{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:26:22Z","timestamp":1774509982709,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-026-04052-4","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:13:15Z","timestamp":1774501995000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of vitreoretinal surgery for familial exudative vitreoretinopathy: a systematic review and meta-analysis of the current literature"],"prefix":"10.1007","volume":"46","author":[{"given":"Marwan","family":"Tahoun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kiraly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"Tahoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsveta","family":"Ivanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Bakr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assad","family":"Jalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"issue":"4","key":"4052_CR1","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/0002-9394(69)91237-9","volume":"68","author":"VG Criswick","year":"1969","unstructured":"Criswick VG, Schepens CL (1969) Familial exudative vitreoretinopathy. Am J Ophthalmol 68(4):578\u2013594","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"4052_CR2","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/S0092-8674(04)00216-8","volume":"116","author":"Q Xu","year":"2004","unstructured":"Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C et al (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116(6):883\u2013895","journal-title":"Cell"},{"issue":"12","key":"4052_CR3","doi-asserted-by":"publisher","first-page":"8614","DOI":"10.1167\/iovs.14-15693","volume":"55","author":"A Rattner","year":"2014","unstructured":"Rattner A, Wang Y, Zhou Y, Williams J, Nathans J (2014) The role of the hypoxia response in shaping retinal vascular development in the absence of Norrin\/Frizzled4 signaling. Invest Ophthalmol Vis Sci 55(12):8614\u20138625","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"4052_CR4","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3928\/23258160-20160229-14","volume":"47","author":"A Thanos","year":"2016","unstructured":"Thanos A, Todorich B, Trese MT (2016) A novel approach to understanding pathogenesis and treatment of capillary dropout in retinal vascular diseases. Ophthalmic Surg Lasers Imaging Retina 47(3):288\u2013292","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"issue":"7","key":"4052_CR5","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.4103\/ijo.IJO_2292_21","volume":"70","author":"V Agrawal","year":"2022","unstructured":"Agrawal V, Kalia S (2022) Management and surgical outcomes of pediatric retinal detachment associated with familial exudative vitreoretinopathy: our experience at a tertiary care ophthalmic center in North India. Indian J Ophthalmol 70(7):2490\u20132496","journal-title":"Indian J Ophthalmol"},{"issue":"6","key":"4052_CR6","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/S0161-6420(98)96002-X","volume":"105","author":"SD Pendergast","year":"1998","unstructured":"Pendergast SD, Trese MT (1998) Familial exudative vitreoretinopathy. Results of surgical management. Ophthalmology 105(6):1015\u20131023","journal-title":"Ophthalmology"},{"issue":"3","key":"4052_CR7","first-page":"176","volume":"7","author":"Z Tauqeer","year":"2018","unstructured":"Tauqeer Z, Yonekawa Y (2018) Familial exudative vitreoretinopathy: pathophysiology, diagnosis, and management. Asia Pac J Ophthalmol (Phila) 7(3):176\u2013182","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"issue":"7","key":"4052_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0271326","volume":"17","author":"X Wang","year":"2022","unstructured":"Wang X, Chen J, Xiong H, Yu X (2022) Genotype-phenotype associations in familial exudative vitreoretinopathy: a systematic review and meta-analysis on more than 3200 individuals. PLoS ONE 17(7):e0271326","journal-title":"PLoS ONE"},{"issue":"11","key":"4052_CR9","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1016\/j.ophtha.2014.05.029","volume":"121","author":"AH Kashani","year":"2014","unstructured":"Kashani AH, Brown KT, Chang E, Drenser KA, Capone A, Trese MT (2014) Diversity of retinal vascular anomalies in patients with familial exudative vitreoretinopathy. Ophthalmology 121(11):2220\u20132227","journal-title":"Ophthalmology"},{"issue":"5","key":"4052_CR10","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.ajo.2014.08.009","volume":"158","author":"T Yamane","year":"2014","unstructured":"Yamane T, Yokoi T, Nakayama Y, Nishina S, Azuma N (2014) Surgical outcomes of progressive tractional retinal detachment associated with familial exudative vitreoretinopathy. Am J Ophthalmol 158(5):1049\u20131055","journal-title":"Am J Ophthalmol"},{"key":"4052_CR11","unstructured":"R Foundation for Statistical Computing V, Austria. R Core Team (2021). 2021"},{"issue":"10","key":"4052_CR12","first-page":"2127","volume":"18","author":"ZBT Munn","year":"2020","unstructured":"Munn ZBT, Moola S, Tufanaru C, Stern C, McArthur A, Stephenson M, Aromataris E (2020) Methodological quality of case series studies: an introduction to the JBI critical appraisal tool. JBI Evid Synth. 18(10):2127\u20132133","journal-title":"JBI Evid Synth."},{"issue":"2","key":"4052_CR13","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1097\/IAE.0000000000004686","volume":"46","author":"H Kondo","year":"2026","unstructured":"Kondo H, Matsushita I, Tsurusaki M (2026) excision of extensive subretinal fibrosis associated with rhegmatogenous retinal detachments in patients with familial exudative vitreoretinopathy. Retina 46(2):281\u2013290","journal-title":"Retina"},{"issue":"8","key":"4052_CR14","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.oret.2025.02.018","volume":"9","author":"T Oga","year":"2025","unstructured":"Oga T, Mano F, Kuniyoshi K, Iwahashi C, Kondo H, Kusaka S (2025) Fluorescein angiography may predict surgical outcomes of tractional retinal detachment in familial exudative vitreoretinopathy. Ophthalmol Retina 9(8):739\u2013746","journal-title":"Ophthalmol Retina"},{"issue":"4","key":"4052_CR15","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1097\/IAE.0000000000004346","volume":"45","author":"J Ma","year":"2024","unstructured":"Ma J, Yuan M, Liu J, Li S, Deng G, Li L et al (2024) Surgical outcomes of tractional maculopathy associated with familial exudative vitreoretinopathy in children. Retina 45(4):649\u2013659","journal-title":"Retina"},{"issue":"9","key":"4052_CR16","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1097\/IAE.0000000000004147","volume":"44","author":"H Liu","year":"2024","unstructured":"Liu H, Peng J, Zhang W, Zhang X, Gu V, Yang Y et al (2024) Anatomic outcomes of lens-sparing vitrectomy for stage 3 OR 4 familial exudative vitreoretinopathy. Retina 44(9):1538\u20131545","journal-title":"Retina"},{"issue":"4","key":"4052_CR17","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1097\/IAE.0000000000004005","volume":"44","author":"N Kitic","year":"2024","unstructured":"Kitic N, Chapron T, Metge-Galatoire F, Chehaibou I, Caputo G, Abdelmassih Y (2024) Early-onset of familial exudative vitreoretinopathy: clinical characteristics, management, and outcomes. Retina 44(4):669\u2013679","journal-title":"Retina"},{"issue":"9","key":"4052_CR18","first-page":"886","volume":"41","author":"Y Qiong","year":"2023","unstructured":"Qiong Y, Wenbin W (2023) Efficacy of scleral buckling for retinal detachment secondary to familial exudative vitreoretinopathy. Chin J Exp Ophthalmol. 41(9):886","journal-title":"Chin J Exp Ophthalmol."},{"issue":"1","key":"4052_CR19","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/IAE.0000000000003280","volume":"42","author":"L Huang","year":"2022","unstructured":"Huang L, Liang T, Lyu J, Jin H, Zhao P (2022) Clinical features and surgical outcomes of encircling scleral buckling with cryotherapy in familial exudative vitreoretinopathy-associated rhegmatogenous retinal detachment. Retina 42(1):55\u201363","journal-title":"Retina"},{"issue":"3","key":"4052_CR20","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.jcjo.2019.11.001","volume":"55","author":"P Sen","year":"2020","unstructured":"Sen P, Singh N, Rishi E, Bhende P, Rao C, Rishi P et al (2020) Outcomes of surgery in eyes with familial exudative vitreoretinopathyassociated retinal detachment. Can J Ophthalmol 55(3):253\u2013262","journal-title":"Can J Ophthalmol"},{"issue":"8","key":"4052_CR21","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1007\/s00417-020-04712-w","volume":"258","author":"S El-Khoury","year":"2020","unstructured":"El-Khoury S, Clement A, Chehaibou I, Abdelmassih Y, Edelson C, Metge F et al (2020) Outcome and risk factors of vitreoretinal surgery in pediatric patients with familial exudative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol 258(8):1617\u20131623","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"11","key":"4052_CR22","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1007\/s00417-018-4035-4","volume":"256","author":"J Ma","year":"2018","unstructured":"Ma J, Hu Y, Lu L, Ding X (2018) 25-gauge lens-sparing vitrectomy with dissection of retrolental adhesions on the peripheral retina for familial exudative vitreoretinopathy in infants. Graefes Arch Clin Exp Ophthalmol 256(11):2233\u20132240","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"7","key":"4052_CR23","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.oret.2017.11.003","volume":"2","author":"S Katagiri","year":"2018","unstructured":"Katagiri S, Yokoi T, Yoshida-Uemura T, Nishina S, Azuma N (2018) Characteristics of retinal breaks and surgical outcomes in rhegmatogenous retinal detachment in familial exudative vitreoretinopathy. Ophthalmol Retina 2(7):720\u2013725","journal-title":"Ophthalmol Retina"},{"issue":"7","key":"4052_CR24","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1136\/bjophthalmol-2016-309526","volume":"101","author":"M Hocaoglu","year":"2017","unstructured":"Hocaoglu M, Karacorlu M, Sayman Muslubas I, Ersoz MG, Arf S (2017) Anatomical and functional outcomes following vitrectomy for advanced familial exudative vitreoretinopathy: a single surgeon\u2019s experience. Br J Ophthalmol 101(7):946\u2013950","journal-title":"Br J Ophthalmol"},{"issue":"8","key":"4052_CR25","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1097\/IAE.0000000000000961","volume":"36","author":"P Fei","year":"2016","unstructured":"Fei P, Yang W, Zhang Q, Jin H, Li J, Zhao P (2016) Surgical management of advanced familial exudative vitreoretinopathy with complications. Retina 36(8):1480\u20131485","journal-title":"Retina"},{"issue":"2","key":"4052_CR26","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/IAE.0b013e31821c3ec5","volume":"32","author":"S Chen","year":"2012","unstructured":"Chen S, Hwang J, Lin C (2012) Clinical characteristics and surgical management of familial exudative vitreoretinopathy-associated rhegmatogenous retinal detachment. Retina 32(2):220\u2013225","journal-title":"Retina"},{"issue":"4","key":"4052_CR27","first-page":"323","volume":"51","author":"D Shukla","year":"2003","unstructured":"Shukla D, Singh J, Sudheer G, Soman M, John RK, Ramasamy K et al (2003) Familial exudative vitreoretinopathy (FEVR) clinical profile and management. Indian J Ophthalmol 51(4):323\u2013328","journal-title":"Indian J Ophthalmol"},{"issue":"6","key":"4052_CR28","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/S0161-6420(99)90268-3","volume":"106","author":"T Ikeda","year":"1999","unstructured":"Ikeda T, Fujikado T, Tano Y, Tsujikawa K, Koizumi K, Sawa H et al (1999) Vitrectomy for rhegmatogenous or tractional retinal detachment with familial exudative vitreoretinopathy. Ophthalmology 106(6):1081\u20131085","journal-title":"Ophthalmology"},{"issue":"8","key":"4052_CR29","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1007\/BF00947005","volume":"235","author":"A Shubert","year":"1997","unstructured":"Shubert A, Tasman W (1997) Familial exudative vitreoretinopathy: surgical intervention and visual acuity outcomes. Graefes Arch Clin Exp Ophthalmol 235(8):490\u2013493","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"7","key":"4052_CR30","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1016\/S0161-6420(99)00731-9","volume":"106","author":"IU Scott","year":"1999","unstructured":"Scott IU, Flynn HW Jr., Azen SP, Lai MY, Schwartz S, Trese MT (1999) Silicone oil in the repair of pediatric complex retinal detachments: a prospective, observational, multicenter study. Ophthalmology 106(7):1399\u20131407 (discussion 407-8)","journal-title":"Ophthalmology"},{"issue":"6","key":"4052_CR31","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3928\/01913913-20061101-05","volume":"43","author":"N Kocak","year":"2006","unstructured":"Kocak N, Saatci AO, Ilhan HD, Yaman A, Oner FH, Kaynak S et al (2006) Pediatric silicone oil surgery. J Pediatr Ophthalmol Strabismus 43(6):353\u2013357","journal-title":"J Pediatr Ophthalmol Strabismus"},{"issue":"2","key":"4052_CR32","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s10792-020-01611-1","volume":"41","author":"S Mishra","year":"2021","unstructured":"Mishra S, Wadhwani M, Kumar A, Chauhan R (2021) Outcome of pediatric retinal detachment using high-density silicone oil. Int Ophthalmol 41(2):575\u2013580","journal-title":"Int Ophthalmol"},{"key":"4052_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.850129","volume":"9","author":"J Peng","year":"2022","unstructured":"Peng J, Zhao Z, Zou Y, Zhang X, Yang Y, Huang Q et al (2022) Dry-lensectomy assisted lensectomy in the management for end-stage familial exudative vitreoretinopathy complicated with anterior segment abnormalities. Front Med 9:850129","journal-title":"Front Med"},{"issue":"4","key":"4052_CR34","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/S0002-9394(14)72661-3","volume":"120","author":"LC Glazer","year":"1995","unstructured":"Glazer LC, Maguire A, Blumenkranz MS, Trese MT, Green WR (1995) Improved surgical treatment of familial exudative vitreoretinopathy in children. Am J Ophthalmol 120(4):471\u2013479","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"4052_CR35","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1001\/jamaophthalmol.2023.6198","volume":"142","author":"W Zhang","year":"2024","unstructured":"Zhang W, Liu H, Chen Y, Zhang X, Gu VY, Xiao H et al (2024) Intra-anterior chamber injection of Ranibizumab in advanced pediatric vitreoretinal diseases. JAMA Ophthalmol 142(2):133\u2013139","journal-title":"JAMA Ophthalmol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-04052-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-026-04052-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-04052-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:13:20Z","timestamp":1774502000000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-026-04052-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4052"],"URL":"https:\/\/doi.org\/10.1007\/s10792-026-04052-4","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]},"assertion":[{"value":"20 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors report no conflict of interest in the production of this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"177"}}