{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:02:26Z","timestamp":1777982546486,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-026-04008-8","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:10:40Z","timestamp":1773306640000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of optic nerve and macula microvasculature in patients with polycythemia vera using optical coherence tomography angiography"],"prefix":"10.1007","volume":"46","author":[{"given":"Emre","family":"Ekici","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Okka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enver","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"4008_CR1","unstructured":"Lu X, Chang R (2024) Polycythemia vera. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 [updated 2023 Apr 24; cited 2024 Oct 26]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557660\/"},{"issue":"20","key":"4008_CR2","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","volume":"127","author":"DA Arber","year":"2016","unstructured":"Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM et al (2016) The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 127(20):2391\u20132405. https:\/\/doi.org\/10.1182\/blood-2016-03-643544","journal-title":"Blood"},{"issue":"5","key":"4008_CR3","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1055\/s-2008-1027304","volume":"225","author":"MS T\u00f6nz","year":"2008","unstructured":"T\u00f6nz MS, Rigamonti V, Iliev ME (2008) Simultaneous, bilateral anterior ischemic optic neuropathy (AION) in polycythemia vera: a case report. Klin Monatsbl Augenheilkd 225(5):504\u2013506. https:\/\/doi.org\/10.1055\/s-2008-1027304","journal-title":"Klin Monatsbl Augenheilkd"},{"issue":"11","key":"4008_CR4","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1038\/leu.2008.253","volume":"22","author":"R Landolfi","year":"2008","unstructured":"Landolfi R, Di Gennaro L, Falanga A (2008) Thrombosis in myeloproliferative disorders: pathogenetic facts and speculation. Leukemia 22(11):2020\u20132028. https:\/\/doi.org\/10.1038\/leu.2008.253","journal-title":"Leukemia"},{"issue":"3","key":"4008_CR5","doi-asserted-by":"publisher","first-page":"275","DOI":"10.4103\/0974-9233.65493","volume":"17","author":"F Elasri","year":"2010","unstructured":"Elasri F, Souhail H, Reda K, Iferkhass S, Idrissi A, Naoumi A, Oubaaz A (2010) Isolated cilioretinal artery occlusion as an initial manifestation of polycythemia vera. Middle East Afr J Ophthalmol 17(3):275\u2013277. https:\/\/doi.org\/10.4103\/0974-9233.65493","journal-title":"Middle East Afr J Ophthalmol"},{"issue":"7","key":"4008_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102230","volume":"9","author":"G Liew","year":"2014","unstructured":"Liew G, Wang JJ, Rochtchina E, Wong TY, Mitchell P (2014) Complete blood count and retinal vessel calibers. PLoS ONE 9(7):e102230. https:\/\/doi.org\/10.1371\/journal.pone.0102230","journal-title":"PLoS ONE"},{"issue":"5","key":"4008_CR7","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1111\/bjh.12290","volume":"161","author":"HS Yang","year":"2013","unstructured":"Yang HS, Joe SG, Kim JG, Park SH, Ko HS (2013) Delayed choroidal and retinal blood flow in polycythaemia vera patients with transient ocular blindness: a preliminary study with fluorescein angiography. Br J Haematol 161(5):745\u2013747. https:\/\/doi.org\/10.1111\/bjh.12290","journal-title":"Br J Haematol"},{"key":"4008_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-015-0005-8","volume":"1","author":"TE de Carlo","year":"2015","unstructured":"de Carlo TE, Romano A, Waheed NK, Duker JS (2015) A review of optical coherence tomography angiography (OCTA). Int J Retina Vitreous 1:5. https:\/\/doi.org\/10.1186\/s40942-015-0005-8","journal-title":"Int J Retina Vitreous"},{"issue":"3","key":"4008_CR9","doi-asserted-by":"publisher","first-page":"195","DOI":"10.5114\/ms.2020.99541","volume":"36","author":"B P\u0142atkowska","year":"2020","unstructured":"P\u0142atkowska B, Kal M, Biskup M (2020) Optical coherence tomography angiography: use in ophthalmological practice. Med Stud 36(3):195\u2013205. https:\/\/doi.org\/10.5114\/ms.2020.99541","journal-title":"Med Stud"},{"issue":"3","key":"4008_CR10","doi-asserted-by":"publisher","first-page":"152","DOI":"10.5336\/ophthal.2022-88447","volume":"31","author":"M Akdo\u011fan","year":"2022","unstructured":"Akdo\u011fan M, Do\u011fan M, Gobeka HH, \u015eabaner MC, Elizade A, Yava\u015fo\u011flu F (2022) Optical coherence tomography angiographic assessment of polycythaemia vera-related retinal microvascular morphological changes: a cross-sectional case-control study. Turk Klinikleri J Ophthalmol 31(3):152\u2013157. https:\/\/doi.org\/10.5336\/ophthal.2022-88447","journal-title":"Turk Klinikleri J Ophthalmol"},{"issue":"23","key":"4008_CR11","doi-asserted-by":"publisher","first-page":"6212","DOI":"10.1158\/1078-0432.CCR-14-0442","volume":"20","author":"B Hu","year":"2014","unstructured":"Hu B, Yang XR, Xu Y, Sun YF, Sun C, Guo W et al (2014) Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res 20(23):6212\u20136222. https:\/\/doi.org\/10.1158\/1078-0432.CCR-14-0442","journal-title":"Clin Cancer Res"},{"issue":"5","key":"4008_CR12","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1055\/s-2003-44552","volume":"29","author":"HC Kwaan","year":"2003","unstructured":"Kwaan HC, Wang J (2003) Hyperviscosity in polycythemia vera and other red cell abnormalities. Semin Thromb Hemost 29(5):451\u2013458. https:\/\/doi.org\/10.1055\/s-2003-44552","journal-title":"Semin Thromb Hemost"},{"issue":"6","key":"4008_CR13","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1111\/bjh.12461","volume":"162","author":"M Sekhar","year":"2013","unstructured":"Sekhar M, McVinnie K, Burroughs AK (2013) Splanchnic vein thrombosis in myeloproliferative neoplasms. Br J Haematol 162(6):730\u2013747. https:\/\/doi.org\/10.1111\/bjh.12461","journal-title":"Br J Haematol"},{"issue":"3","key":"4008_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60030502","volume":"60","author":"M Kal","year":"2024","unstructured":"Kal M, Brzd\u0119k M, Zar\u0119bska-Michaluk D et al (2024) Optical coherence tomography angiography assessment of the optic nerve head in patients hospitalized due to COVID-19 bilateral pneumonia. Medicina 60(3):502. https:\/\/doi.org\/10.3390\/medicina60030502","journal-title":"Medicina"},{"key":"4008_CR15","doi-asserted-by":"publisher","first-page":"573","DOI":"10.3390\/cancers12030573","volume":"12","author":"C Liisborg","year":"2020","unstructured":"Liisborg C, Hasselbalch HC, S\u00f8rensen TL (2020) Ocular manifestations in patients with Philadelphia-negative myeloproliferative neoplasms. Cancers 12:573. https:\/\/doi.org\/10.3390\/cancers12030573","journal-title":"Cancers"},{"key":"4008_CR16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.4103\/ojo.OJO_110_2014","volume":"10","author":"S Ganesan","year":"2017","unstructured":"Ganesan S, Raman R, Sharma T (2017) Polycythemia causing posterior segment vascular occlusions. Oman J Ophthalmol 10:33\u201335. https:\/\/doi.org\/10.4103\/ojo.OJO_110_2014","journal-title":"Oman J Ophthalmol"},{"key":"4008_CR17","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s10384-008-0640-9","volume":"53","author":"R Krishnan","year":"2009","unstructured":"Krishnan R (2009) Peripheral retinal neovascularization associated with polycythemia rubra vera. Jpn J Ophthalmol 53:188\u2013189. https:\/\/doi.org\/10.1007\/s10384-008-0640-9","journal-title":"Jpn J Ophthalmol"},{"key":"4008_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/srep46396","volume":"7","author":"M Sugahara","year":"2017","unstructured":"Sugahara M, Miyata M, Ishihara K et al (2017) Optical coherence tomography angiography to estimate retinal blood flow in eyes with retinitis pigmentosa. Sci Rep 7:46396. https:\/\/doi.org\/10.1038\/srep46396","journal-title":"Sci Rep"},{"key":"4008_CR19","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1159\/000442806","volume":"56","author":"J Nemiroff","year":"2016","unstructured":"Nemiroff J, Phasukkijwatana N, Sarraf D (2016) Optical coherence tomography angiography of deep capillary ischemia. Dev Ophthalmol 56:139\u2013145. https:\/\/doi.org\/10.1159\/000442806","journal-title":"Dev Ophthalmol"},{"key":"4008_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","volume":"64","author":"RF Spaide","year":"2018","unstructured":"Spaide RF, Fujimoto JG, Waheed NK, Sadda SR, Staurenghi G (2018) Optical coherence tomography angiography. Prog Retin Eye Res 64:1\u201355. https:\/\/doi.org\/10.1016\/j.preteyeres.2017.11.003","journal-title":"Prog Retin Eye Res"},{"issue":"11","key":"4008_CR21","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1097\/IAE.0000000000000859","volume":"35","author":"A Couturier","year":"2015","unstructured":"Couturier A, Man\u00e9 V, Bonnin S, Erginay A, Massin P, Gaudric A, Tadayoni R (2015) Capillary plexus anomalies in diabetic retinopathy on optical coherence tomography angiography. Retina 35(11):2384\u20132391. https:\/\/doi.org\/10.1097\/IAE.0000000000000859","journal-title":"Retina"},{"issue":"11","key":"4008_CR22","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1097\/IAE.0000000000000766","volume":"35","author":"GJ Coscas","year":"2015","unstructured":"Coscas GJ, Lupidi M, Coscas F, Cagini C, Souied EH (2015) Optical coherence tomography angiography versus traditional multimodal imaging in assessing the activity of exudative age-related macular degeneration: a new diagnostic challenge. Retina 35(11):2219\u20132228. https:\/\/doi.org\/10.1097\/IAE.0000000000000766","journal-title":"Retina"},{"issue":"1","key":"4008_CR23","first-page":"11","volume":"27","author":"N Bayraktar Bilen","year":"2022","unstructured":"Bayraktar Bilen N, Aydin MS, Polat G\u00fcltekin B, Da\u011fda\u015f S, Ceran F, Kalayc\u0131 D, \u00d6zet G (2022) Assessment of optic disc and macula of polycythemia vera patients by optical coherence tomography angiography. Firat Med J 27(1):11\u201315","journal-title":"Firat Med J"},{"issue":"Suppl 1","key":"4008_CR24","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1159\/000315155","volume":"224","author":"S Scholl","year":"2010","unstructured":"Scholl S, Kirchhof J, Augustin AJ (2010) Pathophysiology of macular edema. Ophthalmologica 224(Suppl 1):8\u201315. https:\/\/doi.org\/10.1159\/000315155","journal-title":"Ophthalmologica"},{"key":"4008_CR25","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000455265","volume":"58","author":"J Cunha-Vaz","year":"2017","unstructured":"Cunha-Vaz J (2017) Mechanisms of retinal fluid accumulation and blood-retinal barrier breakdown. Dev Ophthalmol 58:11\u201320. https:\/\/doi.org\/10.1159\/000455265","journal-title":"Dev Ophthalmol"},{"issue":"10","key":"4008_CR26","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1182\/blood-2012-10-429134","volume":"121","author":"C Patrono","year":"2013","unstructured":"Patrono C, Rocca B, De Stefano V (2013) Platelet activation and inhibition in polycythemia vera and essential thrombocythemia. Blood 121(10):1701\u20131711. https:\/\/doi.org\/10.1182\/blood-2012-10-429134","journal-title":"Blood"},{"key":"#cr-split#-4008_CR27.1","unstructured":"Kohli P, Tripathy K, Patel BC (2024) Macular edema. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing"},{"key":"#cr-split#-4008_CR27.2","unstructured":"2024 Jan-. [Updated 2024 Apr 24]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK576396\/"},{"issue":"7","key":"4008_CR28","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.oret.2024.12.015","volume":"9","author":"BV Duffy","year":"2025","unstructured":"Duffy BV, Castellanos-Canales D, Decker NL, Lee HJ, Yamaguchi TC, Pearce E, Fawzi AA (2025) Foveal avascular zone enlargement correlates with visual acuity decline in patients with diabetic retinopathy. Ophthalmol Retina 9(7):667\u2013676. https:\/\/doi.org\/10.1016\/j.oret.2024.12.015","journal-title":"Ophthalmol Retina"},{"key":"4008_CR29","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.ajo.2025.09.031","volume":"281","author":"C Chen","year":"2026","unstructured":"Chen C, Nodecker KN, Sastry RM et al (2026) Longitudinal evaluation of microvascular changes and imaging biomarkers associated with visual prognosis in retinal artery occlusion. Am J Ophthalmol 281:312\u2013325. https:\/\/doi.org\/10.1016\/j.ajo.2025.09.031","journal-title":"Am J Ophthalmol"},{"issue":"Suppl 5","key":"4008_CR30","doi-asserted-by":"publisher","first-page":"S863","DOI":"10.4103\/IJO.IJO_1322_24","volume":"72","author":"MF Cicek","year":"2024","unstructured":"Cicek MF, Oba T, Agin A, Ayer M, Onder F (2024) Evaluating the impact of polycythemia vera on retinal and optic nerve head microvascularity: an OCTA study. Indian J Ophthalmol 72(Suppl 5):S863\u2013S869. https:\/\/doi.org\/10.4103\/IJO.IJO_1322_24","journal-title":"Indian J Ophthalmol"},{"key":"4008_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/srep42201","volume":"7","author":"JP Campbell","year":"2017","unstructured":"Campbell JP, Zhang M, Hwang TS, Bailey ST, Wilson DJ, Jia Y, Huang D (2017) Detailed vascular anatomy of the human retina by projection-resolved optical coherence tomography angiography. Sci Rep 7:42201. https:\/\/doi.org\/10.1038\/srep42201","journal-title":"Sci Rep"},{"key":"4008_CR32","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ajo.2015.10.008","volume":"161","author":"F Coscas","year":"2016","unstructured":"Coscas F, Glacet-Bernard A, Miere A, Caillaux V, Uzzan J, Lupidi M, Coscas G, Souied EH (2016) Optical coherence tomography angiography in retinal vein occlusion: evaluation of superficial and deep capillary plexa. Am J Ophthalmol 161:160-171.e2. https:\/\/doi.org\/10.1016\/j.ajo.2015.10.008","journal-title":"Am J Ophthalmol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-04008-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-026-04008-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-04008-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:10:47Z","timestamp":1773306647000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-026-04008-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,12]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4008"],"URL":"https:\/\/doi.org\/10.1007\/s10792-026-04008-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7115530\/v1","asserted-by":"object"}]},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,12]]},"assertion":[{"value":"13 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"154"}}