{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:04:20Z","timestamp":1784721860812,"version":"3.55.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100005003","name":"Baskent \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-026-04183-8","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:39:49Z","timestamp":1784720389000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of ocular surface retention of artificial tears by scintigraphy"],"prefix":"10.1007","volume":"46","author":[{"given":"Sena Esra","family":"G\u00fcnay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra Arzu","family":"Gencoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caner","family":"\u0130nceka\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek Dursun","family":"Alt\u0131n\u00f6rs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"issue":"3","key":"4183_CR1","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","volume":"15","author":"F Stapleton","year":"2017","unstructured":"Stapleton F, Alves M, Bunya VY, Jalbert I, Lekhanont K, Malet F et al (2017) TFOS DEWS II epidemiology report. Ocul Surf 15(3):334\u2013365. https:\/\/doi.org\/10.1016\/j.jtos.2017.05.003","journal-title":"Ocul Surf"},{"issue":"3","key":"4183_CR2","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","volume":"15","author":"JP Craig","year":"2017","unstructured":"Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS, Joo CK et al (2017) TFOS DEWS II definition and classification report. Ocul Surf 15(3):276\u2013283. https:\/\/doi.org\/10.1016\/j.jtos.2017.05.008","journal-title":"Ocul Surf"},{"issue":"3","key":"4183_CR3","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","volume":"15","author":"AJ Bron","year":"2017","unstructured":"Bron AJ, de Paiva CS, Chauhan SK, Bonini S, Gabison EE, Jain S et al (2017) TFOS DEWS II pathophysiology report. Ocul Surf 15(3):438\u2013510. https:\/\/doi.org\/10.1016\/j.jtos.2017.05.011","journal-title":"Ocul Surf"},{"issue":"3","key":"4183_CR4","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s40123-023-00877-9","volume":"13","author":"A Ballesteros-S\u00e1nchez","year":"2024","unstructured":"Ballesteros-S\u00e1nchez A, S\u00e1nchez-Gonz\u00e1lez JM, Borrone MA, Borroni D, Rocha-de-Lossada C (2024) The influence of lid-parallel conjunctival folds and conjunctivochalasis on dry eye symptoms with and without contact lens wear: a review of the literature. Ophthalmol Ther 13(3):651\u2013670. https:\/\/doi.org\/10.1007\/s40123-023-00877-9","journal-title":"Ophthalmol Ther"},{"issue":"1","key":"4183_CR5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.4103\/1450-1147.138569.PMID:25191107;PMCID:PMC4149763","volume":"13","author":"ET Detorakis","year":"2014","unstructured":"Detorakis ET, Zissimopoulos A, Ioannakis K, Kozobolis VP (2014) Lacrimal outflow mechanisms and the role of scintigraphy: current trends. World J Nucl Med 13(1):16\u201321. https:\/\/doi.org\/10.4103\/1450-1147.138569.PMID:25191107;PMCID:PMC4149763","journal-title":"World J Nucl Med"},{"issue":"4","key":"4183_CR6","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.jtos.2013.07.003","volume":"11","author":"C Baudouin","year":"2013","unstructured":"Baudouin C, Aragona P, Messmer EM, Tomlinson A, Calonge M, Boboridis KG et al (2013) Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting. Ocul Surf 11(4):246\u2013258. https:\/\/doi.org\/10.1016\/j.jtos.2013.07.003","journal-title":"Ocul Surf"},{"issue":"3","key":"4183_CR7","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.jtos.2017.05.004","volume":"15","author":"JAP Gomes","year":"2017","unstructured":"Gomes JAP, Azar DT, Baudouin C, Efron N, Hirayama M, Horwath-Winter J et al (2017) TFOS DEWS II iatrogenic report. Ocul Surf 15(3):511\u2013538. https:\/\/doi.org\/10.1016\/j.jtos.2017.05.004","journal-title":"Ocul Surf"},{"issue":"12","key":"4183_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11123277","volume":"11","author":"D Borroni","year":"2023","unstructured":"Borroni D, Mazzotta C, Rocha-de-Lossada C, S\u00e1nchez-Gonz\u00e1lez JM, Ballesteros-Sanchez A, Garc\u00eda-Lorente M, Zamorano-Mart\u00edn F, Spinelli A, Schiano-Lomoriello D, Tedesco GR (2023) Dry eye para-inflammation treatment: evaluation of a novel tear substitute containing hyaluronic acid and low-dose hydrocortisone. Biomedicines 11(12):3277. https:\/\/doi.org\/10.3390\/biomedicines11123277","journal-title":"Biomedicines"},{"issue":"2","key":"4183_CR9","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s40123-023-00868-w","volume":"13","author":"A Ballesteros-S\u00e1nchez","year":"2024","unstructured":"Ballesteros-S\u00e1nchez A, S\u00e1nchez-Gonz\u00e1lez JM, Tedesco GR, Rocha-De-Lossada C, Russo F, Spinelli A, Ingrande I, Borroni D (2024) Efficacy and safety of quantum molecular resonance electrotherapy in patients with aqueous-deficient, evaporative and mixed-type dry eye: a randomized interventional study. Ophthalmol Ther 13(2):495\u2013507. https:\/\/doi.org\/10.1007\/s40123-023-00868-w","journal-title":"Ophthalmol Ther"},{"issue":"6","key":"4183_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13061618","volume":"13","author":"A Ballesteros-S\u00e1nchez","year":"2024","unstructured":"Ballesteros-S\u00e1nchez A, S\u00e1nchez-Gonz\u00e1lez JM, Tedesco GR, Rocha-de-Lossada C, Murano G, Spinelli A, Mazzotta C, Borroni D (2024) Evaluating GlicoPro tear substitute derived from Helix aspersa snail mucus in alleviating severe dry eye disease: a first-in-human study on corneal esthesiometry recovery and ocular pain relief. J Clin Med 13(6):1618. https:\/\/doi.org\/10.3390\/jcm13061618","journal-title":"J Clin Med"},{"issue":"5","key":"4183_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11051424","volume":"11","author":"C Garc\u00eda-L\u00f3pez","year":"2022","unstructured":"Garc\u00eda-L\u00f3pez C, G\u00f3mez-Huertas C, S\u00e1nchez-Gonz\u00e1lez JM, Borroni D, Rodr\u00edguez-Calvo-de-Mora M, Romano V, Rachwani-Anil R, Ramos-L\u00f3pez JF, Ortiz-P\u00e9rez S, Rocha-de-Lossada C (2022) Opioids and ocular surface pathology: a literature review of new treatments horizons. J Clin Med 11(5):1424. https:\/\/doi.org\/10.3390\/jcm11051424","journal-title":"J Clin Med"},{"issue":"9","key":"4183_CR12","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1097\/OPX.0000000000002172","volume":"101","author":"T Jia","year":"2024","unstructured":"Jia T, Stapleton F, Iqbal F, Showyin J, Roy D, Roy M et al (2024) Comparison of eye drop retention time using fluorophotometry in three commercially available lubricant eye drops. Optom Vis Sci 101(9):603\u2013607. https:\/\/doi.org\/10.1097\/OPX.0000000000002172","journal-title":"Optom Vis Sci"},{"issue":"Pt 4","key":"4183_CR13","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/eye.1990.83","volume":"4","author":"GR Snibson","year":"1990","unstructured":"Snibson GR, Greaves JL, Soper ND, Prydal JI, Wilson CG, Bron AJ (1990) Precorneal residence times of sodium hyaluronate solutions studied by quantitative gamma scintigraphy. Eye (Lond) 4(Pt 4):594\u2013602. https:\/\/doi.org\/10.1038\/eye.1990.83","journal-title":"Eye (Lond)"},{"issue":"4","key":"4183_CR14","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1097\/00003226-199207000-00003","volume":"11","author":"GR Snibson","year":"1992","unstructured":"Snibson GR, Greaves JL, Soper ND, Tiffany JM, Wilson CG, Bron AJ (1992) Ocular surface residence times of artificial tear solutions. Cornea 11(4):288\u2013293. https:\/\/doi.org\/10.1097\/00003226-199207000-00003","journal-title":"Cornea"},{"issue":"Suppl 1","key":"4183_CR15","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/vop.13065","volume":"26","author":"L Bedos","year":"2023","unstructured":"Bedos L, Allbaugh RA, Roy M, Kubai MA, Sebbag L (2023) Precorneal retention time of ocular lubricants measured with fluorophotometry in healthy dogs. Vet Ophthalmol 26(Suppl 1):81\u201388. https:\/\/doi.org\/10.1111\/vop.13065","journal-title":"Vet Ophthalmol"},{"key":"4183_CR16","doi-asserted-by":"publisher","first-page":"3883","DOI":"10.2147\/OPTH.S428725","volume":"17","author":"S Srinivasan","year":"2023","unstructured":"Srinivasan S, Garofalo R, Williams R (2023) Safe and effective management of dry eye symptoms with hydroxypropyl guar and hyaluronic acid dual-polymer lubricating eye drops: a review of preclinical and clinical studies. Clin Ophthalmol 17:3883\u20133898. https:\/\/doi.org\/10.2147\/OPTH.S428725","journal-title":"Clin Ophthalmol"},{"issue":"13","key":"4183_CR17","first-page":"3670","volume":"55","author":"D Schmidl","year":"2014","unstructured":"Schmidl D, Napora KJ, Werkmeister RM, Rosner P, Garhofer G, Schmetterer L (2014) Effect of lachrymal substitutes on tear film thickness in patients with moderate dry eye syndrome. Invest Ophthalmol Vis Sci 55(13):3670","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4183_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2023.105908","volume":"143","author":"C Guarise","year":"2023","unstructured":"Guarise C, Acquasaliente L, Pasut G, Pavan M, Soato M, Garofolin G et al (2023) The role of high molecular weight hyaluronic acid in mucoadhesion on an ocular surface model. J Mech Behav Biomed Mater 143:105908. https:\/\/doi.org\/10.1016\/j.jmbbm.2023.105908","journal-title":"J Mech Behav Biomed Mater"},{"key":"4183_CR19","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.carbpol.2016.07.106","volume":"153","author":"R Salzillo","year":"2016","unstructured":"Salzillo R, Schiraldi C, Corsuto L, D\u2019Agostino A, Filosa R, De Rosa M et al (2016) Optimization of hyaluronan-based eye drop formulations. Carbohydr Polym 153:275\u2013283. https:\/\/doi.org\/10.1016\/j.carbpol.2016.07.106","journal-title":"Carbohydr Polym"},{"issue":"2","key":"4183_CR20","doi-asserted-by":"publisher","first-page":"670","DOI":"10.22037\/ijpr.2019.1100681","volume":"18","author":"A Mahboubi","year":"2019","unstructured":"Mahboubi A, Gholamreza Alviri M, Afshar M, Farhangi M (2019) Development and validation of a fast, simple and specific stability-indicating RP-HPLC method for determination of dexpanthenol in eye gel formulation. Iran J Pharm Res 18(2):670\u2013676. https:\/\/doi.org\/10.22037\/ijpr.2019.1100681","journal-title":"Iran J Pharm Res"},{"issue":"10","key":"4183_CR21","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.1007\/s10792-023-02751-w","volume":"43","author":"H Sabur","year":"2023","unstructured":"Sabur H, Acar M (2023) Dexpanthenol\/sodium hyaluronate eye drops for corneal epithelial healing following corneal cross-linking in patients with keratoconus. Int Ophthalmol 43(10):3461\u20133469. https:\/\/doi.org\/10.1007\/s10792-023-02751-w","journal-title":"Int Ophthalmol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-04183-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-026-04183-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-04183-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:39:50Z","timestamp":1784720390000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-026-04183-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4183"],"URL":"https:\/\/doi.org\/10.1007\/s10792-026-04183-8","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"assertion":[{"value":"12 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ba\u015fkent University Institutional Review Board and Ethics Committee (Approval No: KA23\/189) with additional approval from the Turkish Medicines and Medical Devices Agency. The study adhered to the Declaration of Helsinki.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from all participants.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"307"}}