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Inclusion criteria was symptomatic cataract in addition to uncontrolled intraocular pressure (IOP) on\u2009\u2265\u20092 IOP lowering agents or contraindication and\/or intolerance to IOP lowering medication. IOP, medications, safety profile and cumulative success rates were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean IOP was 14.8\u2009\u00b1\u20094.5\u00a0mmHg at 3\u00a0years, compared to 18.3\u2009\u00b1\u20095.8\u00a0mmHg preoperatively, an IOP reduction of 19.1% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The mean number of IOP lowering medications was 1.84\u2009\u00b1\u20091.40 at 3\u00a0years, compared to 2.49\u2009\u00b1\u20091.12 medications preoperatively. At 3\u00a0years 24% of eyes were medication free compared to 3% of eyes preoperatively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). At 3\u00a0years the cumulative probability of eyes achieving complete success; an IOP reduction of\u2009\u2265\u200920% and IOP 6\u201321\u00a0mmHg without medication was 37% and the cumulative probability of achieving this with medication (qualified success) was 67%. No cases of endophthalmitis, hypotony or other sight threatening complications were recorded. 5% of eyes required further glaucoma procedures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This large, real-world cohort demonstrates a significant and sustained IOP reduction with an improvement in medication burden 3\u00a0years after iStent inject\u00ae and phacoemulsification. An excellent safety profile was displayed with a low rate of further glaucoma surgery required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10792-025-03848-0","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:25:57Z","timestamp":1763969157000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long-term effectiveness of the trabecular micro-bypass (iStent): 3-year real world data in glaucoma and ocular hypertension"],"prefix":"10.1007","volume":"46","author":[{"given":"Stafford","family":"Sansome","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ujjwal","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Issa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Gin\u00e9s-Gallego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madalina","family":"Pavel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Abu-Bakra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Trikha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avi","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerassimos","family":"Lascaratos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obeda","family":"Kailani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"3848_CR1","unstructured":"Rawal L, GBD 2019 Blindness Causes Collaborators (2021) Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: The Right to Sight: an analysis for the Global Burden of Disease Study."},{"issue":"11","key":"3848_CR2","first-page":"11686","volume":"12","author":"K Allison","year":"2020","unstructured":"Allison K, Patel D, Alabi O (2020) Epidemiology of glaucoma: the past, present, and predictions for the future. 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