{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T19:15:20Z","timestamp":1766171720302,"version":"3.48.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-025-03841-7","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T04:31:50Z","timestamp":1762576310000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence, causative pathogens, risk factors, geographical variations, and outcomes of post-keratoplasty infectious keratitis over the last 15\u00a0years: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"45","author":[{"given":"Asri Salima","family":"Ridwan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikhwanuliman","family":"Putera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alifaturrasyid Syafaatullah","family":"Ridwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina","family":"La Distia Nora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"issue":"195","key":"3841_CR1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ajo.2018.07.040","volume":"1","author":"WB Khor","year":"2018","unstructured":"Khor WB, Prajna VN, Garg P, Mehta JS, Xie L, Liu Z, Padila MDB, Joo CK, Inoue Y, Goseyarakwong P et al (2018) The asia cornea society infectious keratitis study: a prospective multicenter study of infectious keratitis in asia. Am J Ophthalmol 1(195):161\u2013170. https:\/\/doi.org\/10.1016\/j.ajo.2018.07.040","journal-title":"Am J Ophthalmol"},{"issue":"12","key":"3841_CR2","doi-asserted-by":"publisher","first-page":"e1221","DOI":"10.1016\/s2214-109x(17)30393-5","volume":"5","author":"SR Flaxman","year":"2017","unstructured":"Flaxman SR, Bourne RRA, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, Das A, Jonas JB, Keeffe J, Kempen JH et al (2017) Global causes of blindness and distance vision impairment 1990\u20132020: a systematic review and meta-analysis. Lancet Glob Health 5(12):e1221\u2013e1234. https:\/\/doi.org\/10.1016\/s2214-109x(17)30393-5","journal-title":"Lancet Glob Health"},{"issue":"3","key":"3841_CR3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.survophthal.2018.12.003","volume":"64","author":"L Ung","year":"2019","unstructured":"Ung L, Bispo PJM, Shanbhag SS, Gilmore MS, Chodosh J (2019) The persistent dilemma of microbial keratitis: global burden, diagnosis, and antimicrobial resistance. Surv Ophthalmol 64(3):255\u2013271. https:\/\/doi.org\/10.1016\/j.survophthal.2018.12.003","journal-title":"Surv Ophthalmol"},{"issue":"13","key":"3841_CR4","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1001\/jama.2021.0424","volume":"326","author":"ML Durand","year":"2021","unstructured":"Durand ML, Barshak MB, Chodosh J (2021) Infectious keratitis in 2021. JAMA 326(13):1319\u20131320. https:\/\/doi.org\/10.1001\/jama.2021.0424","journal-title":"JAMA"},{"issue":"4","key":"3841_CR5","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1038\/s41433-020-01339-3","volume":"35","author":"DSJ Ting","year":"2021","unstructured":"Ting DSJ, Ho CS, Deshmukh R, Said DG, Dua HS (2021) Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance. Eye 35(4):1084\u20131101. https:\/\/doi.org\/10.1038\/s41433-020-01339-3","journal-title":"Eye"},{"issue":"5","key":"3841_CR6","doi-asserted-by":"publisher","first-page":"104018","DOI":"10.1016\/j.jfo.2023.07.019","volume":"47","author":"EL Erdem","year":"2024","unstructured":"Erdem EL, K\u00f6kta\u015f Z\u00dc, Harbiyeli \u0130\u0130, Atalay E, Kibar F\u0130, Durmaz G, Arslan YK, Seydao\u011flu G\u00dc, Y\u0131ld\u0131r\u0131m N, Ya\u011fmur ME (2024) The effect of climatic and seasonal factors on the microbial keratitis profile. J Fr Ophtalmol 47(5):104018","journal-title":"J Fr Ophtalmol"},{"issue":"6","key":"3841_CR7","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1136\/bjo.2009.169607","volume":"95","author":"A Shah","year":"2011","unstructured":"Shah A, Sachdev A, Coggon D, Hossain P (2011) Geographic variations in microbial keratitis: an analysis of the peer-reviewed literature. Br J Ophthalmol 95(6):762\u2013767. https:\/\/doi.org\/10.1136\/bjo.2009.169607","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"3841_CR8","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1080\/09286580601001347","volume":"14","author":"MJ Bharathi","year":"2007","unstructured":"Bharathi MJ, Ramakrishnan R, Meenakshi R, Padmavathy S, Shivakumar C, Srinivasan M (2007) Microbial keratitis in South India: influence of risk factors, climate, and geographical variation. Ophthalmic Epidemiol 14(2):61\u201369. https:\/\/doi.org\/10.1080\/09286580601001347","journal-title":"Ophthalmic Epidemiol"},{"issue":"3","key":"3841_CR9","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s10792-011-9441-0","volume":"31","author":"AJ Cariello","year":"2011","unstructured":"Cariello AJ, Passos RM, Yu MCZ, Hofling-Lima AL (2011) Microbial keratitis at a referral center in Brazil. Int Ophthalmol 31(3):197\u2013204. https:\/\/doi.org\/10.1007\/s10792-011-9441-0","journal-title":"Int Ophthalmol"},{"key":"3841_CR10","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000015274","author":"RI Barraquer","year":"2019","unstructured":"Barraquer RI, Pareja-Aric\u00f2 L, G\u00f3mez-Benlloch A, Michael R (2019) Risk factors for graft failure after penetrating keratoplasty. Medicine. https:\/\/doi.org\/10.1097\/md.0000000000015274","journal-title":"Medicine"},{"issue":"4","key":"3841_CR11","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1097\/md.0000000000015274","volume":"27","author":"JR Davila","year":"2016","unstructured":"Davila JR, Mian SI (2016) Infectious keratitis after keratoplasty. Curr Opin Ophthalmol 27(4):358\u2013366. https:\/\/doi.org\/10.1097\/md.0000000000015274","journal-title":"Curr Opin Ophthalmol"},{"issue":"7","key":"3841_CR12","doi-asserted-by":"publisher","first-page":"e895","DOI":"10.1111\/aos.14404","volume":"98","author":"N Dohse","year":"2020","unstructured":"Dohse N, Wibbelsman TD, Rapuano SB, Hammersmith KM, Nagra PK, Rapuano CJ, Syed ZA (2020) Microbial keratitis and clinical outcomes following penetrating and endothelial keratoplasty. Acta Ophthalmol 98(7):e895-900. https:\/\/doi.org\/10.1111\/aos.14404","journal-title":"Acta Ophthalmol"},{"issue":"178","key":"3841_CR13","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ajo.2017.03.022","volume":"1","author":"JP Sun","year":"2017","unstructured":"Sun JP, Chen WL, Huang JY, Hou YC, Wang IJ, Hu FR (2017) Microbial keratitis after penetrating keratoplasty. Am J Ophthalmol 1(178):150\u2013156. https:\/\/doi.org\/10.1016\/j.ajo.2017.03.022","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"3841_CR14","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.jtos.2019.08.001","volume":"17","author":"Y Gao","year":"2019","unstructured":"Gao Y, Li C, Bu P, Zhang L, Bouchard CS (2019) Infectious interface keratitis (IIK) following lamellar keratoplasty: a literature review. Ocul Surf 17(4):635\u2013643. https:\/\/doi.org\/10.1016\/j.jtos.2019.08.001","journal-title":"Ocul Surf"},{"key":"3841_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0235233","author":"KY Shin","year":"2020","unstructured":"Shin KY, Lim DH, Han K, Chung TY (2020) Higher incidence of penetrating keratoplasty having effects on repeated keratoplasty in South Korea: a nationwide population-based study. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0235233","journal-title":"PLoS ONE"},{"issue":"12","key":"3841_CR16","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1016\/j.ophtha.2015.08.017","volume":"122","author":"CY Park","year":"2015","unstructured":"Park CY, Lee JK, Gore PK, Lim CY, Chuck RS (2015) Keratoplasty in the United States: A 10\u00a0year review from 2005 through 2014. Ophthalmology 122(12):2432\u20132442. https:\/\/doi.org\/10.1016\/j.ophtha.2015.08.017","journal-title":"Ophthalmology"},{"issue":"11","key":"3841_CR17","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1097\/ico.0000000000003180","volume":"42","author":"G Xiao","year":"2023","unstructured":"Xiao G, Tsou BC, Soiberman US, Prescott CR, Srikumaran D, Woreta FA (2023) Keratoplasty in the United States: trends and indications from 2015 to 2020. Cornea 42(11):1360\u20131364. https:\/\/doi.org\/10.1097\/ico.0000000000003180","journal-title":"Cornea"},{"issue":"34","key":"3841_CR18","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1097\/ICO.0000000000000505","volume":"1","author":"FW Price","year":"2015","unstructured":"Price FW, Feng MT, Price MO (2015) Evolution of endothelial keratoplasty: Where are we headed? Cornea 1(34):S41\u2013S47","journal-title":"Cornea"},{"issue":"4","key":"3841_CR19","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3129\/i09-090","volume":"44","author":"L Rose","year":"2009","unstructured":"Rose L, Kelliher C, Jun AS (2009) Endothelial keratoplasty: historical perspectives, current techniques, future directions. Can J Ophthalmol 44(4):401\u2013405. https:\/\/doi.org\/10.3129\/i09-090","journal-title":"Can J Ophthalmol"},{"key":"3841_CR20","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1136\/bmj.n71","volume":"29","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brenna SE et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 29:372. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"issue":"4","key":"3841_CR21","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/ceo.14354","volume":"52","author":"I Ittah-Cohen","year":"2024","unstructured":"Ittah-Cohen I, Knoeri MJ, Bourcier T, Merabet L, Bouheraoua N, Borderie VM (2024) Infectious keratitis following corneal transplantation: a long-term cohort study. Clin Exp Ophthalmol 52(4):402\u2013415. https:\/\/doi.org\/10.1111\/ceo.14354","journal-title":"Clin Exp Ophthalmol"},{"key":"3841_CR22","doi-asserted-by":"publisher","first-page":"3591","DOI":"10.2147\/opth.s275067","volume":"14","author":"B Griffin","year":"2020","unstructured":"Griffin B, Walkden A, Okonkwo A, Au L, Brahma A, Carley F (2020) Microbial keratitis in corneal transplants: a 12-year analysis. Clin Ophthalmol 14:3591. https:\/\/doi.org\/10.2147\/opth.s275067","journal-title":"Clin Ophthalmol"},{"issue":"4","key":"3841_CR23","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/eye.2017.310","volume":"32","author":"ACO Okonkwo","year":"2018","unstructured":"Okonkwo ACO, Siah WF, Hogg HDJ, Anwar H, Figueiredo FC (2018) Microbial keratitis in corneal grafts: predisposing factors and outcomes. Eye 32(4):775\u2013781. https:\/\/doi.org\/10.1038\/eye.2017.310","journal-title":"Eye"},{"key":"3841_CR24","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000005864","author":"HC Chen","year":"2017","unstructured":"Chen HC, Lee CY, Lin HY, Ma DHK, Chen PYF, Hsiao CH, Yeh LK, Tan HY (2017) Shifting trends in microbial keratitis following penetrating keratoplasty in Taiwan. Medicine. https:\/\/doi.org\/10.1097\/md.0000000000005864","journal-title":"Medicine"},{"issue":"7","key":"3841_CR25","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1097\/ico.0000000000000869","volume":"35","author":"SL Edelstein","year":"2016","unstructured":"Edelstein SL, DeMatteo J, Stoeger CG, MacSai MS, Wang CH (2016) Report of the eye bank association of america medical review subcommittee on adverse reactions reported from 2007 to 2014. Cornea 35(7):917-926A. https:\/\/doi.org\/10.1097\/ico.0000000000000869","journal-title":"Cornea"},{"issue":"2","key":"3841_CR26","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.ajo.2012.07.026","volume":"155","author":"M Constantinou","year":"2013","unstructured":"Constantinou M, Jhanji V, Vajpayee RB (2013) Clinical and microbiological profile of post-penetrating keratoplasty infectious keratitis in failed and clear grafts. Am J Ophthalmol 155(2):233. https:\/\/doi.org\/10.1016\/j.ajo.2012.07.026","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"3841_CR27","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.3390\/jcm11041078","volume":"11","author":"L Pagano","year":"2022","unstructured":"Pagano L, Shah H, Al Ibrahim O, Gadhvi KA, Coco G, Lee JW, Kaye SB, Levis HJ, Hamill KJ, Semeraro F, Romano V (2022) Update on suture techniques in corneal transplantation: a systematic review. J Clin Med 11(4):1078","journal-title":"J Clin Med"},{"issue":"3","key":"3841_CR28","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10792-015-0115-1","volume":"36","author":"L Romero-D\u00edaz de Le\u00f3n","year":"2016","unstructured":"Romero-D\u00edaz de Le\u00f3n L, Morales-Le\u00f3n JE, Ledesma-Gil J, Navas A (2016) Conjunctival and corneal sensitivity in patients under topical antiglaucoma treatment. Int ophthalmol 36(3):299\u2013303","journal-title":"Int ophthalmol"},{"key":"3841_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.10.019","author":"G Martone","year":"2009","unstructured":"Martone G, Frezzotti P, Tosi GM, Traversi C, Mittica V, Malandrini A, Pichierri P, Balestrazzi A, Motolese PA, Motolese I (2009) An in vivo confocal microscopy analysis of effects of topical antiglaucoma therapy with preservative on corneal innervation and morphology. Am J Ophthalmol. https:\/\/doi.org\/10.1016\/j.ajo.2008.10.019","journal-title":"Am J Ophthalmol"},{"key":"3841_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163464","author":"M Nam","year":"2021","unstructured":"Nam M, Kim SW (2021) Changes in corneal epithelial thickness induced by topical antiglaucoma medications. J Clin Med. https:\/\/doi.org\/10.3390\/jcm10163464","journal-title":"J Clin Med"},{"issue":"6","key":"3841_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jcm10061178","volume":"10","author":"KA Knutsson","year":"2021","unstructured":"Knutsson KA, Iovieno A, Matuska S, Fontana L, Rama P (2021) Topical corticosteroids and fungal keratitis: a review of the literature and case series. J Clin Med 10(6):1\u201311. https:\/\/doi.org\/10.3390\/jcm10061178","journal-title":"J Clin Med"},{"key":"3841_CR32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-41588-2","author":"CH Cho","year":"2023","unstructured":"Cho CH, Choi NH, Lee SB (2023) Clinical comparative analysis of culture-proven bacterial keratitis according to prior topical steroid use: a retrospective study in a tertiary referral center of South Korea. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-023-41588-2","journal-title":"Sci Rep"},{"issue":"2","key":"3841_CR33","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3390\/antibiotics11020238","volume":"11","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Cao K, Liu J, Wei Z, Xu X, Liang Q (2022) Pathogens and antibiotic susceptibilities of global bacterial keratitis: a meta-analysis. Antibiotics 11(2):238. https:\/\/doi.org\/10.3390\/antibiotics11020238","journal-title":"Antibiotics"},{"issue":"6","key":"3841_CR34","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1097\/ico.0000000000003102","volume":"42","author":"BM Wong","year":"2023","unstructured":"Wong BM, Bonnet C, Ghaffari R, Houser K, Dematteo J, Lau N et al (2023) Fungal infection after descemet membrane endothelial keratoplasty: incidence and outcomes. Cornea 42(6):687\u2013698. https:\/\/doi.org\/10.1097\/ico.0000000000003102","journal-title":"Cornea"},{"key":"3841_CR35","doi-asserted-by":"publisher","first-page":"707242","DOI":"10.3389\/fmed.2021.707242","volume":"8","author":"A Song","year":"2021","unstructured":"Song A, Deshmukh R, Lin H, Ang M, Mehta JS, Chodosh J, Said DG, Dua HS, Ting DSJ (2021) Post-keratoplasty infectious keratitis: epidemiology, risk factors, management, and outcomes. Front Med 8:707242. https:\/\/doi.org\/10.3389\/fmed.2021.707242","journal-title":"Front Med"},{"issue":"1","key":"3841_CR36","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jcf.2020.12.005","volume":"20","author":"IM Bl","year":"2021","unstructured":"Bl IM (2021) Environmental risks of Pseudomonas aeruginosa-What to advise patients and parents. J Cyst Fibros 20(1):17\u201324. https:\/\/doi.org\/10.1016\/j.jcf.2020.12.005","journal-title":"J Cyst Fibros"},{"issue":"5","key":"3841_CR37","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1167\/iovs.14-13980","volume":"55","author":"SM McClintic","year":"2014","unstructured":"McClintic SM, Prajna NV, Srinivasan M, Mascarenhas J, Lalitha P, Rajaraman R, Oldenburg CE, O\u2019Brien KS, Ray KJ, Acharya NR et al (2014) Visual outcomes in treated bacterial keratitis: 4\u00a0years of prospective follow-up. Invest Ophthalmol Vis Sci 55(5):2935. https:\/\/doi.org\/10.1167\/iovs.14-13980","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"3841_CR38","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1136\/bjo.2004.049072","volume":"89","author":"TKH Butler","year":"2005","unstructured":"Butler TKH, Spencer NA, Chan CCK, Gilhotra JS, McClellan K (2005) Infective keratitis in older patients: a 4\u00a0year review, 1998\u20132002. Br J Ophthalmol 89(5):591. https:\/\/doi.org\/10.1136\/bjo.2004.049072","journal-title":"Br J Ophthalmol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-025-03841-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-025-03841-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-025-03841-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T19:02:08Z","timestamp":1766170928000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-025-03841-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,8]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3841"],"URL":"https:\/\/doi.org\/10.1007\/s10792-025-03841-7","relation":{},"ISSN":["1573-2630"],"issn-type":[{"type":"electronic","value":"1573-2630"}],"subject":[],"published":{"date-parts":[[2025,11,8]]},"assertion":[{"value":"3 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"467"}}