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Anhedonia also is recognized as a transdiagnostic symptom dimension, but its links to other symptom dimensions are not fully elucidated. Given the high rates of depression and anxiety comorbidity in adolescence, we assessed concurrent and longitudinal associations between anhedonia and anxiety symptoms in adolescents diagnosed with MDD. The sample consisted of 157 adolescents with MDD (\n                    <jats:italic>M<\/jats:italic>\n                    <jats:sub>age<\/jats:sub>\n                    = 15.54, 71.34% female) who were followed for several years in a research context involving longitudinal observation and, for a portion of the sample, treatment. Participants regularly completed self-report measures of anhedonia and anxiety symptoms across time. Data were analyzed using multilevel modeling to examine within-person concurrent and temporally lagged effects. Findings indicated that anhedonia was concurrently associated with both social anxiety and generalized anxiety symptoms. Additionally, anhedonia predicted\n                    <jats:italic>only<\/jats:italic>\n                    social anxiety symptoms over time\u2014such that anhedonia at the previous time point predicted subsequent social anxiety but not generalized anxiety. However, neither social anxiety nor generalized anxiety predicted anhedonia temporally. These results suggest that anhedonia may be one driver of comorbid\n                    <jats:italic>social<\/jats:italic>\n                    anxiety symptoms in adolescents with MDD. Putative mechanistic links warrant further investigation, including during transdiagnostic treatments for emotional disorders in adolescents. We highlight avenues for future research and intervention in adolescent MDD.\n                  <\/jats:p>","DOI":"10.1007\/s10802-025-01362-6","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:37:01Z","timestamp":1756280221000},"page":"1595-1610","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Temporal Predictions from Anhedonia To Anxiety in Adolescents with Major Depressive Disorder"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9948-3632","authenticated-orcid":false,"given":"Yannie D.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Towbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-9516","authenticated-orcid":false,"given":"Daniel S.","family":"Pine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-8377","authenticated-orcid":false,"given":"Argyris","family":"Stringaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-5584","authenticated-orcid":false,"given":"Katharina","family":"Kircanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"1362_CR1","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jad.2016.07.031","volume":"206","author":"GC Adams","year":"2016","unstructured":"Adams, G. 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Recruitment began in December of 2018 and is ongoing. Participants were recruited from a metropolitan region and identified through locally distributed postcards aimed at identifying adolescents exhibiting symptoms of MDD.\" to \"Data for the present study was collected as part of the Characterization and Treatment of Depression (CAT-D) study at the National Institute of Mental Health (NIMH), a longitudinal cohort study focused on the characterization and treatment of depression in adolescents (Sadeghi et al., 2022; CAT-D data openly available at https:\/\/github.com\/transatlantic-comppsych\/CATD-study). The cohort encompassed both adolescents with depression and nonpatient controls, monitoring their development and progress over the span of several years. Recruitment began in December of 2018. Participants were recruited primarily from the Washington metropolitan region, identified through locally distributed postcards aimed at identifying adolescents exhibiting symptoms of MDD.\". The update has been made due to unblinded data in the affected sentences.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2025","order":7,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":8,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10802-025-01384-0","URL":"https:\/\/doi.org\/10.1007\/s10802-025-01384-0","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All research procedures were approved by the Institutional Review Board (IRB) at the National Institute of Mental Health (NIMH).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}