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All other authors certify that they have no affiliations with or involvement in any organization or entity\nwith any financial interest (such a s honoraria; educational grants; participation in speakers \u2019 bureaus;\nmembership, employment, consultancies, stock ownership, or other equity interest; and expert\ntestimony or patent licensing arrangements), or non financial interest (such as personal or pr ofessional\nrelationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this\nmanuscript.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study adhered to the tenets of the Declaration of Helsinki and was approved by\nthe local ethics committee (\u00c4rztekammer Saarland, No. 166\/24).","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"I nformed consent was obtained from all individual participants included in the\nstudy.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"317"}}