{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T19:14:52Z","timestamp":1766171692699,"version":"3.48.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-025-03867-x","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T05:27:39Z","timestamp":1763184459000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of t-PTK\u2009+\u2009CXL and CXL with mechanical debridement for keratoconus: fellow eye study"],"prefix":"10.1007","volume":"45","author":[{"given":"Burcin","family":"Kepez Yildiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozum","family":"Yucel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf Berk","family":"Akbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Safa","family":"Balci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fevziye","family":"Ondes Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,15]]},"reference":[{"key":"3867_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40662-015-0030-6","volume":"2","author":"L Mastropasqua","year":"2015","unstructured":"Mastropasqua L (2015) Collagen cross-linking: when and how? A review of the state of the art of the technique and new perspectives. Eye Vis 2:1\u201310","journal-title":"Eye Vis"},{"key":"3867_CR2","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","volume":"135","author":"G Wollensak","year":"2003","unstructured":"Wollensak G, Spoerl E, Seiler T (2003) Riboflavin\/ultraviolet-A\u2013induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 135:620\u2013627","journal-title":"Am J Ophthalmol"},{"key":"3867_CR3","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1016\/j.ophtha.2013.01.012","volume":"120","author":"H Hashemi","year":"2013","unstructured":"Hashemi H, Seyedian MA, Miraftab M et al (2013) Corneal collagen cross-linking with riboflavin and ultraviolet a irradiation for keratoconus: long-term results. Ophthalmology 120:1515\u20131520","journal-title":"Ophthalmology"},{"issue":"4","key":"3867_CR4","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.ophtha.2013.10.028","volume":"121","author":"C Wittig-Silva","year":"2014","unstructured":"Wittig-Silva C, Chan E, Islam FM, Wu T, Whiting M, Snibson GR (2014) A randomized, controlled trial of corneal collagen cross-linking in progressive keratoconus: three-year results. Ophthalmology 121(4):812\u2013821. https:\/\/doi.org\/10.1016\/j.ophtha.2013.10.028","journal-title":"Ophthalmology"},{"key":"3867_CR5","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1097\/ICO.0000000000000248","volume":"33","author":"GD Kymionis","year":"2014","unstructured":"Kymionis GD, Grentzelos MA, Liakopoulos DA et al (2014) Long-term follow-up of corneal collagen cross-linking for keratoconus\u2014the Cretan study. Cornea 33:1071\u20131079","journal-title":"Cornea"},{"key":"3867_CR6","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.jcrs.2008.02.002","volume":"34","author":"S Hayes","year":"2008","unstructured":"Hayes S, O\u2019Brart DP, Lamdin LS et al (2008) Effect of complete epithelial debridement before riboflavin\u2013ultraviolet-A corneal collagen crosslinking therapy. J Cataract Refract Surg 34:657\u2013661","journal-title":"J Cataract Refract Surg"},{"key":"3867_CR7","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.jcrs.2008.11.036","volume":"35","author":"G Wollensak","year":"2009","unstructured":"Wollensak G, Iomdina E (2009) Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement. J Cataract Refract Surg 35:540\u2013546","journal-title":"J Cataract Refract Surg"},{"key":"3867_CR8","doi-asserted-by":"publisher","first-page":"444","DOI":"10.3928\/1081597X-20101201-01","volume":"27","author":"V Kaya","year":"2011","unstructured":"Kaya V, Utine CA, Yilmaz OF (2011) Efficacy of corneal collagen cross-linking using a custom epithelial debridement technique in thin corneas: a confocal microscopy study. J Refract Surg 27:444\u2013450","journal-title":"J Refract Surg"},{"key":"3867_CR9","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1016\/j.ophtha.2012.03.038","volume":"119","author":"GD Kymionis","year":"2012","unstructured":"Kymionis GD, Grentzelos MA, Kounis GA et al (2012) Combined transepithelial phototherapeutic keratectomy and corneal collagen cross-linking for progressive keratoconus. Ophthalmology 119:1777\u20131784","journal-title":"Ophthalmology"},{"key":"3867_CR10","doi-asserted-by":"publisher","first-page":"699","DOI":"10.3928\/1081597X-20160712-01","volume":"32","author":"RN Gaster","year":"2016","unstructured":"Gaster RN, Ben Margines J, Gaster DN et al (2016) Comparison of the effect of epithelial removal by transepithelial phototherapeutic keratectomy or manual debridement on cross-linking procedures for progressive keratoconus. J Refract Surg 32:699\u2013704","journal-title":"J Refract Surg"},{"key":"3867_CR11","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1097\/ICO.0000000000000679","volume":"35","author":"M Kapasi","year":"2016","unstructured":"Kapasi M, Dhaliwal A, Mintsioulis G et al (2016) Long-term results of phototherapeutic keratectomy versus mechanical epithelial removal followed by corneal collagen cross-linking for keratoconus. Cornea 35:157\u2013161","journal-title":"Cornea"},{"key":"3867_CR12","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3928\/1081597X-20140120-03","volume":"30","author":"AJ Kanellopoulos","year":"2014","unstructured":"Kanellopoulos AJ, Asimellis G (2014) Keratoconus management: long-term stability of topography-guided normalization combined with high-fluence CXL stabilization (the Athens Protocol). J Refract Surg 30:88\u201393","journal-title":"J Refract Surg"},{"key":"3867_CR13","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/146543","volume":"2010","author":"GD Kymionis","year":"2010","unstructured":"Kymionis GD, Grentzelos MA, Karavitaki AE, Kounis GA, Kontadakis GA, Yoo S, Pallikaris IG (2010) Transepithelial phototherapeutic keratectomy using a 213\u2010nm solid\u2010state laser system followed by corneal collagen cross\u2010linking with riboflavin and UVA irradiation. J Ophthalmol 2010:146543. https:\/\/doi.org\/10.1155\/2010\/146543","journal-title":"J Ophthalmol"},{"key":"3867_CR14","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.jcjo.2012.03.046","volume":"47","author":"M Kapasi","year":"2012","unstructured":"Kapasi M, Baath J, Mintsioulis G et al (2012) Phototherapeutic keratectomy versus mechanical epithelial removal followed by corneal collagen crosslinking for keratoconus. Can J Ophthalmol 47:344\u2013347","journal-title":"Can J Ophthalmol"},{"key":"3867_CR15","doi-asserted-by":"publisher","first-page":"604","DOI":"10.3928\/1081597X-20090610-06","volume":"25","author":"DZ Reinstein","year":"2009","unstructured":"Reinstein DZ, Archer TJ, Gobbe M (2009) Corneal epithelial thickness profile in the diagnosis of keratoconus. J Refract Surg 25:604\u2013610","journal-title":"J Refract Surg"},{"issue":"8","key":"3867_CR16","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1016\/j.jcrs.2014.12.058","volume":"41","author":"N Cagil","year":"2015","unstructured":"Cagil N, Sarac O, Cakmak HB, Can G, Can E (2015) Mechanical epithelial removal followed by corneal collagen crosslinking in progressive keratoconus: short-term complications. J Cataract Refract Surg 41(8):1730\u20131737. https:\/\/doi.org\/10.1016\/j.jcrs.2014.12.058","journal-title":"J Cataract Refract Surg"},{"key":"3867_CR17","doi-asserted-by":"publisher","first-page":"S812","DOI":"10.3928\/1081597X-20090813-10","volume":"25","author":"AJ Kanellopoulos","year":"2009","unstructured":"Kanellopoulos AJ (2009) Comparison of sequential vs same-day simultaneous collagen cross-linking and topography-guided PRK for treatment of keratoconus. J Refract Surg 25:S812\u2013S818","journal-title":"J Refract Surg"},{"issue":"3","key":"3867_CR18","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3928\/1081597X-20220114-03","volume":"38","author":"D Ozdas","year":"2022","unstructured":"Ozdas D, Yesilirmak N, Sarac O, Cagil N (2022) 36-month outcomes of mechanical and transepithelial PTK epithelium removal techniques prior to accelerated CXL for progressive keratoconus. J Refract Surg 38(3):191\u2013200. https:\/\/doi.org\/10.3928\/1081597X-20220114-03","journal-title":"J Refract Surg"},{"issue":"7","key":"3867_CR19","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.jcrs.2018.04.039","volume":"44","author":"O Sarac","year":"2018","unstructured":"Sarac O, Kosekahya P, Caglayan M, Tanriverdi B, Uzel AGT, Cagil N (2018) Mechanical versus transepithelial phototherapeutic keratectomy epithelial removal followed by accelerated corneal crosslinking for pediatric keratoconus: long-term results. J Cataract Refract Surg 44(7):827\u2013835. https:\/\/doi.org\/10.1016\/j.jcrs.2018.04.039","journal-title":"J Cataract Refract Surg"},{"issue":"7","key":"3867_CR20","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3928\/1081597X-20170504-03","volume":"33","author":"X Chen","year":"2017","unstructured":"Chen X, Stojanovic A, Xu Y, Zhou W, Raeder S, Enayati S, Utheim TP (2017) Medium-to long-term results of corneal cross-linking for keratoconus using phototherapeutic keratectomy for epithelial removal and partial stromal ablation. J Refract Surg 33(7):488\u2013495. https:\/\/doi.org\/10.3928\/1081597X-20170504-03","journal-title":"J Refract Surg"},{"issue":"5","key":"3867_CR21","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.ophtha.2012.10.012","volume":"120","author":"GA Kontadakis","year":"2013","unstructured":"Kontadakis GA, Kymionis GD, Kankariya VP, Pallikaris AI (2013) Effect of corneal collagen cross-linking on corneal innervation, corneal sensitivity, and tear function of patients with keratoconus. Ophthalmology 120(5):917\u2013922. https:\/\/doi.org\/10.1016\/j.ophtha.2012.10.012","journal-title":"Ophthalmology"},{"issue":"10","key":"3867_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076333","volume":"8","author":"BL Kolozsv\u00e1ri","year":"2013","unstructured":"Kolozsv\u00e1ri BL, Berta A, Petrovski G, Mih\u00e1ltz K, Gogol\u00e1k P, Rajnav\u00f6lgyi E, Hassan Z, Sz\u00e9les P, Fodor M (2013) Alterations of tear mediators in patients with keratoconus after corneal crosslinking associate with corneal changes. PLoS ONE 8(10):e76333","journal-title":"PLoS ONE"},{"key":"3867_CR23","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12886-025-03968-2","volume":"25","author":"N Taheri","year":"2025","unstructured":"Taheri N, Lotfi Sadigh A, Abed Nikmanesh S et al (2025) Corneal cross-linking effects on ocular surface parameters and corneal topographic and optical characteristics in progressive keratoconus cases: a prospective single-arm study. BMC Ophthalmol 25:141","journal-title":"BMC Ophthalmol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-025-03867-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-025-03867-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-025-03867-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T19:01:47Z","timestamp":1766170907000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-025-03867-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,15]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3867"],"URL":"https:\/\/doi.org\/10.1007\/s10792-025-03867-x","relation":{},"ISSN":["1573-2630"],"issn-type":[{"type":"electronic","value":"1573-2630"}],"subject":[],"published":{"date-parts":[[2025,11,15]]},"assertion":[{"value":"18 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declared no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study obtained the ethical clearance from the University of Health Sciences Cemil Tascioglu Hospital Ethics Committee with the 1964 Helsinki Declaration.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The written informed consent was provided by all subjects in accordance with the principles of the Helsinki Declaration.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"476"}}