{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:53:45Z","timestamp":1781852025665,"version":"3.54.5"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-026-04140-5","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:29:59Z","timestamp":1781850599000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Topical 0.02% tacrolimus as adjunctive immunoprophylaxis in high-risk penetrating keratoplasty: a four-year retrospective study"],"prefix":"10.1007","volume":"46","author":[{"given":"Luis","family":"Izquierdo Jr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norka","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Padr\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Pomatanta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo Raul","family":"Vera-Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Henriquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"4140_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.656998","volume":"8","author":"M Soifer","year":"2021","unstructured":"Soifer M, Mousa HM, Levy RB, Perez VL (2021) Understanding immune responses to surgical transplant procedures in Stevens Johnsons syndrome patients. Front Med 8:656998. https:\/\/doi.org\/10.3389\/fmed.2021.656998","journal-title":"Front Med"},{"key":"4140_CR2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000003807","author":"J Shimazaki","year":"2025","unstructured":"Shimazaki J, Soma T, Yamada K et al (2025) National survey on corneal transplantation in Japan. Cornea. https:\/\/doi.org\/10.1097\/ICO.0000000000003807","journal-title":"Cornea"},{"key":"4140_CR3","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00417-015-3200-2","volume":"254","author":"JP Szaflik","year":"2016","unstructured":"Szaflik JP, Major J, Izdebska J et al (2016) Systemic immunosuppression with mycophenolate mofetil to prevent corneal graft rejection after high-risk penetrating keratoplasty: a 2-year follow-up study. Arbeitsphysiologie 254:307\u2013314. https:\/\/doi.org\/10.1007\/s00417-015-3200-2","journal-title":"Arbeitsphysiologie"},{"key":"4140_CR4","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.survophthal.2016.12.010","volume":"62","author":"A Di Zazzo","year":"2017","unstructured":"Di Zazzo A, Kheirkhah A, Abud TB et al (2017) Management of high-risk corneal transplantation. Surv Ophthalmol 62:816\u2013827. https:\/\/doi.org\/10.1016\/j.survophthal.2016.12.010","journal-title":"Surv Ophthalmol"},{"key":"4140_CR5","doi-asserted-by":"publisher","first-page":"e922","DOI":"10.1111\/aos.14708","volume":"99","author":"A G\u00f3mez-Benlloch","year":"2021","unstructured":"G\u00f3mez-Benlloch A, Montesel A, Pareja-Aric\u00f2 L et al (2021) Causes of corneal transplant failure: a multicentric study. Acta Ophthalmol 99:e922\u2013e928. https:\/\/doi.org\/10.1111\/aos.14708","journal-title":"Acta Ophthalmol"},{"key":"4140_CR6","doi-asserted-by":"publisher","first-page":"10","DOI":"10.5500\/wjt.v6.i1.10","volume":"6","author":"T Yu","year":"2016","unstructured":"Yu T, Rajendran V, Griffith M et al (2016) High-risk corneal allografts: a therapeutic challenge. World J Transplant 6:10\u201327. https:\/\/doi.org\/10.5500\/wjt.v6.i1.10","journal-title":"World J Transplant"},{"key":"4140_CR7","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1016\/j.ophtha.2006.05.022","volume":"113","author":"MO Price","year":"2006","unstructured":"Price MO, Price FW Jr (2006) Efficacy of topical cyclosporine 0.05% for prevention of cornea transplant rejection episodes. Ophthalmology 113:1785\u20131790. https:\/\/doi.org\/10.1016\/j.ophtha.2006.05.022","journal-title":"Ophthalmology"},{"key":"4140_CR8","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1093\/clinchem\/39.11.2219","volume":"39","author":"PE Wallemacq","year":"1993","unstructured":"Wallemacq PE, Reding R (1993) FK506 (tacrolimus), a novel immunosuppressant in organ transplantation: clinical, biomedical, and analytical aspects. Clin Chem 39:2219\u20132228","journal-title":"Clin Chem"},{"key":"4140_CR9","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1038\/s41433-025-04002-x","volume":"39","author":"J Qedair","year":"2025","unstructured":"Qedair J, Bawazir R, Alghamdi S (2025) Efficacy of topical tacrolimus (FK506) in high-risk penetrating keratoplasty: a systematic review and meta-analysis of comparative studies. Eye (Lond) 39:3237\u20133242. https:\/\/doi.org\/10.1038\/s41433-025-04002-x","journal-title":"Eye (Lond)"},{"key":"4140_CR10","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1016\/s0161-6420(01)00759-x","volume":"108","author":"CML Sloper","year":"2001","unstructured":"Sloper CML, Powell RJ, Dua HS (2001) Tacrolimus (FK506) in the management of high-risk corneal and limbal grafts1 1The authors have no proprietary interest in any aspect of this work. Ophthalmology 108:1838\u20131844. https:\/\/doi.org\/10.1016\/s0161-6420(01)00759-x","journal-title":"Ophthalmology"},{"key":"4140_CR11","first-page":"41","volume-title":"Essentials in Ophthalmology","author":"PW Feng","year":"2023","unstructured":"Feng PW, Amescua G (2023) Risk classification and management of corneal grafts, human leukocyte antigen matching, and options for immunosuppression therapy. Essentials in Ophthalmology. Springer International Publishing, Cham, pp 41\u201358"},{"key":"4140_CR12","doi-asserted-by":"publisher","first-page":"251584142514054","DOI":"10.1177\/25158414251405461","volume":"18","author":"PD Lam","year":"2026","unstructured":"Lam PD, Chan JWT, Tsui RWY et al (2026) The evidence-based indications of 0.1% topical tacrolimus in ophthalmology: a scoping review. Ther Adv Ophthalmol 18:25158414251405460. https:\/\/doi.org\/10.1177\/25158414251405461","journal-title":"Ther Adv Ophthalmol"},{"key":"4140_CR13","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1097\/ICO.0b013e3181655f5c","volume":"27","author":"JS Dhaliwal","year":"2008","unstructured":"Dhaliwal JS, Mason BF, Kaufman SC (2008) Long-term use of topical tacrolimus (FK506) in high-risk penetrating keratoplasty. Cornea 27:488\u2013493. https:\/\/doi.org\/10.1097\/ICO.0b013e3181655f5c","journal-title":"Cornea"},{"key":"4140_CR14","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1136\/bjophthalmol-2013-303639","volume":"97","author":"OA Magalhaes","year":"2013","unstructured":"Magalhaes OA, Marinho DR, Kwitko S (2013) Topical 0.03% tacrolimus preventing rejection in high-risk corneal transplantation: a cohort study. Br J Ophthalmol 97:1395\u20131398. https:\/\/doi.org\/10.1136\/bjophthalmol-2013-303639","journal-title":"Br J Ophthalmol"},{"key":"4140_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007603.pub2","author":"M Abudou","year":"2015","unstructured":"Abudou M, Wu T, Evans JR, Chen X (2015) Immunosuppressants for the prophylaxis of corneal graft rejection after penetrating keratoplasty. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD007603.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"4140_CR16","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/01.ico.0000178731.42187.46","volume":"25","author":"JB Randleman","year":"2006","unstructured":"Randleman JB, Stulting RD (2006) Prevention and treatment of corneal graft rejection: current practice patterns (2004). Cornea 25:286\u2013290. https:\/\/doi.org\/10.1097\/01.ico.0000178731.42187.46","journal-title":"Cornea"},{"key":"4140_CR17","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1016\/j.ajo.2005.07.024","volume":"140","author":"DJ Coster","year":"2005","unstructured":"Coster DJ, Williams KA (2005) The impact of corneal allograft rejection on the long-term outcome of corneal transplantation. Am J Ophthalmol 140:1112\u20131122. https:\/\/doi.org\/10.1016\/j.ajo.2005.07.024","journal-title":"Am J Ophthalmol"},{"key":"4140_CR18","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s00417-010-1388-8","volume":"248","author":"R Sinha","year":"2010","unstructured":"Sinha R, Jhanji V, Verma K et al (2010) Efficacy of topical cyclosporine A 2% in prevention of graft rejection in high-risk keratoplasty: a randomized controlled trial. Graefes Arch Clin Exp Ophthalmol 248:1167\u20131172. https:\/\/doi.org\/10.1007\/s00417-010-1388-8","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"4140_CR19","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.82591","volume":"17","author":"A Al Khathami","year":"2025","unstructured":"Al Khathami A, Alamri RA, Garah RA et al (2025) Topical tacrolimus in the management of high-risk keratoplasty: a systematic review and meta-analysis. Cureus 17:e82591. https:\/\/doi.org\/10.7759\/cureus.82591","journal-title":"Cureus"},{"key":"4140_CR20","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1097\/ICO.0000000000002709","volume":"40","author":"K Yu","year":"2021","unstructured":"Yu K, Lian X-F, Jiang X-Y, Zhou S-Y (2021) Efficacy of immunosuppressants in high rejection risk keratoplasty: a meta-analysis of comparative studies. Cornea 40:800\u2013807. https:\/\/doi.org\/10.1097\/ICO.0000000000002709","journal-title":"Cornea"},{"key":"4140_CR21","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1177\/11206721211023320","volume":"32","author":"RE Marques","year":"2022","unstructured":"Marques RE, Leal I, Guerra PS et al (2022) Topical corticosteroids with topical cyclosporine A versus topical corticosteroids alone for immunological corneal graft rejection. Eur J Ophthalmol 32:1469\u20131481. https:\/\/doi.org\/10.1177\/11206721211023320","journal-title":"Eur J Ophthalmol"},{"key":"4140_CR22","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1016\/s0161-6420(94)31138-9","volume":"101","author":"MG Maguire","year":"1994","unstructured":"Maguire MG, Stark WJ, Gottsch JD et al (1994) Risk factors for corneal graft failure and rejection in the collaborative corneal transplantation studies. Ophthalmology 101:1536\u20131547. https:\/\/doi.org\/10.1016\/s0161-6420(94)31138-9","journal-title":"Ophthalmology"},{"key":"4140_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-021-01851-4","author":"H Zhang","year":"2021","unstructured":"Zhang H, Zhao F, Hutchinson C (2021) Ocular surface and Meibomian gland changes after penetrating keratoplasty: a prospective study. BMC Ophthalmol. https:\/\/doi.org\/10.1186\/s12886-021-01851-4","journal-title":"BMC Ophthalmol"},{"key":"4140_CR24","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s40135-017-0119-2","volume":"5","author":"S Jabbehdari","year":"2017","unstructured":"Jabbehdari S, Rafii AB, Yazdanpanah G et al (2017) Update on the management of high-risk penetrating keratoplasty. Curr Ophthalmol Rep 5:38\u201348. https:\/\/doi.org\/10.1007\/s40135-017-0119-2","journal-title":"Curr Ophthalmol Rep"},{"key":"4140_CR25","doi-asserted-by":"publisher","first-page":"S354","DOI":"10.4103\/IJO.IJO_3043_23","volume":"72","author":"D Wu","year":"2024","unstructured":"Wu D, Chan KE, Lim BXH, Lim D-A et al (2024) Management of corneal neovascularization: current and emerging therapeutic approaches. Indian J Ophthalmol 72:S354\u2013S371","journal-title":"Indian J Ophthalmol"},{"key":"4140_CR26","doi-asserted-by":"publisher","first-page":"791954","DOI":"10.3389\/fbioe.2021.791954","volume":"9","author":"X Lin","year":"2021","unstructured":"Lin X, Yu X, Chen X et al (2021) Inhibition of neovascularization and inflammation in a mouse model of corneal alkali burns using cationic liposomal tacrolimus. Front Bioeng Biotechnol 9:791954. https:\/\/doi.org\/10.3389\/fbioe.2021.791954","journal-title":"Front Bioeng Biotechnol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-04140-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-026-04140-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-04140-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:30:00Z","timestamp":1781850600000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-026-04140-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4140"],"URL":"https:\/\/doi.org\/10.1007\/s10792-026-04140-5","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"5 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"265"}}