{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:10:24Z","timestamp":1792548624402,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the long-term efficacy of corneal crosslinking using the standard protocol (S-CXL) and the accelerated protocol (A-CXL) over a period of 8\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 61 eyes from 61 patients with progressive keratoconus (KC). They were treated with either the S-CXL (3*30, N\u2009=\u200916) or the A-CXL (9*10, N\u2009=\u200945). Visual acuity and corneal parameters, including higher-order aberrations (HOAs), corneal tomography, and corneal densitometry, were recorded prior to the intervention and at four follow-up visits using Scheimpflug tomography. A linear mixed model with Bonferroni correction was used to analyze the longitudinal data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Anterior corneal curvature parameters were significantly reduced in both groups at 3 and 8\u00a0years (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.019). Central and thinnest corneal thickness decreased significantly after 12 and 36\u00a0months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Surface variance and vertical asymmetry indices remained unchanged postoperatively, despite the significant reduction at 8\u00a0years in the A-CXL group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The greatest increase in corneal optical density was observed in both groups at 6\u00a0months in the anterior layer up to a diameter of 10\u00a0mm, which roughly normalized at 12\u00a0months. HOA coma was reduced in both groups at 36 and 96\u00a0months (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.012). In contrast, only the S-CXL group showed a borderline significant improvement in visual acuity after 96\u00a0months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049) which should be interpreted cautiously due to differences in sample size and baseline characteristics. The rate of postoperative complications was comparable in both protocols.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In an 8-year long-term follow-up, both S-CXL and A-CXL successfully halted KC progression. Non-inferiority of the accelerated protocol was demonstrated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10792-025-03919-2","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T05:32:50Z","timestamp":1766554370000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of conventional corneal crosslinking with the accelerated procedure in progressive keratoconus"],"prefix":"10.1007","volume":"46","author":[{"given":"Lisa","family":"Ramm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik Thomas","family":"Trojan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dierk","family":"Wittig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Raiskup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Khoramnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Herber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"3919_CR1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/s0039-6257(97)00119-7","volume":"42","author":"YS Rabinowitz","year":"1998","unstructured":"Rabinowitz YS (1998) Keratoconus. 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