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Pre- and postoperative assessments included monocular and binocular uncorrected and distance-corrected visual acuities at 4\u00a0m (UDVA, DCVA), uncorrected and distance-corrected intermediate and near visual acuities at 66\u00a0cm (UI66VA, DCI66VA) and 40\u00a0cm (UNVA, DCNVA), defocus curve, CS, wavefront aberrometry (RMS, PSF, Strehl ratio), halometry, and subjective outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 3\u00a0months, mean\u2009\u00b1\u2009SD monocular DCVA in the dominant eyes (primary endpoint) was 0.06\u2009\u00b1\u20090.13 logMAR. A statistically significant improvement was observed between preoperative and postoperative monocular and binocular UDVA, UNVA, DCNVA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and DCVA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). Binocular DCI66VA and UI66VA were 0.10\u2009\u00b1\u20090.15 and 0.14\u2009\u00b1\u20090.16 logMAR, respectively. The defocus curve was\u2009\u2264\u20090.20 logMAR from\u2009+\u20090.50 D to \u2013\u00a02.00 D. CS peaked under scotopic conditions at 6\u00a0cpd, total ocular RMS improved from 2.15\u2009\u00b1\u20091.98 to 1.09\u2009\u00b1\u20090.77 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09). NEI-RQL-42 scores indicated favourable patient-reported outcomes, particularly for glare, clarity of vision, and satisfaction with correction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this small prospective pilot study, bilateral implantation of a non-diffractive EDOF IOL was associated with favourable short-term visual outcomes in highly selected patients with stable early keratoconus. These preliminary findings suggest that early stable KC may not represent an absolute contraindication to non-diffractive EDOF IOL implantation, but larger comparative studies with longer follow-up are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10792-026-04186-5","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:33:50Z","timestamp":1785821630000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Visual performance of a non-diffractive extended depth of focus IOL in stable early-stage Keratoconus: prospective pilot study"],"prefix":"10.1007","volume":"46","author":[{"given":"Erika","family":"Bonacci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0866-5683","authenticated-orcid":false,"given":"Camilla","family":"Pagnacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Fasolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Barzaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Bonato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismaila","family":"Idrizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Anastasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Pedrotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"issue":"7","key":"4186_CR1","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.ophtha.2019.02.029","volume":"126","author":"AC Ferdi","year":"2019","unstructured":"Ferdi AC, Nguyen V, Gore DM, Allan BD, Rozema JJ, Watson SL (2019) Keratoconus natural progression: a systematic review and meta-analysis of 11 529 eyes. 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