{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:12:19Z","timestamp":1788793939550,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"DOI":"10.1007\/s10792-026-04248-8","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:19:21Z","timestamp":1788747561000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative evaluation of choroidal thickness and vascularity in subclinical keratoconus: a cross-sectional EDI-OCT study"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7100-9107","authenticated-orcid":false,"given":"Hasan","family":"Kiziltoprak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4933-2500","authenticated-orcid":false,"given":"Burak","family":"\u00d6ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5196-0106","authenticated-orcid":false,"given":"Dilara Ozkoyuncu","family":"Kocabas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2241-0233","authenticated-orcid":false,"given":"Esat","family":"Yetkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7461-6129","authenticated-orcid":false,"given":"Kemal","family":"Tekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"issue":"4","key":"4248_CR1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/ICO.0000000000000408","volume":"34","author":"JA Gomes","year":"2015","unstructured":"Gomes JA, Tan D, Rapuano CJ et al (2015) Global consensus on keratoconus and ectatic diseases. Cornea 34(4):359\u2013369","journal-title":"Cornea"},{"issue":"2","key":"4248_CR2","doi-asserted-by":"publisher","first-page":"e35","DOI":"10.1097\/OPX.0000000000000455","volume":"92","author":"CW McMonnies","year":"2015","unstructured":"McMonnies CW (2015) Inflammation and keratoconus. Optom Vis Sci 92(2):e35\u2013e41","journal-title":"Optom Vis Sci"},{"issue":"18","key":"4248_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15182394","volume":"15","author":"D Kazantzis","year":"2025","unstructured":"Kazantzis D, Machairoudia G, Theodossiadis P et al (2025) Macular choroidal thickness in keratoconus: systematic review and meta-analysis of current evidence. Diagnostics (Basel) 15(18):2394","journal-title":"Diagnostics (Basel)"},{"issue":"1","key":"4248_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-024-03753-7","volume":"24","author":"A Mohammadi","year":"2024","unstructured":"Mohammadi A, Masihpour N, Feghhi M et al (2024) Quantifying choroidal and retinal thicknesses variations via optical coherence tomography in different stages of pediatric keratoconus. BMC Ophthalmol 24(1):488","journal-title":"BMC Ophthalmol"},{"key":"4248_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2025.11.004","author":"K Bayat","year":"2025","unstructured":"Bayat K, Pooyan P, Feizi S et al (2025) Structural alterations in the retina and choroid of keratoconus patients detected by optical coherence tomography: a systematic review and meta-analysis. Surv Ophthalmol. https:\/\/doi.org\/10.1016\/j.survophthal.2025.11.004","journal-title":"Surv Ophthalmol"},{"key":"4248_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/srep21090","volume":"6","author":"R Agrawal","year":"2016","unstructured":"Agrawal R, Gupta P, Tan KA et al (2016) Choroidal vascularity index as a measure of vascular status of the choroid: measurements in healthy eyes from a population-based study. Sci Rep 6:21090","journal-title":"Sci Rep"},{"issue":"5","key":"4248_CR7","first-page":"732","volume":"66","author":"M Zhou","year":"2021","unstructured":"Zhou M, Wang W, Huang W et al (2021) Choroidal vascularity index in glaucoma: a review. Surv Ophthalmol 66(5):732\u2013743","journal-title":"Surv Ophthalmol"},{"issue":"1","key":"4248_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77122-x","volume":"10","author":"J Pinheiro-Costa","year":"2020","unstructured":"Pinheiro-Costa J, Correia PJ, Pinto JV et al (2020) Increased choroidal thickness is not a disease progression marker in keratoconus. Sci Rep 10(1):19938","journal-title":"Sci Rep"},{"issue":"9","key":"4248_CR9","doi-asserted-by":"publisher","first-page":"664","DOI":"10.3928\/23258160-20180831-03","volume":"49","author":"S Akkaya","year":"2018","unstructured":"Akkaya S (2018) Macular and peripapillary choroidal thickness in patients with keratoconus. Ophthalmic Surg Lasers Imaging Retina 49(9):664\u2013673","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"issue":"1","key":"4248_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s10792-019-01156-y","volume":"40","author":"B Bilgin","year":"2020","unstructured":"Bilgin B, Karadag AS (2020) Choroidal thickness in keratoconus. Int Ophthalmol 40(1):135\u2013140","journal-title":"Int Ophthalmol"},{"issue":"20","key":"4248_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14202280","volume":"14","author":"N Burguera-Gim\u00e9nez","year":"2024","unstructured":"Burguera-Gim\u00e9nez N, D\u00edez-Ajenjo M\u00aaA, Briceno-Lopez C et al (2024) Relationship between choroidal thickness and anterior scleral thickness in patients with keratoconus. Diagnostics (Basel) 14(20):2280","journal-title":"Diagnostics (Basel)"},{"issue":"1","key":"4248_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-76464-0","volume":"14","author":"J Sadeghi","year":"2024","unstructured":"Sadeghi J, Barooti Y, Gharaei H, Shoeibi N, Sedaghat M, Yazdani N, Abasi Mehrabadi A, Motamed Shariati M (2024) Retinal neurovascular assessment and choroidal vascularity index in patients with keratoconus. Sci Rep 14(1):24986","journal-title":"Sci Rep"},{"issue":"1","key":"4248_CR13","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-024-03323-2","volume":"44","author":"K Gahramanov","year":"2024","unstructured":"Gahramanov K, Unlu M, Ozer F et al (2024) Is there a relationship between the keratoconus and the peripapillary choroidal vasculature? Int Ophthalmol 44(1):404","journal-title":"Int Ophthalmol"},{"issue":"1","key":"4248_CR14","doi-asserted-by":"publisher","first-page":"36","DOI":"10.4103\/joco.joco_189_22","volume":"35","author":"MN Hashemian","year":"2023","unstructured":"Hashemian MN, Ghafarian S, Riazi-Esfahani H et al (2023) Evaluation of choroidal vascularity index in keratoconus patients: does choroidal vascularity change in keratoconus? J Curr Ophthalmol 35(1):36\u201341","journal-title":"J Curr Ophthalmol"},{"key":"4248_CR15","doi-asserted-by":"publisher","first-page":"1682463","DOI":"10.1155\/2020\/1682463","volume":"2020","author":"R Gutierrez-Bonet","year":"2020","unstructured":"Gutierrez-Bonet R, Ruiz-Medrano J, Biarn\u00e9s M et al (2020) Analysis of choroidal vascularity index in keratoconus patients using swept-source optical coherence tomography-based binarization techniques. J Ophthalmol 2020:1682463","journal-title":"J Ophthalmol"},{"issue":"6","key":"4248_CR16","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1007\/s40123-022-00567-y","volume":"11","author":"X Wei","year":"2022","unstructured":"Wei X, Roy R, Saurabh K et al (2022) Optical coherence tomography-based choroidal structural analysis and vascularity index in best vitelliform macular dystrophy. Ophthalmol Ther 11(6):2141\u20132152","journal-title":"Ophthalmol Ther"},{"issue":"9","key":"4248_CR17","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.14.9.31","volume":"14","author":"P Gil","year":"2025","unstructured":"Gil P, Gil JQ, Cruz N et al (2025) Persistent proinflammatory cytokine profile in the tear fluid of stable keratoconus: rethinking clinical quiescence. Transl Vis Sci Technol 14(9):31","journal-title":"Transl Vis Sci Technol"},{"issue":"7","key":"4248_CR18","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/eye.2015.63","volume":"29","author":"V Galvis","year":"2015","unstructured":"Galvis V, Sherwin T, Tello A et al (2015) Keratoconus: an inflammatory disorder? Eye (Lond) 29(7):843\u2013859","journal-title":"Eye (Lond)"},{"issue":"14","key":"4248_CR19","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.10.14.33","volume":"10","author":"W Kongwattananon","year":"2021","unstructured":"Kongwattananon W, Kumar A, Oyeniran E et al (2021) Changes in choroidal vascularity index (CVI) in intermediate uveitis. Transl Vis Sci Technol 10(14):33","journal-title":"Transl Vis Sci Technol"},{"key":"4248_CR20","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jtos.2021.12.004","volume":"23","author":"H Hashemi","year":"2022","unstructured":"Hashemi H, Heirani M, Ambr\u00f3sio R Jr et al (2022) The link between keratoconus and posterior segment parameters: an updated, comprehensive review. Ocul Surf 23:116\u2013122","journal-title":"Ocul Surf"},{"issue":"5","key":"4248_CR21","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1111\/opo.13511","volume":"45","author":"B Sun","year":"2025","unstructured":"Sun B, Xian Y, Yang D et al (2025) Changes in retinal and choroidal thickness and blood density in participants with keratoconus. Ophthalmic Physiol Opt 45(5):1201\u20131210","journal-title":"Ophthalmic Physiol Opt"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-04248-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10792-026-04248-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-026-04248-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:04:21Z","timestamp":1788793461000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10792-026-04248-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4248"],"URL":"https:\/\/doi.org\/10.1007\/s10792-026-04248-8","relation":{},"ISSN":["1573-2630"],"issn-type":[{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,7]]},"assertion":[{"value":"4 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Ankara Numune Training and Research Hospital Clinical Research Ethics Committee granted ethical permission for the study on October 19, 2020, with approval number 16\u20131073-E. The study was carried out in compliance with the Declaration of Helsinki. Written informed consent was obtained from the volunteers.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"375"}}