chinese children"],"prefix":"10.1007","volume":"45","author":[{"given":"Xuhui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"3791_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1512988","volume":"12","author":"P Chen","year":"2024","unstructured":"Chen P, Ji J, Chen X, Zhang J, Wen X, Liu L (2024) Retinal glia in myopia: current understanding and future directions. 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