{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:38:43Z","timestamp":1791509923618,"version":"4.3.4"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Adelaide University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Thyroid eye disease (TED) is an autoimmune-mediated inflammatory condition of the orbit leading to hypertrophy and inflammation of the orbital extra-ocular muscles (EOMs). Previous studies have sought to quantify this enlargement, but due to the anatomical proximity and limitations in imaging quality, have measured the superior rectus (SR) and Levator Palpebrae Superioris (LPS) complex together rather than measuring the individual muscles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>Retrospective manual measurements from high-field (3-Tesla) fat-suppressed contrast-enhanced T1-weighted magnetic resonance imaging (MRI) of the orbits were taken from patients diagnosed with TED. To produce a control group, orbital MRIs were measured from patients being investigated for other non-TED related orbital pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      47 patients were included with TED with 78 orbits measured (L: 42 R: 37). In the control group, 111 patients with 163 orbits measured were included. In the TED cohort the mean ratio of LPS to SR size was 1.04 (SD: 0.53) compared to 0.947 (SD 0.33) in the non-TED cohort with no statistically significant difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.3381). The LPS in the TED cohort had a mean muscle thickness of 2.4\u00a0mm (SD 0.895), which was higher than the non-TED cohort (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) which had a mean thickness of 1.56\u00a0mm (SD 0.36). This study found LPS enlargement occurred in 48.7% of TED orbits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that absolute LPS enlargement is a common finding in TED, occurring in nearly half of affected orbits. This is the first study to individually segment and quantify the extent of enlargement of the LPS relative to the SR using modern medical imaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10792-026-03967-2","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:39:36Z","timestamp":1769495976000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantification of enlargement of the levator palpebrae superioris muscle in thyroid eye disease"],"prefix":"10.1007","volume":"46","author":[{"given":"Lewis","family":"Hains","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khizar","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Almater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Selva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"3967_CR1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1097\/WNO.0000000000000132","volume":"34","author":"SJC Shan","year":"2014","unstructured":"Shan SJC, Douglas RS (2014) The pathophysiology of thyroid eye disease. 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Jpn J Ophthalmol 68:250\u2013258","journal-title":"Jpn J Ophthalmol"},{"key":"3967_CR5","doi-asserted-by":"publisher","first-page":"548","DOI":"10.4103\/tjo.TJO-D-23-00043","volume":"14","author":"SM Young","year":"2024","unstructured":"Young SM, Kim Y-D, Woo KI (2024) Nonsurgical management of upper eyelid retraction in thyroid eye disease. Taiwan J Ophthalmol 14:548\u2013553","journal-title":"Taiwan J Ophthalmol"},{"key":"3967_CR6","doi-asserted-by":"publisher","first-page":"1387217","DOI":"10.3389\/fendo.2024.1387217","volume":"15","author":"D Liu","year":"2024","unstructured":"Liu D, Duan Y, Huang K et al (2024) Assessing the relationship between levator palpebrae superioris and thyroid-associated ophthalmopathy using the Dixon-T2WI sequence. 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Ophthalmic Plast Reconstr Surg 33:35\u201339","journal-title":"Ophthalmic Plast Reconstr Surg"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-03967-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-026-03967-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-03967-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:39:39Z","timestamp":1769495979000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-026-03967-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3967"],"URL":"https:\/\/doi.org\/10.1007\/s10792-026-03967-2","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]},"assertion":[{"value":"7 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors did not receive support from any organization for the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"This study was approved by the Central Adelaide Local Health Network Human Research Ethics Committee (Approval No. 14279). All elements of the Declaration of Helsinki were adhered to during this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Due to the retrospective nature of this study, the requirement for informed individual patient consent was waived.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"76"}}