{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:14:01Z","timestamp":1778742841622,"version":"3.51.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-026-04098-4","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:04:54Z","timestamp":1778742294000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Corneal epithelial mapping after accelerated corneal cross-linking: early remodeling patterns"],"prefix":"10.1007","volume":"46","author":[{"given":"Suzan Amana","family":"Rattan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayat Abdulkadhim","family":"Jawad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"4098_CR1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.ajo.2016.12.015","volume":"175","author":"DA Godefrooij","year":"2017","unstructured":"Godefrooij DA, de Wit GA, Uiterwaal CS, Imhof SM, Wisse RP (2017) Age-specific incidence and prevalence of keratoconus: a nationwide registration study. Am J Ophthalmol 175:169\u2013172. https:\/\/doi.org\/10.1016\/j.ajo.2016.12.015","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"4098_CR2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1080\/17469899.2018.1555036","volume":"13","author":"M Salom\u00e3o","year":"2018","unstructured":"Salom\u00e3o M, Hoffling-Lima A, Lopes B, Belin M, Sena N, Dawson D, Ambr\u00f3sio R (2018) Recent developments in keratoconus diagnosis. Expert Review of Ophthalmol 13(6):329\u2013341. https:\/\/doi.org\/10.1080\/17469899.2018.1555036","journal-title":"Expert Review of Ophthalmol"},{"issue":"4","key":"4098_CR3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/ICO.0000000000000408","volume":"34","author":"JA Gomes","year":"2015","unstructured":"Gomes JA, Tan D, Rapuano CJ (2015) Global consensus on keratoconus and ectatic diseases. Cornea 34(4):359\u2013369. https:\/\/doi.org\/10.1097\/ICO.0000000000000408","journal-title":"Cornea"},{"key":"4098_CR4","unstructured":"FDA News Release(2015) FDA approves first corneal cross-linking treatment for progressive keratoconus. Available at: https:\/\/www.fda.gov\/news-events\/press-announcements\/"},{"issue":"4","key":"4098_CR5","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.ajo.2008.06.002","volume":"146","author":"C Mazzotta","year":"2008","unstructured":"Mazzotta C, Traversi C, Baiocchi S et al (2008) Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications. Am J Ophthalmol 146(4):527\u2013533. https:\/\/doi.org\/10.1016\/j.ajo.2008.06.002","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"4098_CR6","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.jcrs.2013.09.025","volume":"40","author":"M Tomita","year":"2014","unstructured":"Tomita M, Mita M, Huseynova T (2014) Accelerated versus conventional corneal collagen crosslinking. J Cataract Refract Surg 40(6):1013\u20131020. https:\/\/doi.org\/10.1016\/j.jcrs.2013.09.025","journal-title":"J Cataract Refract Surg"},{"issue":"9","key":"4098_CR7","doi-asserted-by":"publisher","first-page":"S812","DOI":"10.3928\/1081597X-20090813-11","volume":"25","author":"AJ Kanellopoulos","year":"2009","unstructured":"Kanellopoulos AJ (2009) Comparison of sequential vs same-day simultaneous collagen cross-linking and topography-guided PRK for keratoconus: a contralateral eye study. J Refract Surg 25(9):S812\u2013S818. https:\/\/doi.org\/10.3928\/1081597X-20090813-11","journal-title":"J Refract Surg"},{"issue":"12","key":"4098_CR8","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1016\/j.ophtha.2012.07.039","volume":"119","author":"Y Li","year":"2012","unstructured":"Li Y, Tan O, Brass R, Weiss JL, Huang D (2012) Corneal epithelial thickness mapping by Fourier-domain optical coherence tomography in normal and keratoconic eyes. Ophthalmology 119(12):2425\u20132433. https:\/\/doi.org\/10.1016\/j.ophtha.2012.07.039","journal-title":"Ophthalmology"},{"issue":"7","key":"4098_CR9","doi-asserted-by":"publisher","first-page":"604","DOI":"10.3928\/1081597X-20090610-06","volume":"25","author":"DZ Reinstein","year":"2009","unstructured":"Reinstein DZ, Archer TJ, Gobbe M (2009) Corneal epithelial thickness profile in the diagnosis of keratoconus. J Refract Surg 25(7):604\u2013610. https:\/\/doi.org\/10.3928\/1081597X-20090610-06","journal-title":"J Refract Surg"},{"issue":"2","key":"4098_CR10","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.jcrs.2015.09.021","volume":"42","author":"Y Li","year":"2016","unstructured":"Li Y, Chamberlain W, Tan O, Brass R, Weiss JL, Huang D (2016) Subclinical keratoconus detection by pattern analysis of corneal and epithelial thickness maps with optical coherence tomography. J Cataract Refract Surg 42(2):284\u2013295. https:\/\/doi.org\/10.1016\/j.jcrs.2015.09.021","journal-title":"J Cataract Refract Surg"},{"issue":"5","key":"4098_CR11","doi-asserted-by":"publisher","first-page":"324","DOI":"10.3928\/1081597X-20190411-01","volume":"35","author":"R Vinciguerra","year":"2019","unstructured":"Vinciguerra R, Tana F, Rosetta P et al (2019) Corneal epithelial remodeling after transepithelial photorefractive keratectomy in high myopia: a three-dimensional analysis. J Refract Surg 35(5):324\u2013331. https:\/\/doi.org\/10.3928\/1081597X-20190411-01","journal-title":"J Refract Surg"},{"issue":"6","key":"4098_CR12","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1177\/1120672120952034","volume":"30","author":"SA Rattan","year":"2020","unstructured":"Rattan SA, Anwar DS (2020) Comparison of corneal epithelial thickness profile in dry eye patients, keratoconus suspect, and healthy eyes. Eur J Ophthalmol 30(6):1506\u20131511. https:\/\/doi.org\/10.1177\/1120672120952034","journal-title":"Eur J Ophthalmol"},{"issue":"2","key":"4098_CR13","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3928\/1081597X-20140120-08","volume":"30","author":"KM Rocha","year":"2014","unstructured":"Rocha KM, Perez-Straziota CE, Stulting RD, Randleman JB (2014) Epithelial and stromal remodeling after corneal collagen cross-linking evaluated by spectral-domain OCT. J Refract Surg 30(2):122\u2013127. https:\/\/doi.org\/10.3928\/1081597X-20140120-08","journal-title":"J Refract Surg"},{"key":"4098_CR14","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-42634-7_212","volume-title":"Albert and Jakobiec\u2019s Principles and Practice of Ophthalmology","author":"GL Paley","year":"2022","unstructured":"Paley GL, Wagoner MD, Afshari NA, Pineda R, Huang AJW, Kenyon KR (2022) Corneal wound healing, recurrent corneal erosions, and persistent epithelial defects. In: Albert DM, Miller JW, Azar DT, Young LH (eds) Albert and Jakobiec\u2019s Principles and Practice of Ophthalmology. Springer, Cham. https:\/\/doi.org\/10.1007\/978-3-030-42634-7_212"},{"key":"4098_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2023.103728","volume":"43","author":"N Eraslan","year":"2023","unstructured":"Eraslan N, Celikay O (2023) Assessment of corneal sublayer thickness changes in glaucoma patients using optical coherence tomography and correlation of epithelial layer thinning with dry eye monitoring. Photodiagnosis Photodyn Ther 43:103728. https:\/\/doi.org\/10.1016\/j.pdpdt.2023.103728","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"4098_CR16","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ajo.2018.09.008","volume":"197","author":"R Sella","year":"2019","unstructured":"Sella R, Zangwill LM, Weinreb RN, Afshari NA (2019) Repeatability and reproducibility of corneal epithelial thickness mapping with spectral-domain optical coherence tomography in normal and diseased cornea eyes. Am J Ophthalmol 197:88\u201397. https:\/\/doi.org\/10.1016\/j.ajo.2018.09.008","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"4098_CR17","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.jcrs.2017.12.021","volume":"44","author":"ID Haberman","year":"2018","unstructured":"Haberman ID, Lang PZ, Broncano AF, Kim SW, Hafezi F, Randleman JB (2018) Epithelial remodeling after corneal crosslinking using higher fluence and accelerated treatment time. J Cataract Refract Surg 44(3):306\u2013312. https:\/\/doi.org\/10.1016\/j.jcrs.2017.12.021","journal-title":"J Cataract Refract Surg"},{"key":"4098_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/srep32692","volume":"6","author":"X Zhang","year":"2016","unstructured":"Zhang X, Sun L, Chen Y et al (2016) One-year outcomes of pachymetry and epithelium thicknesses after accelerated (45\u2009mW\/cm2) transepithelial corneal collagen cross-linking for keratoconus patients. Sci Rep 6:32692. https:\/\/doi.org\/10.1038\/srep32692","journal-title":"Sci Rep"},{"issue":"8","key":"4098_CR19","doi-asserted-by":"publisher","first-page":"551","DOI":"10.3928\/1081597X-20180702-01","volume":"34","author":"R Atia","year":"2018","unstructured":"Atia R, Jouve L, Sandali O, Laroche L, Borderie V, Bouheraoua N (2018) Early epithelial remodeling after standard and iontophoresis-assisted corneal cross-linking as evaluated by spectral-domain optical coherence tomography. J Refract Surg 34(8):551\u2013558. https:\/\/doi.org\/10.3928\/1081597X-20180702-01","journal-title":"J Refract Surg"},{"issue":"1","key":"4098_CR20","first-page":"74","volume":"12","author":"SA Rattan","year":"2016","unstructured":"Rattan SA (2016) The natural courses of keratometric, pachymetric and visual acuity outcomes during 1year follow up after corneal collagen cross-linking. AL-Kindy Coll Med J 12(1):74\u201378","journal-title":"AL-Kindy Coll Med J"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-04098-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-026-04098-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-04098-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:04:58Z","timestamp":1778742298000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-026-04098-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4098"],"URL":"https:\/\/doi.org\/10.1007\/s10792-026-04098-4","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]},"assertion":[{"value":"6 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"232"}}