{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:05:08Z","timestamp":1792008308898,"version":"4.4.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-026-03943-w","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:33:22Z","timestamp":1769495602000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and efficacy of contact lens-assisted accelerated corneal cross-linking using Nelfilcon A in thin corneas"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8064-6017","authenticated-orcid":false,"given":"Bora Deniz","family":"Argon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Avc\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"issue":"4","key":"3943_CR1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0039-6257(98)00018-8","volume":"42","author":"YS Rabinowitz","year":"1998","unstructured":"Rabinowitz YS (1998) Keratoconus. Surv Ophthalmol 42(4):297\u2013319. https:\/\/doi.org\/10.1016\/S0039-6257(98)00018-8","journal-title":"Surv Ophthalmol"},{"issue":"7","key":"3943_CR2","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.3390\/jcm11071785","volume":"11","author":"P Napolitano","year":"2022","unstructured":"Napolitano P, Tranfa F, D\u2019Andrea L, Caruso C, Rinaldi M, Mazzucco A, Ciampa N, Melenzane A, Costagliola C (2022) Topographic outcomes in keratoconus surgery: epi-on versus epi-off iontophoresis corneal collagen cross-linking. J Clin Med 11(7):1785. https:\/\/doi.org\/10.3390\/jcm11071785","journal-title":"J Clin Med"},{"issue":"5","key":"3943_CR3","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","volume":"135","author":"G Wollensak","year":"2003","unstructured":"Wollensak G, Spoerl E, Seiler T (2003) Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 135(5):620\u2013627. https:\/\/doi.org\/10.1016\/S0002-9394(02)02220-1","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"3943_CR4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.5005\/jp-journals-10025-1204","volume":"11","author":"C Mazzotta","year":"2025","unstructured":"Mazzotta C, Baiocchi S, De Santi MM, Hosny M, Shaheen MS, Barbara A (2025) In vitro histological analysis of the human cornea undergoing conventional and accelerated cross-linking protocol: from the microscope to clinical application. Int J Keratoconus Ectatic Corneal Dis 11(1):21\u201328. https:\/\/doi.org\/10.5005\/jp-journals-10025-1204","journal-title":"Int J Keratoconus Ectatic Corneal Dis"},{"issue":"6","key":"3943_CR5","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1159\/000074071","volume":"35","author":"G Wollensak","year":"2003","unstructured":"Wollensak G, Sp\u00f6rl E, Reber F, Pillunat L, Funk R (2003) Corneal endothelial cytotoxicity of riboflavin\/UVA treatment in vitro. Ophthalmic Res 35(6):324\u2013328. https:\/\/doi.org\/10.1159\/000074071","journal-title":"Ophthalmic Res"},{"key":"3943_CR6","doi-asserted-by":"publisher","first-page":"28330","DOI":"10.1038\/s41598-024-78516-x","volume":"14","author":"A Stoecker","year":"2024","unstructured":"Stoecker A, Pinkert-Leetsch D, Koch T, Ackermann R, Nolte S, van Oterendorp C, Russmann C, Missbach-Guentner J (2024) Collagen crosslinking-induced corneal morphological changes: a three-dimensional light sheet microscopy-based evaluation. Sci Rep 14:28330. https:\/\/doi.org\/10.1038\/s41598-024-78516-x","journal-title":"Sci Rep"},{"issue":"10","key":"3943_CR7","doi-asserted-by":"publisher","first-page":"3920","DOI":"10.1167\/iovs.18-24656","volume":"59","author":"D Wen","year":"2018","unstructured":"Wen D, Li Q, Song B, Tu R, Wang Q, O\u2019Brart DPS, McAlinden C, Huang J (2018) Comparison of standard versus accelerated corneal collagen cross-linking for keratoconus: a meta-analysis. Invest Ophthalmol Vis Sci 59(10):3920\u20133931. https:\/\/doi.org\/10.1167\/iovs.18-24656","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3943_CR8","doi-asserted-by":"publisher","first-page":"6490915","DOI":"10.1155\/2017\/6490915","volume":"2017","author":"Y Han","year":"2017","unstructured":"Han Y, Xu Y, Zhu W, Liu Y, Liu Z, Dou X, Mu G (2017) Thinner corneas appear to have more striking effects of corneal collagen crosslinking in patients with progressive keratoconus. J Ophthalmol 2017:6490915. https:\/\/doi.org\/10.1155\/2017\/6490915","journal-title":"J Ophthalmol"},{"issue":"10","key":"3943_CR9","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1016\/j.ophtha.2024.05.006","volume":"131","author":"MS Cortina","year":"2024","unstructured":"Cortina MS, Greiner MA, Kuo AN, Li JY, Miller DD, Shtein RM, Veldman PB, Yin J, Kim SJ, Shen JF (2024) Safety and efficacy of epithelium-off corneal collagen cross-linking for the treatment of corneal ectasia: a report by the American Academy of Ophthalmology. Ophthalmology 131(10):1234\u20131242. https:\/\/doi.org\/10.1016\/j.ophtha.2024.05.006","journal-title":"Ophthalmology"},{"issue":"4","key":"3943_CR10","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ophtha.2023.12.038","volume":"131","author":"V Jhanji","year":"2024","unstructured":"Jhanji V, Ahmad S, Amescua G, Cheung AY, Choi DS, Lin A, Mian SI, Rhee MK, Viriya ET, Mah FS, Varu DM, American Academy of Ophthalmology Preferred Practice Pattern Cornea\/External Disease Panel (2024) Corneal ectasia preferred practice pattern. Ophthalmology 131(4):205\u2013246. https:\/\/doi.org\/10.1016\/j.ophtha.2023.12.038","journal-title":"Ophthalmology"},{"issue":"1","key":"3943_CR11","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41433-023-02641-6","volume":"38","author":"H Kandel","year":"2024","unstructured":"Kandel H, Abbondanza M, Gupta A, Mills R, Watson AS, Petsoglou C, Kerdraon Y, Watson SL (2024) Comparison of standard versus accelerated corneal collagen cross-linking for keratoconus: 5-year outcomes from the Save Sight Keratoconus Registry. Eye (Lond) 38(1):95\u2013102. https:\/\/doi.org\/10.1038\/s41433-023-02641-6","journal-title":"Eye (Lond)"},{"issue":"1","key":"3943_CR12","doi-asserted-by":"publisher","first-page":"44","DOI":"10.4103\/tjo.TJO-D-23-00055","volume":"14","author":"A Naranjo","year":"2024","unstructured":"Naranjo A, Manche EE (2024) A comprehensive review on corneal crosslinking. Taiwan J Ophthalmol 14(1):44\u201349. https:\/\/doi.org\/10.4103\/tjo.TJO-D-23-00055","journal-title":"Taiwan J Ophthalmol"},{"key":"3943_CR13","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.2147\/OPTH.S508618","volume":"19","author":"RO Nughays","year":"2025","unstructured":"Nughays RO, Bazayd AS, Alshamekh LA, Alshammari RA, Alanazi MA, Dahlan HY, Alsubhi JA, Alshammri SG, AlQurashi NA, Aldajani AH, Alrammah AH, Alenezi MN, Almutairi AA, Alomayri AF, Alghamdi S (2025) Efficacy and safety of epi-on vs epi-off corneal cross-linking in corneal ectasia: a systematic review and meta-analysis of randomized controlled trials. Clin Ophthalmol 19:1531\u20131541. https:\/\/doi.org\/10.2147\/OPTH.S508618","journal-title":"Clin Ophthalmol"},{"issue":"4","key":"3943_CR14","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.jcrs.2008.10.060","volume":"35","author":"F Hafezi","year":"2009","unstructured":"Hafezi F, Mrochen M, Iseli HP, Seiler T (2009) Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas. J Cataract Refract Surg 35(4):621\u2013624. https:\/\/doi.org\/10.1016\/j.jcrs.2008.10.060","journal-title":"J Cataract Refract Surg"},{"issue":"6","key":"3943_CR15","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3928\/1081597X-20140523-01","volume":"30","author":"S Jacob","year":"2014","unstructured":"Jacob S, Kumar DA, Agarwal A, Basu S, Sinha P, Agarwal A (2014) Contact lens-assisted collagen cross-linking (CACXL): a new technique for cross-linking thin corneas. J Refract Surg 30(6):366\u2013372. https:\/\/doi.org\/10.3928\/1081597X-20140523-01","journal-title":"J Refract Surg"},{"issue":"10","key":"3943_CR16","doi-asserted-by":"publisher","first-page":"642","DOI":"10.3928\/1081597X-20190903-01","volume":"35","author":"B Knyazer","year":"2019","unstructured":"Knyazer B, Kormas RM, Chorny A, Lifshitz T, Achiron A, Mimouni M (2019) Corneal cross-linking in thin corneas: 1-year results of accelerated contact lens-assisted treatment of keratoconus. J Refract Surg 35(10):642\u2013648. https:\/\/doi.org\/10.3928\/1081597X-20190903-01","journal-title":"J Refract Surg"},{"issue":"9","key":"3943_CR17","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1097\/ICL.0000000000000799","volume":"47","author":"MM Nour","year":"2021","unstructured":"Nour MM, El-Agha MH, Sherif AM, Shousha SM (2021) Efficacy and safety of contact lens-assisted corneal crosslinking in the treatment of keratoconus with thin corneas. Eye Contact Lens 47(9):500\u2013504. https:\/\/doi.org\/10.1097\/ICL.0000000000000799","journal-title":"Eye Contact Lens"},{"key":"3943_CR18","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.2147\/OPTH.S37335","volume":"6","author":"L Spadea","year":"2012","unstructured":"Spadea L, Mencucci R (2012) Transepithelial corneal collagen cross-linking in ultrathin keratoconic corneas. Clin Ophthalmol 6:1785\u20131792. https:\/\/doi.org\/10.2147\/OPTH.S37335","journal-title":"Clin Ophthalmol"},{"key":"3943_CR19","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.ajo.2020.12.011","volume":"224","author":"F Hafezi","year":"2021","unstructured":"Hafezi F, Kling S, Gilardoni F, Hafezi N, Hillen M, Abrishamchi R, Gomes JAP, Mazzotta C, Randleman JB, Torres-Netto EA (2021) Individualized corneal cross-linking with riboflavin and UV-A in ultrathin corneas: the Sub400 protocol. Am J Ophthalmol 224:133\u2013142. https:\/\/doi.org\/10.1016\/j.ajo.2020.12.011","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"3943_CR20","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1097\/j.jcrs.0000000000001339","volume":"50","author":"B Cronin","year":"2024","unstructured":"Cronin B, Gunn D, Chang CY (2024) Oxygen-supplemented and topography-guided epithelium-on corneal crosslinking with pulsed irradiation for progressive keratoconus. J Cataract Refract Surg 50(3):209\u2013216. https:\/\/doi.org\/10.1097\/j.jcrs.0000000000001339","journal-title":"J Cataract Refract Surg"},{"issue":"4","key":"3943_CR21","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/ICO.0000000000000408","volume":"34","author":"JA Gomes","year":"2015","unstructured":"Gomes JA, Tan D, Rapuano CJ, Belin MW, Ambr\u00f3sio R Jr, Guell JL, Malecaze F, Nishida K, Sangwan VS, Group of Panelists for the Global Delphi Panel of Keratoconus and Ectatic Diseases (2015) Global consensus on keratoconus and ectatic diseases. Cornea 34(4):359\u2013369. https:\/\/doi.org\/10.1097\/ICO.0000000000000408","journal-title":"Cornea"},{"issue":"5","key":"3943_CR22","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1097\/ICO.0000000000002197","volume":"39","author":"TR Ahmad","year":"2020","unstructured":"Ahmad TR, Pasricha ND, Rose-Nussbaumer J, T Oatts J, M Schallhorn J, Indaram M (2020) Corneal collagen cross-linking under general anesthesia for pediatric patients with keratoconus and developmental delay. Cornea 39(5):546\u2013551. https:\/\/doi.org\/10.1097\/ICO.0000000000002197","journal-title":"Cornea"},{"key":"3943_CR23","unstructured":"CIBA Vision Corporation (2003) Focus\u00ae DAILIES\u00ae (nelfilcon A) One-Day soft contact lenses\u2014510(k) Summary (K033701). U.S. Food and Drug Administration. https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf3\/k033701.pdf Accessed 15 September 2025."},{"issue":"11","key":"3943_CR24","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1097\/OPX.0000000000001796","volume":"98","author":"A Kapfelsberger","year":"2021","unstructured":"Kapfelsberger A, Eckstein J, von Ahrentschildt A, Bischoff J, Marx S, Sickenberger W (2021) Ultraviolet and visible transmittance of soft contact lenses with and without ultraviolet blockers. Optom Vis Sci 98(11):1270\u20131278. https:\/\/doi.org\/10.1097\/OPX.0000000000001796","journal-title":"Optom Vis Sci"},{"issue":"1","key":"3943_CR25","doi-asserted-by":"publisher","first-page":"e84","DOI":"10.1111\/aos.13828","volume":"97","author":"G Wollensak","year":"2019","unstructured":"Wollensak G, Sp\u00f6rl E, Herbst H (2019) Biomechanical efficacy of contact lens-assisted collagen cross-linking in porcine eyes. Acta Ophthalmol 97(1):e84\u2013e90. https:\/\/doi.org\/10.1111\/aos.13828","journal-title":"Acta Ophthalmol"},{"issue":"3","key":"3943_CR26","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.jcrs.2017.02.018","volume":"43","author":"I Gustafsson","year":"2017","unstructured":"Gustafsson I, Cardiakides Myers A, Ivarsen A, Hjortdal J\u00d8 (2017) Retrospective analysis of the effects of using sterile water in addition to hypoosmolar riboflavin during corneal collagen crosslinking for keratoconus. J Cataract Refract Surg 43(3):426\u2013427. https:\/\/doi.org\/10.1016\/j.jcrs.2017.02.018","journal-title":"J Cataract Refract Surg"},{"key":"3943_CR27","doi-asserted-by":"publisher","unstructured":"Gustafsson I, Olafsdottir T, Neumann O, Bizios D, Ivarsen A, Hjortdal J\u00d8. A randomised controlled trial on cross-linking protocols for the treatment of progressive keratoconus using isoosmolar and hypoosmolar riboflavin with the addition of sterile water in thin corneae. Acta Ophthalmol. 2025;Epub ahead of print. https:\/\/doi.org\/10.1111\/aos.17551.","DOI":"10.1111\/aos.17551"},{"key":"3943_CR28","doi-asserted-by":"publisher","first-page":"96","DOI":"10.5005\/jp-journals-10025-1164","volume":"7","author":"C Malhotra","year":"2018","unstructured":"Malhotra C, Ramatchandirane B, Jain AK, Gupta A, Ram J, Dhingra D (2018) Transepithelial collagen cross-linking versus contact lens-assisted collagen cross-linking for progressive keratoconus with borderline corneal thickness: a prospective comparative study. Int J Kerat Ectatic Corneal Dis 7:96\u2013104. https:\/\/doi.org\/10.5005\/jp-journals-10025-1164","journal-title":"Int J Kerat Ectatic Corneal Dis"},{"key":"3943_CR29","doi-asserted-by":"publisher","DOI":"10.1177\/11206721211070915","author":"BS Asena","year":"2022","unstructured":"Asena BS, Kaskaloglu M (2022) The utility of contact lens-assisted corneal cross-linking (CACXL) in progressive keratoconus patients with thin corneas. Eur J Ophthalmol. https:\/\/doi.org\/10.1177\/11206721211070915","journal-title":"Eur J Ophthalmol"},{"issue":"2","key":"3943_CR30","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1097\/j.jcrs.0000000000000732","volume":"48","author":"C Malhotra","year":"2022","unstructured":"Malhotra C, Gupta B, Jain AK, Dhar S, Gupta A, Balyan M (2022) Comparison of contact lens-assisted and transepithelial corneal crosslinking with standard epithelium-off crosslinking for progressive keratoconus: 24-month clinical results. J Cataract Refract Surg 48(2):199\u2013207. https:\/\/doi.org\/10.1097\/j.jcrs.0000000000000732","journal-title":"J Cataract Refract Surg"},{"issue":"9","key":"3943_CR31","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3928\/1081597X-20210609-02","volume":"37","author":"R Matlov Kormas","year":"2021","unstructured":"Matlov Kormas R, Abu Tailakh M, Chorny A, Jacob S, Knyazer B (2021) Accelerated CXL versus accelerated contact lens-assisted CXL for progressive keratoconus in adults. J Refract Surg 37(9):623\u2013630. https:\/\/doi.org\/10.3928\/1081597X-20210609-02","journal-title":"J Refract Surg"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-03943-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-026-03943-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-03943-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:33:25Z","timestamp":1769495605000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-026-03943-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3943"],"URL":"https:\/\/doi.org\/10.1007\/s10792-026-03943-w","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]},"assertion":[{"value":"16 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The research adhered to the principles of the Declaration of Helsinki and was approved by the Ethics Committee of Gaziosmanpasa Training and Research Hospital. Written informed consent was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable; this study contains no identifiable individual data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"73"}}